Organotypic culture of normal, dysplastic and squamous cell carcinoma-derived oral cell lines reveals loss of spatial regulation of CD44 and p75NTR in malignancy

Journal of Oral Pathology and Medicine

Volumn 42, Issue 1, 2013, Pages 37-46

  Dalley, Andrew J ^a,b   Abdulmajeed, Ahmad A ^a,b   Upton, Zee ^c   Farah, Camile S ^a,b  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

Author keywords

Cancer stem cells; Differentiation; Oral cancer; Oral dysplasia; Organotypic culture

Indexed keywords

CD24 ANTIGEN; CD44V ANTIGEN; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN P75; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2;

ARTICLE; CANCER CELL CULTURE; DYSPLASIA; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MONOLAYER CULTURE; MOUTH CARCINOMA; PRECANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA; STEM CELL;

ALDEHYDE DEHYDROGENASE; ANTIGENS, CD24; ANTIGENS, CD44; CARCINOMA, SQUAMOUS CELL; CELL CULTURE TECHNIQUES; CELL LINE; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; FLOW CYTOMETRY; HEPATOCYTE NUCLEAR FACTOR 3-ALPHA; HEPATOCYTE NUCLEAR FACTOR 3-BETA; HUMANS; KERATIN-13; KERATIN-19; MOUTH MUCOSA; MOUTH NEOPLASMS; NEOPLASM INVASIVENESS; NEOPLASTIC STEM CELLS; NERVE TISSUE PROTEINS; PRECANCEROUS CONDITIONS; RECEPTORS, NERVE GROWTH FACTOR;

EID: 84871929972     PISSN: 09042512     EISSN: 16000714     Source Type: Journal    
DOI: 10.1111/j.1600-0714.2012.01170.x     Document Type: Article

References (38)

1. Visvader JE, Lindeman GJ. Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer 2008; 8: 755-68.
2. Rosen JM, Jordan CT. The Increasing Complexity of the Cancer Stem Cell Paradigm. Science 2009; 324: 1670-3.
3. Thomson PJ, Hamadah O, Goodson ML, et al. Predicting recurrence after oral precancer treatment: use of cell cycle analysis. Br J Oral Maxillofac Surg 2008; 46: 370-5.
4. Smeets SJ, Van Der Plas M, Schaaij-Visser TBM, et al. Immortalization of oral keratinocytes by functional inactivation of the p53 and pRb pathways. Int J Cancer 2011; 128: 1596-605.
5. Goessel G, Quante M, Hahn WC, et al. Creating oral squamous cancer cells: a cellular model of oral-esophageal carcinogenesis. Proc Natl Acad Sci U S A 2005; 102: 15599-604.
6. Rheinwald JG, Hahn WC, Ramsey MR, et al. A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status. Mol Cell Biol 2002; 22: 5157-72.
7. Shackleton M, Quintana E, Fearon ER, et al. Heterogeneity in Cancer: cancer Stem Cells versus Clonal Evolution. Cell 2009; 138: 822-9.
8. Prince ME, Sivanandan R, Kaczorowski A, et al. Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma. Proc Natl Acad Sci U S A 2007; 104: 973-8.
9. Clay MR, Tarbor M, Owen JH, et al. Single-marker identification of head and neck squamous cell carcinoma cancer stem cells with aldehyde dehydrogenase. Head Neck 2010; 32: 1195-201.
10. Lim YC, Oh SY, Cha YY, et al. Cancer stem cell traits in squamospheres derived from primary head and neck squamous cell carcinomas. Oral Oncol 2011; 47: 83-91.
11. Okamoto A, Chikamatsu K, Sakakura K, et al. Expansion and characterization of cancer stem-like cells in squamous cell carcinoma of the head and neck. Oral Oncol 2009; 45: 633-9.
12. Mack B, Gires O. CD44s and CD44v6 expression in head and neck epithelia. PLoS ONE 2008; 3: e3360.
13. Pries R, Wittkopf N, Trenkle T, et al. Potential stem cell marker CD44 is constitutively expressed in permanent cell lines of head and neck cancer. In vivo 2008; 22: 89-92.
14. Rogers ML, Beare A, Zola H, et al. CD 271 (p75 neurotrophin receptor). J Biol Regul Homeost Agents 2008; 22: 1-6.
15. Vanhecke E, Adriaenssens E, Verbeke S, et al. Brain-Derived Neurotrophic Factor and Neurotrophin-4/5 Are Expressed in Breast Cancer and Can Be Targeted to Inhibit Tumor Cell Survival. Clin Cancer Res 2011; 17: 1741-52.
16. Huang SD, Yuan Y, Liu XH, et al. Self-renewal and chemotherapy resistance of p75(NTR) positive cells in esophageal squamous cell carcinomas. BMC Cancer 2009; 9: article number 9.
17. Okumura T, Shimada Y, Imamura M, et al. Neurotrophin receptor p75(NTR) characterizes human esophageal keratinocyte stem cells in vitro. Oncogene 2003; 22: 4017-26.
18. Dudas J, Bitsche M, Schartinger V, et al. Fibroblasts produce brain-derived neurotrophic factor and induce mesenchymal transition of oral tumor cells. Oral Oncol 2011; 47: 98-103.
19. Nakamura T, Endo KI, Kinoshita S. Identification of human oral keratinocyte stem/progenitor cells by neurotrophin receptor p75 and the role of neurotrophin/p75 signaling. Stem Cells 2007; 25: 628-38.
20. Gao MQ, Choi YP, Kang S, et al. CD24+ cells from hierarchically organized ovarian cancer are enriched in cancer stem cells. Oncogene 2010; 29: 2672-80.
21. Zhang C, Li C, He F, et al. Identification of CD44+CD24+ gastric cancer stem cells. J Cancer Res Clin Oncol 2011; 137: 1679-86.
22. Al-Hajj M, Wicha MS, Benito-Hernandez A, et al. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A 2003; 100: 3983-8.
23. Alison MR, Guppy NJ, Lim SML, et al. Finding cancer stem cells: are aldehyde dehydrogenases fit for purpose?J Pathol 2010; 222: 335-44.
24. Chen YC, Chen YW, Hsu HS, et al. Aldehyde dehydrogenase 1 is a putative marker for cancer stem cells in head and neck squamous cancer. Biochem Biophys Res Commun 2009; 385: 307-13.
25. Chen C, Wei Y, Hummel M, et al. Evidence for Epithelial-Mesenchymal Transition in Cancer Stem Cells of Head and Neck Squamous Cell Carcinoma. PLoS ONE 2011; 6: article number e16466.
26. Chen YC, Chang CJ, Hsu HS, et al. Inhibition of tumorigenicity and enhancement of radiochemosensitivity in head and neck squamous cell cancer-derived ALDH1-positive cells by knockdown of Bmi-1. Oral Oncol 2010; 46: 158-65.
27. Berndt A, Hyckel P, Konneker A, et al. Oral squamous cell carcinoma invasion is associated with a laminin-5 matrix re-organization but independent of basement membrane and hemidesmosome formation - Clues from an in vitro invasion model. Invasion Metastasis 1997; 17: 251-8.
28. Chang SE, Foster S, Betts D, et al. Dok, a cell-line established from human dysplastic oral-mucosa, shows a partially transformed nonmalignant phenotype. Int J Cancer 1992; 52: 896-902.
29. Dickson MA, Hahn WC, Ino Y, et al. Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics. Mol Cell Biol 2000; 20: 1436-47.
30. Ralston DR, Layton C, Dalley AJ, et al. Keratinocytes contract human dermal extracellular matrix and reduce soluble fibronectin production by fibroblasts in a skin composite model. Br J Plast Surg 1997; 50: 408-15.
31. Chan A, Matias MAT, Farah CS. A novel and practical method using HRP-polymer conjugate and microwave treatment for visualization of 2 antigens raised from the same or different species in paraffin-embedded tissues. Appl Immunohistochem 2011; 19: 376-83.
32. Vandervelden LA, Schaafsma HE, Manni JJ, et al. Cytokeratin and vimentin expression in normal epithelium and squamous cell carcinomas of the larynx. Eur Arch Oto-Rhino-Laryn 1997; 254: 376-83.
33. Chakrabarty KH, Heaton M, Dalley AJ, et al. Keratinocyte-driven contraction of reconstructed human skin. Wound Repair Regen 2001; 9: 95-106.
34. Dawson RA, Upton Z, Malda J, et al. Preparation of cultured skin for transplantation using insulin-like growth factor I in conjunction with insulin-like growth factor binding protein 5, epidermal growth factor, and vitronectin. Transplantation 2006; 81: 1668-76.
35. Benayoun BA, Caburet S, Veitia RA. Forkhead transcription factors: key players in health and disease. Trends Genet 2011; 27: 224-32.
36. Myatt SS, Lam EWF. The emerging roles of forkhead box (Fox) proteins in cancer. Nat Rev Cancer 2007; 7: 847-59.
37. Ademuyiwa FO, Thorat MA, Jain RK, et al. Expression of Forkhead- box protein A1, a marker of luminal A type breast cancer, parallels low Oncotype DX 21-gene recurrence scores. Mod Pathol 2010; 23: 270-5.
38. Tang YN, Shu GW, Yuan XW, et al. FOXA2 functions as a suppressor of tumor metastasis by inhibition of epithelial-to-mesenchymal transition in human lung cancers. Cell Res 2011; 21: 316-26.