Autoantibodies and associated T-cell responses to determinants within the 831-860 region of the autoantigen IA-2 in Type 1 diabetes

Journal of Autoimmunity

Volumn 33, Issue 2, 2009, Pages 147-154

  Weenink, S M ^a   Lo, J ^a   Stephenson, C R ^b   McKinney, P A ^b   Ananieva Jordanova, R ^c   Rees Smith, B ^c   Furmaniak, J ^c   Tremble, J M ^d   Bodansky, H J ^b   Christie, M R ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF LEEDS   (United Kingdom)

^c RSR LTD   (United Kingdom)

^d QUEEN ELIZABETH HOSPITAL   (United Kingdom)

Author keywords

Antigen presentation; Autoantibodies; Cytokines; T cells; Type 1 diabetes

Indexed keywords

AUTOANTIGEN; INTERLEUKIN 10; ISLET ANTIGEN 2; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AMINO ACID SUBSTITUTION; ANTIBODY BLOOD LEVEL; ANTIBODY RESPONSE; ANTIGEN BINDING; ARTICLE; B LYMPHOCYTE; CELLULAR IMMUNITY; CHILD; CLINICAL ARTICLE; CYTOKINE RELEASE; FEMALE; HUMAN; INFANT; INSULIN DEPENDENT DIABETES MELLITUS; MALE; PRIORITY JOURNAL; T LYMPHOCYTE;

ADOLESCENT; ADULT; AMINO ACID SUBSTITUTION; ANTIBODIES, MONOCLONAL; AUTOANTIBODIES; AUTOANTIGENS; CHILD; DIABETES MELLITUS, TYPE 1; EPITOPES, T-LYMPHOCYTE; FEMALE; HUMANS; INFANT; INTERFERON-GAMMA; INTERLEUKIN-10; MALE; RECEPTOR-LIKE PROTEIN TYROSINE PHOSPHATASES, CLASS 8; T-LYMPHOCYTES; YOUNG ADULT;

EID: 68349102046     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2009.04.002     Document Type: Article

References (38)

1. Morran M.P., Omenn G.S., and Pietropaolo M. Immunology and genetics of type 1 diabetes. Mt Sinai J Med 75 (2008) 314-327
2. Taplin C.E., and Barker J.M. Autoantibodies in type 1 diabetes. Autoimmunity 41 (2008) 11-18
3. Serreze D.V., Fleming S.A., Chapman H.D., Richard S.D., Leiter E.H., and Tisch R.M. B lymphocytes are critical antigen-presenting cells for the initiation of T cell-mediated autoimmune diabetes in nonobese diabetic mice. J Immunol 161 (1998) 3912-3918
4. Forsgren S., Andersson A., Hillorn A.V., Soderstrom A., and Holmberg D. Immunoglobulin-mediated prevention of autoimmune diabetes in the nonobese diabetic (NOD) mouse. Scand J Immunol 34 (1991) 445-451
5. Noorchashm H., Noorchashm N., Kern J., Rostami S.Y., Barker C.F., and Naji A. B-cells are required for the initiation of insulitis and sialitis in nonobese diabetic mice. Diabetes 46 (1997) 941-946
6. Mamula M.J., and Janeway Jr. C.A. Do B cells drive the diversification of immune responses?. Immunol Today 14 (1993) 151-152
7. Simitsek P.D., Campbell D.G., Lanzavecchia A., Fairweather N., and Watts C. Modulation of antigen processing by bound antibodies can boost or suppress class II major histocompatibility complex presentation of different T cell determinants. J Exp Med 181 (1995) 1957-1963
8. Yanaba K., Bouaziz J.-D., Matsushita T., Magro C.M., St Clair E.W., and Tedder T.F. B-lymphocyte contributions to human autoimmune disease. Immunol Rev 223 (2008) 284-299
9. Silveira P.A., and Grey S.T. B cells in the spotlight: innocent bystanders or major players in the pathogenesis of type 1 diabetes. Trends Endocrinol Metab 17 (2006) 128-135
10. Gorus F., Goubert P., Semaluka C., Vandewalle C., De Schepper J., Scheen A., et al. IA-2 autoantibodies complement GAD65-autoantibodies in new onset IDDM patients and help predict impending diabetes in their siblings. Diabetologia 40 (1997) 95-99
11. Genovese S., Bonfanti R., Bazzigaluppi E., Lampasona V., Benazzi E., Bosi E., et al. Association of IA-2 autoantibodies with HLA DR4 phenotypes in IDDM. Diabetologia 39 (1996) 1223-1226
12. Christie M., Roll U., Payton M., Hatfield E., and Ziegler A. Validity of screening for individuals at risk for type I diabetes by combined analysis of autoantibodies to recombinant proteins. Diabetes Care 20 (1997) 965-970
13. Honeyman M.C., Brusic V., Stone N.L., and Harrison L.C. Neural network-based prediction of candidate T-cell epitopes. Nat Biotechnol 16 (1998) 966-969
14. Hawkes C.J., Schloot N.C., Marks J., Willeman S.J.M., Drijfthout J.W., Mayer E.K., et al. T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes. Diabetes 49 (2000) 356-366
15. Peakman M., Stevens E.J., Lohmann T., Narendran P., Dromey J., Alexander A., et al. Naturally processed and presented epitopes of the islet cell autoantigen IA-2 eluted from HLA-DR4. J Clin Invest 104 (1999) 1449-1457
16. Di Lorenzo T.P., Peakman M., and Roep B.O. Translational mini-review series on type 1 diabetes: systematic analysis of T-cell epitopes in autoimmune diabetes. Clin Exp Immunol 148 (2007) 1-16
17. Bearzatto M., Naserke H., Piquer S., Koczwara K., Lampasona V., Williams A., et al. Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens. J Immunol 168 (2002) 4202-4208
18. Lampasona V., Bearzatto M., Genovese S., Bosi E., Ferrari M., and Bonifacio E. Autoantibodies in insulin-dependent diabetes recognize distinct cytoplasmic domains of the protein tyrosine phosphatase-like IA-2 autoantigen. J Immunol 157 (1996) 2707-2711
19. Farilla L., Tiberti C., Luzzago A., Yu L.P., Eisenbarth G.S., Cortese R., et al. Application of phage display peptide library to autoimmune diabetes: identification of IA-2/ICA512bdc dominant autoantigenic epitopes. Eur J Immunol 32 (2002) 1420-1427
20. Kolm-Litty V., Berlo S., Bonifacio E., Bearzatto M., Engel A.M., Christie M., et al. Human monoclonal antibodies isolated from type I diabetes patients define multiple epitopes in the protein tyrosine phosphatase-like IA-2 antigen. J Immunol 165 (2000) 4676-4684
21. Dromey J.A., Weenink S.M., Peters G.H., Endl J., Tighe P.J., Todd I., et al. Mapping of epitopes for autoantibodies to the type 1 diabetes autoantigen IA-2 by peptide phage display and molecular modeling: overlap of antibody and T cell determinants. J Immunol 172 (2004) 4084-4090
22. Ananieva-Jordanova R., Evans M., Nakamatsu T., Premawardhana L.D.K.E., Sanders J., Powell M., et al. Isolation and characterisation of a human monoclonal autoantibody to the islet cell autoantigen IA-2. J Autoimmun 24 (2005) 337-345
23. Tremble J., Morgenthaler N.G., Vlug A., Powers A.C., Christie M.R., Scherbaum W.A., et al. Human B cells secreting immunoglobulin G to glutamic acid decarboxylase-65 from a nondiabetic patient with multiple autoantibodies and Graves' disease: a comparison with those present in type 1 diabetes. J Clin Endocrinol Metab 82 (1997) 2664-2670
24. Harlow E., and Lane D. Antibodies: a laboratory manual (1988), Cold Spring Harbor Laboratory, Cold Spring Harbor, New York
25. Piquer S., Valera L., Lampasona V., Jardin-Watelet B., Roche S., Granier C., et al. Monoclonal antibody 76F distinguishes IA-2 from IA-2beta and overlaps an autoantibody epitope. J Autoimmun 26 (2006) 215-222
26. Bunce M., O'Neill C.M., Barnardo M.C., Krausa P., Browning M.J., Morris P.J., et al. Phototyping: comprehensive DNA typing for HLA-A, B, C, DRB1, DRB3, DRB4, DRB5 & DQB1 by PCR with 144 primer mixes utilizing sequence-specific primers (PCR-SSP). Tissue Antigens 46 (1995) 355-367
27. Hatfield E.C.I., Hawkes C.J., Payton M.A., and Christie M.R. Cross reactivity between IA-2 and phogrin/IA-2 beta in binding of autoantibodies in IDDM. Diabetologia 40 (1997) 1327-1333
28. Kim S.J., Jeong D.G., Jeong S.K., Yoon T.-S., and Ryu S.E. Crystal structure of the major diabetes autoantigen insulinoma-associated protein 2 reveals distinct immune epitopes. Diabetes 56 (2007) 41-48
29. Arif S., Tree T.I., Astill T.P., Tremble J.M., Bishop A.J., Dayan C.M., et al. Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health. J Clin Invest 113 (2004) 451-463
30. Padoa C.J., Banga J.P., Madet A.-M., Ziegler M., Schlosser M., Ortqvist E., et al. Recombinant Fabs of human monoclonal antibodies specific to the middle epitope of GAD65 inhibit type 1 diabetes-specific GAD65Abs. Diabetes 52 (2003) 2689-2695
31. Fenalti G., Hampe C.S., Arafat Y., Law R.H.P., Banga J.P., Mackay I.R., et al. COOH-terminal clustering of autoantibody and T-cell determinants on the structure of GAD65 provide insights into the molecular basis of autoreactivity. Diabetes 57 (2008) 1293-1301
32. Moss C.X., Tree T.I., and Watts C. Reconstruction of a pathway of antigen processing and class II MHC peptide capture. EMBO J 26 (2007) 2137-2147
33. Ott P.A., Herzog B.A., Quast S., Hofstetter H.H., Boehm B.O., Tary-Lehmann M., et al. Islet-cell antigen-reactive T cells show different expansion rates and Th1/Th2 differentiation in type1 diabetic patients and healthy controls. Clin Immunol 115 (2005) 102-114
34. Durinovic-Bello I., Schlosser M., Riedl M., Maisel N., Rosinger S., Kalbacher H., et al. Pro- and anti-inflammatory cytokine production by autoimmune T cells against preproinsulin in HLA-DRB1*04, DQ8 type 1 diabetes. Diabetologia 47 (2004) 439-450
35. Durinovic-Bello I., Rosinger S., Olson J.A., Congia M., Ahmad R.C., Rickert M., et al. DRB1*0401-restricted human T cell clone specific for the major proinsulin 73-90 epitope expresses a down-regulatory T helper 2 phenotype. Proc Natl Acad Sci U S A 103 (2006) 11683-11688
36. Wong F.S., Wen L., and Tang M. Investigation of the role of B-cells in type 1 diabetes in the NOD mouse. Diabetes 53 (2004) 2581-2587
37. Pakala S.V., Kurrer M.O., and Katz J.D. T helper 2 (Th2) T cells induce acute pancreatitis and diabetes in immune-compromised nonobese diabetic (NOD) mice. J Exp Med 186 (1997) 299-306
38. Lafaille J.J., Keere F.V., and Hsu A.L. Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease. J Exp Med 186 (1997) 307-312