Androgen receptor CAG repeat length modifies the effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on receptor activity in human prostate cells

Reproductive Toxicology

Volumn 35, Issue 1, 2013, Pages 144-149

  Björk, Christel ^a   Lundberg Giwercman, Yvonne ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

2,3,7,8 tetrachlorodibenzo p dioxin; Androgen receptor; Aryl hydrocarbon receptor; Polymorphism; Prostate cancer

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; ANDROGEN RECEPTOR; ANDROSTANOLONE; CYTOCHROME P450 1A1; MESSENGER RNA;

ARTICLE; CAG REPEAT; CANCER CELL; CANCER INCIDENCE; CELL SPECIFICITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; GENETIC VARIABILITY; HUMAN; HUMAN CELL; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN FUNCTION; TOXICOGENETICS;

CELL LINE; CELL LINE, TUMOR; CYTOCHROME P-450 CYP1A1; ENVIRONMENTAL POLLUTANTS; HUMANS; MALE; PROSTATE; RECEPTORS, ANDROGEN; RECEPTORS, ARYL HYDROCARBON; REPETITIVE SEQUENCES, NUCLEIC ACID; RNA, MESSENGER; TETRACHLORODIBENZODIOXIN;

EID: 84871920038     PISSN: 08906238     EISSN: 18731708     Source Type: Journal    
DOI: 10.1016/j.reprotox.2012.10.010     Document Type: Article

References (40)

1. Schecter A., Birnbaum L., Ryan J.J., Constable J.D. Dioxins: an overview. Environmental Research 2006, 101:419-428.
2. Schell L.M., Burnitz K.K., Lathrop P.W. Pollution and human biology. Annals of Human Biology 2010, 37:347-366.
3. Llobet J.M., Domingo J.L., Bocio A., Casas C., Teixido A., Muller L. Human exposure to dioxins through the diet in Catalonia, Spain: carcinogenic and non-carcinogenic risk. Chemosphere 2003, 50:1193-1200.
4. Mocarelli P., Gerthoux P.M., Needham L.L., Patterson D.G., Limonta G., Falbo R., et al. Perinatal exposure to low doses of dioxin can permanently impair human semen quality. Environmental Health Perspectives 2011, 119:713-718.
5. Guo Y.L., Hsu P.C., Hsu C.C., Lambert G.H. Semen quality after prenatal exposure to polychlorinated biphenyls and dibenzofurans. Lancet 2000, 356:1240-1241.
6. Gray L.E., Kelce W.R., Monosson E., Ostby J.S., Birnbaum L.S. Exposure to TCDD during development permanently alters reproductive function in male Long Evans rats and hamsters: reduced ejaculated and epididymal sperm numbers and sex accessory gland weights in offspring with normal androgenic status. Toxicology and Applied Pharmacology 1995, 131:108-118.
7. Mably T.A., Moore R.W., Peterson R.E. In utero and lactational exposure of male rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin, 1. Effects on androgenic status. Toxicology and Applied Pharmacology 1992, 114:97-107.
8. Simanainen U., Haavisto T., Tuomisto J.T., Paranko J., Toppari J., Tuomisto J., et al. Pattern of male reproductive system effects after in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure in three differentially TCDD-sensitive rat lines. Toxicological Sciences 2004, 80:101-108.
9. Bennett C.L., Price D.K., Kim S., Liu D., Jovanovic B.D., Nathan D., et al. Racial variation in CAG repeat lengths within the androgen receptor gene among prostate cancer patients of lower socioeconomic status. Journal of Clinical Oncology 2002, 20:3599-3604.
10. Lange E.M., Sarma A.V., Ray A., Wang Y., Ho L.A., Anderson S.A., et al. The androgen receptor CAG and GGN repeat polymorphisms and prostate cancer susceptibility in African-American men: results from the Flint Men's Health Study. Journal of Human Genetics 2008, 53:220-226.
11. Chamie K., DeVere White R.W., Lee D., Ok J.H., Ellison L.M. Agent Orange exposure, Vietnam war veterans, and the risk of prostate cancer. Cancer 2008, 113:2464-2470.
12. Shah S.R., Freedland S.J., Aronson W.J., Kane C.J., Presti J.C., Amling C.L., et al. Exposure to Agent Orange is a significant predictor of prostate-specific antigen (PSA)-based recurrence and a rapid PSA doubling time after radical prostatectomy. BJU International 2009, 103:1168-1172.
13. Kollara A., Brown T.J. Functional interaction of nuclear receptor coactivator 4 with aryl hydrocarbon receptor. Biochemical and Biophysical Research Communications 2006, 346:526-534.
14. Lin T.M., Ko K., Moore R.W., Simanainen U., Oberley T.D., Peterson R.E. Effects of aryl hydrocarbon receptor null mutation and in utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure on prostate and seminal vesicle development in C57BL/6 mice. Toxicological Sciences 2002, 68:479-487.
15. Gonzalez F.J., Fernandez-Salguero P., Lee S.S., Pineau T., Ward J.M. Xenobiotic receptor knockout mice. Toxicology Letters 1995, 82-83:117-121.
16. Alexander D.L., Ganem L.G., Fernandez-Salguero P., Gonzalez F., Jefcoate C.R. Aryl-hydrocarbon receptor is an inhibitory regulator of lipid synthesis and of commitment to adipogenesis. Journal of Cell Science 1998, 111(Pt 22):3311-3322.
17. Kollara A., Brown T.J. Four and a half LIM domain 2 alters the impact of aryl hydrocarbon receptor on androgen receptor transcriptional activity. Journal of Steroid Biochemistry and Molecular Biology 2010, 118:51-58.
18. Kizu R., Okamura K., Toriba A., Kakishima H., Mizokami A., Burnstein K.L., et al. A role of aryl hydrocarbon receptor in the antiandrogenic effects of polycyclic aromatic hydrocarbons in LNCaP human prostate carcinoma cells. Archives of Toxicology 2003, 77:335-343.
19. Ohtake F., Baba A., Fujii-Kuriyama Y., Kato S. Intrinsic AhR function underlies cross-talk of dioxins with sex hormone signalings. Biochemical and Biophysical Research Communications 2008, 370:541-546.
20. Jana N.R., Sarkar S., Ishizuka M., Yonemoto J., Tohyama C., Sone H. Cross-talk between 2,3,7,8-tetrachlorodibenzo-p-dioxin and testosterone signal transduction pathways in LNCaP prostate cancer cells. Biochemical and Biophysical Research Communications 1999, 256:462-468.
21. Morrow D., Qin C., Smith R., Safe S. Aryl hydrocarbon receptor-mediated inhibition of LNCaP prostate cancer cell growth and hormone-induced transactivation. Journal of Steroid Biochemistry and Molecular Biology 2004, 88:27-36.
22. Ohtake F., Baba A., Takada I., Okada M., Iwasaki K., Miki H., et al. Dioxin receptor is a ligand-dependent E3 ubiquitin ligase. Nature 2007, 446:562-566.
23. Giwercman Y.L., Xu C., Arver S., Pousette A., Reneland R. No association between the androgen receptor gene CAG repeat and impaired sperm production in Swedish men. Clinical Genetics 1998, 54:435-436.
24. Nenonen H., Bjork C., Skjaerpe P.A., Giwercman A., Rylander L., Svartberg J., et al. CAG repeat number is not inversely associated with androgen receptor activity in vitro. Molecular Human Reproduction 2010, 16:153-157.
25. Albertelli M.A., O'Mahony O.A., Brogley M., Tosoian J., Steinkamp M., Daignault S., et al. Glutamine tract length of human androgen receptors affects hormone-dependent and -independent prostate cancer in mice. Human Molecular Genetics 2008, 17:98-110.
26. Albertelli M.A., Scheller A., Brogley M., Robins D.M. Replacing the mouse androgen receptor with human alleles demonstrates glutamine tract length-dependent effects on physiology and tumorigenesis in mice. Molecular Endocrinology 2006, 20:1248-1260.
27. Robins D.M., Albertelli M.A., O'Mahony O.A. Androgen receptor variants and prostate cancer in humanized AR mice. Journal of Steroid Biochemistry and Molecular Biology 2008, 108:230-236.
28. McMillan B.J., Bradfield C.A. The aryl hydrocarbon receptor sans xenobiotics: endogenous function in genetic model systems. Molecular Pharmacology 2007, 72:487-498.
29. Mehta V., Vezina C.M. Potential protective mechanisms of aryl hydrocarbon receptor (AHR) signaling in benign prostatic hyperplasia. Differentiation 2011, 82:211-219.
30. Ohtake F., Fujii-Kuriyama Y., Kato S. AhR acts as an E3 ubiquitin ligase to modulate steroid receptor functions. Biochemical Pharmacology 2009, 77:474-484.
31. Brunnberg S., Andersson P., Poellinger L., Hanberg A. The constitutively active Ah receptor (CA-AhR) mouse as a model for dioxin exposure - effects in reproductive organs. Chemosphere 2011, 85:1701-1706.
32. Abel J., Haarmann-Stemmann T. An introduction to the molecular basics of aryl hydrocarbon receptor biology. Biological Chemistry 2010, 391:1235-1248.
33. Fritz W.A., Lin T.M., Cardiff R.D., Peterson R.E. The aryl hydrocarbon receptor inhibits prostate carcinogenesis in TRAMP mice. Carcinogenesis 2007, 28:497-505.
34. Fritz W.A., Lin T.M., Safe S., Moore R.W., Peterson R.E. The selective aryl hydrocarbon receptor modulator 6-methyl-1,3,8-trichlorodibenzofuran inhibits prostate tumor metastasis in TRAMP mice. Biochemical Pharmacology 2009, 77:1151-1160.
35. Bjork C., Nenonen H., Giwercman A., Bergman A., Rylander L., Giwercman Y.L. Persistent organic pollutants have dose and CAG repeat length dependent effects on androgen receptor activity in vitro. Reproductive Toxicology 2011, 32:293-297.
36. Svensson B.G., Nilsson A., Jonsson E., Schutz A., Akesson B., Hagmar L. Fish consumption and exposure to persistent organochlorine compounds, mercury, selenium and methylamines among Swedish fishermen. Scandinavian Journal of Work, Environment and Health 1995, 21:96-105.
37. Pesatori A.C., Consonni D., Rubagotti M., Grillo P., Bertazzi P.A. Cancer incidence in the population exposed to dioxin after the " Seveso accident": twenty years of follow-up. Environmental Health 2009, 8:39.
38. Gupta A., Ketchum N., Roehrborn C.G., Schecter A., Aragaki C.C., Michalek J.E. Serum dioxin, testosterone, and subsequent risk of benign prostatic hyperplasia: a prospective cohort study of Air Force veterans. Environmental Health Perspectives 2006, 114:1649-1654.
39. Tijet N., Boutros P.C., Moffat I.D., Okey A.B., Tuomisto J., Pohjanvirta R. Aryl hydrocarbon receptor regulates distinct dioxin-dependent and dioxin-independent gene batteries. Molecular Pharmacology 2006, 69:140-153.
40. Yoshioka H., Hiromori Y., Aoki A., Kimura T., Fujii-Kuriyama Y., Nagase H., et al. Possible aryl hydrocarbon receptor-independent pathway of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced antiproliferative response in human breast cancer cells. Toxicology Letters 2012, 211:257-265.