Mitochondrial RNA Import. From Diversity of Natural Mechanisms to Potential Applications.

International Review of Cell and Molecular Biology

Volumn 287, Issue , 2011, Pages 145-190

  Sieber, François ^a   Duchêne, Anne Marie ^a   Maréchal Drouard, Laurence ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

Gene therapy; Macromolecule import; Mitochondrial genetic manipulation; Mitochondrial RNA import; Transfer RNA

Indexed keywords

ADENOSINE TRIPHOSPHATE; DNA; MICRORNA; MITOCHONDRIAL RNA; RIBONUCLEASE P; RIBOSOME RNA; RNA 5S; TRANSFER RNA;

BOOK; FUNGUS; HUMAN; MACROMOLECULE; NONHUMAN; PLANT; PRIORITY JOURNAL; PROTOZOON; RNA TRANSPORT; SACCHAROMYCES CEREVISIAE;

BACTERIA (MICROORGANISMS); MAMMALIA; PROTOZOA;

EID: 79952586137     PISSN: 19376448     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-386043-9.00004-9     Document Type: Chapter

References (170)

1. Adhya S. Leishmania mitochondrial tRNA importers. Int. J. Biochem. Cell Biol. 2008, 40:2681-2685.
2. Ile in mitochondria of the liverwort Marchantia polymorpha. Curr. Genet. 1996, 30:181-185.
3. Alfonzo J.D., Söll D. Mitochondrial tRNA import-the challenge to understand has just begun. Biol. Chem. 2009, 390:717-722.
4. Alfonzo J.D., Blanc V., Estevez A.M., Rubio M.A., Simpson L. C to U editing of the anticodon of imported mitochondrial tRNA(Trp) allows decoding of the UGA stop codon in Leishmania tarentolae. EMBO J. 1999, 18:7056-7062.
5. Bai Y., Hájek P., Chomyn A., Chan E., Seo B.B., Matsuno-Yagi A., et al. Lack of complex I activity in human cells carrying a mutation in MtDNA-encoded ND4 subunit is corrected by the Saccharomyces cerevisiae NADH-quinone oxidoreductase (NDI1) gene. J. Biol. Chem. 2001, 276:38808-38813.
6. Bhattacharyya S.N., Chatterjee S., Adhya S. Mitochondrial RNA import in Leishmania tropica: aptamers homologous to multiple tRNA domains that interact cooperatively or antagonistically at the inner membrane. Mol. Cell. Biol. 2002, 22:4372-4382.
7. Bian Z., Li L.M., Tang R., Hou D.X., Chen X., Zhang C.Y., et al. Identification of mouse liver mitochondria-associated miRNAs and their potential biological functions. Cell Res. 2010, 20:1076-1078.
8. Bonnefoy N., Fox T.D. Directed alteration of Saccharomyces cerevisiae mitochondrial DNA by biolistic transformation and homologous recombination. Methods Mol. Biol. 2007, 372:153-166.
9. Bonnefoy N., Remacle C., Fox T.D. Genetic transformation of Saccharomyces cerevisiae and Chlamydomonas reinhardtii mitochondria. Methods Cell Biol. 2007, 80:525-548.
10. Bonnet C., Kaltimbacher V., Ellouze S., Augustin S., Benit P., Forster V., et al. Allotopic mRNA localization to the mitochondrial surface rescues respiratory chain defects in fibroblasts harboring mitochondrial DNA mutations affecting complex I or v subunits. Rejuvenation Res. 2007, 10:127-144.
11. Bonnet C., Augustin S., Ellouze S., Bénit P., Bouaita A., Rustin P., et al. The optimized allotopic expression of ND1 or ND4 genes restores respiratory chain complex I activity in fibroblasts harboring mutations in these genes. Biochim. Biophys. Acta 2008, 1783:1707-1717.
12. Bouzaidi-Tiali N., Aeby E., Charriere F., Pusnik M., Schneider A. Elongation factor 1a mediates the specificity of mitochondrial tRNA import in T. brucei. EMBO J. 2007, 26:4302-4312.
13. Boxma B., de Graaf R.M., van der Staay G.W., van Alen T.A., Ricard G., Gabaldon T., et al. An anaerobic mitochondrion that produces hydrogen. Nature 2005, 434:74-79.
14. Brubacher-Kauffmann S., Maréchal-Drouard L., Cosset A., Dietrich A., Duchêne A.M. Differential import of nuclear-encoded tRNAGly isoacceptors into Solanum tuberosum mitochondria. Nucleic Acids Res. 1999, 27:2037-2042.
15. Budar F., Pelletier G. Male sterility in plants: occurrence, determinism, significance and use. C. R. Acad. Sci. III Sci. Vie 2001, 324:543-550.
16. Cahill A., Baio D.L., Cunningham C.C. Isolation and characterization of rat liver mitochondrial ribosomes. Anal. Biochem. 1995, 232:47-55.
17. Cai S., Xu Y., Cooper R.J., Ferkowicz M.J., Hartwell J.R., Pollok K.E., et al. Mitochondrial targeting of human O6-methylguanine DNA methyltransferase protects against cell killing by chemotherapeutic alkylating agents. Cancer Res. 2005, 65:3319-3327.
18. Castandet B., Choury D., Bégu D., Jordana X., Araya A. Intron RNA editing is essential for splicing in plant mitochondria. Nucleic Acids Res. 2010, 38, 7112-7121.
19. Ceci L.R., Veronico P., Gallerani R. Identification and mapping of tRNA genes on the Helianthus annuus mitochondrial genome. DNA Seq. 1996, 6:159-166.
20. Chacinska A., Koehler C.M., Milenkovic D., Lithgow T., Pfanner N. Importing mitochondrial proteins: machineries and mechanisms. Cell 2009, 138:628-644.
21. Chang D.D., Clayton D.A. A mammalian mitochondrial RNA processing activity contains nucleus-encoded RNA. Science 1987, 235:1178-1184.
22. Charriere F., Helgadottir S., Horn E.K., Soll D., Schneider A. Dual targeting of a single tRNA(Trp) requires two different tryptophanyl-tRNA synthetases in Trypanosoma brucei. Proc. Natl. Acad. Sci. USA 2006, 103:6847-6852.
23. Chen H.W., Koehler C.M., Teitell M.A. Human polynucleotide phosphorylase: location matters. Trends Cell Biol. 2007, 17:600-608.
24. Chinnery P., Taylor R., Diekert K., Lill R., Turnbull D., Lightowlers R. Peptide nucleic acid and delivery to human mitochondria. Gene Ther. 2000, 7:813.
25. Chiu N., Chiu A., Suyama Y. Native and imported transfer RNA in mitochondria. J. Mol. Biol. 1975, 99:37-50.
26. Cipollone R., Ascenzi P., Visca P. Common themes and variations in the rhodanese superfamily. IUBMB Life 2007, 59:51-59.
27. Claros M.G., Perea J., Shu Y., Samatey F.A., Popot J.L., Jacq C. Limitations to in vivo import of hydrophobic proteins into yeast mitochondria. The case of a cytoplasmically synthesized apocytochrome b. Eur. J. Biochem. 1995, 228:762-771.
28. Cohen J.S., Fox T.D. Expression of green fluorescent protein from a recoded gene inserted into Saccharomyces cerevisiae mitochondrial DNA. Mitochondrion 2001, 1:181-189.
29. Collombet J.M., Wheeler V.C., Vogel F., Coutelle C. Introduction of plasmid DNA into isolated mitochondria by electroporation. A novel approach toward gene correction for mitochondrial disorders. J. Biol. Chem. 1997, 272:5342-5347.
30. Cristodero M., Seebeck T., Schneider A. Mitochondrial translation is essential in bloodstream forms of Trypanosoma brucei. Mol. Microbiol. 2010, 78:757-769.
31. Cwerman-Thibault H., Sahel J.A., Corral-Debrinski M. Mitochondrial medecine: to a new era of gene therapy for mitochondrial DNA mutations. J. Inherit. Metab Dis. 2010, (in press).
32. Delage L., Dietrich A., Cosset A., Maréchal-Drouard L. In vitro import of a nuclearly encoded tRNA into mitochondria of Solanum tuberosum. Mol. Cell. Biol. 2003, 23:4000-4012.
33. Delage L., Duchêne A.-M., Zaepfel M., Maréchal-Drouard L. The anticodon and the D-domain sequences are essential determinants for plant cytosolic tRNA(Val) import into mitochondria. Plant J. 2003, 34:623-633.
34. Dietrich A., Maréchal-Drouard L., Carneiro V., Cosset A., Small I.D. A single base change prevents import of cytosolic tRNA(Ala) into mitochondria in transgenic plants. Plant J. 1996, 10:913-918.
35. Doersen C., Guerrier-Takada C., Altman S., Attardi G. Characterization of an RNase P activity from HeLa cell mitochondria. Comparison with the cytosol RNase P activity. J. Biol. Chem. 1985, 260:5942-5949.
36. Dörner M., Altmann M., Pääbo S., Mörl M. Evidence for import of a lysyl-tRNA into marsupial mitochondria. Mol. Biol. Cell 2001, 12:2688-2698.
37. Druzhyna N.M., Musiyenko S.I., Wilson G.L., LeDoux S.P. Cytokines induce nitric oxide-mediated mtDNA damage and apoptosis in oligodendrocytes. Protective role of targeting 8-oxoguanine glycosylase to mitochondria. J. Biol. Chem. 2005, 280:21673-21679.
38. D'Souza G.G., Rammohan R., Cheng S.M., Torchilin V.P., Weissig V. DQAsome-mediated delivery of plasmid DNA toward mitochondria in living cells. J. Control. Release 2003, 92:189-197.
39. D'Souza G.G., Boddapati S.V., Weissig V. Mitochondrial leader sequence-plasmid DNA conjugates delivered into mammalian cells by DQAsomes co-localize with mitochondria. Mitochondrion 2005, 5:352-358.
40. Duchêne A.-M., Maréchal-Drouard L. The chloroplast-derived trnW and trnM-e genes are not expressed in Arabidopsis mitochondria. Biochem. Biophys. Res. Commun. 2001, 285:1213-1216.
41. Duchêne A.-M., Pujol C., Maréchal-Drouard L. Import of tRNAs and aminoacyl-tRNA synthetases into mitochondria. Curr. Genet. 2009, 55:1-18.
42. Duchêne A.M., El Farouk-Ameqrane S., Sieber F., Maréchal-Drouard L. Import of RNAs into plant mitochondria. Plant Mitochondria, Advances in Plant Biology 2010, vol. 1. Srpinger Science, Berlin, 241-260.
43. Duret L. tRNA gene number and codon usage in the C. elegans genome are co-adapted for optimal translation of highly expressed genes. Trends Genet. 2000, 16:287-289.
44. Eilers M., Schatz G. Binding of a specific ligand inhibits import of a purified precursor protein into mitochondria. Nature 1986, 322:228-232.
45. Ellouze S., Augustin S., Bouaita A., Bonnet C., Simonutti M., Forster V., et al. Optimized allotopic expression of the human mitochondrial ND4 prevents blindness in a rat model of mitochondrial dysfunction. Am. J. Hum. Genet. 2008, 83:373-387.
46. Enriquez J.A., Chomyn A., Attardi G. MtDNA mutation in MERRF syndrome causes defective aminoacylation of tRNA(Lys) and premature translation termination. Nat. Genet. 1995, 10:47-55.
47. Entelis N.S., Krasheninnikov I.A., Martin R.P., Tarassov I. Mitochondrial import of a yeast cytoplasmic tRNA (Lys): possible roles of aminoacylation and modified nucleosides in subcellular partitioning. FEBS Lett. 1996, 384:38-42.
48. Entelis N.S., Kieffer S., Kolesnikova O.A., Martin R.P., Tarassov I. Structural requirements of tRNALys for its import into yeast mitochondria. Proc. Natl. Acad. Sci. USA 1998, 95:2838-2843.
49. Entelis N.S., Kolesnikova O.A., Dogan S., Martin R.P., Tarassov I. 5 S rRNA and tRNA import into human mitochondria. Comparison of in vitro requirements. J. Biol. Chem. 2001, 276:45642-45653.
50. Entelis N.S., Kolesnikova O.A., Martin R.P., Tarassov I. RNA delivery into mitochondria. Adv. Drug Deliv. Rev. 2001, 49:199-215.
51. Entelis N.S., Kolesnikova O., Kazakova H., Brandina I., Kamenski P., Martin R.P., et al. Import of nuclear encoded RNAs into yeast and human mitochondria: experimental approaches and possible biomedical applications. Genet. Eng. (N.Y.) 2002, 24:191-213.
52. Entelis N.S., Brandina I., Kamenski P., Krasheninnikov I.A., Martin R.P., Tarassov I. A glycolytic enzyme, enolase, is recruited as a cofactor of tRNA targeting toward mitochondria in Saccharomyces cerevisiae. Genes Dev. 2006, 20:1609-1620.
53. Esseiva A.C. Mitochondrial tRNA Import in Toxoplasma gondii. J. Biol. Chem. 2004, 279:42363-42368.
54. Estévez A.M., Thiemann O.H., Alfonzo J.D., Simpson L. T7 RNA polymerase-driven transcription in mitochondria of Leishmania tarentolae and Trypanosoma brucei. Mol. Biochem. Parasitol. 1999, 103:251-259.
55. Evans D., Marquez S.M., Pace N.R. RNase P: interface of the RNA and protein worlds. Trends Biochem. Sci. 2006, 31:333-341.
56. Farre J.C., Araya A. RNA splicing in higher plant mitochondria: determination of functional elements in group II intron from a chimeric cox II gene in electroporated wheat mitochondria. Plant J. 2002, 29:203-213.
57. Farré J.-C., Araya A. Gene expression in isolated plant mitochondria: high fidelity of transcription, splicing and editing of a transgene product in electroporated organelles. Nucleic Acids Res. 2001, 29:2484-2491.
58. Farre J.C., Leon G., Jordana X., Araya A. Cis recognition elements in plant mitochondrion RNA editing. Mol. Cell. Biol. 2001, 21:6731-6737.
59. Florentz C., Sohm B., Tryoen-Tóth P., Pütz J., Sissler M. Human mitochondrial tRNAs in health and disease. Cell. Mol. Life Sci. 2003, 60:1356-1375.
60. Foury F., Roganti T., Lecrenier N., Purnelle B. The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae. FEBS Lett. 1998, 440:325-331.
61. Fox T.D., Sanford J.C., McMullin T.W. Plasmids can stably transform yeast mitochondria lacking endogenous mtDNA. Proc. Natl. Acad. Sci. USA 1988, 85:7288-7292.
62. Frechin M., Senger B., Brayé M., Kern D., Martin R.P., Becker H.D. Yeast mitochondrial Gln-tRNA(Gln) is generated by a GatFAB-mediated transamidation pathway involving Arc1p-controlled subcellular sorting of cytosolic GluRS. Genes Dev. 2009, 23:1119-11130.
63. Glover K.E., Spencer D.F., Gray M.W. Identification and structural characterization of nucleus-encoded transfer RNAs imported into wheat mitochondria. J. Biol. Chem. 2001, 276:639-648.
64. Gobert A., Gutmann B., Taschner A., Gössringer M., Holzmann J., Hartmann R.K., et al. A single Arabidopsis organellar protein has RNase P activity. Nat. Struct. Mol. Biol. 2010, 17:740-744.
65. Goldberg A.V., Molik S., Tsaousis A.D., Neumann K., Kuhnke G., Delbac F., et al. Localization and functionality of microsporidian iron-sulphur cluster assembly proteins. Nature 2008, 452:624-628.
66. Leu . Plant Mol. Biol. 1987, 10:13-19.
67. Haeusler R.A., Engelke D.R. Spatial organization of transcription by RNA polymerase III. Nucleic Acids Res. 2006, 34:4826-4836.
68. Hakkaart G.A.J., Dassa E.P., Jacobs H.T., Rustin P. Allotopic expression of a mitochondrial alternative oxidase confers cyanide resistance to human cell respiration. EMBO Rep. 2006, 7:341-345.
69. Harmey M.A., Hallermayer G., Korb H., Neupert W. Transport of cytoplasmically synthesized proteins into the mitochondria in a cell free system from Neurospora crassa. Eur. J. Biochem. 1977, 81:533-544.
70. Hinrichsen I., Bolle N., Paun L., Kempken F. RNA processing in plant mitochondria is independent of transcription. Plant Mol. Biol. 2009, 70:663-668.
71. Holzmann J., Frank P., Löffler E., Bennett K.L., Gerner C., Rossmanith W. RNase P without RNA: identification and functional reconstitution of the human mitochondrial tRNA processing enzyme. Cell 2008, 135:462-474.
72. Initiative T.A.G. Analysis of the genome sequence of the flowering plant Arabidopsis thaliana. Nature 2000, 408:796-815.
73. Kamenski P., Kolesnikova O.A., Jubenot V., Entelis N.S., Krasheninnikov I.A., Martin R.P., et al. Evidence for an adaptation mechanism of mitochondrial translation via tRNA import from the cytosol. Mol. Cell 2007, 26:625-637.
74. Kapushoc S., Alfonzo J.D., Simpson L. Differential localization of nuclear-encoded tRNAs between the cytosol and mitochondrion in Leishmania tarentolae. RNA 2002, 8:57-68.
75. Kiss T., Filipowicz W. Evidence against a mitochondrial location of the 7-2/MRP RNA in mammalian cells. Cell 1992, 70:11-26.
76. Kolesnikova O.A., Entelis N.S., Mireau H., Fox T.D., Martin R.P., Tarassov I. Suppression of mutations in mitochondrial DNA by tRNAs imported from the cytoplasm. Science 2000, 289:1931-1933.
77. Kolesnikova O.A., Entelis N.S., Jacquin-Becker C., Goltzene F., Chrzanowska-Lightowlers Z.M., Lightowlers R.N., et al. Nuclear DNA-encoded tRNAs targeted into mitochondria can rescue a mitochondrial DNA mutation associated with the MERRF syndrome in cultured human cells. Hum. Mol. Genet 2004, 13:2519-2534.
78. Koulintchenko M., Konstantinov Y., Dietrich A. Plant mitochondria actively import DNA via the permeability transition pore complex. EMBO J. 2003, 22:1245-1254.
79. Koulintchenko M., Temperley R.J., Mason P.A., Dietrich A., Lightowlers R.N. Natural competence of mammalian mitochondria allows the molecular investigation of mitochondrial gene expression. Hum. Mol. Genet. 2006, 15:143-154.
80. Kren B.T., Wong P.Y.-P., Sarver A., Zhang X., Zeng Y., Steer C.J. MicroRNAs identified in highly purified liver-derived mitochondria may play a role in apoptosis. RNA Biol. 2009, 6:65-72.
81. Kroemer G., Galluzzi L., Brenner C. Mitochondrial membrane permeabilization in cell death. Physiol. Rev. 2007, 87:99-163.
82. Kumar R., Maréchal-Drouard L., Akama K., Small I.D. Striking differences in mitochondrial tRNA import between different plant species. Mol. Gen. Genet. 1996, 252:404-411.
83. Laforest M.J., Roewer I., Lang B.F. Mitochondrial tRNAs in the lower fungus Spizellomyces punctatus: tRNA editing and UAG 'stop' codons recognized as leucine. Nucleic Acids Res. 1997, 25:626-632.
84. Laforest M., Delage L., Maréchal-Drouard L. The T-domain of cytosolic tRNAVal, an essential determinant for mitochondrial import. FEBS Lett. 2005, 579:1072-1078.
85. Li K., Smagula C.S., Parsons W.J., Richardson J.A., Gonzalez M., Hagler H.K., et al. Subcellular partitioning of MRP RNA assessed by ultrastructural and biochemical analysis. J. Cell Biol. 1994, 124:871-882.
86. Lithgow T., Schneider A. Evolution of macromolecular import pathways in mitochondria, hydrogenosomes and mitosomes. Philos. Trans. R. Soc. Lond. Biol. Sci. 2010, 365:799-817.
87. Magalhaes P., Andreu A., Schon E. Evidence for the presence of 5S rRNA in mammalian mitochondria. Mol. Biol. Cell 1998, 9:2375-2382.
88. Mahapatra S., Adhya S. Import of RNA into Leishmania mitochondria occurs through direct interaction with membrane-bound receptors. J. Biol. Chem. 1996, 271:20432-20437.
89. Mahapatra S., Ghosh S., Bera S.K., Ghosh T., Das A., Adhya S. The D arm of tRNATyr is necessary and sufficient for import into Leishmania mitochondria in vitro. Nucleic Acids Res. 1998, 26:2037-2041.
90. Mahata B., Mukherjee S., Mishra S., Bandyopadhyay A., Adhya S. Functional delivery of a cytosolic tRNA into mutant mitochondria of human cells. Science 2006, 314:471-474.
91. Maréchal-Drouard L., Guillemaut P., Cosset A., Arbogast M., Weber F., Weil J.H., et al. Transfer RNAs of potato (Solanum tuberosum) mitochondria have different genetic origins. Nucleic Acids Res. 1990, 18:3689-3696.
92. Maréchal-Drouard L., Neuburger M., Guillemaut P., Douce R., Weil J.H., Dietrich A. A nuclear-encoded potato (Solanum tuberosum) mitochondrial tRNA(Leu) and its cytosolic counterpart have identical nucleotide sequences. FEBS Lett. 1990, 262:170-172.
93. Maréchal-Drouard L., Dietrich A., Weil J.H. Adaptation of transfer RNA population to codon usage in cellular organelles. Transfer RNA in Protein Synthesis 1992, 125-140. CRC Press, Boca Raton. D. Hatfield, B.J. Lee, R.M. Pirtle (Eds.).
94. Maréchal-Drouard L., Weil J.H., Dietrich A. Transfer RNAs and transfer RNA genes in plants. Annu. Rev. Plant Physiol. 1993, 44:13-32.
95. Margeot A., Blugeon C., Sylvestre J., Vialette S., Jacq C., Corral-Debrinski M. In Saccharomyces cerevisiae, ATP2 mRNA sorting to the vicinity of mitochondria is essential for respiratory function. EMBO J. 2002, 21:6893-6904.
96. Martin R.P., Schneller J.M., Stahl A., Dirheimer G. Import of nuclear deoxyribonucleic acid coded lysine accepting transfer ribonucleic acid (anticodon CUU) into yeast mitochondria. Biochemistry 1979, 18:4600-4605.
97. Michaelis G., Vahrenholtz C., Pratje E. Mitochondrial DNA of Chlamydomonas reinhardtii: the gene for apocytochrome b and the complete functional map of the 15.8 kb DNA. Mol. Gen. Genet. 1990, 223:211-216.
98. Michaud M., Maréchal-Drouard L., Duchêne A.M. RNA trafficking in plant cells: targeting of cytosolic mRNAs to the mitochondrial surface. Plant Mol. Biol. 2010, 73:697-704.
99. Mirande M. The ins and outs of tRNA transport. EMBO Rep. 2007, 8:547-549.
100. Mukherjee S., Mahata B., Mahato B., Adhya S. Targeted mRNA degradation by complex-mediated delivery of antisense RNAs to intracellular human mitochondria. Hum. Mol. Genet. 2008, 17:1292-1298.
101. Muratovska A., Lightowlers R.N., Taylor R.W., Turnbull D.M., Smith R.A., Wilce J.A., et al. Targeting peptide nucleic acid (PNA) oligomers to mitochondria within cells by conjugation to lipophilic cations: implications for mitochondrial DNA replication, expression and disease. Nucleic Acids Res. 2001, 29:1852-1863.
102. Nabholz C., Horn E.K., Schneider A. tRNAs and proteins are imported into mitochondria of Trypanosoma brucei by two distinct mechanisms. Mol. Biol. Cell 1999, 10:2547-2557.
103. Nagao A., Suzuki T., Katoh T., Sakaguchi Y. Biogenesis of glutaminyl-mt tRNAGln in human mitochondria. Proc. Natl. Acad. Sci. USA 2009, 106:16209-16214.
104. Nakabeppu Y. Regulation of intracellular localization of human MTH1, OGG1, and MYH proteins for repair of oxidative DNA damage. Prog. Nucleic Acid Res. Mol. Biol. 2001, 68:75-94.
105. Neupert W., Herrmann J. Translocation of proteins into mitochondria. Annu. Rev. Biochem. 2007, 76:723-749.
106. Notsu Y., Masood S., Nishikawa T., Kubo N., Akiduki G., Nakazono M., et al. The complete sequence of the rice (Oryza sativa L.) mitochondrial genome: frequent DNA sequence acquisition and loss during the evolution of flowering plants. Mol. Genet. Genomics 2002, 268:434-445.
107. Paris Z., Rubio M.A., Lukes J., Alfonzo J.D. Mitochondrial tRNA import in Trypanosoma brucei is independent of thiolation and the Rieske protein. RNA 2009, 15:1398-1406.
108. Pino P., Aeby E., Foth B.J., Sheiner L., Soldati T., Schneider A., et al. Mitochondrial translation in absence of local tRNA aminoacylation and methionyl tRNA formylation in Apicomplexa. Mol. Microbiol. 2010, 76:706-718.
109. Placido A., Gagliardi D., Gallerani R., Grienenberger J., Maréchal-Drouard L. Fate of a larch unedited tRNA precursor expressed in potato mitochondria. J. Biol. Chem. 2005, 280:33573-33579.
110. Placido A., Regina T.M., Quagliariello C., Volpicella M., Gallerani R., Ceci L.R. Mapping of 5' and 3'-ends of sunflower mitochondrial nad6 mRNAs reveals a very complex transcription pattern which includes primary transcripts lacking 5'-UTR. Biochimie 2009, 91:924-932.
111. Placido A., Sieber F., Gobert A., Gallerani R., Giegé P., Maréchal-Drouard L. Plant mitochondria use two pathways for the biogenesis of tRNAHis. Nucleic Acids Res. 2010, 38:7711-7717.
112. Puranam R.S., Attardi G. The RNase P associated with HeLa cell mitochondria contains an essential RNA component identical in sequence to that of the nuclear RNase P. Mol. Cell. Biol. 2001, 21:548-561.
113. Rachek L.I., Grishko V.I., Musiyenko S.I., Kelley M.R., LeDoux S.P., Wilson G.L. Conditional targeting of the DNA repair enzyme hOGG1 into mitochondria. J. Biol. Chem. 2002, 277:44932-44937.
114. Rasmussen A.K., Rasmussen L.J. Targeting of O6-MeG DNA methyltransferase (MGMT) to mitochondria protects against alkylation induced cell death. Mitochondrion 2005, 5:411-417.
115. Remacle C., Cardol P., Coosemans N., Gaisne M., Bonnefoy N. High-efficiency biolistic transformation of Chlamydomonas mitochondria can be used to insert mutations in complex I genes. Proc. Natl. Acad. Sci. USA 2006, 103:4771-4776.
116. Rinehart J. Saccharomyces cerevisiae imports the cytosolic pathway for Gln-tRNA synthesis into the mitochondrion. Genes Dev. 2005, 19:583-592.
117. Rossmanith W., Karwan R.M. Characterization of human mitochondrial RNase P: novel aspects in tRNA processing. Biochem. Biophys. Res. Commun. 1998, 247:234-241.
118. Rubio M.A., Liu X., Yuzawa H., Alfonzo J.D., Simpson L. Selective importation of RNA into isolated mitochondria from Leishmania tarentolae. RNA 2000, 6:988-1003.
119. Rubio M., Rinehart J., Krett B., Duvezin-Caubet S., Reichert A., Soll D., et al. Mammalian mitochondria have the innate ability to import tRNAs by a mechanism distinct from protein import. Proc. Natl. Acad. Sci. USA 2008, 105:9186-9191.
120. Rusconi C.P., Cech T.R. The anticodon is the signal sequence for mitochondrial import of glutamine tRNA in Tetrahymena. Genes Dev. 1996, 10:2870-2880.
121. Rusconi C.P., Cech T.R. Mitochondrial import of only one of three nuclear-encoded glutamine tRNAs in Tetrahymena thermophila. EMBO J. 1996, 15:3286-3295.
122. Rustin P., Jacobs H.T., Dietrich A., Lightowlers R.N., Tarassov I., Corral-Debrinski M. Targeting allotopic material to the mitochondrial compartment: new tools for better understanding mitochondrial physiology and prospect for therapy. Med. Sci. (Paris) 2007, 23:519-525.
123. Salinas T., Schaeffer C., Maréchal-Drouard L., Duchêne A.-M. Sequence dependence of tRNA(Gly) import into tobacco mitochondria. Biochimie 2005, 87:863-872.
124. Salinas T., Duchêne A.-M., Delage L., Nilsson S., Glaser E., Zaepfel M., et al. The voltage-dependent anion channel, a major component of the tRNA import machinery in plant mitochondria. Proc. Natl. Acad. Sci. USA 2006, 103:18362-18367.
125. Salinas T., Duchêne A.-M., Maréchal-Drouard L. Recent advances in tRNA mitochondrial import. Trends Biochem. Sci. 2008, 33:320-329.
126. Schekman R. Editorial expression of concern. Proc. Natl. Acad. Sci. USA 2010, 107:9476.
127. Scherrer R., Yermovsky-Kammerer A., Hadjuk S. A sequence motif within trypanosome precursor tRNAs influences abundance and mitochondrial localization. Mol. Cell. Biol. 2003, 23:9061-9072.
128. Schmidt O., Pfanner N., Meisinger C. Mitochondrial protein import: from proteomics to functional mechanisms. Nat. Rev. Mol. Cell Biol. 2010, 11:655-667.
129. Schneider A., Maréchal-Drouard L. Mitochondrial tRNA import: are there distinct mechanisms?. Trends Cell Biol. 2000, 10:509-513.
130. Schneider A., Martin J., Agabian N. A nuclear-encoded tRNA of Trypanosoma brucei is imported into mitochondria. Mol. Cell. Biol. 1994, 14:2317-2322.
131. Seo B.B., Kitajima-Ihara T., Chan E.K., Scheffler I.E., Matsuno-Yagi A., Yagi T. Molecular remedy of complex I defects: rotenone-insensitive internal NADH-quinone oxidoreductase of Saccharomyces cerevisiae mitochondria restores the NADH oxidase activity of complex I-deficient mammalian cells. Proc. Natl. Acad. Sci. USA 1998, 95:9167-9171.
132. Seo B.B., Nakamaru-Ogiso E., Cruz P., Flotte T.R., Yagi T., Matsuno-Yagi A. Functional expression of the single subunit NADH dehydrogenase in mitochondria in vivo: a potential therapy for complex I deficiencies. Hum. Gene Ther. 2004, 15:887-895.
133. Sharma M.R., Koc E.C., Datta P.P., Booth T.M., Spremulli L.L., Agrawal R.K. Structure of the mammalian mitochondrial ribosome reveals an expanded functional role for its component proteins. Cell 2003, 115:97-108.
134. Shi X., Chen D.T.C., Suyama Y. A nuclear tRNA gene cluster in the protozoan Leishmania tarentolae and differential distribution of nuclear-encoded tRNAs between the cytosol and mitochondria. Mol. Biochem. Parasitol. 1994, 65:23-37.
135. Small I.D., Maréchal-Drouard L., Masson J., Pelletier G., Cosset A., Weil J.H., et al. In vivo import of a normal or mutagenized heterologous transfer RNA into the mitochondria of transgenic plants-towards novel ways of influencing mitochondrial gene expression. EMBO J. 1992, 11:1291-1296.
136. Small I., Akashi K., Chapron A., Dietrich A., Duchêne A.-M., Lancelin D., et al. The strange evolutionary history of plant mitochondrial tRNAs and their aminoacyl-tRNA synthetases. J. Hered. 1999, 90:333-337.
137. Smirnov A., Entelis N.S., Krasheninnikov I.A., Martin R., Tarassov I. Specific features of 5S rRNA structure-its interactions with macromolecules and possible functions. Biochemistry (Mosc) 2008, 73:1418-1437.
138. Smirnov A., Tarassov I., Mager-Heckel A.-M., Letzelter M., Martin R.P., Krasheninnikov I.A., et al. Two distinct structural elements of 5S rRNA are needed for its import into human mitochondria. RNA 2008, 14:749-759.
139. Smirnov A., Comte C., Mager-Heckel A.-M., Addis V., Krasheninnikov I.A., Martin R.P., et al. Mitochondrial enzyme rhodanese is essential for 5S ribosomal RNA import into human mitochondria. J. Biol. Chem. 2010, 285, 30792-30803.
140. Srivastava S., Moraes C.T. Manipulating mitochondrial DNA heteroplasmy by a mitochondrially targeted restriction endonuclease. Hum. Mol. Genet. 2001, 10:3093-3099.
141. Staudinger M., Bolle N., Kempken F. Mitochondrial electroporation and in organello RNA editing of chimeric atp6 transcripts. Mol. Genet. Genomics 2005, 273:130-136.
142. Steele D.F., Butler C.A., Fox T.D. Expression of a recoded nuclear gene inserted into yeast mitochondrial DNA is limited by mRNA-specific translational activation. Proc. Natl. Acad. Sci. USA 1996, 93:5253-5257.
143. Sugiyama Y., Watase Y., Nagase M., Makita N., Yagura S., Hirai A., et al. The complete nucleotide sequence and multipartite organization of the tobacco mitochondrial genome: comparative analysis of mitochondrial genomes in higher plants. Mol. Gen. Genet. 2005, 272:603-615.
144. Suyama Y. The origins of mitochondrial ribonucleic acids in Tetrahymena pyriformis. Biochemistry 1967, 6:2829-2839.
145. Suyama Y. Two dimensional polyacrylamide gel electrophoresis analysis of Tetrahymena mitochondrial tRNA. Curr. Genet. 1986, 10:411-420.
146. Suyama Y., Wong S., Campbell D.A. Regulated tRNA import in Leishmania mitochondria. Biochim. Biophys. Acta 1998, 1396:138-142.
147. Sylvestre J., Margeot A., Jacq C., Dujardin G., Corral-Debrinski M. The role of the 3' untranslated region in mRNA sorting to the vicinity of mitochondria is conserved from yeast to human cells. Mol. Biol. Cell 2003, 14:3848-3856.
148. Szymanski M., Barciszewska M.Z., Erdmann V.A., Barciszewski J. 5 S rRNA: structure and interactions. Biochem. J. 2003, 371:641-651.
149. Tan T., Pach R., Crausaz Esseiva A., Ivens A., Schneider A. tRNAs in Trypanosoma brucei: genomic organization, expression, and mitochondrial import. Mol. Cell. Biol. 2002, 22:3707-3717.
150. Tan T.H.P., Bochud-Allemann N., Schneider A. Eukaryotic-type elongator tRNAMet of Trypanosoma brucei becomes formylated after import into mitochondria. Proc. Natl. Acad. Sci. USA 2002, 99:1152-1157.
151. Tarassov I.A., Entelis N.S. Mitochondrially-imported cytoplasmic tRNA(Lys)(CUU) of Saccharomyces cerevisiae: in vivo and in vitro targetting systems. Nucleic Acids Res. 1992, 20:1277-1281.
152. Tarassov I., Entelis N.S., Martin R.P. An intact protein translocating machinery is required for mitochondrial import of a yeast cytoplasmic tRNA. J. Mol. Biol. 1995, 245:315-323.
153. Tarassov I., Entelis N.S., Martin R.P. Mitochondrial import of a cytoplasmic lysine-tRNA in yeast is mediated by cooperation of cytoplasmic and mitochondrial lysyl-tRNA synthetases. EMBO J. 1995, 14:3461-3471.
154. Taylor R.W., Chinnery P.F., Turnbull D.M., Lightowlers R.N. Selective inhibition of mutant human mitochondrial DNA replication in vitro by peptide nucleic acids. Nat. Genet. 1997, 15:212-215.
155. Taylor R.W., Chinnery P.F., Turnbull D.M., Lightowlers R.N. In vitro genetic modification of mitochondrial function. Hum. Reprod. 2000, 15(Suppl. 2):79-85.
156. Terasawa K., Odahara M., Kabeya Y., Kikugawa T., Sekine Y., Fujiwara M., et al. The mitochondrial genome of the moss Physcomitrella patens sheds new light on mitochondrial evolution in land plants. Mol. Biol. Evol. 2007, 24:699-709.
157. Topper J.N., Bennett J.L., Clayton D.A. A role for RNAase MRP in mitochondrial RNA processing. Cell 1992, 70:16-20.
158. Trifunovic A., Wredenberg A., Falkenberg M., Spelbrink J.N., Rovio A.T., Bruder C.E., et al. Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 2004, 429:417-423.
159. Vestweber D., Schatz G. DNA-protein conjugates can enter mitochondria via the protein import pathway. Nature 1989, 338:170-172.
160. Vinogradova E., Salinas T., Cognat V., Remacle C., Maréchal-Drouard L. Steady-state levels of imported tRNAs in Chlamydomonas mitochondria are correlated with both cytosolic and mitochondrial codon usages. Nucleic Acids Res. 2009, 37:1521-1528.
161. Wang G., Chen H.-W., Oktay Y., Zhang J., Allen E.L., Smith G.M., et al. PNPASE regulates RNA import into mitochondria. Cell 2010, 142:456-467.
162. Wanrooij S., Falkenberg M. The human mitochondrial replication fork in health and disease. Biochim. Biophys. Acta 2010, 1797:1378-1388.
163. Weber T.A., Reichert A.S. Impaired quality control of mitochondria: aging from a new perspective. Exp. Gerontol. 2010, 45:503-511.
164. Weber-Lotfi F., Ibrahim N., Boesch P., Cosset A., Konstantinov Y., Lightowlers R.N., et al. Developing a genetic approach to investigate the mechanism of mitochondrial competence for DNA import. Biochim. Biophys. Acta 2009, 1787:320-327.
165. Weissig V., Torchilin V.P. Towards mitochondrial gene therapy: DQAsomes as a strategy. J. Drug Target. 2001, 9:1-13.
166. Weissig V., Lasch J., Erdos G., Meyer H.W., Rowe T.C., Hughes J. DQAsomes: a novel potential drug and gene delivery system made from Dequalinium. Pharm. Res. 1998, 15:334-337.
167. Weissig V., D'Souza G.G., Torchilin V.P. DQAsome/DNA complexes release DNA upon contact with isolated mouse liver mitochondria. J. Control. Release 2001, 75:401-408.
168. Yermovsky-Kammerer A., Hajduk S. In vitro import of a nuclearly encoded tRNA into the mitochondrion of Trypanosoma brucei. Mol. Cell. Biol. 1999, 19:6253-6259.
169. Yoon Y.G., Koob M.D. Transformation of isolated mammalian mitochondria by bacterial conjugation. Nucleic Acids Res. 2005, 33:e139.
170. Yoshionari S., Koike T., Yokogawa T., Nishikawa K., Ueda T., Miura K., et al. Existence of nuclear-encoded 5S-rRNA in bovine mitochondria. FEBS Lett. 1994, 338:137-142.