Methods to investigate coronary microvascular function in clinical practice

Journal of Cardiovascular Medicine

Volumn 14, Issue 1, 2013, Pages 1-18

  Lanza, Gaetano A ^a   Camici, Paolo G ^b   Galiuto, Leonarda ^a   Niccoli, Giampaolo ^a   Pizzi, Carmine ^c   Di Monaco, Antonio ^a   Sestito, Alfonso ^a   Novo, Salvatore ^d   Piscione, Federico ^e   Tritto, Isabella ^f   Ambrosio, Giuseppe ^f   Bugiardini, Raffaele ^c   Crea, Filippo ^a   Marzilli, Mario ^g  

^a CATHOLIC UNIVERSITY   (Italy)

^b VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^c UNIVERSITY OF BOLOGNA   (Italy)

^d UNIVERSITY OF PALERMO   (Italy)

^e UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^f UNIVERSITY OF PERUGIA   (Italy)

^g UNIVERSITY OF PISA   (Italy)

Author keywords

cardiovascular magnetic resonance; coronary microcirculation; diagnostic investigation; intracoronary Doppler ultrasound; myocardial contrast echocardiography; PET; transthoracic Doppler echocardiography

Indexed keywords

ACETYLCHOLINE; ADENOSINE; BRADYKININ; CORONARY VASODILATING AGENT; DIPYRIDAMOLE; ERGOMETRINE MALEATE; METHYLERGOMETRINE; NITROPRUSSIDE SODIUM; PAPAVERINE; RUBIDIUM 82; SUBSTANCE P;

ACUTE CORONARY SYNDROME; ACUTE HEART INFARCTION; ADRENERGIC STIMULATION; ANGIOCARDIOGRAPHY; BLOOD PRESSURE; CARDIOVASCULAR MAGNETIC RESONANCE; CARDIOVASCULAR RISK; CLINICAL PRACTICE; COLD PRESSOR TEST; CONGESTIVE CARDIOMYOPATHY; CONTRAST ECHOCARDIOGRAPHY; CORONARY ARTERY; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY CALCIFICATION; CORONARY ARTERY CIRCUMFLEX BRANCH; CORONARY ARTERY CONSTRICTION; CORONARY ARTERY PRESSURE; CORONARY ARTERY RECANALIZATION; CORONARY FLOW RESERVE; CORONARY MICROVASCULAR DYSFUNCTION; CORONARY VASCULAR RESISTANCE; DIAGNOSTIC VALUE; DOPPLER ECHOCARDIOGRAPHY; DOPPLER ECHOGRAPHY; DOPPLER FLOWMETRY; DRUG HALF LIFE; HEART LEFT VENTRICLE HYPERTROPHY; HEART MUSCLE BLOOD FLOW; HEART MUSCLE OXYGEN CONSUMPTION; HEART MUSCLE PERFUSION; HEART MUSCLE REVASCULARIZATION; HEART RIGHT ATRIUM PRESSURE; HEART SEPTUM DEFECT; HUMAN; HYPERTROPHIC CARDIOMYOPATHY; INSULIN SENSITIVITY; INTRACORONARY INFUSION; INVASIVE PROCEDURE; LEFT ANTERIOR DESCENDING CORONARY ARTERY; METABOLIC REGULATION; MICROANGIOPATHY; MICROCIRCULATION; NON INVASIVE PROCEDURE; PERCUTANEOUS CORONARY INTERVENTION; PERFUSION PRESSURE; POSITRON EMISSION TOMOGRAPHY; RADIATION EXPOSURE; REVIEW; SENSITIVITY AND SPECIFICITY; SYNDROME X; THERMODILUTION; TRANSTHORACIC ECHOCARDIOGRAPHY;

CORONARY ARTERY DISEASE; CORONARY CIRCULATION; DIAGNOSTIC IMAGING; HUMANS; MICROCIRCULATION;

EID: 84871981135     PISSN: 15582027     EISSN: 15582035     Source Type: Journal    
DOI: 10.2459/JCM.0b013e328351680f     Document Type: Review

References (157)

1. Camici PG, Crea F. Coronary microvascular dysfunction. N Engl J Med 2007; 356:830-840.
2. Lanza GA, Crea F. Primary coronary microvascular dysfunction: clinical presentation, pathophysiology, and management. Circulation 2010; 121:2317-2325.
3. Maseri A. Ischemic heart disease. New York: Churchill Livingstone; 1995.
4. Kaski JC, Rosano GMC, Collins P, et al. Cardiac syndrome X: clinical characteristics and left ventricular function. Long-term follow-up study. J Am Coll Cardiol 1995; 25:807-814.
5. Lamendola P, Lanza GA, Spinelli A, et al. Long-term prognosis of patients with cardiac syndrome X. Int J Cardiol 2010; 140:197-199.
6. Bugiardini R, Bairey Merz CN. Angina with 'normal' coronary arteries: a changing philosophy. JAMA 2005; 293:477-484.
7. Bugiardini R, Manfrini O, De Ferrari GM. Unanswered questions for management of acute coronary syndrome: risk stratification of patients with minimal disease or normal findings on coronary angiography. Arch Intern Med 2006; 166:1391-1395. (Pubitemid 44036351)
8. Neglia D, Michelassi C, Trivieri MG, et al. Prognostic role of myocardial blood flow impairment in idiopathic left ventricular dysfunction. Circulation 2002; 105:186-193. (Pubitemid 34084317)
9. Cecchi F, Olivotto I, Gistri R, et al. Coronary microvascular dysfunction and prognosis in hypertrophic cardiomyopathy. N Engl J Med 2003; 349:1027-1035. (Pubitemid 37087617)
10. Escaned J, Flores A, Garćia-Pav́ia P, et al. Assessment of microcirculatory remodeling with intracoronary flow velocity and pressure measurements: validation with endomyocardial sampling in cardiac allografts. Circulation 2009; 120:1561-1568.
11. Pizzi C, Bugiardini R. Further insights into syndrome X. Heart 2010; 96:1865-1867.
12. Leung DY, Leung M. Noninvasive/invasive imaging: significance and assessment of coronary microvascular dysfunction. Heart 2011; 97:587-595.
13. Marzilli M, Sambuceti G, Fedele S, L'Abbate A. Coronary microcirculatory vasoconstriction during ischemia in patients with unstable angina. J Am Coll Cardiol 2000; 35:327-334. (Pubitemid 30125521)
14. Pries AR, Habazettl H, Ambrosio G, et al. A review of methods for assessment of coronary microvascular disease in both clinical and experimental settings. Cardiovasc Res 2008; 80:165-174.
15. Webb CM, Collins P, Di Mario C. Normal coronary physiology assessed by intracoronary Doppler ultrasound. Herz 2005; 30:8-16. (Pubitemid 40521552)
16. McGuinness ME, Talbert RL. Pharmacologic stress testing: experience with dipyridamole, adenosine, and dobutamine. Am J Hosp Pharm 1994; 51:328-346. (Pubitemid 24046370)
17. Münzel T, Sinning C, Post F, et al. Pathophysiology diagnosis and prognostic implications of endothelial dysfunction. Ann Med 2008; 40:180-196. (Pubitemid 351482543)
18. Bugiardini R, Badimon L, Collins P, et al. Angina 'normal' coronary angiography, and vascular dysfunction: risk assessment strategies. PLoS Med 2007; 4:e12.
19. Sanderson JE, Woo KS, Chung HK, et al. Endothelium-dependent dilation of the coronary arteries in syndrome X: effects of the cold pressor test. Cardiology 1997; 88:414-417. (Pubitemid 27331316)
20. Kiviniemi T. Assessment of coronary blood flow and the reactivity of the microcirculation noninvasively with transthoracic echocardiography. Clin Physiol Funct Imaging 2008; 28:145-155. (Pubitemid 351540499)
21. Meimoun P, Tribouilloy C. Noninvasive assessment of coronary flow and coronary flow reserve by transthoracic Doppler echocardiography: a magic tool for the real world. Eur J Echocardiogr 2008; 9:449-457. (Pubitemid 351882110)
22. Pizzuto F, Voci P, Mariano E, et al. Assessment of flow velocity reserve by transthoracic Doppler echocardiography and venous adenosine infusion before and after left anterior descending coronary artery stenting. J Am Coll Cardiol 2001; 38:155-162. (Pubitemid 32613843)
23. Galderisi M, Cicala S, D'Errico A, et al. Nebivolol improves coronary flow reserve in hypertensive patients without coronary heart disease. J Hypertens 2004; 22:2201-2208. (Pubitemid 39463815)
24. Hozumi T, Yoshida K, Akasaka T, et al. Noninvasive assessment of coronary flow velocity and coronary flow velocity reserve in the left anterior descending coronary artery by Doppler echocardiography: comparison with invasive technique. J Am Coll Cardiol 1998; 32:1251-1259. (Pubitemid 28522380)
25. Hildick-Smith DJ, Maryan R, Shapiro LM. Assessment of coronary flow reserve by adenosine transthoracic echocardiography: validation with intracoronary Doppler. J Am Soc Echocardiogr 2002; 15:984-990.
26. Lethen H, Tries HP, Brechtken J, et al. Comparison of transthoracic Doppler echocardiography to intracoronary Doppler guidewire measurements for assessment of coronary flow reserve in the left anterior descending artery for detection of restenosis after coronary angioplasty. Am J Cardiol 2003; 91:412-417. (Pubitemid 36183558)
27. Ueno Y, Nakamura Y, Takashima H, et al. Noninvasive assessment of coronary flow velocity and coronary flow velocity reserve in the right coronary artery by transthoracic Doppler echocardiography: comparison with intracoronary Doppler guidewire. J Am Soc Echocardiogr 2002; 15:1074-1079. (Pubitemid 36559711)
28. Lethen H, P Tries H, Kersting S, Lambertz H. Validation of noninvasive assessment of coronary flow velocity reserve in the right coronary artery. A comparison of transthoracic echocardiographic results with intracoronary Doppler flow wire measurements. Eur Heart J 2003; 24:1567-1575. (Pubitemid 37012191)
29. Auriti A, Pristipino C, Cianfrocca C, et al. Distal left circumflex coronary artery flow reserve recorded by transthoracic Doppler echocardiography: a comparison with Doppler-wire. Cardiovasc Ultrasound 2007; 5:22.
30. Saraste M, Koskenvuo J, Knuuti J, et al. Coronary flow reserve: measurement with transthoracic Doppler echocardiography is reproducible and comparable with positron emission tomography. Clin Physiol 2001; 21:114-122.
31. Sestito A, Lanza GA, Di Monaco A, et al. Relation between cardiovascular risk factors and coronary microvascular dysfunction in cardiac syndrome X. J Cardiovasc Med (Hagerstown) 2011; 12:322-327.
32. Otsuka R, Watanabe H, Hirata K, et al. Acute effects of passive smoking on the coronary circulation in healthy young adults. JAMA 2001; 286:436-441. (Pubitemid 32681486)
33. Hozumi T, Eisenberg M, Sugioka K, et al. Change in coronary flow reserve on transthoracic Doppler echocardiography after a single high-fat meal in young healthy men. Ann Intern Med 2002; 136: 523-528. (Pubitemid 34252286)
34. Kiviniemi TO, Toikka JO, Koskenvuo JW, et al. Vasodilation of epicardial coronary artery can be measured with transthoracic echocardiography. Ultrasound Med Biol 2007; 33:362-370. (Pubitemid 46275181)
35. Oe H, Hozumi T, Murata E, et al. Arachidonic acid and docosahexaenoic acid supplementation increases coronary flow velocity reserve in Japanese elderly individuals. Heart 2008; 94:316-321. (Pubitemid 351303423)
36. Khan F, Patterson D, Belch JJ, et al. Relationship between peripheral and coronary function using laser Doppler imaging and transthoracic echocardiography. Clin Sci (Lond) 2008; 115:295-300.
37. Shiina Y, Funabashi N, Lee K, et al. Acute effect of oral flavonoid-rich dark chocolate intake on coronary circulation, as compared with nonflavonoid white chocolate, by transthoracic Doppler echocardiography in healthy adults. Int J Cardiol 2009; 131:424-429.
38. Lethen H, Tries HP, Kersting S, et al. Improvement of coronary microvascular function after angiotensin receptor blocker treatment with irbesartan in patients with systemic hypertension. J Clin Hypertens (Greenwich) 2011; 13:155-161.
39. Zhang X, Yang Y, Li Z, et al. Noninvasive evaluation of coronary flow velocity reserve in homozygous familial hypercholesterolemia by transthoracic Doppler echocardiography. Echocardiography 2010; 27:985-989.
40. Rigo F, Gherardi S, Galderisi M, et al. The prognostic impact of coronary flow-reserve assessed by Doppler echocardiography in nonischaemic dilated cardiomyopathy. Eur Heart J 2006; 27:1319-1323. (Pubitemid 43998105)
41. Cortigiani L, Rigo F, Gherardi S, et al. Prognostic implications of coronary flow reserve on left anterior descending coronary artery in hypertrophic cardiomyopathy. Am J Cardiol 2008; 102:1718-1723.
42. Di Monaco A, Bruno I, Sestito A, et al. Cardiac adrenergic nerve function and microvascular dysfunction in patients with cardiac syndrome X. Heart 2009; 95:550-554.
43. Barletta G, Del Pace S, Boddi M, et al. Abnormal coronary reserve and left ventricular wall motion during cold pressor test in patients with previous left ventricular ballooning syndrome. Eur Heart J 2009; 30:3007-3014.
44. Senior R, Becher H, Monaghan M, et al. Contrast echocardiography: evidence-based recommendations by European Association of Echocardiography. Eur J Echocardiogr 2009; 10:194-212.
45. Wein K, Jayaweera AR, Firoozan S, et al. Quantification of myocardial blood flow with ultrasound-induced destruction of microbubbles administered as a constant venous infusion. Circulation 1998; 97:473-483. (Pubitemid 28090220)
46. Muro T, Hozumi T, Watanabe H, et al. Assessment of myocardial perfusion abnormalities by intravenous myocardial contrast echocardiography with harmonic power Doppler imaging: comparison with positron emission tomography. Heart 2003; 89:145-149. (Pubitemid 36115094)
47. Ito H, Tomooka T, Sakai N, et al. Lack of myocardial perfusion immediately after successful thrombolysis. A predictor of poor recovery of left ventricular function in anterior myocardial infarction. Circulation 1992; 85:1699-1705.
48. Ito H, Tomooka T, Sakai N, et al. Time course of functional improvement in stunned myocardium in risk area in patients with reperfused anterior infarction. Circulation 1993; 87:355-362. (Pubitemid 23040903)
49. Kamp O, Lepper W, Vanoverschelde JL, et al. Serial evaluation of perfusion defects in patients with a first acute myocardial infarction referred for primary PTCA using intravenous myocardial contrast echocardiography. Eur Heart J 2001; 22:1485-1495. (Pubitemid 32769176)
50. Balcells E, Powers ER, Lepper W, et al. Detection of myocardial viability by contrast echocardiography in acute infarction predicts recovery of resting function and contractile reserve. J Am Coll Cardiol 2003; 41:827-833. (Pubitemid 36308392)
51. Galiuto L, Lombardo A, Maseri A, et al. Temporal evolution and functional outcome of no reflow: sustained and spontaneously reversible patterns following successful coronary recanalisation. Heart 2003; 89:731-737. (Pubitemid 36760629)
52. Bolognese L, Carrabba N, Parodi G, Santoro GM. Impact of microvascular dysfunction on left ventricular remodeling and long-term clinical outcome after primary coronary angioplasty for acute myocardial infarction. Circulation 2004; 109:1121-1126. (Pubitemid 38332616)
53. Agati L, Tonti G, Pedrizzetti G, et al. Clinical application of quantitative analysis in real-time MCE. Eur J Echocardiogr 2004; 5:S17-S23.
54. Janardhanan R, Moon JC, Pennell DJ, Senior R. Myocardial contrast echocardiography accurately reflects transmurality of myocardial necrosis and predicts contractile reserve after acute myocardial infarction. Am Heart J 2005; 149:355-362. (Pubitemid 40348548)
55. Moir S, Haluska BA, Jenkins C, et al. Myocardial blood volume and perfusion reserve responses to combined dipyridamole and exercise stress: a quantitative approach to contrast stress echocardiography. J Am Soc Echocardiogr 2005; 18:1187-1193. (Pubitemid 41597119)
56. Galiuto L, Garramone B, Burzotta F, et al. REMEDIA Investigators. Thrombus aspiration reduces microvascular obstruction after primary coronary intervention: a myocardial contrast echocardiography substudy of the REMEDIA Trial. J Am Coll Cardiol 2006; 48:1355-1360. (Pubitemid 44436805)
57. Trindade ML, Caldas MA, Tsutsui JM, et al. Determination of size and transmural extent of acute myocardial infarction by real-time myocardial perfusion echocardiography: a comparison with magnetic resonance imaging. J Am Soc Echocardiogr 2007; 20:126-135. (Pubitemid 46176568)
58. Galiuto L, Garramone B, Scarà A, et al. AMICI Investigators. The extent of microvascular damage during myocardial contrast echocardiography is superior to other known indexes of postinfarct reperfusion in predicting left ventricular remodeling: Results of the multicenter AMICI study. J Am Coll Cardiol 2008; 51:552-559.
59. Abdelmoneim SS, Bernier M, Dhoble A, et al. Assessment of the vascularity of a left atrial mass using myocardial perfusion contrast echocardiography. Echocardiography 2008; 25:517-520. (Pubitemid 351623866)
60. Hayat SA, Dwivedi G, Jacobsen A, et al. Effects of left bundle-branch block on cardiac structure, function, perfusion, and perfusion reserve: implications for myocardial contrast echocardiography versus radionuclide perfusion imaging for the detection of coronary artery disease. Circulation 2008; 117:1832-1841. (Pubitemid 351507471)
61. Senior R, Monaghan M, Main ML, et al. RAMP-1 and RAMP-2 Investigators. Detection of coronary artery disease with perfusion stress echocardiography using a novel ultrasound imaging agent: two Phase 3 international trials in comparison with radionuclide perfusion imaging. Eur J Echocardiogr 2009; 10:26-35.
62. Mansencal N, Revault-d'Allonnes L, Pelage JP, et al. Usefulness of contrast echocardiography for assessment of intracardiac masses. Arch Cardiovasc Dis 2009; 102:177-183.
63. Galiuto L, De Caterina AR, Porfidia A, et al. Reversible coronary microvascular dysfunction: a common pathogenetic mechanism in ApicalBallooning or Tako-Tsubo Syndrome. Eur Heart J2010; 31:1319-1327.
64. Galiuto L, DeMaria AN, May-Newman K, et al. Evaluation of dynamic changes in microvascular flow during ischemia-reperfusion by myocardial contrast echocardiography. J Am Coll Cardiol 1998; 32:1096-1101. (Pubitemid 28459605)
65. Niccoli G, Burzotta F, Galiuto L, Crea F. Myocardial no-reflow in humans. J Am Coll Cardiol 2009; 54:281-289.
66. Ito H, Maruyama A, Iwakura K, et al. Clinical implications of the no-reflow phenomenon. A predictor of complications and left ventricular remodeling in reperfused anterior wall myocardial infarction. Circulation 1996; 93:223-228. (Pubitemid 26031478)
67. Galiuto L. Optimal therapeutic strategies in the setting of postinfarct no re-flow: the need for a pathogenetic classification. Heart 2004; 90:123-125. (Pubitemid 38147132)
68. Funaro S, La Torre G, Madonna M, et al. AMICI Investigators. Incidence, determinants, and prognostic value of reverse left ventricular remodelling after primary percutaneous coronary intervention: results of the Acute Myocardial Infarction Contrast Imaging (AMICI) multicenter study. Eur Heart J 2009; 30:566-575.
69. Lombardo A, Rizzello V, Galiuto L, et al. Assessment of resting perfusion defects in patients with acute myocardial infarction: comparison of myocardial contrast echocardiography, combined first-pass/delayed contrast-enhanced magnetic resonance imaging and 99mTC-sestamibi SPECT. Int J Cardiovasc Imaging 2006; 22:417-428. (Pubitemid 43880672)
70. Bielecka-Dabrowa A, Mikhailidis DP, Hannam S, et al. Takotsubo cardiomyopathy: the current state of knowledge. Int J Cardiol 2010; 142:120-125.
71. Galiuto L, Sestito A, Barchetta S, et al. Noninvasive evaluation of flow reserve in the left anterior descending coronary artery in patients with cardiac syndrome X. Am J Cardiol 2007; 99:1378-1383. (Pubitemid 46686641)
72. Grayburn PA. 'Product safety' compromises patient safety (an unjustified black box warning on ultrasound contrast agents by the Food and Drug Administration). Am J Cardiol 2008; 101:892-893.
73. Peng BH, Levin CS. Recent development in PET instrumentation. Curr Pharm Biotechnol 2010; 11:555-571.
74. Kaufmann PA, Camici PG. Myocardial blood flow by PET: technical aspects and clinical applications. J Nucl Med 2005; 46:75-88. (Pubitemid 43086001)
75. Camici PG, Rimoldi OE. The clinical value of myocardial blood flow measurement. J Nucl Med 2009; 50:1076-1087.
76. Bergmann SR, Herrero P, Markham J, et al. Noninvasive quantitation of myocardial bloodflowinhuman subjects with oxygen-15-labeled water and positron emission tomography. J Am Coll Cardiol 1989; 14:639-652. (Pubitemid 19229339)
77. Araujo LI, Lammertsma AA, Rhodes CG, et al. Noninvasive quantification of regional myocardial blood flow in coronary artery disease with oxygen-15-labeled carbon dioxide inhalation and positron emission tomography. Circulation 1991; 83:875-885.
78. Kaufmann PA, Gnecchi-Ruscone T, Yap JT, et al. Assessment of the reproducibility of baseline and hyperemic myocardial blood flow measurements with 15O-labeled water and PET. J Nucl Med 1999; 40:1848-1856. (Pubitemid 29523579)
79. Bellina CR, Parodi O, Camici P, et al. Simultaneous in vitro and in vivo validation of nitrogen-13-ammonia for the assessment of regional myocardial blood flow. J Nucl Med 1990; 31:1335-1343. (Pubitemid 20245930)
80. Hutchins GD, Schwaiger M, Rosenspire KC, et al. Noninvasive quantification of regional blood flow in the human heart using N-13 ammonia and dynamic positron emission tomographic imaging. J Am Coll Cardiol 1990; 15:1032-1042. (Pubitemid 20104558)
81. Krivokapich J, Smith GT, Huang SC, et al. 13N ammonia myocardial imaging at rest and with exercise in normal volunteers. Quantification of absolute myocardial perfusion with dynamic positron emission tomography. Circulation 1989; 80:1328-1337. (Pubitemid 19282523)
82. Herrero P, Markham J, Shelton ME, et al. Noninvasive quantification of regional myocardial perfusion with rubidium-82 and positron emission tomography. Exploration of a mathematical model. Circulation 1990; 82:1377-1386.
83. Scott NS, Le May MR, de Kemp R, et al. Evaluation of myocardial perfusion using rubidium-82 positron emission tomography after myocardial infarction in patients receiving primary stent implantation or thrombolytic therapy. Am J Cardiol 2001; 88:886-889. (Pubitemid 32995925)
84. Schäfers KP, Spinks TJ, Camici PG, et al. Absolute quantification of myocardial blood flow with H(2)(15)O and 3-dimensional PET: an experimental validation. J Nucl Med 2002; 43:1031-1040. (Pubitemid 34847926)
85. Kaufmann PA, Gnecchi-Ruscone T, di Terlizzi M, et al. Coronary heart disease in smokers: vitamin C restores coronary microcirculatory function. Circulation 2000; 102:1233-1238.
86. Tamai O, Matsuoka H, Itabe H, et al. Single LDL apheresis improves endothelium-dependent vasodilation in hypercholesterolemic humans. Circulation 1997; 95:76-82. (Pubitemid 27029946)
87. Gould KL, Martucci JP, Goldberg DI, et al. Short-term cholesterol lowering decreases size and severity of perfusion abnormalities by positron emission tomography after dipyridamole in patients with coronary artery disease. Circulation 1994; 89:1530-1538.
88. Yokoyama I, Ohtake T, Momomura S, et al. Reduced coronary flow reserve in hypercholesterolemic patients without overt coronary stenosis. Circulation 1996; 94:3232-3238. (Pubitemid 26427492)
89. Kaufmann PA, Gnecchi-Ruscone T, Schafers KP, et al. Low density lipoprotein cholesterol and coronary microvascular dysfunction in hypercholesterolemia. J Am Coll Cardiol 2000; 36:103-109. (Pubitemid 30466119)
90. Strauer BE. Ventricular function and coronary hemodynamics in hypertensive heart disease. Am J Cardiol 1979; 44:999-1006. (Pubitemid 10200711)
91. Opherk D, Mall G, Zebe H, et al. Reduction of coronary reserve: a mechanism for angina pectoris in patients with arterial hypertension and normal coronary arteries. Circulation 1984; 69:1-7. (Pubitemid 14215854)
92. Brush JE Jr, Cannon RO 3rd, Schenke WH, et al. Angina due to coronary microvascular disease in hypertensive patients without left ventricular hypertrophy. N Engl J Med 1988; 319:1302-1307. (Pubitemid 19003391)
93. Vogt M, Motz W, Strauer BE. Coronary haemodynamics in hypertensive heart disease. Eur Heart J 1992; 13 (Suppl D):44-49.
94. Tanaka M, Fujiwara H, Onodera T, et al. Quantitative analysis of narrowing of intramyocardial small arteries in normal heart, hypertensive hearts, and hearts with hypertrophic cardiomyopathy. Circulation 1986; 76:1130-1139.
95. Schwartzkopff B, Motz W, Frenzel H, et al. Structural and functional alterations of the intramyocardial coronary arterioles in patients with arterial hypertension. Circulation 1993; 88:993-1003. (Pubitemid 23264015)
96. Gimelli A, Schneider-Eicke J, Neglia D, et al. Homogeneously reduced versus regionally impaired myocardial blood flow in hypertensive patients: two different patterns of myocardial perfusion associated with degree of hypertrophy. J Am Coll Cardiol 1998; 31:366-373. (Pubitemid 28153457)
97. Di Carli MF, Janisse J, Grunberger G, Ager J. Role of chronic hyperglycemia in the pathogenesis of coronary microvascular dysfunction in diabetes. J Am Coll Cardiol 2003; 41:1387-1393. (Pubitemid 36439001)
98. Camici P, Chiriatti G, Lorenzoni R, et al. Coronary vasodilation is impaired in both hypertrophied and nonhypertrophied myocardium of patients with hypertrophic cardiomyopathy: a study with nitrogen-13 ammonia and positron emission tomography. J Am Coll Cardiol 1991; 17:879-886.
99. Camici PG, Cecchi RG, Montereggi A, et al. Dipyridamole-induced subendocardial underperfusion in hypertrophic cardiomyopathy assessed by positron-emission tomography. Coron Art Dis 1991; 2:837-841.
100. Gistri R, Cecchi F, Choudhury L, et al. Effect of verapamil on absolute myocardial blood flow in hypertrophic cardiomyopathy. Am J Cardiol 1994; 74:363-368. (Pubitemid 24253474)
101. Choudhury L, Elliott P, Rimoldi O, et al. Transmural myocardial blood flow distribution in hypertrophic cardiomyopathy and effect of treatment. Basic Res Cardiol 1999; 94:49-59. (Pubitemid 29103612)
102. Basso C, Thiene G, Corrado D, et al. Hypertrophic cardiomyopathy and sudden death in the young: pathologic evidence of myocardial ischemia. Hum Pathol 2000; 31:988-998.
103. Maron BJ, Wolfson JK, Epstein SE, Roberts WC. Intramural ('small vessel') coronary artery disease in hypertrophic cardiomyopathy. J Am Coll Cardiol 1986; 8:545-557. (Pubitemid 16048006)
104. Neglia D, Parodi O, Gallopin M, et al. Myocardial blood flow response to pacing tachycardia and to dipyridamole infusion in patients with dilated cardiomyopathy without overt heart failure. A quantitative assessment by positron emission tomography. Circulation 1995; 92:796-804.
105. Canetti M, Akhter MW, Lerman A, et al. Evaluation of myocardial blood flow reserve in patients with chronic congestive heart failure due to idiopathic dilated cardiomyopathy. Am J Cardiol 2003; 92:1246-1249. (Pubitemid 37377848)
106. Rosen SD, Uren NG, Kaski JC, et al. Coronary vasodilator reserve, pain perception, and sex in patients with syndrome X. Circulation 1994; 90:50-60. (Pubitemid 24203662)
107. Bøttcher M, Botker HE, Sonne H, et al. Endothelium-dependent and-independent perfusion reserve and the effect of L-arginine on myocardial perfusioninpatients with syndromeX.Circulation 1999; 99:1795-1801. (Pubitemid 29181406)
108. de Vries J, De Jongste MJ, Jessurun GA, et al. Myocardial perfusion quantification in patients suspected of cardiac syndrome X with positive and negative exercise testing: a [13N]ammonia positron emission tomography study. Nucl Med Commun 2006; 27:791-794. (Pubitemid 44401247)
109. Meeder JG, Blanksma PK, van der Wall EE, et al. Coronary vasomotion in patients with syndrome X: evaluation with positron emission tomography and parametric myocardial perfusion imaging. Eur J Nucl Med 1997; 24:530-537. (Pubitemid 27239212)
110. Galassi AR, Crea F, Araujo LI, et al. Comparison of regional myocardial blood flow in syndrome X and one-vessel coronary artery disease. Am J Cardiol 1993; 72:134-139. (Pubitemid 23205866)
111. Jerosch-Herold M, Seethamraju RT, Swingen CM, et al. Analysis of myocardial perfusion MRI. J Magn Reson Imaging 2004; 19:758-770. (Pubitemid 38788658)
112. Rosen BD, Lima JA, Nasir K, et al. Lower myocardial perfusion reserve is associated with decreased regional left ventricular function in asymptomatic participants of the multiethnic study of atherosclerosis. Circulation 2006; 114:289-297. (Pubitemid 44297095)
113. Patel AR, Epstein FH, Kramer CM. Evaluation of the microcirculation: advances in cardiac magnetic resonance perfusion imaging. J Nucl Cardiol 2008; 15:698-708.
114. Avegliano G, Huguet M, Costabel JP, et al. Morphologic pattern of late gadolinium enhancement in Takotsubo cardiomyopathy detected by early cardiovascular magnetic resonance. Clin Cardiol 2011; 34:178-182.
115. Petersen SE, Jerosch-Herold M, Hudsmith LE, et al. Evidence for microvascular dysfunction in hypertrophic cardiomyopathy: new insights from multiparametric magnetic resonance imaging. Circulation 2007; 115:2418-2425. (Pubitemid 46717964)
116. Hombach V, Merkle N, Torzewski J, et al. Electrocardiographic and cardiac magnetic resonance imaging parametersas predictors of aworse outcome in patients with idiopathic dilated cardiomyopathy. Eur Heart J 2009; 30:2011-2018.
117. Panting JR, Gatehouse PD, Yang GZ, et al. Abnormal subendocardial perfusion in cardiac syndrome X detected by cardiovascular magnetic resonance imaging. N Engl J Med 2002; 346:1948-1953. (Pubitemid 34651354)
118. Lanza GA, Buffon A, Sestito A, et al. Relation between stress-induced myocardial perfusion defects on cardiovascular magnetic resonance and coronary microvascular dysfunction in patients with cardiac syndrome X. J Am Coll Cardiol 2008; 51:466-472.
119. Kim RJ, Fieno DS, Parrish TB, et al. Relationship of MRI delayed contrast enhancement to irreversible injury, infarct age, and contractile function. Circulation 1999; 100:1992-2002. (Pubitemid 29529292)
120. Esposito G, Dellegrottaglie S, Chiariello M. The extent of irreversible myocardial damage and the potential for left ventricular repair after primary percutaneous coronary intervention. Am Heart J 2010; 160 (6 Suppl): S4-S10.
121. Hombach V, Merkle N, Bernhard P, et al. Prognostic significance of cardiac magnetic resonance imaging: Update 2010. Cardiol J 2010; 17:549-557.
122. Plein S, Kozerke S, Suerder D, et al. High spatial resolution myocardial perfusion cardiac magnetic resonance for the detection of coronary artery disease. Eur Heart J 2008; 29:2148-2155.
123. Raman SV, Simonetti OP, Winner MW III, Ambrosio G. Cardiac magnetic resonance with edema imaging identifies myocardium at risk and predicts worse outcome in patients with non-ST-segment elevation acute coronary syndrome. J Am Coll Cardiol 2010; 55:2480-2488.
124. Plein S, Schwitter J, Suerder D, Kozerke S. k-Space and time sensitivity encoding accelerated myocardial perfusion MR imaging at 3.0 T: comparison with 1.5 T. Radiology 2008; 249:493-500.
125. Hsu LY, Kellman P, Arai AE. Nonlinear myocardial signal intensity correction improves quantification of contrast-enhanced first-pass MR perfusion in humans. J Magn Reson Imaging 2008; 27:793-801. (Pubitemid 351508094)
126. Kuo PH, Kanal E, Abu-Alfa AK, Cowper SE. Gadolinium-based MR contrast agents and nephrogenic systemic fibrosis. Radiology 2007; 242:647-649.
127. Tong CY, Prato FS, Wisenberg G, et al. Techniques for the measurement of the local myocardial extraction efficiency for inert diffusible contrast agents such as gadopentate dimeglumine. Magn Reson Med 1993; 30:332-336. (Pubitemid 23264611)
128. Tong CY, Prato FS, Wisenberg G, et al. Measurement of the extraction efficiency and distribution volume for Gd-DTPA in normal and diseased canine myocardium. Magn Reson Med 1993; 30:337-346. (Pubitemid 23264612)
129. Zierler K. Indicator dilution methods for measuring blood flow, volume, and other properties of biological systems: a brief history and memoir. Ann Biomed Eng 2000; 28:836-848. (Pubitemid 32085368)
130. Jerosch-Herold M, Swingen C, Seethamraju RT. Myocardial blood flow quantification with MRI by model-independent deconvolution. Med Phys 2002; 29:886-897. (Pubitemid 34525918)
131. Marcus ML, Wilson RF, White CW. Methods of measurement of myocardial blood flow in patients: a critical review. Circulation 1987; 76:245-253. (Pubitemid 17127003)
132. Pijls NH, De Bruyne B, Smith L, et al. Coronary thermodilution to assess flow reserve: validation in humans. Circulation 2002; 105:2482-2486. (Pubitemid 34568968)
133. Melikian N, Kearney MT, Thomas MR, et al. A simple thermodilution technique to assess coronary endothelium-dependent microvascular function in humans: validation and comparison with coronary flow reserve. Eur Heart J 2007; 28:2188-2194. (Pubitemid 47428940)
134. Kelm M, Strauer BE. Coronary flow reserve measurements in hypertension. Med Clin North Am 2004; 88:99-113. (Pubitemid 38160943)
135. Joye JD, Schulman DS. Clinical application of coronary flow reserve using an intracoronary Doppler guide wire. Cardiol Clin 1997; 15:101-129. (Pubitemid 27106420)
136. Tahk SJ, Choi BJ, Choi SY, et al. Distal protection device protects microvascular integrity during primary percutaneous intervention in acute myocardial infarction: a prospective, randomized, multicenter trial. Int J Cardiol 2008; 123:162-168.
137. Spaan JA, Piek JJ, Hoffman JI, Siebes M. Physiological basis of clinically used coronary hemodynamic indices. Circulation 2006; 113:446-455. (Pubitemid 43803207)
138. Knaapen P, Camici PG, Marques KM, et al. Coronary microvascular resistance: methods for its quantification in humans. Basic Res Cardiol 2009; 104:485-498.
139. Fearon WF, Balsam LB, Farouque HM, et al. Novel index for invasively assessing the coronary microcirculation. Circulation 2003; 107:3129-3132. (Pubitemid 36793080)
140. Kolyva C, Spaan JA, Piek JJ, Siebes M. Windkesselness of coronary arteries hampers assessment of human coronary wave speed by single-point technique. Am J Physiol Heart Circ Physiol 2008; 295:H482-H490.
141. Gibson CM, Murphy S, Menown IB, et al. Determinants of coronary blood
142. Molloi S, Ersahin A, Tang J, et al. Quantification of volumetric coronary blood flow with dual-energy digital subtraction angiography. Circulation 1996; 93:1919-1927.
143. Zhang Z, Takarada S, Molloi S. Quantification of coronary microvascular resistance using angiographic images for volumetric blood flow measurement: in vivo validation. Am J Physiol Heart Circ Physiol 2011; 300:H2096-H2104.
144. Porto I, Hamilton-Craig C, Brancati M, et al. Angiographic assessment of microvascular perfusion: myocardial blush in clinical practice. Am Heart J 2010; 160:1015-1022.
145. Manfrini O, Pizzi C, Morgagni G, et al. Effect of pravastatin on myocardial perfusion after percutaneous transluminal coronary angioplasty. Am J Cardiol 2004; 93:1391-1393. (Pubitemid 38692468)
146. Valgimigli M, Campo G, Malagutti P, et al. Persistent coronary no flow after wire insertion is an early and readily available mortality risk factor despite successful mechanical intervention in acute myocardial infarction: a pooled analysis from the STRATEGY (Single High-Dose Bolus Tirofiban and Sirolimus-Eluting Stent Versus Abciximab and Bare-Metal Stent in Acute Myocardial Infarction) and MULTISTRATEGY (Multicenter Evaluation of Single High-Dose Bolus Tirofiban Versus Abciximab With Sirolimus-Eluting Stent or Bare-Metal Stent in Acute Myocardial Infarction Study) trials. JACC Cardiovasc Interv 2011; 4:51-62.
147. Dong-bao L, Qi H, Zhi L, et al. Predictors and long-term prognosis of angiographic slow/no-reflow phenomenon during emergency percutaneous coronary intervention for ST-elevated acute myocardial infarction. Clin Cardiol 2010; 33:E7-E12.
148. Serruys PW, di Mario C, Piek J, et al. Prognostic value of intracoronary flow velocity and diameter stenosis in assessing the short-and long-term outcomes of coronary balloon angioplasty: the DEBATE Study (Doppler Endpoints Balloon Angioplasty Trial Europe). Circulation 1997; 96:3369-3377. (Pubitemid 27513407)
149. Tsagalou EP, Anastasiou-Nana M, Agapitos E, et al. Depressed coronary flow reserve is associated with decreased myocardial capillary density in patients with heart failure due to idiopathic dilated cardiomyopathy. J Am Coll Cardiol 2008; 52:1391-1398.
150. Kyriakidis MK, Dernellis JM, Androulakis AE, et al. Changes in phasic coronary blood flow velocity profile and relative coronary flow reserve in patients with hypertrophic obstructive cardiomyopathy. Circulation 1997; 96:834-841. (Pubitemid 27329617)
151. Nishikawa S, Ito K, Adachi Y, et al. Ampulla ('takotsubo') cardiomyopathy of both ventricles: evaluation of microcirculation disturbance using 99mTc-tetrofosmin myocardial single photon emission computed tomography and Doppler guide wire. Circ J 2004; 68:1076-1080. (Pubitemid 39540140)
152. Chauhan A, Mullins PA, Taylor G, et al. Both endothelium-dependent and endothelium-independent function is impaired in patients with angina pectoris and normal coronary angiograms. Eur Heart J 1997; 18:60-68. (Pubitemid 27105772)
153. Egashira K, Inou T, Hirooka Y, et al. Evidence of impaired endothelium-dependent coronary vasodilatation in patients with angina pectoris and normal coronary angiograms. N Engl J Med 1993; 328:1659-1664. (Pubitemid 23157347)
154. Bugiardini R. Normal coronary arteries: clinical implications and further classification. Herz 2005; 30:3-7. (Pubitemid 40521551)
155. Bugiardini R, Manfrini O, Pizzi C, et al. Endothelial function predicts future developmentof coronary artery disease: astudy of women with chest pain and normal coronary angiograms. Circulation 2004; 109:2518-2523. (Pubitemid 38720550)
156. Murakami H, Urabe K, Nishimura M. Inappropriate microvascular constriction produced transient ST-segment elevation in patients with syndrome X. J Am Coll Cardiol 1998; 32:1287-1294.
157. Siebes M, Verhoeff BJ, Meuwissen M, et al. Single-wire pressure and flow velocity measurement to quantify coronary stenosis hemodynamics and effects of percutaneous interventions. Circulation 2004; 109:756-762. (Pubitemid 38222896)