Autoantibodies to IA-2 in IDDM location of major antigenic determinants

Diabetes

Volumn 46, Issue 1, 1997, Pages 40-43

  Zhang, Baowei ^a   Lan, Michael S ^a   Notkins, Abner Louis ^a  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN TYROSINE PHOSPHATASE;

ADOLESCENT; ADULT; AMINO TERMINAL SEQUENCE; ANTIGEN ANTIBODY REACTION; ANTIGEN DETECTION; ANTIGEN RECOGNITION; ARTICLE; CHILD; CLINICAL ARTICLE; HUMAN; IMMUNOREACTIVITY; INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL;

EID: 0031024367     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.46.1.40     Document Type: Article

References (15)

1. Lan MS, Lu J, Goto Y, Notkins AL: Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma. DNA Cell Biol 13:505-514, 1994
2. Lu J, Notkins AL, Lan MS: Isolation, sequence and expression of a novel mouse brain cDNA, mIA-2, and its relatedness to members of the protein tyrosine phophatase family. Biochem Biaphys Res Commun 204:930-936, 1994
3. Lan MS, Wasserfall CW, Maclaren NK, Notkins AL: IA-2, a transmembrane protein tyrosine phosphatase family, is a major autoantigen in insulin-dependent diabetes mellitus. Proc Natl Acad Sci USA 93:6367-6370, 1996
4. Rabin DU, Pleasic SM, Shapiro JA, Yoo-Warren H, Oles J, Hicks JM, Goldstein DE, Rae PMM: Islet cell antigen 512 is a diabetes-specific islet autoantigen related to protein tyrosine phosphatases. J Immunol 152:3183-3188, 1994
5. Payton MA, Hawkes CJ, Christie MR: Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). J Clin Invest 96:1506-1511, 1995
6. Passini N, Larigan D, Genovese S, Appella E, Sinigaglia F, Rogge L: The 37/40-kilodalton autoantigen in insulin-dependent diabetes mellitus is the putative tyrosine phosphatase IA-2. Proc Natl Acad Sci USA 92:9412-9416, 1995
7. Bonifacio E, Lampasona V, Genovese S, Ferrari M, Bosi E: Identification of protein tyrosine phosphatase-like IA2 (islet cell antigen 512) as the insulin-dependent diabetes-related 37/40K autoantigen and a target of islet-cell antibodies. J Immunol 155:5419-5426, 1995
8. Lu J, Li Q, Xie H, Chen Z-J, Borovitskaya AE, Maclaren NK, Notkins AL, Lan MS: Identification of a second transmembrane protein tyrosine phosphatase, IA-2β, as an autoantigen in insulin-dependent diabetes mellitus: precursor of the 37-kDa tryptic fragment. Proc Natl Acad Sci USA 93:2307-2311, 1996
9. Christie MR, Tun RYM, Lo SSS, Cassidy D, Brown TJ, Hollands J, Shattock M, Bottazzo GF, Leslie RDG: Antibodies to GAD and tryptic fragments of islet 64K antigen as distinct markers for development of IDDM. Diabetes 41:782-787, 1992
10. Baekkeskov S, Aanstoot H-J, Christgau S, Reetz A, Solimena M, Cascalho M, Folli F, Richter-Oleson H, DeCamilli P: Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature 347:151-156, 1990
11. Baekkeskov S, Landin M, Kristensen JK, Srikanta S, Bruining GJ, Mandrup-Poulsen T, De Beaufort C, Soeldner JS, Eisenbarth G, Lindgren F, Sundkvist G, Lernmark A: Antibodies to a 64,000-Mr human islet cell antigen precede the clinical onset of insulin-dependent diabetes. J Clin Invest 79:926-934, 1987
12. Atkinson M, Maclaren NK, Scharp DW, Lacy PE, Riley W: 64,000 Mr autoantibodies as predictors of insulin-dependent diabetes. Lancet 335:1357-1360, 1990
13. Kozak M, An analysis of 5′ noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Acids Res 15:8125-8132, 1987
14. Grubin CE, Daniels T, Toivola B, Landin-Olsson M, Hagopian WA, Li L, Karlsen AE, Boel E, Michelsen B, Lernmark A: A novel radioligand binding assay to determine diagnostic accuracy of isoform-specific glutamic acid decarboxylase antibodies in childhood IDDM. Diabetologia 37:344-350, 1994
15. Atkinson MA, Maclaren NK: The pathogenesis of insulin-dependent diabetes mellitus. N Engl J Med 331:1428-1436, 1994