Repetitive adenovirus administration to the parotid gland: Role of immunological barriers and induction of oral tolerance

Human Gene Therapy

Volumn 9, Issue 3, 1998, Pages 305-313

  Kagami, Hideaki ^a,b   Atkinson, Jane C ^a   Michalek, Suzanne M ^c   Handelman, Beverly ^a   Yu, Shawn ^a   Baum, Bruce J ^a   O'Connell, Brian ^a,d  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

^b NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUFFER; CHLORAMPHENICOL; CHLORAMPHENICOL ACETYLTRANSFERASE; COENZYME A; COLLAGENASE; GAMMA INTERFERON; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; TISSUE EXTRACT;

ADENOVIRUS; ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; BIOASSAY; DOWN REGULATION; DRUG TOLERANCE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GENE TRANSFER; HUMAN; HUMAN CELL; IMMUNITY; MAGNETIC BEAD; MONONUCLEAR CELL; NONHUMAN; ORAL DRUG ADMINISTRATION; PAROTID GLAND; RAT; REINFECTION; SALIVA; SPLEEN; ULTRAVIOLET RADIATION;

ADENOVIRIDAE; ANIMALIA; FELIS CATUS;

EID: 0032501956     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1998.9.3-305     Document Type: Article

References (6)

1. ADESANYA, M.R., REDMAN, R.S., BAUM, B.J., and O'CONNELL, B.C. (1996). Immediate inflammatory responses to adenovirus-mediated gene transfer in rat salivary glands. Hum. Gene Then 7, 1085-1093.
2. ARMENTANO, D., ZABNER, J., SACKS, C, SOOKDEO, C.C., SMITH, M.P., ST. GEORGE, J.A., WADSWORTH, S.C., SMITH, A.E., and GREGORY, R.J. (1997). Effect of the E4 region on the persistence of transgene expression from adenovirus vectors. J. Virol. 71, 2408-2416.
3. CHALLACOMBE, S.J., and TOMASI, T.B., JR. (1980). Systemic tolerance and secretory immunity after oral immunization. J. Exp. Med. 152, 1459-1472.
4. CHALLACOMBE, S.J., and SHIRLAW, P.J. (1994). Immunology of diseases of the oral cavity. In Handbook of Mucosal Immunology. P.L. Ogra, J. Mestecky, M.E. Lamm, W. Strober, J.R. McGhee, and J. Beinenstock, eds. (San Diego, Academic Press) pp. 607-624.
5. YANG, Y., TRINCHIERI, G., and WILSON, J.M. (1995b). Recombinant IL-12 prevents formation of blocking antibodies to recombinant adenovirus and allows repeated gene therapy to mouse lung. Nature Med. 1, 890-893.
6. ZABNER, J., RAMSEY, B.W., MEEKER, D.P., AITKEN, M.L., BALFOUR, R.P., GIBSON, R.L., LAUNSPACH, J., MOSCICKI, R.A., RICHARDS, S.M., STANDAERT, T.A., WILLIAMS-WARREN, J., WADSWORTH, S.C., SMITH, A.E., and WELSH, M.J. (1996). Repeat administration of an adenovirus vector encoding cystic fibrosis transmembrane conductance regulator to the nasal epithelium of patients with cystic fibrosis. J. Clin. Invest. 97, 1504-1511.