Comparison of dose-response relations between 4-week inhalation and intratracheal instillation of NiO nanoparticles using polimorphonuclear neutrophils in bronchoalveolar lavage fluid as a biomarker of pulmonary inflammation

Inhalation Toxicology

Volumn 25, Issue 1, 2013, Pages 29-36

  Mizuguchi, Yohei ^a   Myojo, Toshihiko ^a   Oyabu, Takako ^a   Hashiba, Masayoshi ^a   Lee, Byeong Woo ^a   Yamamoto, Makoto ^a   Todoroki, Motoi ^a   Nishi, Kenichiro ^a   Kadoya, Chikara ^a   Ogami, Akira ^a   Morimoto, Yasuo ^a   Tanaka, Isamu ^a   Shimada, Manabu ^b   Uchida, Kunio ^c   Endoh, Shigehisa ^c   Nakanishi, Junko ^c  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

Author keywords

Inhalation; Instillation; Nanoparticles; Nickel oxide; PMNs; Polymorphonuclear neutrophils

Indexed keywords

BIOLOGICAL MARKER; METAL OXIDE; NANOPARTICLE; NICKEL; NICKEL MONOXIDE; UNCLASSIFIED DRUG;

AEROSOL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DOSE RESPONSE; EXPOSURE; INHALATION; LUNG ALVEOLUS MACROPHAGE; LUNG BURDEN; LUNG LAVAGE; LUNG PARENCHYMA; MALE; NEUTROPHIL; NEUTROPHIL COUNT; NONHUMAN; PARTICLE SIZE; PNEUMONIA; PRIORITY JOURNAL; RAT; SUSPENSION; TRACHEA;

ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; DOSE-RESPONSE RELATIONSHIP, DRUG; INHALATION EXPOSURE; INSTILLATION, DRUG; LEUKOCYTE COUNT; MACROPHAGES, ALVEOLAR; MALE; MICROSCOPY, ELECTRON, SCANNING; MICROSCOPY, ELECTRON, TRANSMISSION; NANOPARTICLES; NEUTROPHILS; NICKEL; PARTICLE SIZE; PNEUMONIA; RATS; RATS, WISTAR; SURFACE PROPERTIES; TOXICITY TESTS, SUBACUTE; TRACHEA;

ANIMALIA; RATTUS;

EID: 84872035798     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.3109/08958378.2012.751470     Document Type: Article

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