Killer B lymphocytes: The evidence and the potential

Inflammation Research

Volumn 58, Issue 7, 2009, Pages 345-357

  Lundy, Steven K ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

B lymphocytes; Cell based therapy; Fas ligand; Immune regulation; Th cell apoptosis

Indexed keywords

FAS LIGAND;

ANIMAL; AUTOIMMUNITY; B LYMPHOCYTE; CELL DEATH; HUMAN; IMMUNOLOGY; REVIEW;

ANIMALS; AUTOIMMUNITY; B-LYMPHOCYTES; CELL DEATH; FAS LIGAND PROTEIN; HUMANS;

EID: 84871872554     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-009-0014-x     Document Type: Review

References (111)

1. Acosta Rodriguez EV, Zuniga E, Montes CL, Gruppi A. Interleukin-4 biases differentiation of B cells from Trypanosoma cruzi-infected mice and restrains their fratricide: role of Fas ligand down-regulation and MHC class II-transactivator up-regulation. J Leukoc Biol. 2003;73:127-36. (Pubitemid 36125683)
2. Ahuja A, Shupe J, Dunn R, Kashgarian M, Kehry MR, Shlomchik MJ. Depletion of B cells in murine lupus: efficacy and resistance. J Immunol. 2007;179:3351-61.
3. Akdis M, Trautmann A, Klunker S, Daigle I, Kucuksezer UC, Deglmann W, et al. T helper (Th) 2 predominance in atopic diseases is due to preferential apoptosis of circulating memory/effector Th1 cells. FASEB J. 2003;17:1026-35. (Pubitemid 36676389)
4. Al-Qaoud KM, Fleischer B, Hoerauf A. The Xid defect imparts susceptibility to experimental murine filariosis - association with a lack of antibody and IL-10 production by B cells in response to phosphorylcholine. Int Immunol. 1998;10:17-25. (Pubitemid 28048352)
5. Alderson MR, Lynch DH. Receptors and ligands that mediate activation-induced death of T cells. Springer Semin Immunopathol. 1998;19:289-300. (Pubitemid 28085264)
6. Anel A, Bosque A, Naval J, Pineiro A, Larrad L, Alava MA, et al. Apo2L/TRAIL and immune regulation. Front Biosci. 2007;12:2074-84.
7. Arnold LW, McCray SK, Tatu C, Clarke SH. Identification of a precursor to phosphatidyl choline-specific B-1 cells suggesting that B-1 cells differentiate from splenic conventional B cells in vivo: cyclosporin A blocks differentiation to B-1. J Immunol. 2000;164:2924-30. (Pubitemid 30148949)
8. Bonardelle D, Benihoud K, Kiger N, Bobe P. B lymphocytes mediate Fas-dependent cytotoxicity in MRL/lpr mice. J Leukoc Biol. 2005;78:1052-9. (Pubitemid 41572468)
9. Boros DL. Immunoregulation of granuloma formation in murine schistosomiasis mansoni. Ann N Y Acad Sci. 1986;465:313-23. (Pubitemid 16006572)
10. Boros DL. T helper cell populations, cytokine dynamics, and pathology of the schistosome egg granuloma. Microbes Infect. 1999;1:511-6.
11. Bussing A, Stein GM, Pfuller U, Schietzel M. Induction of Fas ligand (CD95L) by the toxic mistletoe lectins in human lymphocytes. Anticancer Res. 1999;19:1785-90. (Pubitemid 29392738)
12. Carter LL, Leach MW, Azoitei ML, Cui J, Pelker JW, Jussif J, et al. PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis. J Neuroimmunol. 2007;182:124-34. (Pubitemid 46039761)
13. Cheever AW, Byram JE, Hieny S, von Lichtenberg F, Lunde MN, Sher A. Immunopathology of Schistosoma japonicum and S. mansoni infection in B cell depleted mice. Parasite Immunol. 1985;7:399-413. (Pubitemid 16242726)
14. Collins M, Ling V, Carreno BM. The B7 family of immuneregulatory ligands. Genome Biol. 2005;6:223.
15. - B cells with anti-Ig, but not LPS, induces surface CD5: two B-cell activation pathways. Int Immunol. 1991;3:467-76.
16. Cooke A, Tonks P, Jones FM, O'Shea H, Hutchings P, Fulford AJ, et al. Infection with Schistosoma mansoni prevents insulin dependent diabetes mellitus in non-obese diabetic mice. Parasite Immunol. 1999;21:169-76. (Pubitemid 29158763)
17. Duan B, Morel L. Role of B-1a cells in autoimmunity. Autoimmun Rev. 2006;5:403-8. (Pubitemid 44143033)
18. Duddy M, Niino M, Adatia F, Hebert S, Freedman M, Atkins H, et al. Distinct effector cytokine profiles of memory and naive human B cell subsets and implication in multiple sclerosis. J Immunol. 2007;178:6092-9. (Pubitemid 46717389)
19. Edwards JC, Szczepanski L, Szechinski J, Filipowicz-Sosnowska A, Emery P, Close DR, et al. Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis. N Engl J Med. 2004;350:2572-81. (Pubitemid 38758544)
20. Elliott DE, Li J, Blum A, Metwali A, Qadir K, Urban JF Jr, et al. Exposure to schistosome eggs protects mice from TNBSinduced colitis. Am J Physiol Gastrointest Liver Physiol. 2003;284:G385-91. (Pubitemid 36227886)
21. Elliott DE, Summers RW, Weinstock JV. Helminths as governors of immune-mediated inflammation. Int J Parasitol. 2007;37:457-64. (Pubitemid 46399709)
22. + T regulatory cells dominate multiple immune evasion mechanisms in early but not late phases of tumor development in a B cell lymphoma model. J Immunol. 2007;178:6840-8.
23. Fillatreau S, Gray D, Anderton SM. Not always the bad guys: B cells as regulators of autoimmune pathology. Nat Rev Immunol. 2008;8:391-7. (Pubitemid 351595221)
24. Fillatreau S, Sweenie CH, McGeachy MJ, Gray D, Anderton SM. B cells regulate autoimmunity by provision of IL-10. Nat Immunol. 2002;3:944-50. (Pubitemid 35154008)
25. Fischer GM, Solt LA, Hastings WD, Yang K, Gerstein RM, Nikolajczyk BS, et al. Splenic and peritoneal B-1 cells differ in terms of transcriptional and proliferative features that separate peritoneal B-1 from splenic B-2 cells. Cell Immunol. 2001;213:62-71. (Pubitemid 34074971)
26. Gagro A, McCloskey N, Challa A, Holder M, Grafton G, Pound JD, et al. CD5-positive and CD5-negative human B cells converge to an indistinguishable population on signalling through B-cell receptors and CD40. Immunology. 2000;101:201-9.
27. Gaubert S, Viana da Costa A, Maurage CA, Lima EC, Fontaine J, Lafitte S, et al. X-linked immunodeficiency affects the outcome of Schistosoma mansoni infection in the murine model. Parasite Immunol. 1999;21:89-101. (Pubitemid 29086309)
28. Gourley TS, Patel DR, Nickerson K, Hong SC, Chang CH. Aberrant expression of Fas ligand in mice deficient for the MHC class II transactivator. J Immunol. 2002;168:4414-9. (Pubitemid 34441342)
29. Grullich C, Richter M, Exner S, Finke J. Fas ligand is not constitutively expressed in low-grade B-cell lymphoma and B-lymphoblastoid cells. Eur J Haematol. 2003;71:184-8. (Pubitemid 37082841)
30. Hahne M, Renno T, Schroeter M, Irmler M, French L, Bornard T, et al. Activated B cells express functional Fas ligand. Eur J Immunol. 1996;26:721-4. (Pubitemid 26091406)
31. Hamaguchi Y, Uchida J, Cain DW, Venturi GM, Poe JC, Haas KM, et al. The peritoneal cavity provides a protective niche for B1 and conventional B lymphocytes during anti-CD20 immunotherapy in mice. J Immunol. 2005;174:4389-99. (Pubitemid 40396022)
32. Hayakawa K, Asano M, Shinton SA, Gui M, Allman D, Stewart CL, et al. Positive selection of natural autoreactive B cells. Science. 1999;285:113-6. (Pubitemid 29307578)
33. Hayakawa K, Asano M, Shinton SA, Gui M, Wen LJ, Dashoff J, et al. Positive selection of anti-thy-1 autoreactive B-1 cells and natural serum autoantibody production independent from bone marrow B cell development. J Exp Med. 2003;197:87-99. (Pubitemid 36110260)
34. Hitoshi Y, Okada Y, Sonoda E, Tominaga A, Makino M, Suzuki K, et al. Delayed progression of a murine retrovirus-induced acquired immunodeficiency syndrome in X-linked immunodeficient mice. J Exp Med. 1993;177:621-6. (Pubitemid 23104273)
35. Ishida M, Iwai Y, Tanaka Y, Okazaki T, Freeman GJ, Minato N, et al. Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues. Immunol Lett. 2002;84:57-62. (Pubitemid 34879920)
36. Kemp TJ, Moore JM, Griffith TS. Human B cells express functional TRAIL/Apo-2 ligand after CpG-containing oligodeoxynucleotide stimulation. J Immunol. 2004;173:892-9. (Pubitemid 38924262)
37. Kim SH, Kim S, Oligino TJ, Robbins PD. Effective treatment of established mouse collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express FasL. Mol Ther. 2002;6:584-90. (Pubitemid 35363690)
38. Kim YS, Park GB, Song HK, Hur I, Lee HK, Kang JS, et al. Cross-linking of CD54 on Burkitt lymphoma cell line Raji and Ramos induces FasL expression by reactive oxygen species and apoptosis of adjacent cells in Fas/FasL interaction. J Immunother. 2007;30:727-39. (Pubitemid 47480756)
39. Kojima Y, Tsurumi H, Goto N, Shimizu M, Kasahara S, Yamada T, et al. Fas and Fas ligand expression on germinal center type-diffuse large B-cell lymphoma is associated with the clinical outcome. Eur J Haematol. 2006;76:465-72.
40. Kondo E, Yoshino T, Nishiuchi R, Sakuma I, Nishizaki K, Kayagaki N, et al. Expression of Fas ligand mRNA in germinal centres of the human tonsil. J Pathol. 1997;183:75-9. (Pubitemid 27368530)
41. Kosiewicz MM, Krishnan A, Worthington MT, Matriano JA, Ross WG. B cells engineered to express Fas ligand suppress presensitized antigen-specific T cell responses in vivo. Eur J Immunol. 2002;32:1679-87. (Pubitemid 34679155)
42. La Flamme AC, Ruddenklau K, Backstrom BT. Schistosomiasis decreases central nervous system inflammation and alters the progression of experimental autoimmune encephalomyelitis. Infect Immun. 2003;71:4996-5004. (Pubitemid 37070742)
43. Lampropoulou V, Hoehlig K, Roch T, Neves P, Gomez EC, Sweenie CH, et al. TLR-activated B cells suppress T cellmediated autoimmunity. J Immunol. 2008;180:4763-73.
44. Leandro MJ, Cambridge G, Ehrenstein MR, Edwards JC. Reconstitution of peripheral blood B cells after depletion with rituximab in patients with rheumatoid arthritis. Arthritis Rheum. 2006;54:613-20. (Pubitemid 43228639)
45. Lund FE, Garvy BA, Randall TD, Harris DP. Regulatory roles for cytokine-producing B cells in infection and autoimmune disease. Curr Dir Autoimmun. 2005;8:25-54.
46. Lund FE, Hollifield M, Schuer K, Lines JL, Randall TD, Garvy BA. B cells are required for generation of protective effector and memory CD4 cells in response to Pneumocystis lung infection. J Immunol. 2006;176:6147-54.
47. Lundy SK, Berlin AA, Martens TF, Lukacs NW. Deficiency of regulatory B cells increases allergic airway inflammation. Inflamm Res. 2005;54:514-21. (Pubitemid 43042239)
48. Lundy SK, Boros DL. Fas ligand-expressing B-1a lymphocytes mediate CD4(+)-T-cell apoptosis during schistosomal infection: induction by interleukin 4 (IL-4) and IL-10. Infect Immun. 2002;70:812-9. (Pubitemid 34083844)
49. Lundy SK, Lerman SP, Boros DL. Soluble egg antigen-stimulated T helper lymphocyte apoptosis and evidence for cell death mediated by FasL(+) T and B cells during murine Schistosoma mansoni infection. Infect Immun. 2001;69:271-80. (Pubitemid 32038323)
50. Maglione PJ, Xu J, Chan J. B cells moderate inflammatory progression and enhance bacterial containment upon pulmonary challenge with Mycobacterium tuberculosis. J Immunol. 2007;178:7222-34. (Pubitemid 46847448)
51. Mangan NE, Fallon RE, Smith P, van Rooijen N, McKenzie AN, Fallon PG. Helminth infection protects mice from anaphylaxis via IL-10-producing B cells. J Immunol. 2004;173:6346-56. (Pubitemid 39487794)
52. + T regulatory cells and IL-10 via B7 is essential for recovery from experimental autoimmune encephalomyelitis. J Immunol. 2007;178:3447-56.
53. Mariani SM, Krammer PH. Differential regulation of TRAIL and CD95 ligand in transformed cells of the T and B lymphocyte lineage. Eur J Immunol. 1998;28:973-82. (Pubitemid 28116210)
54. Mariani SM, Krammer PH. Surface expression of TRAIL/Apo-2 ligand in activated mouse T and B cells. Eur J Immunol. 1998;28:1492-8. (Pubitemid 28221151)
55. Martin F, Kearney JF. B1 cells: similarities and differences with other B cell subsets. Curr Opin Immunol. 2001;13:195-201. (Pubitemid 32176039)
56. Mauri C, Ehrenstein MR. The 'short' history of regulatory B cells. Trends Immunol. 2008;29:34-40.
57. Mauri C, Gray D, Mushtaq N, Londei M. Prevention of arthritis by interleukin 10-producing B cells. J Exp Med. 2003;197:489-501. (Pubitemid 36278604)
58. Meiler F, Zimmermann M, Blaser K, Akdis CA, Akdis M. T-cell subsets in the pathogenesis of human asthma. Curr Allergy Asthma Rep. 2006;6:91-6.
59. Melo ME, Qian J, El-Amine M, Agarwal RK, Soukhareva N, Kang Y, et al. Gene transfer of Ig-fusion proteins into B cells prevents and treats autoimmune diseases. J Immunol. 2002;168:4788-95. (Pubitemid 34441388)
60. + (CD5) B cells that recognize phosphatidyl choline. Relationship to cells that secrete hemolytic antibody specific for autologous erythrocytes. J Exp Med. 1988;168:687-98.
61. Minagawa R, Okano S, Tomita Y, Kishihara K, Yamada H, Nomoto K, et al. The critical role of Fas-Fas ligand interaction in donor-specific transfusion-induced tolerance to H-Y antigen. Transplantation. 2004;78:799-806. (Pubitemid 39298521)
62. Minoprio P, el Cheikh MC, Murphy E, Hontebeyrie-Joskowicz M, Coffman R, Coutinho A, et al. Xid-associated resistance to experimental Chagas' disease is IFN-gamma dependent. J Immunol. 1993;151:4200-8. (Pubitemid 23298753)
63. Mizoguchi A, Bhan AK. A case for regulatory B cells. J Immunol. 2006;176:705-10. (Pubitemid 43099663)
64. Mizoguchi A, Mizoguchi E, Takedatsu H, Blumberg RS, Bhan AK. Chronic intestinal inflammatory condition generates IL-10- producing regulatory B cell subset characterized by CD1d upregulation. Immunity. 2002;16:219-30. (Pubitemid 34211962)
65. Montecino-Rodriguez E, Leathers H, Dorshkind K. Identification of a B-1 B cell-specified progenitor. Nat Immunol. 2006;7:293-301.
66. Mullauer L, Mosberger I, Chott A. Fas ligand expression in nodal non-Hodgkin's lymphoma. Mod Pathol. 1998;11:369-75. (Pubitemid 28208099)
67. Nagafuchi H, Wakisaka S, Takeba Y, Takeno M, Sakane T, Suzuki N. Aberrant expression of Fas ligand on anti-DNA autoantibody secreting B lymphocytes in patients with systemic lupus erythematosus: "immune privilege"-like state of the autoreactive B cells. Clin Exp Rheumatol. 2002;20:625-31. (Pubitemid 35243774)
68. Nilsson N, Ingvarsson S, Borrebaeck CA. Immature B cells in bone marrow express Fas/FasL. Scand J Immunol. 2000;51:279-84. (Pubitemid 30151511)
69. Noorchashm H, Reed AJ, Rostami SY, Mozaffari R, Zekavat G, Koeberlein B, et al. B cell-mediated antigen presentation is required for the pathogenesis of acute cardiac allograft rejection. J Immunol. 2006;177:7715-22. (Pubitemid 44846287)
70. O'Garra A, Howard M. IL-10 production by CD5 B cells. Ann N Y Acad Sci. 1992;651:182-99.
71. Palanivel V, Posey C, Horauf AM, Solbach W, Piessens WF, Harn DA. B-cell outgrowth and ligand-specific production of IL-10 correlate with Th2 dominance in certain parasitic diseases. Exp Parasitol. 1996;84:168-77. (Pubitemid 26399783)
72. Pers JO, Daridon C, Bendaoud B, Devauchelle V, Berthou C, Saraux A, et al. B-cell depletion and repopulation in autoimmune diseases. Clin Rev Allergy Immunol. 2008;34:50-5.
73. Rich RF, Cook WJ, Green WR. Spontaneous in vivo retrovirusinfected T and B cells, but not dendritic cells, mediate antigenspecific Fas ligand/Fas-dependent apoptosis of anti-retroviral CTL. Virology. 2006;346:287-300. (Pubitemid 43357873)
74. Sampalo A, Navas G, Medina F, Segundo C, Camara C, Brieva JA. Chronic lymphocytic leukemia B cells inhibit spontaneous Ig production by autologous bone marrow cells: role of CD95- CD95L interaction. Blood. 2000;96:3168-74.
75. Samuelsson A, Sonnerborg A, Heuts N, Coster J, Chiodi F. Progressive B cell apoptosis and expression of Fas ligand during human immunodeficiency virus type 1 infection. AIDS Res Hum Retroviruses. 1997;13:1031-8. (Pubitemid 27330090)
76. Sasaki H, Schmitt DA, Matsumoto K, Pollard RB, Suzuki F. Demonstrations of a B-cell population that regulates the immune response in spleens of mice infected with herpes simplex virus type I. Clin Immunol Immunopathol. 1993;66:169-75. (Pubitemid 23111967)
77. + T lymphocytes in macaques by infection with a pathogenic simian/human immunodeficiency virus. Clin Exp Immunol. 2000;122:381-9.
78. Satpute SR, Soukhareva N, Scott DW, Moudgil KD. Mycobacterial Hsp65-IgG-expressing tolerogenic B cells confer protection against adjuvant-induced arthritis in Lewis rats. Arthritis Rheum. 2007;56:1490-6. (Pubitemid 46764077)
79. Sedger LM, Glaccum MB, Schuh JC, Kanaly ST, Williamson E, Kayagaki N, et al. Characterization of the in vivo function of TNF-alpha-related apoptosis-inducing ligand, TRAIL/Apo2L, using TRAIL/Apo2L gene-deficient mice. Eur J Immunol. 2002;32:2246-54. (Pubitemid 34965887)
80. Sewell D, Qing Z, Reinke E, Elliot D, Weinstock J, Sandor M, et al. Immunomodulation of experimental autoimmune encephalomyelitis by helminth ova immunization. Int Immunol. 2003;15:59-69. (Pubitemid 36163769)
81. Sharpe AH, Wherry EJ, Ahmed R, Freeman GJ. The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection. Nat Immunol. 2007;8:239-45. (Pubitemid 46745373)
82. Silvestris F, Cafforio P, Tucci M, Grinello D, Dammacco F. Upregulation of osteoblast apoptosis by malignant plasma cells: a role in myeloma bone disease. Br J Haematol. 2003;122:39-52. (Pubitemid 36819337)
83. Silvestris F, Tucci M, Cafforio P, Dammacco F. Fas-L upregulation by highly malignant myeloma plasma cells: role in the pathogenesis of anemia and disease progression. Blood. 2001;97:1155-64. (Pubitemid 32183734)
84. Singh A, Carson WF, Secor ER Jr, Guernsey LA, Flavell RA, Clark RB, et al. Regulatory role of B cells in a murine model of allergic airway disease. J Immunol. 2008;180:7318-26.
85. Song H, Park G, Kim YS, Hur I, Kim H, Ryu JW, et al. B7-H4 reverse signaling induces the apoptosis of EBV-transformed B cells through Fas ligand up-regulation. Cancer Lett. 2008;266:227-37.
86. - B cells: possible involvement in age-associated cytokine dysregulation. Int Immunol. 1997;9:745-54.
87. Strater J, Mariani SM, Walczak H, Rucker FG, Leithauser F, Krammer PH, et al. CD95 ligand (CD95L) in normal human lymphoid tissues: a subset of plasma cells are prominent producers of CD95L. Am J Pathol. 1999;154:193-201. (Pubitemid 29031626)
88. Takahashi T, Tanaka M, Brannan CI, Jenkins NA, Copeland NG, Suda T, et al. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell. 1994;76:969-76. (Pubitemid 24106378)
89. Tang Y, Kim WK, Holmes KL, Hugin AW, Kenny JJ, Chattopadhyay SK, et al. Contribution of B cell subsets to delayed development of MAIDS in Xid mice. Cell Immunol. 1995;165:1-6.
90. Tanner JE, Alfieri C. Epstein-Barr virus induces Fas (CD95) in T cells and Fas ligand in B cells leading to T-cell apoptosis. Blood. 1999;94:3439-47. (Pubitemid 29536139)
91. Tian J, Zekzer D, Hanssen L, Lu Y, Olcott A, Kaufman DL. Lipopolysaccharide-activated B cells down-regulate Th1 immunity and prevent autoimmune diabetes in nonobese diabetic mice. J Immunol. 2001;167:1081-9. (Pubitemid 32660868)
92. + T lymphocytes to the killing efficacy of Fas (Apo-1/CD95) ligand + tumor cells in B chronic lymphocytic leukemia. Blood. 1998;91:4273-81.
93. Truman JP, Choqueux C, Tschopp J, Vedrenne J, Le Deist F, Charron D, et al. HLA class II-mediated death is induced via Fas/Fas ligand interactions in human splenic B lymphocytes. Blood. 1997;89:1996-2007. (Pubitemid 27132115)
94. Tsitoura DC, Yeung VP, DeKruyff RH, Umetsu DT. Critical role of B cells in the development of T cell tolerance to aeroallergens. Int Immunol. 2002;14:659-67. (Pubitemid 34649721)
95. Tumang JR, Hastings WD, Bai C, Rothstein TL. Peritoneal and splenic B-1 cells are separable by phenotypic, functional, and transcriptomic characteristics. Eur J Immunol. 2004;34:2158-67. (Pubitemid 39256097)
96. + T-cell subsets. Proc Natl Acad Sci U S A. 1994;91:18-22.
97. Villunger A, Egle A, Marschitz I, Kos M, Bock G, Ludwig H, et al. Constitutive expression of Fas (Apo-1/CD95) ligand on multiple myeloma cells: a potential mechanism of tumorinduced suppression of immune surveillance. Blood. 1997;90:12-20. (Pubitemid 27276541)
98. Watt V, Ronchese F, Ritchie D. Resting B cells suppress tumor immunity via an MHC class-II dependent mechanism. J Immunother. 2007;30:323-32. (Pubitemid 46586648)
99. + T cell colitis through interaction with regulatory T cell subsets. Proc Natl Acad Sci U S A. 2005;102:2010-5.
100. Weinstock JV, Summers RW, Elliott DE, Qadir K, Urban JF Jr, Thompson R. The possible link between de-worming and the emergence of immunological disease. J Lab Clin Med. 2002;139:334-8. (Pubitemid 34604653)
101. Werner-Klein M, Dresch C, Marconi P, Brocker T. Transcriptional targeting of B cells for induction of peripheral CD8 T cell tolerance. J Immunol. 2007;178:7738-46. (Pubitemid 46898045)
102. Xiu Y, Wong CP, Bouaziz JD, Hamaguchi Y, Wang Y, Pop SM, et al. B lymphocyte depletion by CD20 monoclonal antibody prevents diabetes in nonobese diabetic mice despite isotypespecific differences in Fc{gamma}R effector functions. J Immunol. 2008;180:2863-75.
103. + phenotype controls T cell-dependent inflammatory responses. Immunity. 2008;28:639-50.
104. Yanaba K, Hamaguchi Y, Venturi GM, Steeber DA, St Clair EW, Tedder TF. B cell depletion delays collagen-induced arthritis in mice: arthritis induction requires synergy between humoral and cell-mediated immunity. J Immunol. 2007;179:1369-80.
105. Zhan HG, Mountz JD, Fleck M, Zhou T, Hsu HC. Specific deletion of autoreactive T cells by adenovirus-transfected, Fas ligand-producing antigen-presenting cells. Immunol Res. 2002;26:235-46. (Pubitemid 35177500)
106. Zhang HG, Liu D, Heike Y, Yang P, Wang Z, Wang X, et al. Induction of specific T-cell tolerance by adenovirus-transfected, Fas ligand-producing antigen presenting cells. Nat Biotechnol. 1998;16:1045-9.
107. Zhang X, Deriaud E, Jiao X, Braun D, Leclerc C, Lo-Man R. Type I interferons protect neonates from acute inflammation through interleukin 10-producing B cells. J Exp Med. 2007;204:1107-18. (Pubitemid 46798154)
108. Zhong X, Tumang JR, Gao W, Bai C, Rothstein TL. PD-L2 expression extends beyond dendritic cells/macrophages to B1 cells enriched for V(H)11/V(H)12 and phosphatidylcholine binding. Eur J Immunol. 2007;37:2405-10. (Pubitemid 47423611)
109. - B cells differ in ability to stimulate antigen specific T cells. Arch Immunol Ther Exp (Warsz). 1994;42:115-23.
110. Zoi-Toli O, Meijer CJ, Oudejans JJ, de Vries E, van Beek P, Willemze R. Expression of Fas and Fas ligand in cutaneous B-cell lymphomas. J Pathol. 1999;189:533-8.
111. + B lymphocytes susceptible to Fas/Fas ligand-mediated fratricide. J Immunol. 2002;168:3965-73.