Distinct energy requirements for human memory CD4 T-cell homeostatic functions

FASEB Journal

Volumn 27, Issue 1, 2013, Pages 342-349

  Taub, Dennis D ^a   Hesdorffer, Charles S ^a   Ferrucci, Luigi ^a   Madara, Karen ^a   Schwartz, Janice B ^b,c   Goetzl, Edward J ^a,b,c  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Adherence; Apoptosis; Chemotaxis; Fatty acid oxidation; Glycolysis; Immunosenescence

Indexed keywords

COLLAGEN; INTERLEUKIN 2; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; RANTES; SPHINGOSINE 1 PHOSPHATE;

ADULT; AGED; AGING; APOPTOSIS; ARTICLE; CD4+ T LYMPHOCYTE; CHEMOTAXIS; CLINICAL ARTICLE; ENERGY; ENZYME LINKED IMMUNOSORBENT ASSAY; FATTY ACID OXIDATION; FEMALE; FLOW CYTOMETRY; GLYCOLYSIS; HUMAN; HUMAN CELL; LYMPHOCYTE DIFFERENTIATION; MALE; MEMORY T LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION;

APOPTOSIS; CD4-POSITIVE T-LYMPHOCYTES; CHEMOKINE CCL19; ENERGY METABOLISM; FATTY ACIDS; GLYCOLYSIS; HOMEOSTASIS; HUMANS; IMMUNOLOGIC MEMORY; LYSOPHOSPHOLIPIDS; MIDDLE AGED; OXIDATION-REDUCTION; SPHINGOSINE;

EID: 84871894994     PISSN: None     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.12-217620     Document Type: Article

References (26)

1. Fox, C. J., Hammerman, P. S., and Thompson, C. B. (2005) Fuel feeds function: energy metabolism and the T-cell response. Nat. Rev. Immunol. 5, 844-852 (Pubitemid 41581666)
2. Gerriets, V. A., and Rathmell, J. C. (2012) Metabolic pathways in T cell fate and function. Trends Immunol. 33, 168-173
3. Cham, C. M., and Gajewski, T. F. (2005) Glucose availability regulates IFN-γ production and p70S6 kinase activation in CD8+ effector T cells. J. Immunol. 174, 4670-4677
4. Jacobs, S. R., Herman, C. E., Maciver, N. J., Wofford, J. A., Wieman, H. L., Hammen, J. J., and Rathmell, J. C. (2008) Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways. J. Immunol. 180, 4476-4486
5. Maciver, N. J., Jacobs, S. R., Wieman, H. L., Wofford, J. A., Coloff, J. L., and Rathmell, J. C. (2008) Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival. J. Leukoc. Biol. 84, 949-957
6. Tamas, P., Hawley, S. A., Clarke, R. G., Mustard, K. J., Green, K., Hardie, D. G., and Cantrell, D. A. (2006) Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes. J. Exp. Med. 203, 1665-1670 (Pubitemid 44036271)
7. MacIver, N. J., Blagih, J., Saucillo, D. C., Tonelli, L., Griss, T., Rathmell, J. C., and Jones, R. G. (2011) The liver kinase B1 is a central regulator of T cell development, activation, and metabolism. J. Immunol. 187, 4187-4198
8. Michalek, R. D., Gerriets, V. A., Jacobs, S. R., Macintyre, A. N., MacIver, N. J., Mason, E. F., Sullivan, S. A., Nichols, A. G., and Rathmell, J. C. (2011) Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets. J. Immunol. 186, 3299-3303
9. Pearce, E. L., Walsh, M. C., Cejas, P. J., Harms, G. M., Shen, H., Wang, L. S., Jones, R. G., and Choi, Y. (2009) Enhancing CD8 T-cell memory by modulating fatty acid metabolism. Nature 460, 103-107
10. Araki, K., Turner, A. P., Shaffer, V. O., Gangappa, S., Keller, S. A., Bachmann, M. F., Larsen, C. P., and Ahmed, R. (2009) mTOR regulates memory CD8 T-cell differentiation. Nature 460, 108-112
11. Chi, H. (2012) Regulation and function of mTOR signalling in T cell fate decisions. Nat. Rev. Immunol. 12, 325-338
12. Delgoffe, G. M., Kole, T. P., Zheng, Y., Zarek, P. E., Matthews, K. L., Xiao, B., Worley, P. F., Kozma, S. C., and Powell, J. D. (2009) The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity 30, 832-844
13. MacLeod, M. K., Kappler, J. W., and Marrack, P. (2010) Memory CD4 T cells: generation, reactivation and re-assignment. Immunology 130, 10-15
14. Francus, T., Francus, Y., and Siskind, G. W. (1991) Memory T cells enhance the expression of high-avidity naive B cells. Cell. Immunol. 134, 520-527
15. Crotty, S., Kersh, E. N., Cannons, J., Schwartzberg, P. L., and Ahmed, R. (2003) SAP is required for generating long-term humoral immunity. Nature 421, 282-287 (Pubitemid 36139134)
16. Sun, J. C., Williams, M. A., and Bevan, M. J. (2004) CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection. Nat. Immunol. 5, 927-933 (Pubitemid 39276237)
17. McKinstry, K. K., Strutt, T. M., Kuang, Y., Brown, D. M., Sell, S., Dutton, R. W., and Swain, S. L. (2012) Memory CD4+ T cells protect against influenza through multiple synergizing mechanisms. J. Clin. Invest. 122, 2847-2856
18. Graeler, M., Shankar, G., and Goetzl, E. J. (2002) Cutting edge: suppression of T cell chemotaxis by sphingosine 1-phosphate. J. Immunol. 169, 4084-4087 (Pubitemid 35178174)
19. Goetzl, E. J., Huang, M. C., Kon, J., Patel, K., Schwartz, J. B., Fast, K., Ferrucci, L., Madara, K., Taub, D. D., and Longo, D. L. (2010) Gender specificity of altered human immune cytokine profiles in aging. FASEB J. 24, 3580-3589
20. Hardie, D. G., Salt, I. P., Hawley, S. A., and Davies, S. P. (1999) AMP-activated protein kinase: an ultrasensitive system for monitoring cellular energy charge. Biochem. J. 338, 717-722 (Pubitemid 29140078)
21. Deberardinis, R. J., Lum, J. J., and Thompson, C. B. (2006) Phosphatidylinositol 3-kinase-dependent modulation of carnitine palmitoyltransferase 1A expression regulates lipid metabolism during hematopoietic cell growth. J. Biol. Chem. 281, 37372-37380 (Pubitemid 46042041)
22. Younes, S. A., Punkosdy, G., Caucheteux, S., Chen, T., Grossman, Z., and Paul, W. E. (2011) Memory phenotype CD4 T cells undergoing rapid, nonburst-like, cytokine-driven proliferation can be distinguished from antigen-experienced memory cells. PLoS Biol. 9, e1001171
23. Chan, O., Burke, J. D., Gao, D. F., and Fish, E. N. (2012) The chemokine CCL5 regulates glucose uptake and AMPK signaling in activated T cells to facilitate chemotaxis. J. Biol. Chem. 287, 29406-29416
24. Watt, M. J., and Hoy, A. J. (2012) Lipid metabolism in skeletal muscle: generation of adaptive and maladaptive intracellular signals for cellular function. Am. J. Physiol. Endocrinol. Metab. 302, E1315-E1328
25. Finkel, T. (2012) Signal transduction by mitochondrial oxidants. J. Biol. Chem. 287, 4434-4440
26. Naik, E., and Dixit, V. M. (2011) Mitochondrial reactive oxygen species drive proinflammatory cytokine production. J. Exp. Med. 208, 417-420