Electrospun synthetic and natural nanofibers for regenerative medicine and stem cells

Biotechnology Journal

Volumn 8, Issue 1, 2013, Pages 59-72

  Kai, Dan ^a   Jin, Guorui ^b   Prabhakaran, Molamma P ^b   Ramakrishna, Seeram ^b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Cell infiltration; Electrospinning; Nanofibers; Stem cell differentiation; Tissue engineering

Indexed keywords

CELL BEHAVIORS; CELL INFILTRATION; CELLULAR RESPONSE; ELECTROSPUNS; FUNCTIONAL TISSUE; MACROPOROUS; NANOFIBROUS SCAFFOLDS; NATIVE EXTRACELLULAR MATRIX; PARTICULATE LEACHING; POLYMER NANOFIBERS; PROCESSING TECHNIQUE; REGENERATIVE MEDICINE; STEM CELL DIFFERENTIATION; THREE-DIMENSIONAL PRINTING; TISSUE REGENERATION;

ELECTROSPINNING; LEACHING; NANOFIBERS; STEM CELLS; TISSUE; TISSUE ENGINEERING;

SCAFFOLDS (BIOLOGY);

ALKALINE PHOSPHATASE; ALPHA2 INTEGRIN; ALPHA5 INTEGRIN; BETA1 INTEGRIN; BETA3 INTEGRIN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; FIBRONECTIN; LAMININ; MACROGOL; MOLECULAR SCAFFOLD; NANOFIBER; OSTEOCALCIN; POLITEF; POLYCAPROLACTONE; POLYGLACTIN; POLYLACTIC ACID; TRANSCRIPTION FACTOR RUNX2;

ADSORPTION; BASEMENT MEMBRANE; BONE DEVELOPMENT; CARTILAGE CELL; CELL ADHESION; CELL DIFFERENTIATION; CELL FUNCTION; CELL INFILTRATION; CELL INTERACTION; CELL PROLIFERATION; CELL SHAPE; CELL STRUCTURE; CELL SURVIVAL; CYTOSKELETON; DNA REPLICATION; ELECTROSPINNING; ELECTROSTATIC PRECIPITATION; EMBRYONIC STEM CELL; EXTRACELLULAR MATRIX; FIBROBLAST; HEMATOPOIETIC STEM CELL; HUMAN; MACROPHAGE; MESENCHYMAL STEM CELL; MICROENVIRONMENT; MINERALIZATION; NANOFABRICATION; NERVE FIBER GROWTH; NEURAL STEM CELL; NONHUMAN; OLIGODENDROGLIA; OSTEOBLAST; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGENERATIVE MEDICINE; REVIEW; SMOOTH MUSCLE FIBER; STATIC ELECTRICITY; STEM CELL; TISSUE REGENERATION; UMBILICAL VEIN ENDOTHELIAL CELL;

ANIMALS; HUMANS; NANOFIBERS; REGENERATIVE MEDICINE; STEM CELLS; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 84871806074     PISSN: 18606768     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.201200249     Document Type: Review

References (83)

1. Bentley, T. S., Hanson, S. G., US organ and tissue transplant cost estimates and discussion. Milliman Research Report 2011. Available online: http://publications.milliman.com/research/health-rr/pdfs/2011-us-organ-tissue.pdf.
2. Smith, L. A., Liu, X. H., Ma, P. X., Tissue engineering with nano-fibrous scaffolds. Soft Matter 2008, 4, 2144-2149.
3. Langer, R., Vacanti, J. P., Tissue Engineering. Science 1993, 260, 920-926.
4. Abbott, A., Cell culture: Biology's new dimension. Nature 2003, 424, 870-872.
5. Kubinova, S., Sykova, E., Nanotechnologies in regenerative medicine. Minim. Invasive Ther. Allied Technol. 2010, 19, 144-156.
6. Holzwarth, J. M., Ma, P. X., Biomimetic nanofibrous scaffolds for bone tissue engineering. Biomaterials 2011, 32, 9622-9629.
7. Teo, W. E., Ramakrishna, S., Electrospun nanofibers as a platform for multifunctional, hierarchically organized nanocomposite. Compos. Sci. Technol. 2009, 69, 1804-1817.
8. Reneker, D. H., Chun, I., Nanometre diameter fibres of polymer, produced by electrospinning. Nanotechnology 1996, 7, 216-223.
9. Subbiah, T., Bhat, G. S., Tock, R. W., Pararneswaran, S., Ramkumar, S. S., Electrospinning of nanofibers. J. Appl. Polym. Sci. 2005, 96, 557-569.
10. Pham, Q. P., Sharma, U., Mikos, A. G., Electrospinning of polymeric nanofibers for tissue engineering applications: A review. Tissue Eng. 2006, 12, 1197-1211.
11. Bhardwaj, N., Kundu, S. C., Electrospinning: A fascinating fiber fabrication technique. Biotechnol. Adv. 2010, 28, 325-347.
12. Park, S. H., Yang, D. Y., Fabrication of aligned electrospun nanofibers by inclined gap method. J. Appl. Polym. Sci. 2011, 120, 1800-1807.
13. Lu, P., Ding, B., Applications of electrospun fibers. Recent Pat. Nanotechnology 2008, 2, 169-182.
14. Gunn, J., Zhang, M. Q., Polyblend nanofibers for biomedical applications: perspectives and challenges. Trends Biotechnol. 2010, 28, 189-197.
15. Agarwal, S., Wendorff, J. H., Greiner, A., Progress in the field of electrospinning for tissue engineering applications. Adv. Mater. 2009, 21, 3343-3351.
16. Ji, W., Sun, Y., Yang, F., Van Den Beucken, J. et al., Bioactive electrospun scaffolds delivering growth factors and genes for tissue engineering applications. Pharm. Res. 2011, 28, 1259-1272.
17. Moghe, A. K., Gupta, B. S., Co-axial electrospinning for nanofiber structures: Preparation and applications. Polym. Rev. 2008, 48, 353-377.
18. Moghe, A. K., Gupta, B. S., Hybrid nanofiber structures for tissue engineering. AATCC Rev. 2009, 9, 43-47.
19. Temenoff, J., Mikos, A., Biomaterials The Intersection of Biology and Materials Science, Pearson Prentice Hall, New York 2008.
20. Borradori, L., Sonnenberg, A., Structures and function of hemidesmosomes: More than simple adhesion complexes. J. Invest.Dermatol. 1999, 112, 411-418.
21. Wozniak, M. A., Modzelewska, K., Kwong, L., Keely, P. J., Focal adhesion regulation of cell behavior. Biochim. Biophys. Acta-Mol. Cell Res. 2004, 1692, 103-119.
22. Leung, V., Ko, F., Biomedical applications of nanofibers. Polym. Adv. Technol. 2011, 22, 350-365.
23. Krasteva, V., Pehlivanova, V., Seifert, B., Luetzow, K. et al., Influence of AC electric fields on the adsorption of plasma proteins onto nanofiber biomaterials. C. R. Acad. Bulg. Sci. 2011, 64, 535-544.
24. Ainslie, K. M., Bachelder, E. M., Borkar, S., Zahr, A. S. et al., Cell adhesion on nanofibrous polytetrafluoroethylene (nPTFE). Langmuir 2007, 23, 747-754.
25. Woo, K. M., Jun, J. H., Chen, V. J., Seo, J. Y. et al., Nano-fibrous scaffolding promotes osteoblast differentiation and biomineralization. Biomaterials 2007, 28, 335-343.
26. Ivanov, D. B., Philippova, M. P., Tkachuk, V. A., Structure and functions of classical cadherins. Biochemistry-Moscow 2001, 66, 1174-1186.
27. Ley, K., Functions of selectins, Results Probl. Cell Differ. 2001, 33, 177-200.
28. Senapati, S., Das, S., Batra, S. K., Mucin-interacting proteins: from function to therapeutics. Trends Biochem. Sci. 2010, 35, 236-245.
29. Harburger, D. S., Calderwood, D. A., Integrin signalling at a glance. J. Cell Sci. 2009, 122, 159-163.
30. Li, W. J., Danielson, K. G., Alexander, P. G., Tuan, R. S., Biological response of chondrocytes cultured in three-dimensional nanofibrous poly(epsilon-caprolactone) scaffolds. J. Biomed. Mater. Res. Part A 2003, 67A, 1105-1114.
31. Bondar, B., Fuchs, S., Motta, A., Migliaresi, C., Kirkpatrick, C. J., Functionality of endothelial cells on silk fibroin nets: Comparative study of micro- and nanometric fibre size. Biomaterials 2008, 29, 561-572.
32. Ma, K., Chan, C. K., Liao, S., Hwang, W. Y. K. et al., Electrospun nanofiber scaffolds for rapid and rich capture of bone marrow-derived hematopoietic stem cells. Biomaterials 2008, 29, 2096-2103.
33. Tocce, E. J., Broderick, A. H., Murphy, K. C., Liliensiek, S. J. et al., Functionalization of reactive polymer multilayers with RGD and an antifouling motif: RGD density provides control over human corneal epithelial cell-substrate interactions. J. Biomed. Mater. Res. Part A 2012, 100A, 84-93.
34. Gentsch, R., Pippig, F., Schmidt, S., Cernoch, P. et al., Single-Step Electrospinning to Bioactive Polymer Nanofibers. Macromolecules 2011, 44, 453-461.
35. Wang, Y. Y., Lu, L. X., Feng, Z. Q., Xiao, Z. D., Huang, N. P., Cellular compatibility of RGD-modified chitosan nanofibers with aligned or random orientation. Biomed. Mater. 2010, 5. 054112.
36. Morgan, D. O., The Cell Cycle: Principles of Control, New Science Press, London 2007.
37. Prakash, S., Khan, A., Paul, A., Nanoscaffold based stem cell regeneration therapy: recent advancement and future potential. Expert Opin. Biol. Ther. 2010, 10, 1649-1661.
38. He, C., Xu, X., Zhang, F., Cao, L. et al., Fabrication of fibrinogen/P(LLA-CL) hybrid nanofibrous scaffold for potential soft tissue engineering applications. J. Biomed. Mater. Res. Part A 2011, 97A, 339-347.
39. Neal, R. A., Tholpady, S. S., Foley, P. L., Swami, N. et al., Alignment and composition of laminin-polycaprolactone nanofiber blends enhance peripheral nerve regeneration. J. Biomed. Mater. Res. Part A 2012, 100A, 406-423.
40. Prabhakaran, M. P., Venugopal, J. R., Ter Chyan, T., Hai, L. B. et al., Electrospun biocomposite nanofibrous scaffolds for neural tissue engineering. Tissue Eng.Part A 2008, 14, 1787-1797.
41. Gomez, N., Schmidt, C. E., Nerve growth factor-immobilized polypyrrole: bioactive electrically conducting polymer for enhanced neurite extension. J. Biomed. Mater. Res. Part A 2007, 81, 135-149.
42. Guimard, N. K., Gomez, N., Schmidt, C. E., Conducting polymers in biomedical engineering. Prog. Polym. Sc. 2007, 32, 876-921.
43. Prabhakaran, M. P., Ghasemi-Mobarakeh, L., Jin, G. R., Ramakrishna, S., Electrospun conducting polymer nanofibers and electrical stimulation of nerve stem cells. J. Biosci. Bioeng. 2011, 112, 501-507.
44. Jun, I., Jeong, S., Shin, H., The stimulation of myoblast differentiation by electrically conductive sub-micron fibers. Biomaterials 2009, 30, 2038-2047.
45. Li, M., Guo, Y., Wei, Y., MacDiarmid, A. G., Lelkes, P. I., Electrospinning polyaniline-contained gelatin nanofibers for tissue engineering applications. Biomaterials 2006, 27, 2705-2715.
46. Kai, D., Prabhakaran, M. P., Jin, G. R., Ramakrishna, S., Polypyrrole-contained electrospun conductive nanofibrous membranes for cardiac tissue engineering. J. Biomed. Mater. Res. Part A 2011, 99A, 376-385.
47. Min, B., Jeong, L., Nam, Y., Kim, J. et al., Formation of silk fibroin matrices with different texture and its cellular response to normal human keratinocytes. Int. J. Biol. Macromol. 2004, 34, 223-230.
48. Ahmed, I., Ponery, A. S., Nur-E-Kamal, A., Kamal, J. et al., Morphology, cytoskeletal organization, and myosin dynamics of mouse embryonic fibroblasts cultured on nanofibrillar surfaces. Mol. Cell. Biochem. 2007, 301, 241-249.
49. Factor, S. M., Robinson, T. F., Comparative connective - Tissue structure - Fuction - Relationships in biologic pumps. Lab. Invest. 1988, 58, 150-156.
50. Ma, Z., He, W., Yong, T., Ramakrishna, S., Grafting of gelatin on electrospun poly (caprolactone) nanofibers to improve endothelial cell spreading and proliferation and to control cell orientation. Tissue Eng. 2005, 11, 1149-1158.
51. Kai, D., Prabhakaran, M. P., Jin, G. R., Ramakrishna, S., Guided orientation of cardiomyocytes on electrospun aligned nanofibers for cardiac tissue engineering. Journal of Biomed. Mater. Res. Part B 2011, 98B, 379-386.
52. Kijenska, E., Prabhakaran, M. P., Swieszkowski, W., Kurzydlowski, K. J., Ramakrishna, S., Electrospun bio-composite P(LLA-CL)/collagen I/collagen III scaffolds for nerve tissue engineering. J. Biomed. Mater. Res. Part B 2012, 100B, 1093-1102.
53. Li, W. J., Jiang, Y. J., Tuan, R. S., Chondrocyte phenotype in engineered fibrous matrix is regulated by fiber size. Tissue Eng. 2006, 12, 1775-1785.
54. He, L. M., Liao, S. S., Quan, D. P., Ma, K. et al., Synergistic effects of electrospun PLLA fiber dimension and pattern on neonatal mouse cerebellum C17.2 stem cells. Acta Biomater. 2010, 6, 2960-2969.
55. Sun, X., Fu, X., Sheng, Z., Cutaneous stem cells: something new and something borrowed. Wound Repair and Regen. 2007, 15, 775-785.
56. Lim, S. H., Mao, H. Q., Electrospun scaffolds for stem cell engineering. Adv. Drug Deliv. Rev. 2009, 61, 1084-1096.
57. Kolambkar, Y. M., Peister, A., Ekaputra, A. K., Hutmacher, D. W., Guldberg, R. E., Colonization and osteogenic differentiation of different stem cell sources on electrospun nanofiber meshes. Tissue Eng. Part A 2010, 16, 3219-3230.
58. Xin, X., Hussain, M., Mao, J. J., Continuing differentiation of human mesenchymal stem cells and induced chondrogenic and osteogenic lineages in electrospun PLGA nanofiber scaffold. Biomaterials 2007, 28, 316-325.
59. Lim, S. H., Liu, X. Y., Song, H., Yarema, K. J., Mao, H.-Q., The effect of nanofiber-guided cell alignment on the preferential differentiation of neural stem cells. Biomaterials 2010, 31, 9031-9039.
60. Mahairaki, V., Lim, S. H., Christopherson, G. T., Xu, L. et al., Nanofiber matrices promote the neuronal differentiation of human embryonic stem cell-derived neural precursors in vitro. Tissue Eng. Part A 2011, 17, 855-863.
61. Jin, G. R., Prabhakaran, M. P., Ramakrishna, S., Stem cell differentiation to epidermal lineages on electrospun nanofibrous substrates for skin tissue engineering. Acta Biomater. 2011, 7, 3113-3122.
62. Prabhakaran, M., Venugopal, J., Ramakrishna, S., Mesenchymal stem cell differentiation to neuronal cells on electrospun nanofibrous substrates for nerve tissue engineering. Biomaterials 2009, 30, 4996-5003.
63. Bao, C., Chen, W., Weir, M. D., Thein-Han, W., Xu, H. H. K., Effects of electrospun submicron fibers in calcium phosphate cement scaffold on mechanical properties and osteogenic differentiation of umbilical cord stem cells. Acta Biomater. 2011, 7, 4037-4044.
64. Lee, J. H., Rim, N. G., Jung, H. S., Shin, H., Control of osteogenic differentiation and mineralization of human mesenchymal stem cells on somposite nanofibers containing poly [lactic-co-(glycolic acid)] and hydroxyapatite. Macromol. Biosci. 2010, 10, 173-182.
65. Bakhru, S., Nain, A. S., Highley, C., Wang, J. et al., Direct and cell signaling-based, geometry-induced neuronal differentiation of neural stem cells. Integr. Biology 2011, 3, 1207-1214.
66. Xie, J., Willerth, S. M., Li, X., Macewan, M. R. et al., The differentiation of embryonic stem cells seeded on electrospun nanofibers into neural lineages. Biomaterials 2009, 30, 354-362.
67. Jiang, X., Cao, H. Q., Shi, L. Y., Ng, S. Y. et al., Nanofiber topography and sustained biochemical signaling enhance human mesenchymal stem cell neural commitment. Acta Biomater. 2012, 8, 1290-1302.
68. Ma, J., He, X., Jabbari, E., Osteogenic differentiation of marrow stromal cells on random and aligned electrospun poly(L-lactide) nanofibers. Ann. Biomed. Eng. 2011, 39, 14-25.
69. Binulal, N. S., Deepthy, M., Selvamurugan, N., Shalumon, K. T. et al., Role of nanofibrous poly(caprolactone) acaffolds in human mesenchymal stem cell attachment and spreading for in vitro bone tissue engineering-response to osteogenic regulators. Tissue Eng. Part A 2010, 16, 393-404.
70. Yang, F., Murugan, R., Wang, S., Ramakrishna, S., Electrospinning of nano/micro scale poly(L-lactic acid) aligned fibers and their potential in neural tissue engineering. Biomaterials 2005, 26, 2603-2610.
71. Christopherson, G. T., Song, H., Mao, H.-Q., The influence of fiber diameter of electrospun substrates on neural stem cell differentiation and proliferation. Biomaterials 2009, 30, 556-564.
72. Nam, J., Johnson, J., Lannutti, J. J., Agarwal, S., Modulation of embryonic mesenchymal progenitor cell differentiation via control over pure mechanical modulus in electrospun nanofibers. Acta Biomater. 2011, 7, 1516-1524.
73. Chen, V. J., Ma, P. X., Nano-fibrous poly(L-lactic acid) scaffolds with interconnected spherical macropores. Biomaterials 2004, 25, 2065-2073.
74. Wei, G. B., Ma, P. X., Macroporous and nanofibrous polymer scaffolds and polymer/bone-like apatite composite scaffolds generated by sugar spheres. J. Biomed. Mater. Res. Part A 2006, 78A, 306-315.
75. Nam, J., Huang, Y., Agarwal, S., Lannutti, J., Improved cellular infiltration in electrospun fiber via engineered porosity. Tissue Eng. 2007, 13, 2249-2257.
76. Lee, Y. H., Lee, J. H., An, I. G., Kim, C. et al., Electrospun dual-porosity structure and biodegradation morphology of Montmorillonite reinforced PLLA nanocomposite scaffolds. Biomaterials 2005, 26, 3165-3172.
77. Simonet, M., Schneider, O. D., Neuenschwander, P., Stark, W. J., Ultraporous 3D polymer meshes by low-temperature electrospinning: Use of ice crystals as a removable void template. Polymer Eng. Sci. 2007, 47, 2020-2026.
78. Baker, B. M., Gee, A. O., Metter, R. B., Nathan, A. S. et al., The potential to improve cell infiltration in composite fiber-aligned electrospun scaffolds by the selective removal of sacrificial fibers. Biomaterials 2008, 29, 2348-2358.
79. Tuzlakoglu, K., Bolgen, N., Salgado, A. J., Gomes, M. E. et al., Nano- and micro-fiber combined scaffolds: A new architecture for bone tissue engineering. J. Mater. Sci. Mater. Med. 2005, 16, 1099-1104.
80. Park, S. H., Kim, T. G., Kim, H. C., Yang, D.-Y., Park, T. G., Development of dual scale scaffolds via direct polymer melt deposition and electrospinning for applications in tissue regeneration. Acta Biomater. 2008, 4, 1198-1207.
81. Baker, B. M., Handorf, A. M., Ionescu, L. C., Li, W. J., Mauck, R. L., New directions in nanofibrous scaffolds for soft tissue engineering and regeneration. Expert Rev. Med. Devices 2009, 6, 515-532.
82. Stankus, J. J., Guan, J. J., Fujimoto, K., Wagner, W. R., Microintegrating smooth muscle cells into a biodegradable, elastomeric fiber matrix. Biomaterials 2006, 27, 735-744.
83. Townsend-Nicholson, A., Jayasinghe, S. N., Cell electrospinning: a unique biotechnique for encapsulating living organisms for generating active biological microthreads/scaffolds. Biomacromolecules 2006, 7, 3364-3369.