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Volumn 90, Issue 5-6, 2012, Pages 242-246

Antitumor action of α1-adrenoceptor blockers on human bladder, prostate and renal cancer cells

Author keywords

1 Adrenoceptor blocker; Apoptosis; Bladder cancer; Prostate cancer; Renal cancer

Indexed keywords

NAFTOPIDIL; PRAZOSIN;

EID: 84866488801     PISSN: 00317012     EISSN: 14230313     Source Type: Journal    
DOI: 10.1159/000342797     Document Type: Article
Times cited : (26)

References (31)
  • 2
    • 3042616560 scopus 로고    scopus 로고
    • 2-Adrenergic receptor subtypes - Novel functions uncovered in gene-targeted mouse models
    • DOI 10.1016/j.biolcel.2004.03.006, PII S0248490004000796
    • Brede M, Philipp M, Knaus A, Muthig V, Hein L: α2-Adrenergic receptor subtypes - novel functions uncovered in gene-targeted mouse models. Biol Cell 2004;96:343-348. (Pubitemid 38807899)
    • (2004) Biology of the Cell , vol.96 , Issue.5 , pp. 343-348
    • Brede, M.1    Philipp, M.2    Knaus, A.3    Muthig, V.4    Hein, L.5
  • 3
    • 0030776329 scopus 로고    scopus 로고
    • Modulation of human cardiac function through 4 β-adrenoceptor populations
    • DOI 10.1007/PL00004999
    • Kaumann AJ, Molenaar P: Modulation of human cardiac function through 4 β-adrenoceptor populations. Naunyn Schmiedebergs Arch Pharmacol 1997;355:667-681. (Pubitemid 27395692)
    • (1997) Naunyn-Schmiedeberg's Archives of Pharmacology , vol.355 , Issue.6 , pp. 667-681
    • Kaumann, A.J.1    Molenaar, P.2
  • 4
    • 83655165092 scopus 로고    scopus 로고
    • Advances in the design and synthesis of prazosin derivatives over the last ten years
    • Desiniotis A, Kyprianou N: Advances in the design and synthesis of prazosin derivatives over the last ten years. Expert Opin Ther Targets 2011;15:1405-1418.
    • (2011) Expert Opin Ther Targets , vol.15 , pp. 1405-1418
    • Desiniotis, A.1    Kyprianou, N.2
  • 5
    • 71349084602 scopus 로고    scopus 로고
    • Apoptosis induction by doxazosin and other quinazoline α1-adrenoceptor antagonists: A new mechanism for cancer treatment?
    • Kyprianou N, Vaughan TB, Michel MC: Apoptosis induction by doxazosin and other quinazoline α1-adrenoceptor antagonists: a new mechanism for cancer treatment? Naunyn Schmiedebergs Arch Pharmacol 2009; 380:473-477.
    • (2009) Naunyn Schmiedebergs Arch Pharmacol , vol.380 , pp. 473-477
    • Kyprianou, N.1    Vaughan, T.B.2    Michel, M.C.3
  • 6
    • 36849034109 scopus 로고    scopus 로고
    • Naftopidil, a selective α-1 adrenoceptor antagonist, inhibits growth of human prostate cancer cells by G1 cell cycle arrest
    • DOI 10.1002/ijc.23095
    • Kanda H, Ishii K, Ogura Y, Imamura T, Kanai M, Arima K, Sugimura Y: Naftopidil, a selective α-1 adrenoceptor antagonist, inhibits growth of human prostate cancer cells by G1 cell cycle arrest. Int J Cancer 2008;122: 444-451. (Pubitemid 350234734)
    • (2008) International Journal of Cancer , vol.122 , Issue.2 , pp. 444-451
    • Kanda, H.1    Ishii, K.2    Ogura, Y.3    Imamura, T.4    Kanai, M.5    Arima, K.6    Sugimura, Y.7
  • 7
    • 78650841605 scopus 로고    scopus 로고
    • Naftopidil, a selective α1-adrenoceptor antagonist, suppresses human prostate tumor growth by altering interactions between tumor cells and stroma
    • Hori Y, Ishii K, Kanda H, Iwamoto Y, Nishikawa K, Soga N, Kise H, Arima K, Sugimura Y: Naftopidil, a selective α1-adrenoceptor antagonist, suppresses human prostate tumor growth by altering interactions between tumor cells and stroma. Cancer Prev Res (Phila) 2011;4:87-96.
    • (2011) Cancer Prev Res (Phila) , vol.4 , pp. 87-96
    • Hori, Y.1    Ishii, K.2    Kanda, H.3    Iwamoto, Y.4    Nishikawa, K.5    Soga, N.6    Kise, H.7    Arima, K.8    Sugimura, Y.9
  • 8
    • 44349101126 scopus 로고    scopus 로고
    • Spontaneous regression of an asymptomatic meningioma associated with discontinuation of progesterone agonist administration
    • Kanda H, Ishii K, Ogura Y, Imamura T, Kanai M, Arima K, Sugimura Y: Spontaneous regression of an asymptomatic meningioma associated with discontinuation of progesterone agonist administration. Neurol Med Chir (Tokyo) 2008;48:227-230.
    • (2008) Neurol Med Chir (Tokyo) , vol.48 , pp. 227-230
    • Kanda, H.1    Ishii, K.2    Ogura, Y.3    Imamura, T.4    Kanai, M.5    Arima, K.6    Sugimura, Y.7
  • 10
    • 58149234675 scopus 로고    scopus 로고
    • Inhibition of human prostate cancer cells proliferation by a selective α1-adrenoceptor antagonist labedipinedilol-A involves cell cycle arrest and apoptosis
    • Liou SF, Lin HH, Liang JC, Chen IJ, Yeh JL: Inhibition of human prostate cancer cells proliferation by a selective α1-adrenoceptor antagonist labedipinedilol-A involves cell cycle arrest and apoptosis. Toxicology 2009; 256:13-24.
    • (2009) Toxicology , vol.256 , pp. 13-24
    • Liou, S.F.1    Lin, H.H.2    Liang, J.C.3    Chen, I.J.4    Yeh, J.L.5
  • 11
    • 35448965498 scopus 로고    scopus 로고
    • Prazosin displays anticancer activity against human prostate cancers: Targeting DNA and cell cycle
    • Lin SC, Chueh SC, Hsiao CJ, Li TK, Chen TH, Liao CH, Lyu PC, Guh JH: Prazosin displays anticancer activity against human prostate cancers: targeting DNA and cell cycle. Neoplasia 2007;9:830-839.
    • (2007) Neoplasia , vol.9 , pp. 830-839
    • Lin, S.C.1    Chueh, S.C.2    Hsiao, C.J.3    Li, T.K.4    Chen, T.H.5    Liao, C.H.6    Lyu, P.C.7    Guh, J.H.8
  • 13
    • 33947641548 scopus 로고    scopus 로고
    • 1,-blockers in prostate cancer cells: Biomolecular implications and clinical relevance
    • Alberti C: Apoptosis induction by quinazoline- derived α1-blockers in prostate cancer cells: biomolecular implications and clinical relevance. Eur Rev Med Pharmacol Sci 2007; 11:59-64. (Pubitemid 46487898)
    • (2007) European Review for Medical and Pharmacological Sciences , vol.11 , Issue.1 , pp. 59-64
    • Alberti, C.1
  • 14
    • 31544446659 scopus 로고    scopus 로고
    • Doxazosin induces apoptosis of benign and malignant prostate cells via a death receptor-mediated pathway
    • DOI 10.1158/0008-5472.CAN-05-2039
    • Garrison JB, Kyprianou N: Doxazosin induces apoptosis of benign and malignant prostate cells via a death receptor-mediated pathway. Cancer Res 2006;66:464-472. (Pubitemid 43166055)
    • (2006) Cancer Research , vol.66 , Issue.1 , pp. 464-472
    • Garrison, J.B.1    Kyprianou, N.2
  • 15
    • 4544274852 scopus 로고    scopus 로고
    • Induction of anoikis by doxazosin in prostate cancer cells is associated with activation of caspase-3 and a reduction of focal adhesion kinase
    • DOI 10.1007/s00240-003-0365-7
    • Walden PD, Globina Y, Nieder A: Induction of anoikis by doxazosin in prostate cancer cells is associated with activation of caspase- 3 and a reduction of focal adhesion kinase. Urol Res 2004;32:261-265. (Pubitemid 39222602)
    • (2004) Urological Research , vol.32 , Issue.4 , pp. 261-265
    • Walden, P.D.1    Globina, Y.2    Nieder, A.3
  • 16
    • 0038792746 scopus 로고    scopus 로고
    • Quinazoline-based α1-adrenoceptor antagonists induce prostate cancer cell apoptosis via TGF-β signalling and IκBα induction
    • DOI 10.1038/sj.bjc.6600961
    • Partin JV, Anglin IE, Kyprianou N: Quinazoline- based α1-adrenoceptor antagonists induce prostate cancer cell apoptosis via TGF-β signalling and IκBα induction. Br J Cancer 2003;88:1615-1621. (Pubitemid 36713791)
    • (2003) British Journal of Cancer , vol.88 , Issue.10 , pp. 1615-1621
    • Partin, J.V.1    Anglin, I.E.2    Kyprianou, N.3
  • 17
    • 27944474670 scopus 로고    scopus 로고
    • Growth inhibitory effect of doxazosin on prostate and bladder cancer cells. Is the serotonin receptor pathway involved?
    • Siddiqui EJ, Shabbir M, Thompson CS, Mumtaz FH, Mikhailidis DP: Growth inhibitory effect of doxazosin on prostate and bladder cancer cells. Is the serotonin receptor pathway involved? Anticancer Res 2005; 25:4281-4286. (Pubitemid 41665217)
    • (2005) Anticancer Research , vol.25 , Issue.6 , pp. 4281-4286
    • Siddiqui, E.J.1    Shabbir, M.2    Thompson, C.S.3    Mumtaz, F.H.4    Mikhailidis, D.P.5
  • 18
    • 0037376011 scopus 로고    scopus 로고
    • Doxazosin and terazosin suppress prostate growth by inducing apoptosis: Clinical significance
    • DOI 10.1097/01.ju.0000033280.29453.72
    • Kyprianou N: Doxazosin and terazosin suppress prostate growth by inducing apoptosis: clinical significance. J Urol 2003;169: 1520-1525. (Pubitemid 36323836)
    • (2003) Journal of Urology , vol.169 , Issue.4 , pp. 1520-1525
    • Kyprianou, N.1
  • 19
    • 0037362966 scopus 로고    scopus 로고
    • Anoikis induction by quinazoline based α1-adrenoceptor antagonists in prostate cancer cells: Antagonistic effect of BCL-2
    • DOI 10.1097/01.ju.0000042453.12079.77
    • Keledjian K, Kyprianou N: Anoikis induction by quinazoline based α1-adrenoceptor antagonists in prostate cancer cells: antagonistic effect of bcl-2. J Urol 2003;169:1150-1156. (Pubitemid 36188191)
    • (2003) Journal of Urology , vol.169 , Issue.3 , pp. 1150-1156
    • Keledjian, K.1    Kyprianou, N.2
  • 20
    • 0035996399 scopus 로고    scopus 로고
    • Induction of prostate apoptosis by α1-adrenoceptor antagonists: Mechanistic significance of the quinazoline component
    • DOI 10.1038/sj.pcan.4500561
    • Anglin IE, Glassman DT, Kyprianou N: Induction of prostate apoptosis by α1- adrenoceptor antagonists: mechanistic significance of the quinazoline component. Prostate Cancer Prostatic Dis 2002;5:88-95. (Pubitemid 34777889)
    • (2002) Prostate Cancer and Prostatic Diseases , vol.5 , Issue.2 , pp. 88-95
    • Anglin, I.E.1    Glassman, D.T.2    Kyprianou, N.3
  • 21
    • 0035984238 scopus 로고    scopus 로고
    • α1-adrenoceptor antagonists radiosensitize prostate cancer cells via apoptosis induction
    • Cuellar DC, Rhee J, Kyprianou N: α1-Adrenoceptor antagonists radiosensitize prostate cancer cells via apoptosis induction. Anticancer Res 2002;22:1673-1679. (Pubitemid 34839180)
    • (2002) Anticancer Research , vol.22 , Issue.3 , pp. 1673-1679
    • Cuellar, D.C.1    Rhee, J.2    Kyprianou, N.3
  • 22
    • 0034256510 scopus 로고    scopus 로고
    • Induction of apoptosis in the prostate by α1-adrenoceptor antagonists: A novel effect of 'old' drugs
    • Kyprianou N, Jacobs SC: Induction of apoptosis in the prostate by α1-adrenoceptor antagonists: a novel effect of 'old' drugs. Curr Urol Rep 2000;1:89-96.
    • (2000) Curr Urol Rep , vol.1 , pp. 89-96
    • Kyprianou, N.1    Jacobs, S.C.2
  • 23
    • 0037079614 scopus 로고    scopus 로고
    • Quinazoline-derived α1-adrenoceptor antagonists induce prostate cancer cell apoptosis via an α1-adrenoceptor-independent action
    • Benning CM, Kyprianou N: Quinazolinederived α1-adrenoceptor antagonists induce prostate cancer cell apoptosis via an α1- adrenoceptor-independent action. Cancer Res 2002;62:597-602. (Pubitemid 34106437)
    • (2002) Cancer Research , vol.62 , Issue.2 , pp. 597-602
    • Benning, C.M.1    Kyprianou, N.2
  • 24
    • 0034662630 scopus 로고    scopus 로고
    • Suppression of human prostate cancer cell growth by α1-adrenoceptor antagonists doxazosin and terazosin via induction of apoptosis
    • Kyprianou N, Benning CM: Suppression of human prostate cancer cell growth by α1- adrenoceptor antagonists doxazosin and terazosin via induction of apoptosis. Cancer Res 2000;60:4550-4555. (Pubitemid 32103639)
    • (2000) Cancer Research , vol.60 , Issue.16 , pp. 4550-4555
    • Kyprianou, N.1    Benning, C.M.2
  • 25
    • 24044518203 scopus 로고    scopus 로고
    • Maspin sensitizes prostate cancer cells to doxazosin-induced apoptosis
    • DOI 10.1038/sj.onc.1208684, PII 1208684
    • Tahmatzopoulos A, Sheng S, Kyprianou N: Maspin sensitizes prostate cancer cells to doxazosin-induced apoptosis. Oncogene 2005;24:5375-5383. (Pubitemid 43080107)
    • (2005) Oncogene , vol.24 , Issue.34 , pp. 5375-5383
    • Tahmatzopoulos, A.1    Sheng, S.2    Kyprianou, N.3
  • 26
    • 79955575350 scopus 로고    scopus 로고
    • Antiangiogenic effects and mechanism of prazosin
    • Liao CH, Guh JH, Chueh SC, Yu HJ: Antiangiogenic effects and mechanism of prazosin. Prostate 2011;71:976-984.
    • (2011) Prostate , vol.71 , pp. 976-984
    • Liao, C.H.1    Guh, J.H.2    Chueh, S.C.3    Yu, H.J.4
  • 27
    • 0035399469 scopus 로고    scopus 로고
    • Reduction of human prostate tumor vascularity by the α1- adrenoceptor antagonist terazosin
    • DOI 10.1002/pros.1083
    • Keledjian K, Borkowski A, Kim G, Isaacs JT, Jacobs SC, Kyprianou N: Reduction of human prostate tumor vascularity by the α1- adrenoceptor antagonist terazosin. Prostate 2001;48:71-78. (Pubitemid 32613870)
    • (2001) Prostate , vol.48 , Issue.2 , pp. 71-78
    • Keledjian, K.1    Borkowski, A.2    Kim, G.3    Isaacs, J.T.4    Jacobs, S.C.5    Kyprianou, N.6
  • 28
    • 18444392731 scopus 로고    scopus 로고
    • Doxazosin inhibits human vascular endothelial cell adhesion, migration, and invasion
    • DOI 10.1002/jcb.20240
    • Keledjian K, Garrison JB, Kyprianou N: Doxazosin inhibits human vascular endothelial cell adhesion, migration, and invasion. J Cell Biochem 2005;94:374-388. (Pubitemid 41420315)
    • (2005) Journal of Cellular Biochemistry , vol.94 , Issue.2 , pp. 374-388
    • Keledjian, K.1    Garrison, J.B.2    Kyprianou, N.3
  • 29
    • 18844390469 scopus 로고    scopus 로고
    • Effect of terazosin on tissue vascularity and apoptosis in transitional cell carcinoma of bladder
    • DOI 10.1016/j.urology.2004.12.015, PII S009042950401475X
    • Tahmatzopoulos A, Lagrange CA, Zeng L, Mitchell BL, Conner WT, Kyprianou N: Effect of terazosin on tissue vascularity and apoptosis in transitional cell carcinoma of bladder. Urology 2005;65:1019-1023. (Pubitemid 40693015)
    • (2005) Urology , vol.65 , Issue.5 , pp. 1019-1023
    • Tahmatzopoulos, A.1    LaGrange, C.A.2    Zeng, L.3    Mitchell, B.L.4    Conner, W.T.5    Kyprianou, N.6
  • 30
    • 80051796256 scopus 로고    scopus 로고
    • α1-Adrenergic drugs modulate differentiation and cell death of human erythroleukemia cells through non adrenergic mechanism
    • Fuchs R, Schraml E, Leitinger G, Stelzer I, Allard N, Haas HS, Schauenstein K, Sadjak A: α1-Adrenergic drugs modulate differentiation and cell death of human erythroleukemia cells through non adrenergic mechanism. Exp Cell Res 2011;317:2239-2251.
    • (2011) Exp Cell Res , vol.317 , pp. 2239-2251
    • Fuchs, R.1    Schraml, E.2    Leitinger, G.3    Stelzer, I.4    Allard, N.5    Haas, H.S.6    Schauenstein, K.7    Sadjak, A.8
  • 31
    • 0032587629 scopus 로고    scopus 로고
    • 1-adrenoceptors
    • DOI 10.1254/jjp.79.447
    • Takei R, Ikegaki I, Shibata K, Tsujimoto G, Asano T: Naftopidil, a novel α1-adrenoceptor antagonist, displays selective inhibition of canine prostatic pressure and high affinity binding to cloned human α1-adrenoceptors. Jpn J Pharmacol 1999;79:447-454. (Pubitemid 29213362)
    • (1999) Japanese Journal of Pharmacology , vol.79 , Issue.4 , pp. 447-454
    • Takei, R.1    Ikegaki, I.2    Shibata, K.3    Tsujimoto, G.4    Asano, T.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.