Mapping of novel autoreactive epitopes of the diabetes-associated autoantigen IA-2

Clinical and Experimental Immunology

Volumn 122, Issue 2, 2000, Pages 157-163

  Seissler, J ^a   Schott, M ^a   Morgenthaler, N G ^a   Scherbaum, W A ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Autoantibodies; Epitopes; Type 1 diabetes; Tyrosine phosphatase IA 2; Tyrosine phosphatase IA 2

Indexed keywords

AMINO ACID; ANTIBODY III IA 2; AUTOANTIBODY; AUTOANTIGEN IA 2; AUTOANTIGEN IA 2IC; CHIMERIC PROTEIN; EPITOPE; IA ANTIBODY; IA ANTIGEN; MUTANT PROTEIN; PROTEIN SUBUNIT; PROTEIN TYROSINE PHOSPHATASE; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AMINO TERMINAL SEQUENCE; ANTIBODY DETECTION; ANTIGEN ANTIBODY REACTION; ANTIGEN BINDING; ARTICLE; AUTOIMMUNE DISEASE; CARBOXY TERMINAL SEQUENCE; CHILD; CONFORMATION; CONTROLLED STUDY; FEMALE; GENE DELETION; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PRIORITY JOURNAL; TARGET CELL;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODY SPECIFICITY; AUTOANTIBODIES; AUTOANTIGENS; BASE SEQUENCE; CODON, INITIATOR; DIABETES MELLITUS, TYPE 1; EPITOPE MAPPING; IMMUNODOMINANT EPITOPES; MEMBRANE PROTEINS; MICE; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; PROTEIN-TYROSINE-PHOSPHATASE; RECOMBINANT FUSION PROTEINS; SEQUENCE DELETION; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0033742699     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2000.01352.x     Document Type: Article

References (26)

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3. ICA 512, a receptor tyrosine phosphatase-like protein, is concentrated in neurosecretory granule membranes
4. Pancreatic islet cell cytoplasmic antibody in diabetes is represented by antibodies to islet cell antigen 512 and glutamic acid decarboxylase
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8. Combined analysis and single-step detection of GAD65 and IA2 autoantibodies in IDDM can replace the histochemical islet cell antibody test
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15. B lymphocytes are crucial antigen-presenting cells in the pathogenic autoimmune response to GAD65 antigen in nonobese diabetic mice
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