Four and a half LIM domain 2 alters the impact of aryl hydrocarbon receptor on androgen receptor transcriptional activity

Journal of Steroid Biochemistry and Molecular Biology

Volumn 118, Issue 1-2, 2010, Pages 51-58

  Kollara, Alexandra ^a,b   Brown, Theodore J ^a,b  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Androgen receptor; Aryl hydrocarbon receptor; Dioxin; Four and a half LIM domain 2; PC 3 cells; Prostate specific antigen

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; ANDROGEN RECEPTOR; AROMATIC HYDROCARBON RECEPTOR; FOUR AND A HALF LIM DOMAIN 2; HYPOXIA INDUCIBLE FACTOR 1BETA; LIM KINASE; NUCLEAR RECEPTOR COACTIVATOR 4; PROSTATE SPECIFIC ANTIGEN; STEROID RECEPTOR COACTIVATOR 1; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; NONHUMAN; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REPORTER GENE; SIGNAL TRANSDUCTION; TRANSACTIVATION; TRANSCRIPTION INITIATION;

ANIMALS; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR; CELL PROLIFERATION; CERCOPITHECUS AETHIOPS; CHROMATIN IMMUNOPRECIPITATION; COS CELLS; DIHYDROTESTOSTERONE; DNA; GENE EXPRESSION REGULATION; GENES, REPORTER; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOPRECIPITATION; MUSCLE PROTEINS; NUCLEAR RECEPTOR COACTIVATOR 1; NUCLEAR RECEPTOR COACTIVATORS; PROMOTER REGIONS, GENETIC; PROSTATE-SPECIFIC ANTIGEN; PROTEIN BINDING; RECEPTORS, ANDROGEN; RECEPTORS, ARYL HYDROCARBON; SIGNAL TRANSDUCTION; TETRACHLORODIBENZODIOXIN; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 72449182600     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2009.09.017     Document Type: Article

References (37)

1. Beischlag T.V., Luis Morales J., Hollingshead B.D., and Perdew G.H. The aryl hydrocarbon receptor complex and the control of gene expression. Crit. Rev. Eukaryot. Gene Expr. 18 3 (2008) 207-250
2. Jana N.R., Sarkar S., Ishizuka M., Yonemoto J., Tohyama C., and Sone H. Cross-talk between 2,3,7,8-tetrachlorodibenzo-p-dioxin and testosterone signal transduction pathways in LNCaP prostate cancer cells. Biochem. Biophys. Res. Commun. 256 3 (1999) 462-468
3. Kizu R., Okamura K., Toriba A., Kakishima H., Mizokami A., Burnstein K.L., and Hayakawa K. A role of aryl hydrocarbon receptor in the antiandrogenic effects of polycyclic aromatic hydrocarbons in LNCaP human prostate carcinoma cells. Arch. Toxicol. 77 6 (2003) 335-343
4. Fritz W.A., Lin T.M., Cardiff R.D., and Peterson R.E. The aryl hydrocarbon receptor inhibits prostate carcinogenesis in TRAMP mice. Carcinogenesis 28 2 (2007) 497-505
5. Barnes-Ellerbe S., Knudsen K.E., and Puga A. 2,3,7,8-Tetrachlorodibenzo-p-dioxin blocks androgen-dependent cell proliferation of LNCaP cells through modulation of pRB phosphorylation. Mol. Pharmacol. 66 3 (2004) 502-511
6. Morrow D., Qin C., Smith III R., and Safe S. Aryl hydrocarbon receptor-mediated inhibition of LNCaP prostate cancer cell growth and hormone-induced transactivation. J. Steroid Biochem. Mol. Biol. 88 1 (2004) 27-36
7. Vinggaard A.M., Hnida C., and Larsen J.C. Environmental polycyclic aromatic hydrocarbons affect androgen receptor activation in vitro. Toxicology 145 2-3 (2000) 173-183
8. Ohtake F., Baba A., Fujii-Kuriyama Y., and Kato S. Intrinsic AhR function underlies cross-talk of dioxins with sex hormone signalings. Biochem. Biophys. Res. Commun. 370 4 (2008) 541-546
9. Ohtake F., Baba A., Takada I., Okada M., Iwasaki K., Miki H., Takahashi S., Kouzmenko A., Nohara K., Chiba T., Fujii-Kuriyama Y., and Kato S. Dioxin receptor is a ligand-dependent E3 ubiquitin ligase. Nature 446 7135 (2007) 562-566
10. Matthews J., and Gustafsson J.A. Estrogen receptor and aryl hydrocarbon receptor signaling pathways. Nucl. Recept. Signal (2006) e016
11. Safe S., and Wormke M. Inhibitory aryl hydrocarbon receptor-estrogen receptor alpha cross-talk and mechanisms of action. Chem. Res. Toxicol. 16 7 (2003) 807-816
12. Beischlag T.V., Wang S., Rose D.W., Torchia J., Reisz-Porszasz S., Muhammad K., Nelson W.E., Probst M.R., Rosenfeld M.G., and Hankinson O. Recruitment of the NCoA/SRC-1/p160 family of transcriptional coactivators by the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator complex. Mol. Cell Biol. 22 12 (2002) 4319-4333
13. Nguyen T.A., Hoivik D., Lee J.E., and Safe S. Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex. Arch. Biochem. Biophys. 367 2 (1999) 250-257
14. Kollara A., and Brown T.J. Functional interaction of nuclear receptor coactivator 4 with aryl hydrocarbon receptor. Biochem. Biophys. Res. Commun. 346 2 (2006) 526-534
15. Kollara A., and Brown T.J. Modulation of aryl hydrocarbon receptor activity by four and a half LIM domain 2. Int. J. Biochem. Cell Biol. 41 5 (2009) 1182-1188
16. Heemers H.V., and Tindall D.J. Androgen receptor (AR) coregulators: a diversity of functions converging on and regulating the AR transcriptional complex. Endocr. Rev. 28 7 (2007) 778-808
17. Heinlein C.A., and Chang C. Androgen receptor (AR) coregulators: an overview. Endocr. Rev. 23 2 (2002) 175-200
18. Trapman J., and Brinkmann A.O. The androgen receptor in prostate cancer. Pathol. Res. Pract. 192 7 (1996) 752-760
19. Heisler L.E., Evangelou A., Lew A.M., Trachtenberg J., Elsholtz H.P., and Brown T.J. Androgen-dependent cell cycle arrest and apoptotic death in PC-3 prostatic cell cultures expressing a full-length human androgen receptor. Mol. Cell Endocrinol. 126 1 (1997) 59-73
20. Mizokami A., Gotoh A., Yamada H., Keller E.T., and Matsumoto T. Tumor necrosis factor-alpha represses androgen sensitivity in the LNCaP prostate cancer cell line. J. Urol. 164 3 Pt 1 (2000) 800-805
21. Sambrook J., and Russell D.W. Molecular Cloning: A Laboratory Manual (2001), Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
22. Lanzino M., De Amicis F., McPhaul M.J., Marsico S., Panno M.L., and Ando S. Endogenous coactivator ARA70 interacts with estrogen receptor alpha (ERalpha) and modulates the functional ERalpha/androgen receptor interplay in MCF-7 cells. J. Biol. Chem. 280 21 (2005) 20421-20430
23. Romijn J.C., Verkoelen C.F., and Schroeder F.H. Application of the MTT assay to human prostate cancer cell lines in vitro: establishment of test conditions and assessment of hormone-stimulated growth and drug-induced cytostatic and cytotoxic effects. Prostate 12 1 (1988) 99-110
24. Kollara A., Diamandis E.P., and Brown T.J. Secretion of endogenous kallikreins 2 and 3 by androgen receptor-transfected PC-3 prostate cancer cells. J. Steroid Biochem. Mol. Biol. 84 5 (2003) 493-502
25. Shen R., Sumitomo M., Dai J., Harris A., Kaminetzky D., Gao M., Burnstein K.L., and Nanus D.M. Androgen-induced growth inhibition of androgen receptor expressing androgen-independent prostate cancer cells is mediated by increased levels of neutral endopeptidase. Endocrinology 141 5 (2000) 1699-1704
26. Yeh S., and Chang C. Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells. Proc. Natl. Acad. Sci. U.S.A. 93 11 (1996) 5517-5521
27. Bevan C.L., Hoare S., Claessens F., Heery D.M., and Parker M.G. The AF1 and AF2 domains of the androgen receptor interact with distinct regions of SRC1. Mol. Cell Biol. 19 12 (1999) 8383-8392
28. Muller J.M., Isele U., Metzger E., Rempel A., Moser M., Pscherer A., Breyer T., Holubarsch C., Buettner R., and Schule R. FHL2, a novel tissue-specific coactivator of the androgen receptor. EMBO J. 19 3 (2000) 359-369
29. Brunnberg S., Pettersson K., Rydin E., Matthews J., Hanberg A., and Pongratz I. The basic helix-loop-helix-PAS protein ARNT functions as a potent coactivator of estrogen receptor-dependent transcription. Proc. Natl. Acad. Sci. U.S.A. 100 11 (2003) 6517-6522
30. Ruegg J., Swedenborg E., Wahlstrom D., Escande A., Balaguer P., Pettersson K., and Pongratz I. The transcription factor ARNT functions as an estrogen receptor beta selective co-activator, and its recruitment to alternative pathways mediates anti-estrogenic effects of dioxin. Mol. Endocrinol. 22 2 (2008) 304-316
31. Rowan B.G., Weigel N.L., and O'Malley B.W. Phosphorylation of steroid receptor coactivator-1. Identification of the phosphorylation sites and phosphorylation through the mitogen-activated protein kinase pathway. J. Biol. Chem. 275 6 (2000) 4475-4483
32. Dovio A., Sartori M.L., De Francia S., Mussino S., Perotti P., Saba L., Abbadessa G., Racca S., and Angeli A. Differential expression of determinants of glucocorticoid sensitivity in androgen-dependent and androgen-independent human prostate cancer cell lines. J. Steroid Biochem. Mol. Biol. 116 1-2 (2009) 29-36
33. Tilley W.D., Bentel J.M., Aspinall J.O., Hall R.E., and Horsfall D.J. Evidence for a novel mechanism of androgen resistance in the human prostate cancer cell line, PC-3. Steroids 60 1 (1995) 180-186
34. Tilley W.D., Wilson C.M., Marcelli M., and McPhaul M.J. Androgen receptor gene expression in human prostate carcinoma cell lines. Cancer Res. 50 17 (1990) 5382-5386
35. Alimirah F., Chen J., Basrawala Z., Xin H., and Choubey D. DU-145 and PC-3 human prostate cancer cell lines express androgen receptor: implications for the androgen receptor functions and regulation. FEBS Lett. 580 9 (2006) 2294-2300
36. Montgomery B.T., Young C.Y., Bilhartz D.L., Andrews P.E., Prescott J.L., Thompson N.F., and Tindall D.J. Hormonal regulation of prostate-specific antigen (PSA) glycoprotein in the human prostatic adenocarcinoma cell line, LNCaP. Prostate 21 1 (1992) 63-73
37. Lin P., Chang J.T., Ko J.L., Liao S.H., and Lo W.S. Reduction of androgen receptor expression by benzo[alpha]pyrene and 7,8-dihydro-9,10-epoxy-7,8,9,10-tetrahydrobenzo[alpha]pyrene in human lung cells. Biochem. Pharmacol. 67 8 (2004) 1523-1530