B cells are required for generation of protective effector and memory CD4 cells in response to Pneumocystis lung infection

Journal of Immunology

Volumn 176, Issue 10, 2006, Pages 6147-6154

  Lund, Frances E ^a   Hollifield, Melissa ^b   Schuer, Kevin ^b   Lines, J Louise ^b   Randall, Troy D ^a   Garvy, Beth A ^b,c  

^a TRUDEAU INSTITUTE   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APC; CD4 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ADOPTIVE TRANSFER; ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; B LYMPHOCYTE ACTIVATION; BONE MARROW CELL; CELL PROTECTION; CHIMERA; EFFECTOR CELL; IMMUNE RESPONSE; INFECTION CONTROL; LUNG ALVEOLUS MACROPHAGE; LUNG INFECTION; MEMORY CELL; MOUSE; NONHUMAN; OPPORTUNISTIC INFECTION; PNEUMOCYSTIS; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

EID: 33646480336     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.176.10.6147     Document Type: Article

References (28)

1. + T cells into severe combined immunodeficiency mice. J. Clin. Invest. 90: 673-678.
2. + cells in resistance to Pneumocystis carinii pneumonia in mice. J. Exp. Med. 172: 937-945.
3. Shellito, J., V. V. Suzara, W. Blumenfeld, J. M. Beck, H. J. Steger, and T. H. Ermak. 1990. A new model of Pneumocystis carinii infection in mice selectively depleted of helper T lymphocytes. J. Clin. Invest. 85: 1686-1693.
4. Garvy, B. A., J. A. Wiley, F. Gigliotti, and A. G. Harmsen. 1997. Protection against Pneumocystis carinii pneumonia by antibodies generated from either T helper 1 or T helper 2 responses. Infect. Immun. 65: 5052-5056.
5. Lund, F. E., K. Schuer, M. Hollifield, T. D. Randall, and B. A. Garvy. 2003. Clearance of Pneumocystis carinii in mice is dependent on B cells but not on P. carinii-specific antibody. J. Immunol. 171: 1423-1430.
6. Steele, C., L. Marrero, S. Swain, A. G. Harmsen, M. Zheng, G. D. Brown, S. Gordon, J. E. Shellito, and S. K. Kolls. 2003. Alveolar macrophage-mediated killing of Pneumocystis carinii f. sp. muris involves molecular recognition by the Dectin-1 β-glucan receptor. J. Exp. Med. 198: 1677-1688.
7. Wiley, J. A., and A. G. Harmsen. 1995. CD40 ligand is required for resolution of Pneumocystis carinii pneumonia in mice. J. Immunol. 155: 3525-3529.
8. Macy, J. D., E. C. Weir, S. R. Compton, M. J. Shlomchik, and D. G. Brownstein. 2000. Dual infection with Pneumocystis carinii and Pasturella pneumotropica in B cell-deficient mice: diagnosis and therapy. Comp. Med. 50: 49-55.
9. Marcotte, H., D. Levesque, K. Delanay, A. Bourgeault, R. de la Durantaye, S. Brochu, and M. C. Lavoie. 1996. Pneumocystis carinii infection in transgenic B cell-deficient mice. J. Infect. Dis. 173: 1034-1037.
10. + T cell priming in vivo. J. Immunol. 162: 5695-5703.
11. Rivera, A., C.-C. Chen, N. Ron, J. P. Dougherty, and Y. Ron. 2001. Role of B cells as antigen-presenting cells in vivo revisited: antigen-specific B cells are essential for T cell expansion in lymph nodes and for systemic T cell responses to low antigen concentrations. Int. Immunol. 13: 1583-1593.
12. Yang, X., and R. C. Brunham. 1998. Gene knockout B cell-deficient mice demonstrate that B cells play an important role in the initiation of T cell responses to Chlamydia trachomatis (mouse pneumonitis) lung infection. J. Immunol. 161: 1439-1446.
13. + T cell functionality in virus-infected mice lacking a normal B cell compartment. J. Immunol. 171: 4733-4741.
14. Linton, P.-J., B. Bautista, E, Biederman, E. S. Bradley, J. Harbertson, R. M. Kondrack, R. C. Padrick, and L. M. Bradley. 2003. Costimulation via OX40L expressed by B cells is sufficient to determine the extent of primary CD4 cell expansion and Th2 cytokine secretion in vivo. J. Exp. Med. 197: 875-883.
15. Linton, P.-J., J. Harbertson, and L. M. Bradley. 2000. A critical role for B cells in the development of memory CD4 cells. J. Immunol. 165: 5558-5565.
16. Ngo, V. N., R. J. Cornall, and J. G. Cyster. 2001. Splenic T zone development is B cell dependent. J. Exp. Med. 194: 1649-1660.
17. Garvy, B. A., R. A. B. Ezekowitz, and A. G. Harmsen. 1997. Role of interferon-γ in the host immune and inflammatory response to P. carinii infection. Infect. Immun. 65: 373-379.
18. Janeway, C. A., Jr., Y. Ron, and M. E. Katz. 1987. The B cell is the initiating antigen-presenting cell in peripheral lymph nodes. J. Immunol. 138: 1051-1055.
19. Ron, Y., and J. Sprent. 1987. T cell priming in vivo: a major role for B cells in presenting antigen to T cells in lymph nodes. J. Immunol. 138: 2848-2856.
20. Gerloni, M., M. Rizzi, P. Castiglioni, and M. Zanetti. 2004. T cell immunity using transgenic B lymphocytes. Proc. Natl. Acad. Sci. USA 101: 3892-3897.
21. Matsuzaki, G., H. M. Vordermeier, A. Hashimoto, K. Nomoto, and J. Ivanyi. 1999. The role of B cells in the establishment of T cell response in mice infected with an intracellular bacteria, Listeria monocytogenes. Cell. Immunol. 194: 178-185.
22. -/-) mice with Salmonella enterica serovar typhimurium infection. Infect. Immun. 71: 6808-6819.
23. Bergmann, C. C., C. Ramakrishna, M. Kornacki, and S. A. Stohlman. 2001. Impaired T cell immunity in B cell-deficient mice following viral central nervous system infection. J. Immunol. 167: 1575-1583.
24. Homann, D., A. Tishon, D. P. Berger, W. O. Weigle, M. G. von Herrath, and M. B. A. Oldstone. 1998. Evidence for an underlying CD4 helper and CD8 T-cell defect in B-cell-deficient mice: failure to clear persistent virus infection after adoptive immunotherapy with virus-specific memory cells from μMT/μMT mice. J. Virol. 72: 9208-9216.
25. Kopf, M., F. Brombacher, and M. F. Bachmann. 2002. Role of IgM antibodies versus B cells in influenza virus-specific immunity. Eur. J. Immunol. 32: 2229-2236.
26. Langhorne, J., C. Cross, E. Seixas, C. Li, and T. von der Weid. 1998. A role for B cells in the development of T cell helper function in a malaria infection in mice. Proc. Natl. Acad. Sci. USA 95: 1730-1734.
27. -/- (B-cell-deficient) mice fail to mount solid acquired resistance to oral challenge with virulent Salmonella enterica serovar typhimurium and show impaired Th1 T-cell responses to Salmonella antigens. Infect. Immun. 68: 46-53.
28. Smith, K. M., J. M. Brewer, A. M. Mowat, Y. Ron, and P. Garside. 2004. The influence of follicular migration on T-cell differentiation. Immunology 111: 248-251.