-
1
-
-
0035856920
-
Global and societal implications of the diabetes epidemic
-
Zimmet P., Alberti K.G., Shaw J. Global and societal implications of the diabetes epidemic. Nature 2001, 414:782-787.
-
(2001)
Nature
, vol.414
, pp. 782-787
-
-
Zimmet, P.1
Alberti, K.G.2
Shaw, J.3
-
2
-
-
0030843960
-
Genetic and environmental factors in relative body weight and human adiposity
-
Maes H.H., Neale M.C., Eaves L.J. Genetic and environmental factors in relative body weight and human adiposity. Behavior Genetics 1997, 27:325-351.
-
(1997)
Behavior Genetics
, vol.27
, pp. 325-351
-
-
Maes, H.H.1
Neale, M.C.2
Eaves, L.J.3
-
5
-
-
34250612718
-
The leptin melanocortin pathway and the control of body weight: lessons from human and murine genetics
-
Oswal A., Yeo G.S. The leptin melanocortin pathway and the control of body weight: lessons from human and murine genetics. Obesity Reviews 2007, 8:293-306.
-
(2007)
Obesity Reviews
, vol.8
, pp. 293-306
-
-
Oswal, A.1
Yeo, G.S.2
-
6
-
-
34249777814
-
Variation in FTO contributes to childhood obesity and severe adult obesity
-
Dina C., et al. Variation in FTO contributes to childhood obesity and severe adult obesity. Nature Genetics 2007, 39:724-726.
-
(2007)
Nature Genetics
, vol.39
, pp. 724-726
-
-
Dina, C.1
-
7
-
-
34248594090
-
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
-
Frayling T.M., et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007, 316:889-894.
-
(2007)
Science
, vol.316
, pp. 889-894
-
-
Frayling, T.M.1
-
8
-
-
34547625955
-
Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits
-
Scuteri A., et al. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genetics 2007, 3(e115).
-
(2007)
PLoS Genetics
, vol.3
, Issue.e115
-
-
Scuteri, A.1
-
9
-
-
78049337953
-
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
-
Speliotes E.K., et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nature Genetics 2010, 42:937-948.
-
(2010)
Nature Genetics
, vol.42
, pp. 937-948
-
-
Speliotes, E.K.1
-
10
-
-
58149163142
-
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
-
Willer C.J., et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nature Genetics 2009, 41:25-34.
-
(2009)
Nature Genetics
, vol.41
, pp. 25-34
-
-
Willer, C.J.1
-
11
-
-
77953292057
-
The genetics of obesity: FTO leads the way
-
Fawcett K.A., Barroso I. The genetics of obesity: FTO leads the way. Trends in Genetics 2010, 26:266-274.
-
(2010)
Trends in Genetics
, vol.26
, pp. 266-274
-
-
Fawcett, K.A.1
Barroso, I.2
-
12
-
-
57749121512
-
An obesity-associated FTO gene variant and increased energy intake in children
-
Cecil J.E., Tavendale R., Watt P., Hetherington M.M., Palmer C.N. An obesity-associated FTO gene variant and increased energy intake in children. New England Journal of Medicine 2008, 359:2558-2566.
-
(2008)
New England Journal of Medicine
, vol.359
, pp. 2558-2566
-
-
Cecil, J.E.1
Tavendale, R.2
Watt, P.3
Hetherington, M.M.4
Palmer, C.N.5
-
13
-
-
67649852402
-
Variation in the FTO gene influences food intake but not energy expenditure
-
Haupt A., et al. Variation in the FTO gene influences food intake but not energy expenditure. Experimental and Clinical Endocrinology and Diabetes 2009, 117:194-197.
-
(2009)
Experimental and Clinical Endocrinology and Diabetes
, vol.117
, pp. 194-197
-
-
Haupt, A.1
-
14
-
-
64349124477
-
Obesity, FTO gene variant, and energy intake in children
-
author reply 1572
-
Jonsson A., Franks P.W. Obesity, FTO gene variant, and energy intake in children. New England Journal of Medicine 2009, 360:1571-1572. author reply 1572.
-
(2009)
New England Journal of Medicine
, vol.360
, pp. 1571-1572
-
-
Jonsson, A.1
Franks, P.W.2
-
15
-
-
48749132799
-
Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure
-
Speakman J.R., Rance K.A., Johnstone A.M. Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure. Obesity (Silver Spring) 2008, 16:1961-1965.
-
(2008)
Obesity (Silver Spring)
, vol.16
, pp. 1961-1965
-
-
Speakman, J.R.1
Rance, K.A.2
Johnstone, A.M.3
-
16
-
-
53849088890
-
The fat mass- and obesity-associated locus and dietary intake in children
-
Timpson N.J., et al. The fat mass- and obesity-associated locus and dietary intake in children. American Journal of Clinical Nutrition 2008, 88:971-978.
-
(2008)
American Journal of Clinical Nutrition
, vol.88
, pp. 971-978
-
-
Timpson, N.J.1
-
17
-
-
58149508094
-
The FTO gene and measured food intake in children
-
(London)
-
Wardle J., Llewellyn C., Sanderson S., Plomin R. The FTO gene and measured food intake in children. International Journal of Obesity 2009, 33:42-45. (London).
-
(2009)
International Journal of Obesity
, vol.33
, pp. 42-45
-
-
Wardle, J.1
Llewellyn, C.2
Sanderson, S.3
Plomin, R.4
-
18
-
-
70350647201
-
Postprandial responses in hunger and satiety are associated with the rs9939609 single nucleotide polymorphism in FTO
-
Den Hoed M., Westerterp-Plantenga M.S., Bouwman F.G., Mariman E.C., Westerterp K.R. Postprandial responses in hunger and satiety are associated with the rs9939609 single nucleotide polymorphism in FTO. American Journal of Clinical Nutrition 2009, 90:1426-1432.
-
(2009)
American Journal of Clinical Nutrition
, vol.90
, pp. 1426-1432
-
-
Den Hoed, M.1
Westerterp-Plantenga, M.S.2
Bouwman, F.G.3
Mariman, E.C.4
Westerterp, K.R.5
-
19
-
-
77953362586
-
Genetic associations with acute stress-related changes in eating in the absence of hunger
-
Rutters F., et al. Genetic associations with acute stress-related changes in eating in the absence of hunger. Patient Education and Counseling 2010, 79:367-371.
-
(2010)
Patient Education and Counseling
, vol.79
, pp. 367-371
-
-
Rutters, F.1
-
20
-
-
51649128621
-
Obesity associated genetic variation in FTO is associated with diminished satiety
-
Wardle J., et al. Obesity associated genetic variation in FTO is associated with diminished satiety. Journal of Clinical Endocrinology and Metabolism 2008, 93:3640-3643.
-
(2008)
Journal of Clinical Endocrinology and Metabolism
, vol.93
, pp. 3640-3643
-
-
Wardle, J.1
-
21
-
-
72749115949
-
The FTO gene rs9939609 obesity-risk allele and loss of control over eating
-
Tanofsky-Kraff M., et al. The FTO gene rs9939609 obesity-risk allele and loss of control over eating. American Journal of Clinical Nutrition 2009, 90:1483-1488.
-
(2009)
American Journal of Clinical Nutrition
, vol.90
, pp. 1483-1488
-
-
Tanofsky-Kraff, M.1
-
22
-
-
47549107452
-
Lack of association of fatness-related FTO gene variants with energy expenditure or physical activity
-
Berentzen T., et al. Lack of association of fatness-related FTO gene variants with energy expenditure or physical activity. Journal of Clinical and Endocrinology and Metabolism 2008, 93:2904-2908.
-
(2008)
Journal of Clinical and Endocrinology and Metabolism
, vol.93
, pp. 2904-2908
-
-
Berentzen, T.1
-
23
-
-
42449153273
-
Genetic variants of FTO influence adiposity, insulin sensitivity, leptin levels, and resting metabolic rate in the Quebec family study
-
Do R., et al. Genetic variants of FTO influence adiposity, insulin sensitivity, leptin levels, and resting metabolic rate in the Quebec family study. Diabetes 2008, 57:1147-1150.
-
(2008)
Diabetes
, vol.57
, pp. 1147-1150
-
-
Do, R.1
-
24
-
-
67449141659
-
Several obesity- and nutrient-related gene polymorphisms but not FTO and UCP variants modulate postabsorptive resting energy expenditure and fat-induced thermogenesis in obese individuals: the NUGENOB study
-
(London)
-
Goossens G.H., et al. Several obesity- and nutrient-related gene polymorphisms but not FTO and UCP variants modulate postabsorptive resting energy expenditure and fat-induced thermogenesis in obese individuals: the NUGENOB study. International Journal of Obesity 2009, 33:669-679. (London).
-
(2009)
International Journal of Obesity
, vol.33
, pp. 669-679
-
-
Goossens, G.H.1
-
25
-
-
65249108267
-
FTO genotype is associated with body mass index after the age of seven years but not with energy intake or leisure-time physical activity
-
Hakanen M., et al. FTO genotype is associated with body mass index after the age of seven years but not with energy intake or leisure-time physical activity. Journal of Clinical and Endocrinology and Metabolism 2009, 94:1281-1287.
-
(2009)
Journal of Clinical and Endocrinology and Metabolism
, vol.94
, pp. 1281-1287
-
-
Hakanen, M.1
-
26
-
-
67349234146
-
Assessing the effect of interaction between an FTO variant (rs9939609) and physical activity on obesity in 15,925 Swedish and 2511 Finnish adults
-
Jonsson A., et al. Assessing the effect of interaction between an FTO variant (rs9939609) and physical activity on obesity in 15,925 Swedish and 2511 Finnish adults. Diabetologia 2009, 52:1334-1338.
-
(2009)
Diabetologia
, vol.52
, pp. 1334-1338
-
-
Jonsson, A.1
-
27
-
-
77950663129
-
FTO variant rs9939609 is associated with body mass index and waist circumference, but not with energy intake or physical activity in European- and African-American youth
-
Liu G., et al. FTO variant rs9939609 is associated with body mass index and waist circumference, but not with energy intake or physical activity in European- and African-American youth. BMC Medical Genetics 2010, 11:57.
-
(2010)
BMC Medical Genetics
, vol.11
, pp. 57
-
-
Liu, G.1
-
28
-
-
0032886705
-
Cloning of Fatso (Fto), a novel gene deleted by the Fused toes (Ft) mouse mutation
-
Peters T., Ausmeier K., Ruther U. Cloning of Fatso (Fto), a novel gene deleted by the Fused toes (Ft) mouse mutation. Mammalian Genome 1999, 10:983-986.
-
(1999)
Mammalian Genome
, vol.10
, pp. 983-986
-
-
Peters, T.1
Ausmeier, K.2
Ruther, U.3
-
29
-
-
33947146101
-
Defects in brain patterning and head morphogenesis in the mouse mutant fused toes
-
Anselme I., Laclef C., Lanaud M., Ruther U., Schneider-Maunoury S. Defects in brain patterning and head morphogenesis in the mouse mutant fused toes. Developmental Biology 2007, 304:208-220.
-
(2007)
Developmental Biology
, vol.304
, pp. 208-220
-
-
Anselme, I.1
Laclef, C.2
Lanaud, M.3
Ruther, U.4
Schneider-Maunoury, S.5
-
30
-
-
0028025622
-
Programmed cell death is affected in the novel mouse mutant Fused toes (Ft)
-
van der Hoeven F., et al. Programmed cell death is affected in the novel mouse mutant Fused toes (Ft). Development 1994, 120:2601-2607.
-
(1994)
Development
, vol.120
, pp. 2601-2607
-
-
van der Hoeven, F.1
-
31
-
-
36749041363
-
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase
-
Gerken T., et al. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science 2007, 318:1469-1472.
-
(2007)
Science
, vol.318
, pp. 1469-1472
-
-
Gerken, T.1
-
32
-
-
39049154918
-
The FTO (fat mass and obesity associated) gene codes for a novel member of the non-heme dioxygenase superfamily
-
Sanchez-Pulido L., Andrade-Navarro M.A. The FTO (fat mass and obesity associated) gene codes for a novel member of the non-heme dioxygenase superfamily. BMC Biochemistry 2007, 8:23.
-
(2007)
BMC Biochemistry
, vol.8
, pp. 23
-
-
Sanchez-Pulido, L.1
Andrade-Navarro, M.A.2
-
33
-
-
33847050240
-
Non-heme dioxygenases: Cellular sensors and regulators jelly rolled into one?
-
Ozer A., Bruick R.K. Non-heme dioxygenases: cellular sensors and regulators jelly rolled into one?. Nature Chemical Biology 2007, 3:144-153.
-
(2007)
Nature Chemical Biology
, vol.3
, pp. 144-153
-
-
Ozer, A.1
Bruick, R.K.2
-
34
-
-
54849381000
-
Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO
-
Jia G., et al. Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO. FEBS Letters 2008, 582:3313-3319.
-
(2008)
FEBS Letters
, vol.582
, pp. 3313-3319
-
-
Jia, G.1
-
35
-
-
77951623073
-
Crystal structure of the FTO protein reveals basis for its substrate specificity
-
Han Z., et al. Crystal structure of the FTO protein reveals basis for its substrate specificity. Nature 2010, 464:1205-1209.
-
(2010)
Nature
, vol.464
, pp. 1205-1209
-
-
Han, Z.1
-
36
-
-
77449126999
-
Prevalence of loss-of-function FTO mutations in lean and obese individuals
-
Meyre D., et al. Prevalence of loss-of-function FTO mutations in lean and obese individuals. Diabetes 2010, 59:311-318.
-
(2010)
Diabetes
, vol.59
, pp. 311-318
-
-
Meyre, D.1
-
37
-
-
81355146483
-
N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
-
Jia G., et al. N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nature Chemical Biology 2011, 7:885-887.
-
(2011)
Nature Chemical Biology
, vol.7
, pp. 885-887
-
-
Jia, G.1
-
38
-
-
0027423649
-
A novel method for the determination of post-transcriptional modification in RNA by mass spectrometry
-
Kowalak J.A., Pomerantz S.C., Crain P.F., McCloskey J.A. A novel method for the determination of post-transcriptional modification in RNA by mass spectrometry. Nucleic Acids Research 1993, 21:4577-4585.
-
(1993)
Nucleic Acids Research
, vol.21
, pp. 4577-4585
-
-
Kowalak, J.A.1
Pomerantz, S.C.2
Crain, P.F.3
McCloskey, J.A.4
-
40
-
-
84860779086
-
Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
-
Dominissini D., et al. Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature 2012, 485:201-206.
-
(2012)
Nature
, vol.485
, pp. 201-206
-
-
Dominissini, D.1
-
41
-
-
84862649489
-
Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons
-
Meyer K.D., et al. Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell 2012, 149:1635-1646.
-
(2012)
Cell
, vol.149
, pp. 1635-1646
-
-
Meyer, K.D.1
-
42
-
-
0030712151
-
Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase
-
Bokar J.A., Shambaugh M.E., Polayes D., Matera A.G., Rottman F.M. Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase. RNA 1997, 3:1233-1247.
-
(1997)
RNA
, vol.3
, pp. 1233-1247
-
-
Bokar, J.A.1
Shambaugh, M.E.2
Polayes, D.3
Matera, A.G.4
Rottman, F.M.5
-
43
-
-
67649875640
-
Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations
-
Boissel S., et al. Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations. American Journal of Human Genetics 2009, 85:106-111.
-
(2009)
American Journal of Human Genetics
, vol.85
, pp. 106-111
-
-
Boissel, S.1
-
44
-
-
67349211789
-
Inactivation of the Fto gene protects from obesity
-
Fischer J., et al. Inactivation of the Fto gene protects from obesity. Nature 2009, 458:894-898.
-
(2009)
Nature
, vol.458
, pp. 894-898
-
-
Fischer, J.1
-
45
-
-
70149100469
-
A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene
-
Church C., et al. A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene. PLoS Genetics 2009, 5:e1000599.
-
(2009)
PLoS Genetics
, vol.5
-
-
Church, C.1
-
46
-
-
77649303960
-
Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats
-
Tung Y.C., et al. Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats. PLoS One 2010, 5:e8771.
-
(2010)
PLoS One
, vol.5
-
-
Tung, Y.C.1
-
47
-
-
42249083837
-
The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain
-
Fredriksson R., et al. The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain. Endocrinology 2008, 149:2062-2071.
-
(2008)
Endocrinology
, vol.149
, pp. 2062-2071
-
-
Fredriksson, R.1
-
48
-
-
77954694568
-
Identification of the global transcriptomic response of the hypothalamic arcuate nucleus to fasting and leptin
-
Jovanovic Z., Tung Y.C., Lam B.Y., O'Rahilly S., Yeo G.S. Identification of the global transcriptomic response of the hypothalamic arcuate nucleus to fasting and leptin. Journal of Neuroendocrinology 2010, 22:915-925.
-
(2010)
Journal of Neuroendocrinology
, vol.22
, pp. 915-925
-
-
Jovanovic, Z.1
Tung, Y.C.2
Lam, B.Y.3
O'Rahilly, S.4
Yeo, G.S.5
-
49
-
-
78649512744
-
The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice
-
Gao X., et al. The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice. PLoS One 2010, 5:e14005.
-
(2010)
PLoS One
, vol.5
-
-
Gao, X.1
-
50
-
-
78649459183
-
Overexpression of Fto leads to increased food intake and results in obesity
-
Church C., et al. Overexpression of Fto leads to increased food intake and results in obesity. Nature Genetics 2010, 42:1086-1092.
-
(2010)
Nature Genetics
, vol.42
, pp. 1086-1092
-
-
Church, C.1
-
51
-
-
84860871770
-
Kinetic analysis of FTO (fat mass and obesity-associated) reveals that it is unlikely to function as a sensor for 2-oxoglutarate
-
Ma M., Harding H.P., O'Rahilly S., Ron D., Yeo G.S. Kinetic analysis of FTO (fat mass and obesity-associated) reveals that it is unlikely to function as a sensor for 2-oxoglutarate. Biochemical Journal 2012, 444:183-187.
-
(2012)
Biochemical Journal
, vol.444
, pp. 183-187
-
-
Ma, M.1
Harding, H.P.2
O'Rahilly, S.3
Ron, D.4
Yeo, G.S.5
-
52
-
-
76449104211
-
Effects of alpha-ketoglutarate on neutrophil intracellular amino and alpha-keto acid profiles and ROS production
-
Muhling J., et al. Effects of alpha-ketoglutarate on neutrophil intracellular amino and alpha-keto acid profiles and ROS production. Amino Acids 2010, 38:167-177.
-
(2010)
Amino Acids
, vol.38
, pp. 167-177
-
-
Muhling, J.1
-
53
-
-
84877577199
-
-
FTO expression is regulated by availability of essential amino acids International Journal of Obesity 2012 (London)
-
Cheung, M.K., Gulati, P., O'Rahilly, S., Yeo, G.S. FTO expression is regulated by availability of essential amino acids International Journal of Obesity 2012 (London), http://dx.doi.org/10.1038/ijo.2012.77.
-
-
-
Cheung, M.K.1
Gulati, P.2
O'Rahilly, S.3
Yeo, G.S.4
|