The core cysteines, (C909) of islet antigen-2 and (C945) of islet antigen-2β, are crucial to autoantibody binding in type 1 diabetes

Diabetes

Volumn 62, Issue 1, 2013, Pages 214-222

  Elvers, Karen T ^a   Geoghegan, Ivey ^a   Shoemark, Debbie K ^a   Lampasona, Vito ^b   Bingley, Polly J ^a   Williams, Alistair J K ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; AUTOANTIBODY; C909; C945; CYSTEINE; GLUTAMIC ACID; ISLET ANTIGEN 2BETA; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ANTIGEN BINDING; ARTICLE; CHILD; FEMALE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; MUTATION; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SITE DIRECTED MUTAGENESIS;

ADOLESCENT; ADULT; AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; AUTOANTIBODIES; CHILD; CHILD, PRESCHOOL; CYSTEINE; DIABETES MELLITUS, TYPE 1; EPITOPE MAPPING; FEMALE; HUMANS; MALE; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; RECEPTOR-LIKE PROTEIN TYROSINE PHOSPHATASES, CLASS 8; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84872032786     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db11-1590     Document Type: Article

References (39)

1. Lu J, Li Q, Xie H, et al. Identification of a second transmembrane protein tyrosine phosphatase, IA-2beta, as an autoantigen in insulin-dependent diabetes mellitus: precursor of the 37-kDa tryptic fragment. Proc Natl Acad Sci USA 1996;93:2307-2311
2. Rabin DU, Pleasic SM, Shapiro JA, et al. Islet cell antigen 512 is a diabetes-specific islet autoantigen related to protein tyrosine phosphatases. J Immunol 1994;152:3183-3188 (Pubitemid 24098017)
3. Bonifacio E, Lampasona V, Bingley PJ. IA-2 (islet cell antigen 512) is the primary target of humoral autoimmunity against type 1 diabetes-associated tyrosine phosphatase autoantigens. J Immunol 1998;161:2648-2654 (Pubitemid 28397086)
4. Solimena M, Dirkx R Jr, Hermel JM, et al. ICA 512, an autoantigen of type I diabetes, is an intrinsic membrane protein of neurosecretory granules. EMBO J 1996;15:2102-2114 (Pubitemid 26141127)
5. Payton MA, Hawkes CJ, Christie MR. Relationship of the 37,000- and 40,000-M(r) tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). J Clin Invest 1995;96:1506-1511
6. Lampasona V, Bearzatto M, Genovese S, Bosi E, Ferrari M, Bonifacio E. Autoantibodies in insulin-dependent diabetes recognize distinct cytoplasmic domains of the protein tyrosine phosphatase-like IA-2 autoantigen. J Immunol 1996;157:2707-2711 (Pubitemid 126450489)
7. Notkins AL, Zhang B, Matsumoto Y, Lan MS. Comparison of IA-2 with IA-2beta and with six other members of the protein tyrosine phosphatase family: recognition of antigenic determinants by IDDM sera. J Autoimmun 1997;10:245-250 (Pubitemid 27286530)
8. Zhang B, Lan MS, Notkins AL. Autoantibodies to IA-2 in IDDM: location of major antigenic determinants. Diabetes 1997;46:40-43 (Pubitemid 27009947)
9. Verge CF, Gianani R, Kawasaki E, et al. Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies. Diabetes 1996;45:926-933 (Pubitemid 26225509)
10. Bingley PJ, Christie MR, Bonifacio E, et al. Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes 1994;43:1304-1310
11. Lan MS, Lu J, Goto Y, Notkins AL. Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma. DNA Cell Biol 1994;13:505-514 (Pubitemid 24291404)
12. Bearzatto M, Naserke H, Piquer S, et al. Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. J Immunol 2002;168:4202-4208 (Pubitemid 34298429)
13. Kawasaki E, Sera Y, Fujita N, et al. Association between IA-2 autoantibody epitope specificities and age of onset in Japanese patients with autoimmune diabetes. J Autoimmun 2001;17:323-331 (Pubitemid 34098416)
14. Tonks NK. Redox redux: revisiting PTPs and the control of cell signaling. Cell 2005;121:667-670 (Pubitemid 40797589)
15. Naserke HE, Ziegler AG, Lampasona V, Bonifacio E. Early development and spreading of autoantibodies to epitopes of IA-2 and their association with progression to type 1 diabetes. J Immunol 1998;161:6963-6969 (Pubitemid 28562244)
16. Hawkes CJ, Wasmeier C, Christie MR, Hutton JC. Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase-like protein (phogrin) related to IA-2. Diabetes 1996;45:1187-1192 (Pubitemid 26296317)
17. Hatfield EC, Hawkes CJ, Payton MA, Christie MR. Cross reactivity between IA-2 and phogrin/IA-2beta in binding of autoantibodies in IDDM. Diabetologia 1997;40:1327-1333 (Pubitemid 27469674)
18. Piquer S, Valera L, Lampasona V, et al. Monoclonal antibody 76F distinguishes IA-2 from IA-2beta and overlaps an autoantibody epitope. J Autoimmun 2006;26:215-222
19. Miao D, Yu L, Tiberti C, et al. ICA512(IA-2) epitope specific assays distinguish transient from diabetes associated autoantibodies. J Autoimmun 2002;18:191-196 (Pubitemid 36268635)
20. Seissler J, Schott M, Morgenthaler NG, Scherbaum WA. Mapping of novel autoreactive epitopes of the diabetes-associated autoantigen IA-2. Clin Exp Immunol 2000;122:157-163
21. Kawasaki E, Yu L, Rewers MJ, Hutton JC, Eisenbarth GS. Definition of multiple ICA512/phogrin autoantibody epitopes and detection of intramolecular epitope spreading in relatives of patients with type 1 diabetes. Diabetes 1998;47:733-742 (Pubitemid 28201802)
22. Bonifacio E, Lampasona V, Genovese S, Ferrari M, Bosi E. Identification of protein tyrosine phosphatase-like IA2 (islet cell antigen 512) as the insulin-dependent diabetes-related 37/40K autoantigen and a target of islet-cell antibodies. J Immunol 1995;155:5419-5426
23. Dromey JA, Weenink SM, Peters GH, et al. Mapping of epitopes for autoantibodies to the type 1 diabetes autoantigen IA-2 by peptide phage display and molecular modeling: overlap of antibody and T cell determinants. J Immunol 2004;172:4084-4090 (Pubitemid 38375220)
24. Weenink SM, Lo J, Stephenson CR, et al. Autoantibodies and associated T-cell responses to determinants within the 831-860 region of the autoantigen IA-2 in Type 1 diabetes. J Autoimmun 2009;33:147-154
25. Bearzatto M, Lampasona V, Belloni C, Bonifacio E. Fine mapping of diabetes-associated IA-2 specific autoantibodies. J Autoimmun 2003;21:377-382 (Pubitemid 37414932)
26. Kim SJ, Jeong DG, Jeong SK, Yoon TS, Ryu SE. Crystal structure of the major diabetes autoantigen insulinoma-associated protein 2 reveals distinctive immune epitopes. Diabetes 2007;56:41-48
27. Kolm-Litty V, Berlo S, Bonifacio E, et al. Human monoclonal antibodies isolated from type I diabetes patients define multiple epitopes in the protein tyrosine phosphatase-like IA-2 antigen. J Immunol 2000;165:4676-4684
28. Xie H, Zhang B, Matsumoto Y, Li Q, Notkins AL, Lan MS. Autoantibodies to IA-2 and IA-2 beta in insulin-dependent diabetes mellitus recognize conformational epitopes: location of the 37- and 40-kDa fragments determined. J Immunol 1997;159:3662-3667 (Pubitemid 127482127)
29. Sica MP, Primo ME, Ermácora MR, Poskus E. High-yield expression of properly folded insulinoma-associated protein intracellular domain (IA-2ic) in Escherichia coli. Biotechnol Appl Biochem 2003;37:301-309 (Pubitemid 36713039)
30. Williams AJ, Somerville M, Rokni S, et al. Azide and Tween-20 reduce binding to autoantibody epitopes of islet antigen-2; implications for assay performance and reproducibility. J Immunol Methods 2009;351:75-79
31. von Montfort C, Sharov VS, Metzger S, Schöneich C, Sies H, Klotz LO. Singlet oxygen inactivates protein tyrosine phosphatase-1B by oxidation of the active site cysteine. Biol Chem 2006;387:1399-1404 (Pubitemid 44691420)
32. Yang J, Groen A, Lemeer S, et al. Reversible oxidation of the membrane distal domain of receptor PTPalpha is mediated by a cyclic sulfenamide. Biochemistry 2007;46:709-719 (Pubitemid 46137775)
33. Bingley PJ, Bonifacio E, Williams AJ, Genovese S, Bottazzo GF, Gale EA. Prediction of IDDM in the general population: strategies based on combinations of autoantibody markers. Diabetes 1997;46:1701-1710 (Pubitemid 27456400)
34. Bonifacio E, Yu L, Williams AK, et al. Harmonization of glutamic acid decarboxylase and islet antigen-2 autoantibody assays for national institute of diabetes and digestive and kidney diseases consortia. J Clin Endocrinol Metab 2010;95:3360-3367
35. Almo SC, Bonanno JB, Sauder JM, et al. Structural genomics of protein phosphatases. J Struct Funct Genomics 2007;8:121-140 (Pubitemid 50007113)
36. Barr AJ, Ugochukwu E, Lee WH, et al. Large-scale structural analysis of the classical human protein tyrosine phosphatome. Cell 2009;136:352-363
37. Achenbach P, Koczwara K, Knopff A, Naserke H, Ziegler AG, Bonifacio E. Mature high-affinity immune responses to (pro)insulin anticipate the autoimmune cascade that leads to type 1 diabetes. J Clin Invest 2004;114:589-597 (Pubitemid 39572109)
38. Decochez K, Truyen I, van der Auwera B, et al.; Belgian Diabetes Registry. Combined positivity for HLA DQ2/DQ8 and IA-2 antibodies defines population at high risk of developing type 1 diabetes. Diabetologia 2005;48:687-694 (Pubitemid 40591224)
39. Long AE, Gillespie KM, Rokni S, Bingley PJ, Williams AJ. Rising incidence of type 1 diabetes is associated with altered immunophenotype at diagnosis. Diabetes 2012;61:683-686