Heterologous expression of adenovirus E3-gp19K in an E1a-deleted adenovirus vector inhibits MHC I expression in vitro, but does not prolong transgene expression in vivo

Gene Therapy

Volumn 4, Issue 4, 1997, Pages 351-360

  Schowalter, D B ^a   Tubb, J C ^a   Liu, M ^a   Wilson, C B ^a   Kay, M A ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Adenovirus; Congenic mice strains; E3 region; E3 gp19K protein; Hepatic gene therapy; Immune evasion; RSV LTR

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; VIRUS PROTEIN;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ARTICLE; CONTROLLED STUDY; EXPRESSION VECTOR; FIBROBLAST CULTURE; FLOW CYTOMETRY; GENE EXPRESSION; GENE TRANSFER; GENETIC TRANSDUCTION; IMMUNOPRECIPITATION; LIVER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; TRANSGENE; VIRUS RECOMBINANT;

EID: 0030943737     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300398     Document Type: Article

References (44)

1. Barr D et al. Strain related variations in adenovirus-mediated transgene expression from mouse hepatocytes in vivo: comparisons between immunocompetent and immunodefirient inbred strains. Gene Therapy 1995; 2: 151-154.
2. Smith TA et al. Adenovirus mediated expression of therapeutic plasma levels of human factor IX in mice. Nat Genet 1993; 5: 397-402.
3. Yang Y, Ertl HCJ, Wilson JM. MHC class 1 restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses. Immunity 1994; 1: 433-442.
4. Yang Y et al. Immune response to viral antigens versus transgene product in the elimination of recombinant adenovirus-infected hepatocytes in vivo. Gene Therapy 1996; 3: 137-144.
5. Kay MA et al. Long-term hepatic adenovirus-mediated gene expression in mice following CTLA4Ig administration. Nat Genet 1995; 11: 191-197.
6. Kolls JK et al. Use of transient CD4 lymphocyte depletion to prolong transgene expression of El-deleted adenoviral vectors. Hum Gene Ther 1996; 7: 489-497.
7. Sawchuck SJ et al. Anti-T cell receptor monoclonal antibody prolongs transgene expression following adenovirus-mediated in vivo gene transfer to mouse synovium. Hum Gene Ther 1996; 7: 499-506.
8. Yang Y, Trinchieri G, Wilson JM. Recombinant IL-12 prevents formation of blocking IgA antibodies to recombinant adenovirus and allows repeated gene therapy to mouse lung. Nature Med 1995; 1: 890-893.
9. Gooding LR, Wold WSM. Molecular mechanisms by which adenoviruses counteract antiviral immune defenses. Crit Rev Immunol 1990; 10: 53-71.
10. Wold WSM, Gooding LR. Region E3 of adenovirus: a cassette of genes involved in host immunosurveillance and virus-cell interactions. Virology 1991; 184: 1-8.
11. Wold WSM, Tollefson AE, Hermiston TW. Strategies of immune modulation by adenoviruses. In: McFadden G (ed). Viroceptors, Virokins, and related Immune Modulators Encoded by DNA Viruses. RG Landes: Austin, TX, 1994, pp 147-185.
12. Gooding LR et al. A 14 700 MW protein from the E3 region of adenovirus inhibits cytolysis by tumor necrosis factor. Cell 1988; 53: 341-346.
13. Ranheim TS et al. Characterization of mutants within the gene for the adenovirus E3 14.7-kilodalton protein which prevents cytolysis by tumor necrosis factor. J Virol 1993; 67: 2159-2167.
14. Wold WSM. Adenovirus genes that modulate the sensitivity of virus-infected cells to lysis by TNF. J Cell Biochem 1993; 53: 329-335.
15. Rawle FC, Tollefson AE, Wold WSM, Gooding LR. Mouse anti-adenovirus cytotoxic T lymphocytes. Inhibition of lysis by E3 gp19K but not E3 14.7K. J Immunol 1989; 143: 2031-2037.
16. Burgert HG, Kvist S. An adenovirus type 2 glycoprotein blocks cell surface expression of human histocompatibility class I antigens. Cell 1985; 41: 987-997
17. Andersson M, Paabo S, Nilsson T, Peterson PA. Impaired intracellular transport of class I MHC antigens as a possible means for adenoviruses to evade immune surveillance. Cell 1985; 43: 215-222.
18. Fejer G et al. Characterization of trangenic mice containing adenovirus early region 3 genomic DNA. J Virol 1994; 68: 5871-5881.
19. Lee MG et al. The constitutive expression of the immunomodulatory gp19K protein in E1-E3-adenoviral vectors strongly reduces the host cytotoxic T cell response against the vector. Gene Therapy 1995; 2: 256-262.
20. Hermiston TW et al. Deletion mutation analysis of the adenovirus type 2 E3-gpl9K protein: identification of the sequences within the endoplasmic reticulum lumenal domain that are required for class I antigen binding and protection from adenovirus-specific cytotoxic T lymphocytes. Virology 1993; 67: 5289-5298.
21. Kornuc M et al. Adenovirus region 3 promoter regulation by E1A/E1B is independent of alterations in DNA binding and gene activation by CREB/ATF and AP1. J Virol 1990; 64: 2004-2013.
22. Korner H, Fritzsche U, Burgert H-G. Tumor necrosis factor stimulates expression of adenovirus early region 3 proteins: implications for viral persistence. Proc Natl Acad Sci USA 1992; 89: 11857-11861.
23. Williams JL el al. Lymphoid specific gene expression of the adenovirus early region 3 promoter is mediated by NF-κB binding motifs. EMBO J 1990; 9: 4435-4442
24. Burgert HG, Kvist S. The E3/19K protein of adenovirus type 2 binds to the domains of histocompatibility antigens required for CTL recognition. EMBO J 1987; 6: 2019-2026.
25. b n-restricted SV40-specific CTL mediated lysis. Virology 1988; 165: 357-366.
26. Kay MA et al. In vivo hepatic gene therapy: complete albeit transient correction of factor IX deficiency in hemophilia B dogs. Proc Natl Acad Sci USA 1994; 91: 2353-2357.
27. Li Q et al. Assessment of recombinant adenoviral vectors for hepatic gene therapy. Hum Gene Ther 1993; 4: 403-409.
28. Vrancken-Peeters MJTFD et al. Method for multiple portal vein infusions in mice: quantitation of adenovirus-mediated hepatic gene transfer. BioTechniques 1996; 20: 278-285.
29. Yang Y et al. Upregulation of class I major histocompatibility complex antigens by interferon gamma is necessary for T cell mediated elimination of recombinant adenovirus-infected hepatocytes in vivo. Proc Natl Acad Sci USA 1995; 92: 7257-7261.
30. Wold WSM et al. The 19 kDa glycoprotein coded by region E3 of adenovirus. J Biol Chem 1985; 260: 2424-2431.
31. Efrat S, Fejer G, Brownlee M, Horowitz MS. Prolonged survival of pancreatic islet allografts mediated by adenovirus immunoregulatory transgenes. Proc Natl Acad Sci USA 1994; 92: 6947-6951.
32. Grunhaus A, Cho S, Horwitz MS. Association of vaccinia virus expressed adenovirus E3-19K glycoprotein with class I MHC and its effects on virulence in a murine pneumonia model. Virology 1994; 200: 535-540.
33. Sparer TE et al. The role of human adenovirus early region 3 proteins (gp19K, 10.4K, 14.5K, and 14.7K) in a murine pneumonia model. J Virol 1996; 70: 2431-2439.
34. Ginsberg HS et al. Role of early region 3 (E3) in pathogenesis of adenovirus disease. Proc Natl Acad Sci USA 1989; 86: 3823-3827.
35. Riddell SR et al Class I MHC-restricted cytotoxic T-lymphocyte recognition of cells infected with human cytomegalovirus does not require endogenous viral gene expression. J Immunol 1991; 146: 2795-2804
36. Fruh K et al. A viral inhibitor of peptide transporters for antigen presentation. Nature 1995; 375: 415-418.
37. Hill A et al. Herpes simplex virus turns off the TAP to evade host immunity. Nature 1995; 375: 411-415.
38. Kay MA et al. Hepatic gene therapy; persistent expression of human alpha 1-antitrypsin in mice after direct gene delivery in vivo. Hum Gene Ther 1992; 3: 641-647.
39. Stratford-Perricaudet LD et al. Widespread long-term gene transfer to mouse skeletal muscles and heart. J Clin Invest 1992; 90: 626-630.
40. Graham F, Prevec L. Adenovirus-based expression vectors and recombinant vaccines. Biotechnology 1992; 20: 363-390.
41. Hitt M et al. Construction and propagation of human adenovirus vectors. In: Celis J (ed). Cell Biology: A Laboratory Handbook. Academic Press: San Diego, 1994, pp 479-491.
42. Bett AJ et al. An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3. Proc Natl Acad Sci USA 1994; 91: 8802-8806.
43. Lieber A, Vrancken-Peeters MJTFD, Kay MA Adenovirusmediated transfer of the amphotrophic retrovirus receptor cDNA increases retroviral transduction in cultured cells. Hum Gene Ther 1995; 6: 5-11.
44. Trask B. Fluorescence in situ hybridization. In: Birren B et al. (eds). Genome Analysis: A Laboratory Manual. Cold Spring Harbor Laboratory Press: Cold Spring Harbor, 1997 (in press).