Comparative pulmonary toxicity inhalation and instillation studies with different TiO2 particle formulations: Impact of surface treatments on particle toxicity

Toxicological Sciences

Volumn 88, Issue 2, 2005, Pages 514-524

  Warheit, David B ^a   Brock, W J ^a,b   Lee, K P ^a,c   Webb, T R ^a   Reed, K L ^a  

^a DUPONT COMPANY   (United States)

^b Brock Scientific Consulting   (United States)

^c NONE

Author keywords

Particle coatings; Pulmonary toxicity; Surface treatments on particles; Titanium dioxide particles

Indexed keywords

ALUMINUM OXIDE; SILICON DIOXIDE; SODIUM CHLORIDE; TITANIUM DIOXIDE;

AEROSOL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; HISTOPATHOLOGY; LUNG LAVAGE; LUNG TOXICITY; MALE; NONHUMAN; PARTICLE SIZE; RAT; TOXICITY TESTING;

ADMINISTRATION, INHALATION; AEROSOLS; ALUMINUM OXIDE; ANIMALS; BIOLOGICAL MARKERS; BRONCHOALVEOLAR LAVAGE FLUID; COATED MATERIALS, BIOCOMPATIBLE; DOSE-RESPONSE RELATIONSHIP, DRUG; INTUBATION, INTRATRACHEAL; LUNG; MACROPHAGES, ALVEOLAR; MALE; NEUTROPHILS; PARTICLE SIZE; RATS; RATS, SPRAGUE-DAWLEY; SILICON DIOXIDE; TITANIUM;

ANIMALIA;

EID: 27944510243     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfi331     Document Type: Article

References (15)

1. Bermudez, E., Mangum, J. B., Asgharian, B., Wong, B. A., Reverdy, E. E., Janszen, D. B., Hext, P. M., Warheit, D. B., and Everitt, J. I. (2002). Long-term pulmonary responses of three laboratory rodent species to subchronic inhalation of pigmentary titanium dioxide particles. Toxicol. Sci. 70, 86-97.
2. Brunauer, S., Emmett, P. H., and Teller, E. (1938). Adsorption of gases in multimolecular layers. J. Amer. Chem. Soc. 60, 309-319.
3. Hext, P. M. (1994). Current perspectives on particulate induced pulmonary tumours. Human Exper. Toxicol. 13, 700-715.
4. Hohr, D., Steinfartz, Y., Schins, R. P. F., Knaapen, A. M., Martra, G., Fubini, B., and Borm, P. J. A. (2002). The surface area rather than the surface coating determines the acute inflammatory response after instillation of fine and ultrafine TiO2 in the rat. Int. J. Hygiene Environ. Health 205, 239-244.
5. Lee, K. P., Henry, N. W., III, Trochimowicz, H. J., and Reinhardt, C. F. (1986). Pulmonary response to impaired lung clearance in rats following excessive titanium dioxide dust deposition. Environ. Res. 41, 144-167.
6. Muhle, H., Bellmann, B., Creutzenberg, O., Dasenbrock, C., Ernst, H., Kilpper, R., MacKenzie, J. C., Morrow, P., Mohr, U., and Takenaka, S. (1991). Pulmonary response to toner upon chronic inhalation exposure in rats. Fundam. Appl. Toxicol. 17, 280-299.
7. Oberdorster, G. (2001). Pulmonary effects of inhaled ultrafine particles. Int. Arch. Occup Environ Health 74, 1-8.
8. Pott, F., Althoff, G. H., Roller, M., Hohr, D., and Friemann, J. (1998a). High acute toxicity of hydrophobic ultrafine titanium dioxide in an intratracheal study with several dusts in rats. In Relationships Between Respiratory Disease and Exposure to Air Pollution (U. Mohr, D. L. Dungworth, J. D. Brain, K. E. Driscoll, R. C. Grafstrom, and C. C. Harris, Eds.), pp. 270-272. ILSI Press, Washington, DC.
9. Pott, F., Roller, M., Althoff, G. H., Hohr, D., and Friemann, J. (1998b). Acute lung toxicity of hydrophobic titanium dioxide in an intratracheal carcinogenicity study with nineteen dusts in rats. In Health Effects of Particulate Matter in Ambient Air. Proceedings of an International Conference Sponsored by the Air and Waste Management Association and the Czech Medical Association (J. Vostal, Ed.), pp. 301-307.
10. Rehn, B., Seiler, F., Rehn, S., Bruch, J., and Maier, M. (2003). Investigations on the inflammatory and genotoxic lung effects of two types of titanium dioxide: Untreated and surface treated. Toxicol. Appl. Pharmacol. 189, 84-95.
11. Vu, V. T. (1996). Use of hazard and risk information in risk management decisions: Solid particles and fibers, under EPA's TSCA and EPCRA. Inhal. Toxicol. 8(Suppl.), 181-191.
12. Warheit, D. B., Carakostas, M. C., Hartsky, M. A., and Hansen, J. F. (1991). Development of a short-term inhalation bioassay to assess pulmonary toxicity of inhaled particles: Comparisons of pulmonary responses to carbonyl iron and silica. Toxicol. Appl. Pharmacol. 107, 350-368.
13. Warheit, D. B., Hansen, J. F, Yuen, I. S., Kelly, D. P., Snajdr, S., and Hartsky, M. A. (1997). Inhalation of high concentrations of low toxicity dusts in rats results in pulmonary and macrophage clearance impairments. Toxicol. Appl. Pharmacol. 145, 10-22.
14. Warheit, D. B., Reed, K. L., and Webb, T. R. (2003). Development of pulmonary bridging studies Pulmonary toxicity studies in rats with triethoxyoctylsilane (OTES)-coated pigment-grade titanium dioxide particles. Exp. Lung Res. 29, 593-606.
15. 2 particle induced pulmonary inflammation and neutrophil apoptotic responses in rats. Exp. Lung Res. 28, 641-670.