Distinct mechanisms mediate naïve and memory CD8 T-cell tolerance

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 52, 2012, Pages 21438-21443

  Jellison, Evan R ^a   Turner, Michael J ^a,b   Blair, David A ^a,c   Lingenheld, Elizabeth G ^a   Zu, Li ^a   Puddington, Lynn ^a   Lefranco̧is, Leo ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b SANOFI   (France)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

AIRE; Autoimmunity; Transgenic mouse

Indexed keywords

HYBRID PROTEIN; INTERLEUKIN 7 RECEPTOR; L SELECTIN; OVALBUMIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CD8+ T LYMPHOCYTE; CELL EXPANSION; CONTROLLED STUDY; DENDRITIC CELL; IMMUNOLOGICAL TOLERANCE; INFLAMMATION; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, CD8; AUTOANTIGENS; CD8-POSITIVE T-LYMPHOCYTES; IMMUNE TOLERANCE; IMMUNOLOGIC MEMORY; LYMPHOCYTE ACTIVATION; LYMPHOID TISSUE; MICE; MICE, TRANSGENIC;

MUS MUSCULUS;

EID: 84871825500     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1217409110     Document Type: Article

References (41)

1. Gallegos AM, Bevan MJ (2006) Central tolerance: Good but imperfect. Immunol Rev 209:290-296.
2. Xing Y, Hogquist KA (2012) T-cell tolerance: Central and peripheral. Cold Spring Harb Perspect Biol 4(6):4.
3. Metzger TC, Anderson MS (2011) Control of central and peripheral tolerance by Aire. Immunol Rev 241(1):89-103.
4. Liston A, Rudensky AY (2007) Thymic development and peripheral homeostasis of regulatory T cells. Curr Opin Immunol 19(2):176-185. (Pubitemid 46356966)
5. Pape KA, Merica R, Mondino A, Khoruts A, Jenkins MK (1998) Direct evidence that functionally impaired CD4+ T cells persist in vivo following induction of peripheral tolerance. J Immunol 160(10):4719-4729. (Pubitemid 28215304)
6. Mueller DL (2010) Mechanisms maintaining peripheral tolerance. Nat Immunol 11(1):21-27.
7. Lee JW, et al. (2007) Peripheral antigen display by lymph node stroma promotes T cell tolerance to intestinal self. Nat Immunol 8(2):181-190.
8. Gardner JM, et al. (2008) Deletional tolerance mediated by extrathymic Aire-expressing cells. Science 321(5890):843-847.
9. Kreuwel HT, Aung S, Silao C, Sherman LA (2002) Memory CD8(+) T cells undergo peripheral tolerance. Immunity 17(1):73-81. (Pubitemid 34874620)
10. Probst HC, Lagnel J, Kollias G, van den Broek M (2003) Inducible transgenic mice reveal resting dendritic cells as potent inducers of CD8+ T cell tolerance. Immunity 18(5):713-720. (Pubitemid 36588587)
11. Chastain EM, Miller SD (2012) Molecular mimicry as an inducing trigger for CNS autoimmune demyelinating disease. Immunol Rev 245(1):227-238.
12. Rashid T, Ebringer A (2012) Autoimmunity in rheumatic diseases is induced by microbial infections via crossreactivity or molecular mimicry. Autoimmune Dis 2012:539282.
13. Wei CH, et al. (2005) Tissue-resident memory CD8+ T cells can be deleted by soluble, but not cross-presented antigen. J Immunol 175(10):6615-6623. (Pubitemid 41598904)
14. Knoechel B, Lohr J, Kahn E, Bluestone JA, Abbas AK (2005) Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen. J Exp Med 202(10):1375-1386. (Pubitemid 41668740)
15. Steptoe RJ, et al. (2007) Cognate CD4+ help elicited by resting dendritic cells does not impair the induction of peripheral tolerance in CD8+ T cells. J Immunol 178(4):2094-2103. (Pubitemid 46233406)
16. Kurts C, Kosaka H, Carbone FR, Miller JF, Heath WR (1997) Class I-restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8(+) T cells. J Exp Med 186(2):239-245. (Pubitemid 27328024)
17. Vezys V, Olson S, Lefrançois L (2000) Expression of intestine-specific antigen reveals novel pathways of CD8 T cell tolerance induction. Immunity 12(5):505-514.
18. Kenna TJ, Thomas R, Steptoe RJ (2008) Steady-state dendritic cells expressing cognate antigen terminate memory CD8+ T-cell responses. Blood 111(4):2091-2100. (Pubitemid 351451521)
19. Obst R, van Santen HM, Mathis D, Benoist C (2005) Antigen persistence is required throughout the expansion phase of a CD4(+) T cell response. J Exp Med 201(10):1555-1565. (Pubitemid 40721001)
20. Han S, Asoyan A, Rabenstein H, Nakano N, Obst R (2010) Role of antigen persistence and dose for CD4+ T-cell exhaustion and recovery. Proc Natl Acad Sci USA 107(47):20453-20458.
21. Legname G, et al. (2000) Inducible expression of a p56Lck transgene reveals a central role for Lck in the differentiation of CD4 SP thymocytes. Immunity 12(5):537-546.
22. Urlinger S, et al. (2000) Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity. Proc Natl Acad Sci USA 97(14):7963-7968. (Pubitemid 30460756)
23. Brocker T, Riedinger M, Karjalainen K (1997) Driving gene expression specifically in dendritic cells. Adv Exp Med Biol 417:55-57. (Pubitemid 27427719)
24. Mallo M, Kanzler B, Ohnemus S (2003) Reversible gene inactivation in the mouse. Genomics 81(4):356-360. (Pubitemid 36379157)
25. Hogquist KA, et al. (1994) T cell receptor antagonist peptides induce positive selection. Cell 76(1):17-27. (Pubitemid 24035278)
26. Turner MJ, Jellison ER, Lingenheld EG, Puddington L, Lefrançois L (2008) Avidity maturation of memory CD8 T cells is limited by self-antigen expression. J Exp Med 205(8):1859 - 1868.
27. Anderson MS, et al. (2002) Projection of an immunological self shadow within the thymus by the aire protein. Science 298(5597):1395-1401. (Pubitemid 35346134)
28. Moon JJ, et al. (2007) Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude. Immunity 27(2):203-213. (Pubitemid 47284919)
29. Obar JJ, Khanna KM, Lefrançois L (2008) Endogenous naive CD8+ T cell precursor frequency regulates primary and memory responses to infection. Immunity 28(6):859-869.
30. Schluns KS, Kieper WC, Jameson SC, Lefrançois L (2000) Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo. Nat Immunol 1(5):426-432.
31. Cui W, Joshi NS, Jiang A, Kaech SM (2009) Effects of Signal 3 during CD8 T cell priming: Bystander production of IL-12 enhances effector T cell expansion but promotes terminal differentiation. Vaccine 27(15):2177-2187.
32. Obar JJ, Lefrançois L (2010) Early signals during CD8 T cell priming regulate the generation of central memory cells. J Immunol 185(1):263-272.
33. Busch DH, Pilip I, Pamer EG (1998) Evolution of a complex T cell receptor repertoire during primary and recall bacterial infection. J Exp Med 188(1):61-70. (Pubitemid 28328606)
34. Kim SK, Brehm MA, Welsh RM, Selin LK (2002) Dynamics of memory T cell proliferation under conditions of heterologous immunity and bystander stimulation. J Immunol 169(1):90-98. (Pubitemid 34686124)
35. Wherry EJ, et al. (2007) Molecular signature of CD8+ T cell exhaustion during chronic viral infection. Immunity 27(4):670-684. (Pubitemid 47615511)
36. Joshi NS, et al. (2007) Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor. Immunity 27(2):281-295. (Pubitemid 47284924)
37. Obar JJ, Lefrançois L (2010) Early events governing memory CD8+ T-cell differentiation. Int Immunol 22(8):619-625.
38. Vezys V, Lefrançois L (2002) Cutting edge: Infl ammatory signals drive organ-specific autoimmunity to normally cross-tolerizing endogenous antigen. J Immunol 169(12):6677-6680. (Pubitemid 36899250)
39. Belz GT, Bedoui S, Kupresanin F, Carbone FR, Heath WR (2007) Minimal activation of memory CD8+ T cell by tissue-derived dendritic cells favors the stimulation of naive CD8+ T cells. Nat Immunol 8(10):1060- 1066.
40. Khanna KM, et al. (2008) In situ imaging reveals different responses by naïve and memory CD8 T cells to late antigen presentation by lymph node DC after influenza virus infection. Eur J Immunol 38(12):3304-3315.
41. Blair DA, Lefrançois L (2007) Increased competition for antigen during priming negatively impacts the generation of memory CD4 T cells. Proc Natl Acad Sci USA 104(38):15045-15050. (Pubitemid 47619590)