A novel hybrid adenoretroviral vector with more extensive E3 deletion extends transgene expression in submandibular glands

Human Gene Therapy Methods

Volumn 23, Issue 3, 2012, Pages 169-181

  Zheng, Changyu ^a   Cotrim, Ana P ^a   Nikolov, Nikolay ^a   Mineshiba, Fumi ^a,b   Swaim, William ^a   Baum, Bruce J ^a  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^b OKAYAMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; CHEMOKINE; CYTOKINE; ELONGATION FACTOR 1ALPHA; ENDOTOXIN; ERYTHROPOIETIN; HYBRID PROTEIN; N (4 METHOXYPHENYLACETYL)DEHYDROALANINE; RETROVIRUS VECTOR; ELONGATION FACTOR 1; PRIMER DNA;

ACINAR CELL; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CANNULATION; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DNA INTEGRATION; EPITHELIUM CELL; GENE DELETION; GENE EXPRESSION; GENETIC TRANSDUCTION; GENOMICS; HEMATOCRIT; HYBRID; IMMUNE RESPONSE; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN VIVO STUDY; INFLAMMATORY INFILTRATE; LONG TERMINAL REPEAT; MALE; MOLONEY LEUKEMIA ONCOVIRUS; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RAT; SALIVARY GLAND; SUBMANDIBULAR GLAND; TRANSGENE; VIRAL GENE DELIVERY SYSTEM; ADENOVIRUS; ANIMAL; BLOOD; CELL CULTURE; EVALUATION; FLUORESCENT ANTIBODY TECHNIQUE; GENE THERAPY; GENE TRANSFER; GENE VECTOR; GENETICS; HUMAN; METABOLISM; METHODOLOGY; ULTRACENTRIFUGATION; WISTAR RAT;

ADENOVIRIDAE; ANIMALS; CELLS, CULTURED; DNA PRIMERS; ERYTHROPOIETIN; FLUORESCENT ANTIBODY TECHNIQUE; GENE TRANSFER TECHNIQUES; GENETIC THERAPY; GENETIC VECTORS; HEMATOCRIT; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; PEPTIDE ELONGATION FACTOR 1; POLYMERASE CHAIN REACTION; RATS; RATS, WISTAR; SUBMANDIBULAR GLAND; TRANSGENES; ULTRACENTRIFUGATION;

EID: 84872049797     PISSN: 19466536     EISSN: 19466544     Source Type: Journal    
DOI: 10.1089/hgtb.2011.175     Document Type: Article

References (62)

1. Adesanya, M.R., Redman, R.S., Baum, B.J., et al. (1996). Immediate inflammatory responses to adenovirus-mediated gene transfer in rat salivary glands. Hum. Gene Ther. 7, 1085-1093. (Pubitemid 26202726)
2. Amalfitano, A., and Chamberlain, J.S. (1997). Isolation and characterization of packaging cell lines that coexpress the adenovirus E1, DNA polymerase, and preterminal proteins: implications for gene therapy. Gene Ther. 4, 258-263. (Pubitemid 27182080)
3. Basagoudanavar, S.H., Goswami, P.P., and Tiwari, V. (2006). Cellular immune responses to 35 kDa recombinant antigen of mycobacterium avium paratuberculosis. Vet. Res. Commun. 30, 357-367.
4. Baum, B.J., Berkman, M.E., Marmary, Y., et al. (1999). Polarized secretion of transgene products from salivary glands in vivo. Hum. Gene Ther. 10, 2789-2797.
5. Baum, B.J., Wellner, R.B., and Zheng, C. (2002). Gene transfer to salivary glands. Int. Rev. Cytol. 213, 93-146. (Pubitemid 34112917)
6. Baum, B.J., Voutetakis,A., andWang, J. (2004). Salivary glands: novel target sites for gene therapeutics. TrendsMol.Med. 10, 585-590. (Pubitemid 39573149)
7. Baum, B.J., Zheng, C., Cotrim, A.P., et al. (2009). Aquaporin-1 gene transfer to correct radiation-induced salivary hypofunction. Handb. Exp. Pharmacol. 190, 403-418.
8. Baum, B.J., Adriaansen, J., Cotrim, A.P., et al. (2010). Gene therapy of salivary diseases. Methods Mol. Biol. 666, 3-20.
9. Baum, C., Kustikova, O., Modlich, U., et al. (2006). Mutagenesis and oncogenesis by chromosomal insertion of gene transfer vectors. Hum. Gene Ther. 17, 253-263.
10. Bett, A.J., Haddara, W., Prevec, L., et al. (1994). An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3. Proc. Natl. Acad. Sci. U.S.A. 91, 8802-8806.
11. Bett, A.J., Krougliak, V., and Graham, F.L. (1995). DNA sequence of the deletion/insertion in early region 3 of Ad5 dl309. Virus Res. 39, 75-82.
12. Chen, C.J., Kono, H., Golenbock, D., et al. (2007). Identification of a key pathway required for the sterile inflammatory response triggered by dying cells. Nat. Med. 13, 851-856. (Pubitemid 47038190)
13. Delporte, C., O'Connell, B.C., He, X., et al. (1997). Increased fluid secretion after adenoviral-mediated transfer of the aquaporin-1 cDNA to irradiated rat salivary glands. Proc. Natl. Acad. Sci. U.S.A. 94, 3268-3273. (Pubitemid 27157300)
14. Efrat, S., Serreze, D., Svetlanov, A., et al. (2001). Adenovirus early region 3 (E3) immunomodulatory genes decrease the incidence of autoimmune diabetes in NOD mice. Diabetes. 50, 980-984. (Pubitemid 32374527)
15. Foged, C., and Sundblad, A. (2008). Immune reactions towards biopharmaceuticals-a general mechanistic overview. In Immunogenicity of Biopharmaceuticals. M. van de Weert and E.H. Moller, eds. (Springer, New York, NY) pp. 1-26.
16. Friedman, J.M., and Horwitz, M.S. (2002). Inhibition of tumor necrosis factor alpha-induced NF-jB activation by the adenovirus E3-10.4/14.5K complex. J. Virol. 76, 5515-5521. (Pubitemid 34517901)
17. Gantzer, M., Spitz, E., Accard, N., et al. (2002). Constitutive expression of the adenovirus E3-14.7K protein does not prolong adenovirus vector DNA persistence but protects mice against lipopolysaccharide-induced acute hepatitis. Hum. Gene Ther. 13, 921-933. (Pubitemid 34539369)
18. Gao, R., Yan, X., Zheng, C., et al. (2011). AAV2-mediated transfer of the human aquaporin-1 cDNA restores fluid secretion from irradiated miniature pig parotid glands. Gene Ther. 18, 38-42.
19. Greber, U.F., Webster, P., Weber, J., et al. (1996). The role of the adenovirus protease on virus entry into cells. EMBO J. 15, 1766-1777. (Pubitemid 26119212)
20. Greber, U.F., Suomalainen, M., Stidwill, R.P., et al. (1997). The role of the nuclear pore complex in adenovirus DNA entry. EMBO J. 16, 5998-6007. (Pubitemid 27427295)
21. Hacein-Bey-Abina, S., Von Kalle, C., Schmidt, M., et al. (2003). LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science 302, 415-419. (Pubitemid 37296260)
22. Harel, J., Rassart, E., and Jolicoeur, P. (1981). Cell cycle dependence of synthesis of unintegrated viral DNA in mouse cells newly infected with murine leukemia virus. Virology 110, 202-207. (Pubitemid 11056892)
23. Harui, A., Suzuki, S., Kochanek, S., et al. (1999). Frequency and stability of chromosomal integration of adenovirus vectors. J. Virol. 73, 6141-6146. (Pubitemid 29274908)
24. Hirt, B. (1967). Mouse cellular DNA enclosed in polyoma viral capsids (pseudovirions). Proc. Natl. Acad. Sci. U.S.A. 58, 1381-1388.
25. Hori, S., Haury, M., and Coutinho, A., et al. (2002). Specificity requirements for selection and effector functions of CD25+4 + regulatory T cells in anti-myelin basic protein T cell receptor transgenic mice. Proc. Natl. Acad. Sci. U.S.A. 99, 8213-8218. (Pubitemid 34651032)
26. Horwitz, M.S. (2004). Function of adenovirus E3 proteins and their interactions with immunoregulatory cell proteins. J. Gene Med. 6, s172-s183. (Pubitemid 40228026)
27. Human adenovirus C serotype 5, complete genome. GeneBank: AY339865. http://www.ncbi.nlm.nih.gov/nuccore/AY339865; 2007.
28. Ilan, Y., Droguett, G., Chowdhury, N.R., et al. (1997). Insertion of the adenoviral E3 region into a recombinant viral vector prevents antiviral humoral and cellular immune responses and permits long-term gene expression. Proc. Natl. Acad. Sci. U.S.A. 94, 2587-2592.
29. Jooss, K., and Chirmule, N. (2003). Immunity to adenovirus and adeno-associated viral vectors: implications for gene therapy. Gene Ther. 10, 955-963. (Pubitemid 36722430)
30. Kagami, H., Atkinson, J.C., Michalek, S.M., et al. (1998). Repetitive adenovirus administration to the parotid gland: role of immunological barriers and induction of oral tolerance. Hum. Gene Ther. 9, 305-313. (Pubitemid 28085018)
31. Katano, H., Kok, M.R., Cotrim, A.P., et al. (2006). Enhanced transduction of mouse salivary glands with AAV5-based vectors. Gene Ther. 13, 594-601.
32. Kruisbeek, A.M. (1997). In vitro assays for mouse lymphocyte function. In Current Protocols in Immunology. J.E. Coligan, A.M. Kruisbeek, D.H. Margulies, E.M. Shevach, W. Strober, and R. Coico, eds. ( John Wiley & Sons, Inc, Hoboken, NJ) pp. 3.12.1-3.12.14.
33. Lesokhin, A.M., Delgado-Lopez, F., and Horwitz, M.S. (2002). Inhibition of chemokine expression by adenovirus early region three (E3) genes. J. Virol. 76, 8236-8243. (Pubitemid 34809078)
34. Lichtenstein, D.L., Toth, K., Doronin, K., et al. (2004a). Functions and mechanisms of action of the adenovirus E3 proteins. Int. Rev. Immunol. 23, 75-111. (Pubitemid 38121748)
35. Lichtenstein, D.L., Doronin, K., Toth, K., et al. (2004b). Adenovirus E3-6.7K protein is required in conjunction with the E3-RID protein complex for the internalization and degradation of TRAIL receptor 2. J. Virol. 78, 12297-12307. (Pubitemid 39458749)
36. Lipson, S.M., Poshni, I.A., Ashley, R.L., et al. (1993). Presumptive identification of common adenovirus serotypes by the development of differential cytopathic effects in the human lung carcinoma (A549) cell culture. FEMS Microbiol. Lett. 113, 175-182. (Pubitemid 23316265)
37. Miller, D.G., Adam, M.A., and Miller, A.D. (1990). Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection. Mol. Cell. Biol. 10, 4239-4242.
38. Murphy, K., Janeway, C.A., Travers, P., et al. (2011). An introduction to immunobiology and innate immunity. In Janeway's Immunobiology. K. Murphy, ed. (Garland Science, New York, NY) pp. 1-98.
39. O'Connell, B.C., Xu, T., Walsh, T.J., et al. (1996). Transfer of a gene encoding the anticandidal protein histatin 3 to salivary glands. Hum. Gene Ther. 7, 2255-2261. (Pubitemid 27021460)
40. Passineau, M.J., Fahrenholz, T., Machen, L., et al. (2011). a-Galactosidase A expressed in the salivary glands partially corrects organ biochemical deficits in the Fabry mouse through endocrine trafficking. Hum. Gene Ther. 22, 293-301.
41. Peng, A., Gaitonde, P., Kosloski, M.P., et al. (2009). Effect of route of administration of human recombinant factor VIII on its immunogenicity in Hemophilia A mice. J. Pharm. Sci. 98, 4480-4484.
42. Poller, W., Schneider-Rasp, S., Liebert, U., et al. (1996). Stabilization of transgene expression by incorporation of E3 region genes into an adenoviral factor IX vector and by transient anti-CD4 treatment of the host. Gene Ther. 3, 521-530. (Pubitemid 26197542)
43. Redman, R.S. (1995). Proliferative activity by cell type in the developing rat parotid gland. Anat. Rec. 241, 529-540.
44. Schaack, J., Ho, W.Y., Freimuth, P., et al. (1990). Adenovirus terminal protein mediates both nuclear matrix association and efficient transcription of adenovirus DNA. Genes Dev. 4, 1197-1208.
45. Schowalter, D.B., Tubb, J.C., Liu, M., et al. (1997). Heterologous expression of adenovirus E3-gp19K in an E1a-deleted adenovirus vector inhibits MHC I expression in vitro, but does not prolong transgene expression in vivo. Gene Ther. 4, 351-360. (Pubitemid 27170728)
46. Sprangers, M.C., Lakhai, W., Koudstaal, W., et al. (2003). Quantifying adenovirus-neutralizing antibodies by luciferase transgene detection: addressing preexisting immunity to vaccine and gene therapy vectors. J. Clin. Microbiol. 41, 5046-5052. (Pubitemid 37429914)
47. Springett, G.M., Moen, R.C., Anderson, S., et al. (1989). Infection efficiency of T lymphocytes with amphotropic retroviral vectors is cell cycle dependent. J. Virol. 63, 3865-3869. (Pubitemid 19205460)
48. Tollefson, A.E., Scaria, A., Hermiston, T.W., et al. (1996). The adenovirus death protein (E3-11.6K) is required at very late stages of infection for efficient cell lysis and release of adenovirus from infected cells. J. Virol. 70, 2296-2306. (Pubitemid 26087592)
49. von Herrath, M.G., Efrat, S., Oldstone, M.B., and Horwitz, M.S. (1997). Expression of adenoviral E3 transgenes in b cells prevents autoimmune diabetes. Proc. Natl. Acad. Sci. U.S.A. 94, 9808-9813. (Pubitemid 27408146)
50. Voutetakis, A., Kok, M.R., Zheng, C., et al. (2004). Reengineered salivary glands are stable endogenous bioreactors for systemic gene therapeutics. Proc. Natl. Acad. Sci. U.S.A. 101, 3053-3058. (Pubitemid 38327733)
51. Voutetakis, A., Bossis, I., Kok, M.R., et al. (2005). Salivary glands as a potential gene transfer target for gene therapeutics of some monogenetic endocrine disorders. J. Endocrinol. 185, 363-372. (Pubitemid 40883381)
52. Voutetakis, A., Zheng, C., Mineshiba, F., et al. (2007). Adenoassociated virus serotype 2-mediated gene transfer to the parotid glands of nonhuman primates. Hum. Gene Ther. 18, 142-150. (Pubitemid 46446051)
53. Yang, Y., Li, Q., Ertl, H.C., et al. (1995). Cellular and humoral immune responses to viral antigens create barriers to lungdirected gene therapy with recombinant adenoviruses. J. Virol. 69, 2004-2015.
54. Zheng, C., and Baum, B.J. (2002). Long-term expression after infection by the hybrid vector AdLTR-luc is from integrated transgene. Biochem. Biophys. Res. Commun. 291, 34-40. (Pubitemid 34681134)
55. Zheng, C., Baum, B.J., Iadarola, M.J., et al. (2000). Genomic integration and gene expression by a modified adenoviral vector. Nat. Biotechnol. 18, 176-180. (Pubitemid 30091178)
56. Zheng, C., Wang, J., and Baum, B.J. (2003a). Integration efficiency of a hybrid adenoretroviral vector. Biochem. Biophys. Res. Commun. 300, 115-120. (Pubitemid 36042938)
57. Zheng, C., O'Connell, B.C., and Baum, B.J. (2003b). Inclusion of Moloney murine leukemia virus elements upstream of the transgene cassette in an E1-deleted adenovirus leads to an unusual genomic integration in epithelial cells. Virology 313, 460-472. (Pubitemid 37040686)
58. Zheng, C., Vitolo, J.M., Zhang, W., et al. (2008). Extended transgene expression from a nonintegrating adenoviral vector containing retroviral elements. Mol. Ther. 16, 1089-1097. (Pubitemid 351737074)
59. Zheng, C., Cotrim, A.P., Sunshine, A.N., et al. (2009). Prevention of radiation-induced oral mucositis after adenoviral vector-mediated transfer of the keratinocyte growth factor cDNA to mouse submandibular glands. Clin. Cancer Res. 15, 4641-4648.
60. Zheng, C., Nikolov, N.P., Alevizos, I., et al. (2010). Transient detection of E1-containing adenovirus in saliva after the delivery of a first-generation adenoviral vector to human parotid gland. J. Gene Med. 12, 3-10.
61. Zheng, C., Shinomiya, T., Goldsmith, C.M., et al. (2011a). Convenient and reproducible in vivo gene transfer to mouse parotid glands. Oral Dis. 17, 77-82.
62. Zheng, C., Cotrim, A.P., Rowzee, A., et al. (2011b). Prevention of radiation-induced salivary hypofunction following hKGF gene delivery to murine submandibular glands. Clin. Cancer Res. 17, 2842-2851.