Detection of coronary artery disease with perfusion stress echocardiography using a novel ultrasound imaging agent: Two Phase 3 international trials in comparison with radionuclide perfusion imaging

European Journal of Echocardiography

Volumn 10, Issue 1, 2009, Pages 26-35

  Senior, Roxy ^a,s,t   Monaghan, Mark ^b   Main, Michael L ^c   Zamorano, Jose L ^d   Tiemann, Klaus ^e   Agati, Luciano ^f   Weissman, Neil J ^g   Klein, Allan L ^h   Marwick, Thomas H ⁱ   Ahmad, Masood ^j   DeMaria, Anthony N ^k   Zabalgoitia, Miguel ^l   Becher, Harald ^m   Kaul, Sanjiv ⁿ   Udelson, James E ^o   Wackers, Frans J ^p   Walovitch, Richard C ^q   Picard, Michael H ^r  

^a NORTHWICK PARK HOSPITAL   (United Kingdom)

^b KING S COLLEGE HOSPITAL   (United Kingdom)

^c SAINT LUKE S MID AMERICA HEART INSTITUTE   (United States)

^d HOSPITAL CLÍNICO SAN CARLOS   (Spain)

^e UNIVERSITY OF BONN   (Germany)

^f SAPIENZA UNIVERSITY OF ROME   (Italy)

^g WASHINGTON HOSPITAL CENTER   (United States)

^h LERNER RESEARCH INSTITUTE   (United States)

ⁱ UNIVERSITY OF QUEENSLAND   (Australia)

^j UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^k UCSD MEDICAL CENTER   (United States)

^l UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^m JOHN RADCLIFFE HOSPITAL   (United Kingdom)

ⁿ OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^o TUFTS MEDICAL CENTER   (United States)

^p YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^q Acusphere Inc   (United States)

^r MASSACHUSETTS GENERAL HOSPITAL   (United States)

^s MIDDLESEX UNIVERSITY   (United Kingdom)

^t IMPERIAL COLLEGE LONDON   (United Kingdom)

more..

Author keywords

Contrast echocardiography; Echocardiography; Myocardial perfusion; Nuclear imaging; Stress echocardiography

Indexed keywords

ADENOSINE; AMINOPHYLLINE; DIPYRIDAMOLE; HYDROCORTISONE; METHOXY ISOBUTYL ISONITRILE TECHNETIUM TC 99M; MICROSPHERE; PARACETAMOL; PERFLUBUTANE; TECHNETIUM 99M; TETROFOSMIN; THALLIUM 201;

ADULT; AGED; ANGIOCARDIOGRAPHY; ARTICLE; BRONCHOSPASM; CHILL; CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DIAGNOSTIC ACCURACY; DISEASE SEVERITY; DIZZINESS; FEMALE; FEVER; FLUSHING; HEADACHE; HEART MUSCLE ISCHEMIA; HEART MUSCLE PERFUSION; HOT FLUSH; HUMAN; HYPOTENSION; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NAUSEA; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; SIDE EFFECT; SINGLE BLIND PROCEDURE; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; STRESS ECHOCARDIOGRAPHY; THORAX PAIN; UNSPECIFIED SIDE EFFECT; WHEEZING;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AREA UNDER CURVE; CONTRAST MEDIA; CORONARY ARTERY DISEASE; DIPYRIDAMOLE; ECHOCARDIOGRAPHY, STRESS; FEMALE; FLUOROCARBONS; GATED BLOOD-POOL IMAGING; HUMANS; IMAGE ENHANCEMENT; IMAGE INTERPRETATION, COMPUTER-ASSISTED; INTERNATIONAL COOPERATION; MALE; MIDDLE AGED; OBSERVER VARIATION; ROC CURVE; SENSITIVITY AND SPECIFICITY; STATISTICS, NONPARAMETRIC; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; YOUNG ADULT;

EID: 58449106005     PISSN: 15252167     EISSN: 15322114     Source Type: Journal    
DOI: 10.1093/ejechocard/jen321     Document Type: Article

References (39)

1. Beller GA. Detection of coronary artery disease. In: Clinical Nuclear Cardiology. Philadelphia (PA): W.B. Saunders; 1995. p82-136.
2. Cuocolo A, Acampa W, Imbriaco M, De LN, Iovino GL, Salvatore M. The many ways to myocardial perfusion imaging. Q J Nucl Med Mol Imaging 2005;49:4-18.
3. Gibbons RJ, Abrams J, Chatterjee K et al. ACC/AHA 2002 Guideline update for the management of patients with chronic stable angina. 2002. http:// www.acc.org/qualityandscience/clinical/guidelines/stable/stable-clean.pdf(April 2008).
4. Popma JJ, Chan S. Cardiac Catheterization and Percutaneous Coronary Intervention. In: Cannon CP, O'Gara PT (eds). Critical Pathways in Cardiology. Philadephia (PA): Lippincott Williams & Wilkins; 2001. p142-7.
5. Yu CM, Sanderson JE, Marwick TH, Oh JK. Tissue Doppler imaging a new prognosticator for cardiovascular diseases. J Am Coll Cardiol 2007;49:1903-14.
6. Baghdasarian SB, Heller GV. The role of myocardial perfusion imaging in the diagnosis of patients with coronary artery disease: developments over the past year. Curr Opin Cardiol 2005;20:369-74.
7. Senior R, Monaghan M, Becher H, Mayet J, Nihoyannopoulos P. Stress echocardiography for the diagnosis and risk stratification of patients with suspected or known coronary artery disease: a critical appraisal. Supported by the British Society of Echocardiography. Heart 2005;91:427-36.
8. Leong-Poi H, Rim SJ, Le DE, Fisher NG, Wei K, Kaul S. Perfusion versus function: the ischemic cascade in demand ischemia: implications of single-vessel versus multivessel stenosis. Circulation 2002;105:987-92.
9. Rainbird AJ, Mulvagh SL, Oh JK et al. Contrast dobutamine stress echocardiography: clinical practice assessment in 300 consecutive patients. J Am Soc Echocardiogr 2001;14:378-85.
10. Definity. Package Insert. 2007. Billerica, MA: Bristol-Myers Squibb.
11. Optison. Package Insert. 2007. Princeton, NJ: GE Healthcare.
12. Straub JA, Chickering DE, Church CC, Shah B, Hanlon T, Bernstein H. Porous PLGA microparticles: AI-700, an intravenously administered ultrasound contrast agent for use in echocardiography. J Control Release 2005;108:21-32.
13. Senior R. Imagify (perflubutane polymer microspheres) injectable suspension for the assessment of coronary artery disease. Expert Rev Cardiovasc Ther 2007;5:413-21.
14. Liu YH, Sinusas AJ, Deman P, Zaret BL, Wackers FJ. Quantification of SPECT myocardial perfusion images: methodology and validation of the Yale-CQ method. J Nucl Cardiol 1999;6:190-204.
15. Eagle KA, Guyton RA, Davidoff R et al. ACC/AHA Guidelines for Coronary Artery Bypass Graft Surgery: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1991 Guidelines for Coronary Artery Bypass Graft Surgery). American College of Cardiology/American Heart Association. J Am Coll Cardiol 1999;34:1262-347.
16. Alderman EL, Stadius M. The angiographic definitions of the Bypass Angioplasty Revascularization Investigation. Coron Artery Dis 1992;3:1189-207.
17. Nam JM, Blackwelder WC. Analysis of the ratio of marginal probabilities in a matched-pair setting. Stat Med 2002;21:689-99.
18. Klocke FJ, Baird MG, Bateman TM et al. ACC/AHA/ASNC guidelines for the clinical use of cardiac radionuclide imaging: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/ASNC Committee to Revise the 1995 Guidelines for the Clinical Use of Cardiac Radionuclide Imaging). Guidelines for the Clinical Use of Cardiac Radionuclide Imaging. 1-69. http://www.acc.org/clinical/guidelines/ radio/index.pdf (February 2008).
19. Bin JP, Le E, Pelberg RA, Coggins MP, Wei K, Kaul S. Mechanism of inducible regional dysfunction during dipyridamole stress. Circulation 2002;106:112-7.
20. Fung AY, Gallagher KP, Buda AJ. The physiologic basis of dobutamine as compared with dipyridamole stress interventions in the assessment of critical coronary stenosis. Circulation 1987;76:943-51.
21. Soman P, Lahiri A, Senior R. Vasodilator stress induces infrequent wall thickening abnormalities compared to perfusion defects in mild-to-moderate coronary artery disease: implications for the choice of imaging modality with vasodilator stress. Echocardiography 2004;21:307-12.
22. Dijkmans PA, Senior R, Becher H et al. Myocardial contrast echocardiography evolving as a clinically feasible technique for accurate, rapid, and safe assessment of myocardial perfusion: the evidence so far. J Am Coll Cardiol 2006;48:2168-77.
23. Jeetley P, Hickman M, Kamp O et al. Myocardial contrast echocardiography for the detection of coronary artery stenosis: a prospective multicenter study in comparison with single-photon emission computed tomography. J Am Coll Cardiol 2006;47:141-5.
24. Peltier M, Vancraeynest D, Pasquet A et al. Assessment of the physiologic significance of coronary disease with dipyridamole real-time myocardial contrast echocardiography. Comparison with technetium-99 m sestamibi single-photon emission computed tomography and quantitative coronary angiography. J Am Coll Cardiol 2004;43:257-64.
25. Senior R, Lepper W, Pasquet A et al. Myocardial perfusion assessment in patients with medium probability of coronary artery disease and no prior myocardial infarction: comparison of myocardial contrast echocardiography with 99mTc single-photon emission computed tomography. Am Heart J 2004;147:1100-5.
26. Cardiolite. Package Insert. 2003. North Billerica (MA): Bristol-Myers Squibb.
27. Myoview. Package Insert. 2006. Arlington Heights (IL): GE Healthcare.
28. Kuersten B, Murthy TH, Li P et al. Ultraharmonic myocardial contrast imaging: in vivo experimental and clinical data from a novel technique. J Am Soc Echocardiogr 2001;14:910-6.
29. Malm S, Frigstad S, Torp H, Wiseth R, Skjarpe T. Quantitative adenosine real-time myocardial contrast echocardiography for detection of angiographically significant coronary artery disease. J Am Soc Echocardiogr 2006;19:365-72.
30. Yu EH, Skyba DM, Leong-Poi H et al. Incremental value of parametric quantitative assessment of myocardial perfusion by triggered low-power myocardial contrast echocardiography. J Am Coll Cardiol 2004;43:1807-13.
31. Main ML, Goldman JH, Grayburn PA. Thinking outside the 'box'-the ultrasound contrast controversy. J Am Coll Cardiol 2007;50:2434-7.
32. Dipyridamole. Package Insert. 2004. Bedford (OH): Ben Venue Laboratories, Inc.
33. Hayat SA, Dwivedi G, Jacobsen A, Lim TK, Kinsey C, Senior R. Effects of left bundle-branch block on cardiac structure, function, perfusion, and perfusion reserve: implications for myocardial contrast echocardiography versus radionuclide perfusion imaging for the detection of coronary artery disease. Circulation 2008;117:1832-41.
34. Ito H. Trends in myocardial contrast echocardiography: parameteric versus volumetric imaging. Expert Rev Cardiovasc Ther 2005;3:133-42.
35. Malm S, Frigstad S, Helland F, Oye K, Slordahl S, Skjarpe T. Quantification of resting myocardial blood flow velocity in normal humans using real-time contrast echocardiography. A feasibility study. Cardiovasc Ultrasound 2005;3:16.
36. Moir S, Haluska BA, Jenkins C, McNab D, Marwick TH. Myocardial blood volume and perfusion reserve responses to combined dipyridamole and exercise stress: a quantitative approach to contrast stress echocardiography. J Am Soc Echocardiogr 2005;18:1187-93.
37. Vogel R, Indermuhle A, Reinhardt J et al. The quantification of absolute myocardial perfusion in humans by contrast echocardiography: algorithm and validation. J Am Coll Cardiol 2005;45:754-62.
38. Cerqueira MD, Nguyen P, Staehr P, Underwood SR, Iskandrian AE. Effects of age, gender, obesity, and diabetes on the efficacy and safety of the selective a 2A agonist regadenoson versus adenosine in myocardial perfusion imaging: integrated ADVANCE-MPI trial results. J Am Coll Cardiol Img 2008;1:307-16.
39. Udelson JE. Lessons from the development of new adenosine A2A receptor agonists. J Am Coll Cardiol Img 2008;1:317-20.