Memory phenotype cd4 t cells undergoing rapid, nonburst-like, cytokine-driven proliferation can be distinguished from antigen-experienced memory cells

PLoS Biology

Volumn 9, Issue 10, 2011, Pages

  Younes, Souheil Antoine ^a   Punkosdy, George ^a   Caucheteux, Stephane ^a   Chen, Tao ^a   Grossman, Zvi ^a   Paul, William E ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CD3 ANTIGEN; INTERLEUKIN 7 RECEPTOR ALPHA; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE RECEPTOR BETA CHAIN; BROXURIDINE; CYTOKINE; HLA ANTIGEN CLASS 2; INTERLEUKIN 7 RECEPTOR; INTERLEUKIN 7 RECEPTOR, ALPHA CHAIN; INTERLEUKIN-7 RECEPTOR, ALPHA CHAIN; KI 67 ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; MKI67 PROTEIN, MOUSE;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; CELL DIVISION; CONTROLLED STUDY; GENETIC VARIABILITY; LYMPH NODE CELL; LYMPHOCYTE PROLIFERATION; LYMPHOCYTIC CHORIOMENINGITIS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MEMORY CELL; MOUSE; NONHUMAN; ANIMAL; BIOSYNTHESIS; CELL PROLIFERATION; DRUG EFFECT; GERMFREE ANIMAL; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; METABOLISM;

LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MUS;

ANIMALS; BROMODEOXYURIDINE; CD4-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CYTOKINES; GERM-FREE LIFE; HISTOCOMPATIBILITY ANTIGENS CLASS II; IMMUNOLOGIC MEMORY; KI-67 ANTIGEN; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MICE; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, INTERLEUKIN-7;

EID: 80055063032     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.1001171     Document Type: Article

References (37)

1. Surh, CD, Sprent J, (2008) Homeostasis of naïve and memory T cells. Immunity 29: 848-862.
2. Tough, DF, Sprent J, (1994) Turnover of naïve- and memory-phenotype T cells. J Exp Med 179: 1127-1135.
3. Min B, Thornton A, Caucheteux S. M, Younes S. A, Oh K, et al. (2007) Gut flora antigens are not important in the maintenance of regulatory T cellheterogeneity and homeostasis. Eur J Immunol 37: 1916-1923.
4. Li J, Huston G, Swain S. L, (2003) IL-7 promotes the transition of CD4 effectors to persistent memory cells. J Exp Med 198: 1807-1815.
5. Purton J. F, Tan J. T, Rubinstein M. P, Kim D. M, Sprent J, et al. (2007) Antiviral CD4+ memory T cells are IL-15 dependent. J Exp Med 204: 951-961.
6. Pepper M, Linehan J. L, Pagan A. J, Zell T, Dileepan T, et al. (2010) Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cells. Nat Immunol 11: 83-89.
7. Lenz D. C, Kurz S. K, Lemmens E, Schoenberger S. P, Sprent J, et al. (2004) IL-7 regulates basal homeostatic proliferation of antiviral CD4+ T cell memory. Proc Natl Acad Sci U S A 101: 9357-9362.
8. Swain S. L, Hu H, Huston G, (1999) Class II-independent generation of CD4 memory T cells from effectors. Science 286: 1381-1383.
9. Boyman O, Purton J. F, Surh C. D, Sprent J, (2007) Cytokines and T-cell homeostasis. Curr Opin Immunol 19: 320-326.
10. Geginat J, Campagnaro S, Sallusto F, Lanzavecchia A, (2002) TCR-independent proliferation and differentiation of human CD4+ T cell subsets induced by cytokines. Adv Exp Med Biol 512: 1070-112.
11. Lohning M, Hegazy A. N, Pinschewer D. D, Busse D, Lang K. S, et al. (2008) Long-lived virus-reactive memory T cells Generated from purified cytokine-secreting T helper type 1 and type 2 effectors. J Exp Med 205: 53-61.
12. Singh V, Gowthaman U, Jain S, Parihar P, Banskar S, et al. (2010) Coadministration of interleukins 7 and 15 with bacilli Calmette-Guerin mounts enduring T cell memory response against Mycobacterium tuberculosis. J Infect Dis 202: 480-489.
13. Tan J. T, Ernst B, Kieper W. C, LeRoy E, Sprent J, et al. (2002) Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cells. J Exp Med 195: 1523-1532.
14. Tokoyoda K, Zehentmeier S, Hegazy A. N, Albrecht I, Grun J. R, et al. (2009) Professional memory CD4+ T lymphocytes preferentially reside and rest in the bone marrow. Immunity 30: 721-730.
15. Combadere B, Blanc C, Li T, Carcelain G, Delaugerre C, et al. (2000) CD4+Ki67+ lymphocytes in HIV-infected patients are Effector T cells accumulated in the G1 phase of the cell cycle. Eur J Immunol 30: 3598-3603.
16. Picker L. J, Hagen S. J, Lum R, Reed-Inderbitzin E. F, Daly L. M, et al. (2004) Insufficient production and tissue delivery of CD4+ memory T cells in rapidly progressive simian immunodeficiency virus infection. J Exp Med 200: 1299-1314.
17. Grossman Z, Meier-Schellersheim M, Paul W. E, Picker L. J, (2006) Pathogenesis of HIV infection: what the virus spares is as important as what it destroys. Nat Med 12: 289-295.
18. Grossman Z, Picker L. J, (2008) Pathogenic mechanisms in simian immunodeficiency virus infection. Curr Opin HIV AIDS 3: 380-386.
19. Douek D. C, Roederer M, Koup R. A, (2009) Emerging concepts in the immunopathogenesis of AIDS. Annu Rev Med 60: 471-484.
20. Okoye A, Meier-Schellersheim M, Brenchley J. M, Hagen S. I, Walker J. M, et al. (2007) Progressive CD4+ central memory T cell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infection. J Exp Med 204: 2171-2185.
21. Pitcher C. J, Hagen S. I, Walker J. M, Lum R, Mitchell B. L, et al. (2002) Development and homeostasis of T cell memory in rhesus macaque. J Immunol 168: 29-43.
22. Dorfman J. R, Stefanova I, Yasutomo K, Germain R. N, (2000) CD4+ T cell survival is not directly linked to self-MHC-induced TCR signaling. Nat Immunol 1: 329-335.
23. Min B, McHugh R, Sempowski G. D, Mackall C, Foucras G, et al. (2003) Neonates support lymphopenia-induced proliferation. Immunity 18: 131-140.
24. Min B, Paul W. E, (2005) Endogenous proliferation: burst-like CD4 T cell proliferation in lymphopenic settings. Semin Immunol 17: 201-207.
25. Seddon B, Tomlinson P, Zamoyska R, (2003) Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells. Nat Immunol 4: 680-686.
26. Surh C. D, Boyman O, Purton J. F, Sprent J, (2006) Homeostasis of memory T cells. Immunol Rev 211: 154-163.
27. Leignadier J, Hardy M. P, Cloutier M, Rooney J, Labrecque N, (2008) Memory T-lymphocyte survival does not require T-cell receptor expression. Proc Natl Acad Sci U S A 105: 20440-20445.
28. Kieper W. C, Troy A, Burghardt J. T, Ramsey C, Lee J. Y, et al. (2005) Recent immune status determines the source of antigens that drive homeostatic T cell expansion. J Immunol 174: 3158-3163.
29. Min B, Foucras G, Meier-Schellersheim M, Paul W. E, (2004) Spontaneous proliferation, a response of naïve CD4 T cells determined by the diversity of the memory cell repertoire. Proc Natl Acad Sci U S A 101: 3874-3879.
30. Bruno L, von Boehmer H, Kirberg J, (1996) Cell divisions in the compartment of naïve and memory T lymphocytes. Eur J Immunol 26: 3179-3184.
31. Cederbom, L, Bandeira A, Coutinho A, Ivars F, (1998) Naturally activated CD4+ T cells are highly enriched for cytokine-producing cells. Eur J Immunol 28: 1934-1940.
32. Jiang H. Q, Thurnheer M. C, Zuercher A. W, Boiko N. V, Bos N. A, et al. (2004) Interactions of commensal gut microbes with subsets of B- and T-cells in the murine host. Vaccine 22: 805-811.
33. Weinreich M. A, Odumade O. A, Jameson S. C, Hogquist K. A, (2010) T cells expressing the transcription factor PLZF regulate the development of memory-like CD8+ T cells. Nat Immunol 8: 709-716.
34. Haluszczak C, Akue A. D, Hamilton S. E, Johnson L. D, Pujanauski L, et al. (2009) The antigen-specific CD8+ T cell repertoire in unimmunized mice includes memory phenotype cells bearing markers of homeostatic expansion. J Exp Med 206: 435-448.
35. Grossman Z, Min B, Meier-Schellersheim M, Paul W. E, (2004) Concomitant regulation of T-cell activation and homeostasis. Nat Rev Immunol 4: 387-395.
36. Grossman Z, Paul W. E, (2000) Self-tolerance: context dependent tuning of T cell antigen recognition. Semin Immunol 12: 197-203; discussion, 257-344.
37. Grossman Z, Paul W. E, (2001) Autoreactivity, dynamic tuning and selectivity. Curr Opin Immunol 13: 687-698.