-
1
-
-
70349229624
-
Pronuclear DNA injection for the production of transgenic rats
-
Cozzi, J. et al. Pronuclear DNA injection for the production of transgenic rats. Methods Mol. Biol. 561, 73-88 (2009).
-
(2009)
Methods Mol. Biol.
, vol.561
, pp. 73-88
-
-
Cozzi, J.1
-
2
-
-
33746634679
-
Heritable and stable gene knockdown in rats
-
DOI 10.1073/pnas.0604657103
-
Dann, C. T., Alvarado, A. L., Hammer, R. E. & Garbers, D. L. Heritable and stable gene knockdown in rats. Proc. Natl. Acad. Sci. U S A. 103, 11246-11251 (2006). (Pubitemid 44156504)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.30
, pp. 11246-11251
-
-
Dann, C.T.1
Alvarado, A.L.2
Hammer, R.E.3
Garbers, D.L.4
-
3
-
-
0037685273
-
Production of knockout rats using ENU mutagenesis and a yeast-based screening assay
-
DOI 10.1038/nbt830
-
Zan, Y. et al. Production of knockout rats using ENU mutagenesis and a yeastbased screening assay. Nat. Biotechnol. 21, 645-651 (2003). (Pubitemid 36638091)
-
(2003)
Nature Biotechnology
, vol.21
, Issue.6
, pp. 645-651
-
-
Zan, Y.1
Haag, J.D.2
Chen, K.-S.3
Shepel, L.A.4
Wigington, D.5
Wang, Y.-R.6
Hu, R.7
Lopez-Guajardo, C.C.8
Brosel, H.L.9
Porter, K.I.10
Leonard, R.A.11
Hitt, A.A.12
Schommer, S.L.13
Elegbede, A.F.14
Gould, M.N.15
-
4
-
-
77449094451
-
ENU mutagenesis to generate genetically modified rat models
-
van Boxtel, R., Gould, M. N., Cuppen, E. & Smits, B. M. ENU mutagenesis to generate genetically modified rat models. Methods Mol. Biol. 597, 151-167 (2010).
-
(2010)
Methods Mol. Biol.
, vol.597
, pp. 151-167
-
-
Van Boxtel, R.1
Gould, M.N.2
Cuppen, E.3
Smits, B.M.4
-
5
-
-
33947377836
-
Transposon-tagged mutagenesis in the rat
-
DOI 10.1038/nmeth1002, PII NMETH1002
-
Kitada, K. et al. Transposon-tagged mutagenesis in the rat. Nat. Methods 4, 131-133 (2007). (Pubitemid 46454680)
-
(2007)
Nature Methods
, vol.4
, Issue.2
, pp. 131-133
-
-
Kitada, K.1
Ishishita, S.2
Tosaka, K.3
Takahashi, R.-I.4
Ueda, M.5
Keng, V.W.6
Horie, K.7
Takeda, J.8
-
6
-
-
70349777492
-
Generating mutant rats using the sleeping beauty transposon system
-
Kitada, K., Keng, V. W., Takeda, J. & Horie, K. Generating mutant rats using the Sleeping Beauty transposon system. Methods 49, 236-242 (2009).
-
(2009)
Methods
, vol.49
, pp. 236-242
-
-
Kitada, K.1
Keng, V.W.2
Takeda, J.3
Horie, K.4
-
7
-
-
77953025048
-
Generating knockout rats by transposon mutagenesis in spermatogonial stem cells
-
Izsvák, Z. et al. Generating knockout rats by transposon mutagenesis in spermatogonial stem cells. Nat. Methods 7, 443-445 (2010).
-
(2010)
Nat. Methods
, vol.7
, pp. 443-445
-
-
Izsvák, Z.1
-
8
-
-
67749106611
-
Knockout rats via embryo microinjection of zinc-finger nucleases
-
Geurts, A. M. et al. Knockout rats via embryo microinjection of zinc-finger nucleases. Science 325, 433 (2009).
-
(2009)
Science
, vol.325
, pp. 433
-
-
Geurts, A.M.1
-
9
-
-
77749273530
-
Generation of knockout rats with X-linked severe combined immunodeficiency (X-SCID) using zinc-finger nucleases
-
Mashimo, T. et al. Generation of knockout rats with X-linked severe combined immunodeficiency (X-SCID) using zinc-finger nucleases. PLoS One 5, e8870 (2010).
-
(2010)
PLoS One
, vol.5
-
-
Mashimo, T.1
-
10
-
-
57649181379
-
Capture of authentic embryonic stem cells from rat blastocysts
-
Buehr, M. et al. Capture of authentic embryonic stem cells from rat blastocysts. Cell 135, 1287-1298 (2008).
-
(2008)
Cell
, vol.135
, pp. 1287-1298
-
-
Buehr, M.1
-
11
-
-
57649245579
-
Germline competent embryonic stem cells derived from rat blastocysts
-
Li, P. et al. Germline competent embryonic stem cells derived from rat blastocysts. Cell 135, 1299-1310 (2008).
-
(2008)
Cell
, vol.135
, pp. 1299-1310
-
-
Li, P.1
-
12
-
-
77956294479
-
Generation of genetically modified rats from embryonic stem cells
-
Kawamata, M. & Ochiya, T. Generation of genetically modified rats from embryonic stem cells. Proc. Natl. Acad. Sci. USA 107, 14223-14228 (2010).
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 14223-14228
-
-
Kawamata, M.1
Ochiya, T.2
-
13
-
-
79960330734
-
Generation of germline-competent rat induced pluripotent stem cells
-
Hamanaka, S. et al. Generation of germline-competent rat induced pluripotent stem cells. PLoS One 6, e22008 (2011).
-
(2011)
PLoS One
, vol.6
-
-
Hamanaka, S.1
-
14
-
-
77954512704
-
Rat transgenesis via embryonic stem cells electroporated with the Kusabira-orange gene
-
Hirabayashi, M. et al. Rat transgenesis via embryonic stem cells electroporated with the Kusabira-orange gene. Mol. Reprod. Dev. 77, 474 (2010).
-
(2010)
Mol. Reprod. Dev.
, vol.77
, pp. 474
-
-
Hirabayashi, M.1
-
15
-
-
77956524118
-
Production of p53 gene knockout rats by homologous recombination in embryonic stem cells
-
Tong, C., Li, P., Wu, N. L., Yan, Y. & Ying, Q. L. Production of p53 gene knockout rats by homologous recombination in embryonic stem cells. Nature 467, 211-213 (2010).
-
(2010)
Nature
, vol.467
, pp. 211-213
-
-
Tong, C.1
Li, P.2
Wu, N.L.3
Yan, Y.4
Ying, Q.L.5
-
16
-
-
0026561121
-
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
-
Donehower, L. A. et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356, 215-221 (1992).
-
(1992)
Nature
, vol.356
, pp. 215-221
-
-
Donehower, L.A.1
-
17
-
-
0029347164
-
High-frequency developmental abnormalities in p53-deficient mice
-
Armstrong, J. F., Kaufman, M. H., Harrison, D. J. & Clarke, A. R. High-frequency developmental abnormalities in p53-deficient mice. Curr. Biol. 5, 931-936 (1995).
-
(1995)
Curr. Biol.
, vol.5
, pp. 931-936
-
-
Armstrong, J.F.1
Kaufman, M.H.2
Harrison, D.J.3
Clarke, A.R.4
-
18
-
-
0029007405
-
A subset of p53-deficient embryos exhibit exencephaly
-
Sah, V. P. et al.A subset of p53-deficient embryos exhibit exencephaly. Nat. Genet. 10, 175-180 (1995).
-
(1995)
Nat. Genet.
, vol.10
, pp. 175-180
-
-
Sah, V.P.1
-
19
-
-
70350567735
-
20 years studying p53 functions in genetically engineered mice
-
Donehower, L. A. & Lozano, G. 20 years studying p53 functions in genetically engineered mice. Nat. Rev. Cancer 9, 831-841 (2009).
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 831-841
-
-
Donehower, L.A.1
Lozano, G.2
-
20
-
-
79953647406
-
Beyond knockout rats: New insights into finer genome manipulation in rats
-
Huang, G. et al. Beyond knockout rats: new insights into finer genome manipulation in rats. Cell Cycle 10, 1059-1066 (2011).
-
(2011)
Cell Cycle
, vol.10
, pp. 1059-1066
-
-
Huang, G.1
-
21
-
-
80053266411
-
Homozygous and heterozygous p53 knockout rats develop metastasizing sarcomas with high frequency
-
van Boxtel, R. et al. Homozygous and heterozygous p53 knockout rats develop metastasizing sarcomas with high frequency. Am. J. Pathol. 179, 1616-1622 (2011).
-
(2011)
Am. J. Pathol.
, vol.179
, pp. 1616-1622
-
-
Van Boxtel, R.1
-
23
-
-
13944273471
-
P53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression
-
DOI 10.1038/ncb1211
-
Lin, T. et al. p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression. Nat. Cell Biol. 7, 165-171 (2005). (Pubitemid 40268131)
-
(2005)
Nature Cell Biology
, vol.7
, Issue.2
, pp. 165-171
-
-
Lin, T.1
Chao, C.2
Saito, S.3
Mazur, S.J.4
Murphy, M.E.5
Appella, E.6
Xu, Y.7
-
24
-
-
69349100179
-
Suppression of induced pluripotent stem cell generation by the p53-21 pathway
-
Hong et al. Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature 460, 1132-1135 (2009).
-
(2009)
Nature
, vol.460
, pp. 1132-1135
-
-
Hong1
-
25
-
-
69349094006
-
A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity
-
Marion et al. A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity. Nature 460, 1149-1153 (2009).
-
(2009)
Nature
, vol.460
, pp. 1149-1153
-
-
Marion1
-
26
-
-
77449139166
-
Establishment of embryonic stem cells from rat blastocysts
-
Kawamata, M. & Ochiya, T. Establishment of embryonic stem cells from rat blastocysts. Methods Mol. Biol. 597, 169-177 (2010).
-
(2010)
Methods Mol. Biol.
, vol.597
, pp. 169-177
-
-
Kawamata, M.1
Ochiya, T.2
-
27
-
-
79958232983
-
Gene-manipulated embryonic stem cells for rat transgenesis
-
Kawamata, M. & Ochiya, T. Gene-manipulated embryonic stem cells for rat transgenesis. Cell Mol. Life Sci. 68, 1911-1915 (2011).
-
(2011)
Cell Mol. Life Sci.
, vol.68
, pp. 1911-1915
-
-
Kawamata, M.1
Ochiya, T.2
-
28
-
-
63849308553
-
The roles of p53 and p21 in normal development and hyperthermia-induced malformations
-
Hosako, H. et al. The roles of p53 and p21 in normal development and hyperthermia-induced malformations. Birth Defects Res. B Dev. Reprod. Toxicol. 86, 40-47 (2009).
-
(2009)
Birth Defects Res. B Dev. Reprod. Toxicol.
, vol.86
, pp. 40-47
-
-
Hosako, H.1
-
29
-
-
38849200354
-
Sex difference in neural tube defects in p53-null mice is caused by differences in the complement of X not Y genes
-
DOI 10.1002/dneu.20581
-
Chen, X. et al. Sex difference in neural tube defects in p53-null mice is caused by differences in the complement of X not Y genes. Dev. Neurobiol. 68, 265-273 (2008). (Pubitemid 351199422)
-
(2008)
Developmental Neurobiology
, vol.68
, Issue.2
, pp. 265-273
-
-
Chen, X.1
Watkins, R.2
Delot, E.3
Reliene, R.4
Schiestl, R.H.5
Burgoyne, P.S.6
Arnold, A.P.7
-
30
-
-
79951807417
-
Tbx6-dependent Sox2 regulation determines neural or mesodermal fate in axial stem cells
-
Takemoto, T. et al. Tbx6-dependent Sox2 regulation determines neural or mesodermal fate in axial stem cells. Nature 470, 394-398 (2011).
-
(2011)
Nature
, vol.470
, pp. 394-398
-
-
Takemoto, T.1
-
31
-
-
33744957725
-
The Sox2 regulatory region 2 functions as a neural stem cell-specific enhancer in the telencephalon
-
DOI 10.1074/jbc.M512669200
-
Miyagi, S. et al. The Sox2 regulatory region 2 functions as a neural stem cellspecific enhancer in the telencephalon. J. Biol. Chem. 281, 13374-13381 (2006). (Pubitemid 43855248)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.19
, pp. 13374-13381
-
-
Miyagi, S.1
Nishimoto, M.2
Saito, T.3
Ninomiya, M.4
Sawamoto, K.5
Okano, H.6
Muramatsu, M.7
Oguro, H.8
Iwama, A.9
Okuda, A.10
-
32
-
-
70249114821
-
Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases
-
Hockemeyer, D. et al. Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases. Nat. Biotechnol. 27, 851-857 (2009).
-
(2009)
Nat. Biotechnol.
, vol.27
, pp. 851-857
-
-
Hockemeyer, D.1
-
33
-
-
79960833952
-
Generation of isogenic pluripotent stem cells differing exclusively at two early onset parkinson point mutations
-
Soldner, F. et al. Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations. Cell 146, 318-331 (2011).
-
(2011)
Cell
, vol.146
, pp. 318-331
-
-
Soldner, F.1
-
34
-
-
77957005768
-
Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases
-
Meyer, M., de Angelis, M. H., Wurst, W. & Kühn, R. Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases. Proc. Natl. Acad. Sci. USA 107, 15022-15026 (2010).
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 15022-15026
-
-
Meyer, M.1
De Angelis, M.H.2
Wurst, W.3
Kühn, R.4
-
35
-
-
78651322138
-
Targeted integration in rat and mouse embryos with zinc-finger nucleases
-
Cui, X. et al. Targeted integration in rat and mouse embryos with zinc-finger nucleases. Nat. Biotechnol. 29, 64-67 (2011).
-
(2011)
Nat. Biotechnol.
, vol.29
, pp. 64-67
-
-
Cui, X.1
-
36
-
-
68949117500
-
Return to the rat
-
Abbott, A. Return to the rat. Nature 460, 788 (2009).
-
(2009)
Nature
, vol.460
, pp. 788
-
-
Abbott, A.1
-
37
-
-
0037444426
-
Transgenic rat model of Huntington's disease
-
von Horsten, S. et al. Transgenic rat model of Huntington's disease. Hum. Mol. Genet. 12, 617-24 (2003).
-
(2003)
Hum. Mol. Genet.
, vol.12
, pp. 617-624
-
-
Von Horsten, S.1
-
38
-
-
34247231997
-
A target-selected Apc-mutant rat kindred enhances the modeling of familial human colon cancer
-
DOI 10.1073/pnas.0611690104
-
Amos-Landgraf, J. M. et al. A target-selected Apc-mutant rat kindred enhances the modeling of familial human colon cancer. Proc. Natl. Acad. Sci. U.S.A. 104, 4036-41 (2007). (Pubitemid 47181574)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.10
, pp. 4036-4041
-
-
Amos-Landgraf, J.M.1
Kwong, L.N.2
Kendziorski, C.M.3
Reichelderfer, M.4
Torrealba, J.5
Weichert, J.6
Haag, J.D.7
Chen, K.-S.8
Waller, J.L.9
Gould, M.N.10
Dove, W.F.11
|