Interleukin-4-induced β-catenin regulates the conversion of macrophages to multinucleated giant cells

Molecular Immunology

Volumn 54, Issue 2, 2013, Pages 157-163

  Binder, Flora ^a,b   Hayakawa, Morisada ^a   Choo, Min Kyung ^a   Sano, Yasuyo ^a   Park, Jin Mo ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIV GRENOBLE ALPES   (France)

Author keywords

Beta catenin; Cytokine; Macrophage

Indexed keywords

BETA CATENIN; CHITIN; INTERLEUKIN 4;

ANIMAL EXPERIMENT; ARTICLE; CELL VIABILITY; CYTOKINE PRODUCTION; CYTOLOGY; GENE DELETION; GIANT CELL; MACROPHAGE; MOUSE; NONHUMAN; PERITONEAL CAVITY; PERITONITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANIMALS; BETA CATENIN; CELLS, CULTURED; CHITIN; GENE EXPRESSION REGULATION; GIANT CELLS; INTERLEUKIN-4; MACROPHAGES; MICE; MICE, TRANSGENIC; MYELOID CELLS; PERITONITIS;

MUS;

EID: 84871811883     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2012.12.004     Document Type: Article

References (39)

1. Brault V., Moore R., Kutsch S., Ishibashi M., Rowitch D.H., McMahon A.P., Sommer L., Boussadia O., Kemler R. Inactivation of the β-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. Development 2001, 128:1253-1264.
2. Chawla A., Nguyen K.D., Goh Y.P. Macrophage-mediated inflammation in metabolic disease. Nature Reviews Immunology 2011, 11:738-749.
3. Chen G.H., Olszewski M.A., McDonald R.A., Wells J.C., Paine R., Huffnagle G.B., Toews G.B. Role of granulocyte macrophage colony-stimulating factor in host defense against pulmonary Cryptococcus neoformans infection during murine allergic bronchopulmonary mycosis. American Journal of Pathology 2007, 170:1028-1040.
4. Clausen B.E., Burkhardt C., Reith W., Renkawitz R., Förster I. Conditional gene targeting in macrophages and granulocytes using LysMcre mice. Transgenic Research 1999, 8:265-277.
5. Fleetwood A.J., Dinh H., Cook A.D., Hertzog P.J., Hamilton J.A. GM-CSF- and M-CSF-dependent macrophage phenotypes display differential dependence on type I interferon signaling. Journal of Leukocyte Biology 2009, 86:411-421.
6. Ganz T. Iron in innate immunity: starve the invaders. Current Opinion in Immunology 2009, 21:63-67.
7. Gocheva V., Wang H.W., Gadea B.B., Shree T., Hunter K.E., Garfall A.L., Berman T., Joyce J.A. IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion. Genes & Development 2010, 24:241-255.
8. Goenka S., Kaplan M.H. Transcriptional regulation by STAT6. Immunologic Research 2011, 50:87-96.
9. Gordon S., Martinez F.O. Alternative activation of macrophages: mechanism and functions. Immunity 2010, 32:593-604.
10. Helming L., Gordon S. Macrophage fusion induced by IL-4 alternative activation is a multistage process involving multiple target molecules. European Journal of Immunology 2007, 37:33-42.
11. Helming L., Tomasello E., Kyriakides T.R., Martinez F.O., Takai T., Gordon S., Vivier E. Essential role of DAP12 signaling in macrophage programming into a fusion-competent state. Science Signaling 2008, 1:ra11.
12. Helming L., Gordon S. Molecular mediators of macrophage fusion. Trends in Cell Biology 2009, 19:514-522.
13. Helming L., Winter J., Gordon S. The scavenger receptor CD36 plays a role in cytokine-induced macrophage fusion. Journal of Cell Science 2009, 122:453-459.
14. Jay S.M., Skokos E., Laiwalla F., Krady M.M., Kyriakides T.R. Foreign body giant cell formation is preceded by lamellipodia formation and can be attenuated by inhibition of Rac1 activation. American Journal of Pathology 2007, 171:632-640.
15. Kang K., Reilly S.M., Karabacak V., Gangl M.R., Fitzgerald K., Hatano B., Lee C.H. Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity. Cell Metabolism 2008, 7:485-495.
16. Krausgruber T., Blazek K., Smallie T., Alzabin S., Lockstone H., Sahgal N., Hussell T., Feldmann M., Udalova I.A. IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses. Nature Immunology 2011, 12:231-238.
17. Kuroda E., Ho V., Ruschmann J., Antignano F., Hamilton M., Rauh M.J., Antov A., Flavell R.A., Sly L.M., Krystal G. SHIP represses the generation of IL-3-induced M2 macrophages by inhibiting IL-4 production from basophils. Journal of Immunology 2009, 183:3652-3660.
18. Kyriakides T.R., Foster M.J., Keeney G.E., Tsai A., Giachelli C.M., Clark-Lewis I., Rollins B.J., Bornstein P. The CC chemokine ligand, CCL2/MCP1, participates in macrophage fusion and foreign body giant cell formation. American Journal of Pathology 2004, 165:2157-2166.
19. Lawrence T., Natoli G. Transcriptional regulation of macrophage polarization: enabling diversity with identity. Nature Reviews Immunology 2011, 11:750-761.
20. MacLauchlan S., Skokos E.A., Meznarich N., Zhu D.H., Raoof S., Shipley J.M., Senior R.M., Bornstein P., Kyriakides T.R. Macrophage fusion, giant cell formation, and the foreign body response require matrix metalloproteinase 9. Journal of Leukocyte Biology 2009, 85:617-626.
21. Moreno J.L., Mikhailenko I., Tondravi M.M., Keegan A.D. IL-4 promotes the formation of multinucleated giant cells from macrophage precursors by a STAT6-dependent, homotypic mechanism: contribution of E-cadherin. Journal of Leukocyte Biology 2007, 82:1542-1553.
22. Murray P.J., Wynn T.A. Protective and pathogenic functions of macrophage subsets. Nature Reviews Immunology 2011, 11:723-737.
23. Novack D.V., Teitelbaum S.L. The osteoclast: friend or foe?. Annual Review of Pathology 2008, 3:457-484.
24. Otero K., Turnbull I.R., Poliani P.L., Vermi W., Cerutti E., Aoshi T., Tassi I., Takai T., Stanley S.L., Miller M., Shaw A.S., Colonna M. Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and β-catenin. Nature Immunology 2009, 10:734-743.
25. Pajcini K.V., Pomerantz J.H., Alkan O., Doyonnas R., Blau H.M. Myoblasts and macrophages share molecular components that contribute to cell-cell fusion. Journal of Cell Biology 2008, 180:1005-1019.
26. Park J.M., Brady H., Ruocco M.G., Sun H., Williams D., Lee S.J., Kato T., Richards N., Chan K., Mercurio F., Karin M., Wasserman S.A. Targeting of TAK1 by the NF-κB protein Relish regulates the JNK-mediated immune response in Drosophila. Genes Development 2004, 18:584-594.
27. Paul W.E., Zhu J. How are T(H)2-type immune responses initiated and amplified?. Nature Reviews Immunology 2010, 10:225-235.
28. Reese T.A., Liang H.E., Tager A.M., Luster A.D., Van Rooijen N., Voehringer D., Locksley R.M. Chitin induces accumulation in tissue of innate immune cells associated with allergy. Nature 2007, 447:92-96.
29. Satoh T., Takeuchi O., Vandenbon A., Yasuda K., Tanaka Y., Kumagai Y., Miyake T., Matsushita K., Okazaki T., Saitoh T., Honma K., Matsuyama T., Yui K., Tsujimura T., Standley D.M., Nakanishi K., Nakai K., Akira S. The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection. Nature Immunology 2010, 11:936-944.
30. Seder R.A., Paul W.E., Dvorak A.M., Sharkis S.J., Kagey-Sobotka A., Niv Y., Finkelman F.D., Barbieri S.A., Galli S.J., Plaut M. Mouse splenic and bone marrow cell populations that express high-affinity Fc epsilon receptors and produce interleukin 4 are highly enriched in basophils. Proceedings of the National Academy of Sciences of the United States of America 1991, 88:2835-2839.
31. Sica A., Mantovani A. Macrophage plasticity and polarization: in vivo veritas. Journal of Clinical Investigation 2012, 122:787-795.
32. Sissons J.R., Peschon J.J., Schmitz F., Suen R., Gilchrist M., Aderem A. MicroRNA regulation of macrophage fusion into multinucleated giant cells. Journal of Immunology 2012, 189:23-27.
33. Valenta T., Hausmann G., Basler K. The many faces and functions of β-catenin. EMBO Journal 2012, 31:2714-2736.
34. Van den Bossche J., Bogaert P., Van Hengel J., Guérin C.J., Berx G., Movahedi K., Van den Bergh R., Pereira-Fernandes A., Geuns J.M., Pircher H., Dorny P., Grooten J., De Baetselier P., Van Ginderachter J.A. Alternatively activated macrophages engage in homotypic and heterotypic interactions through IL-4 and polyamine-induced E-cadherin/catenin complexes. Blood 2009, 114:4664-4674.
35. Voehringer D., Shinkai K., Locksley R.M. Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production. Immunity 2004, 20:267-277.
36. Xu H., Zhu J., Smith S., Foldi J., Zhao B., Chung A.Y., Outtz H., Kitajewski J., Shi C., Weber S., Saftig P., Li Y., Ozato K., Blobel C.P., Ivashkiv L.B., Hu X. Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization. Nature Immunology 2012, 13:642-650.
37. Yagi M., Miyamoto T., Sawatani Y., Iwamoto K., Hosogane N., Fujita N., Morita K., Ninomiya K., Suzuki T., Miyamoto K., Oike Y., Takeya M., Toyama Y., Suda T. DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cells. Journal of Experimental Medicine 2005, 202:345-351.
38. Yang P., An H., Liu X., Wen M., Zheng Y., Rui Y., Cao X. The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway. Nature Immunology 2010, 11:487-494.
39. Yu M., Qi X., Moreno J.L., Farber D.L., Keegan A.D. NF-κB signaling participates in both RANKL- and IL-4-induced macrophage fusion: receptor cross-talk leads to alterations in NF-κB pathways. Journal of Immunology 2011, 187:1797-1806.