Macroporous and nanofibrous polymer scaffolds and polymer/bone-like apatite composite scaffolds generated by sugar spheres

Journal of Biomedical Materials Research - Part A

Volumn 78, Issue 2, 2006, Pages 306-315

  Wei, Guobao ^a   Ma, Peter X ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Apatite; Composite; Matrix; Nano fiber; Polymer; Scaffold; Sugar

Indexed keywords

BONE; HEAT TREATMENT; LEACHING; NANOSTRUCTURED MATERIALS; ORGANIC POLYMERS; PHASE SEPARATION; SCAFFOLDS; SUGAR (SUCROSE);

APATITE; COMPOSITE; MATRIX; NANO FIBER;

POLYMERS;

APATITE; POLYLACTIC ACID; POLYMER;

ARTICLE; BODY FLUID; BONE MATRIX; LEACHING; PHASE SEPARATION; POROSITY; TISSUE ENGINEERING; TISSUE REGENERATION;

APATITES; BIOPOLYMERS; BODY FLUIDS; LACTIC ACID; MICROSCOPY, ELECTRON, SCANNING; NANOSTRUCTURES; POLYMERS; POROSITY;

EID: 33745936923     PISSN: 00219304     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.30704     Document Type: Article

References (23)

1. Ma PX. Scaffolds for tissue fabrication. Mater Today 2004;7(5):30-40.
2. Ma PX. Tissue engineering. In: Kroschwitz J, editor. Encyclopedia of Polymer Science and Technology. New York: Wiley; 2005;12:261-291.
3. Zhang RY, Ma PX. Poly(α-hydroxyl acids) hydroxyapatite porous composites for bone-tissue engineering. I. Preparation and morphology. J Biomed Mater Res 1999;44:446-455.
4. Ma PX, Zhang RY. Synthetic nano-scale fibrous extracellular matrix. J Biomed Mater Res 1999;46:60-72.
5. Ma PX, Zhang RY. Microtubular architecture of biodegradable polymer scaffolds. J Biomed Mater Res 2001;56:469-477.
6. Ishaug SL, Crane GM, Miller MJ, Yasko AW, Yaszemski MJ, Mikos AG. Bone formation by three-dimensional stromal osteoblast culture in biodegradable polymer scaffolds. J Biomed Mater Res 1997;36:17-28.
7. Liu XH, Ma PX. Polymeric scaffolds for bone tissue engineering. Ann Biomed Eng 2004;32:477-486.
8. Lu JX, Flautre B, Anselme K, Hardouin P, Gallur A, Descamps M, Thierry B. Role of interconnections in porous bioceramics on bone recolonization in vitro and in vivo. J Mater Sci Mater Med 1999;10:111-120.
9. Woo KM, Chen VJ, Ma PX. Nano-fibrous scaffolding architecture selectively enhances protein adsorption contributing to cell attachment. J Biomed Mater Res A 2003;67:531-537.
10. Webster TJ, Waid MC, McKenzie JL, Price RL, Ejiofor JU. Nano-biotechnology: Carbon nanofibres as improved neural and orthopaedic implants. Nanotechnology 2004;15:48-54.
11. Geesink RGT, Degroot K, Klein C. Bonding of bone to apatite-coated implants. J Bone Joint Surg Br 1988;70:17-22.
12. Cook SD, Thomas KA, Dalton JE, Volkman TK, Whitecloud TS, Kay JF. Hydroxylapatite coating of porous implants improves bone ingrowth and interface attachment strength. J Biomed Mater Res 1992;26:989-1001.
13. Ma PX, Zhang RY, Xiao GZ, Franceschi R. Engineering new bone tissue in vitro on highly porous poly(α-hydroxyl acids)/hydroxyapatite composite scaffolds. J Biomed Mater Res 2001;54:284-293.
14. Woo KM, Zhang RY, Deng HY, Ma PX. Protein-mediated osteoblast survival and migration on biodegradable polymer/hydroxyapatite scaffolds. Trans Soc Biomater 2002;25:605.
15. Wei G, Ma PX. Structure and properties of nano-hydroxyapatite/polymer composite scaffolds for bone tissue engineering. Biomaterials 2004;25:4749-4757.
16. Zhang RY, Ma PX. Porous poly(L-lactic acid)/apatite composites created by biomimetic process. J Biomed Mater Res 1999;45:285-293.
17. Thomson RC, Yaszemski MJ, Powers JM, Mikos AG. Hydroxyapatite fiber reinforced poly(α-hydroxy ester) foams for bone regeneration. Biomaterials 1998;19:1935-1943.
18. Zhang RY, Ma PX. Synthetic nano-fibrillar extracellular matrices with predesigned macroporous architectures. J Biomed Mater Res 2000;52:430-438.
19. Chen VJ, Ma PX. Nano-fibrous poly(L-lactic acid) scaffolds with interconnected spherical macropores. Biomaterials 2004;25:2065-2073.
20. Mikos AG, Thorsen AJ, Czerwonka LA, Bao Y, Langer R, Winslow DN, Vacanti JP. Preparation and characterization of poly(L-lactic acid) foams. Polymer 1994;35:1068-1077.
21. Xu CY, Inai R, Kotaki M, Ramakrishna S. Aligned biodegradable nanotibrous structure: A potential scaffold for blood vessel engineering. Biomaterials 2004;25:877-886.
22. Zhang RY, Ma PX. Biomimetic polymer/apatite composite scaffolds for mineralized tissue engineering. Macromol Biosci 2004;4:100-111.
23. Sun LM, Berndt CC, Gross KA, Kucuk A. Material fundamentals and clinical performance of plasma-sprayed hydroxyapatite coatings: A review. J Biomed Mater Res 2001;58:570-592.