Arsenic, asbestos and radon: Emerging players in lung tumorigenesis

Environmental Health: A Global Access Science Source

Volumn 11, Issue 1, 2012, Pages

  Hubaux, Roland ^a   Becker Santos, Daiana D ^a   Enfield, Katey Ss ^a   Lam, Stephen ^a   Lam, Wan L ^a   Martinez, Victor D ^a  

^a BRITISH COLUMBIA CANCER RESEARCH CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ARSENIC; ARSENIC ACID; ASBESTOS; CARCINOGEN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; GLUTATHIONE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; PROTEIN P53; RADON; S ADENOSYLMETHIONINE;

ARSENIC; ASBESTOS; CARCINOGEN; ENVIRONMENTAL HAZARD; GENOMICS; POLLUTION EXPOSURE; PUBLIC HEALTH; RADON; RESPIRATORY DISEASE; SMOKING; TOBACCO; TUMOR;

BYSTANDER EFFECT; CARCINOGENICITY; DNA DAMAGE; DNA SEQUENCE; ENVIRONMENTAL EXPOSURE; EPIGENETICS; GENOMIC INSTABILITY; HUMAN; LUNG CANCER; LUNG CARCINOGENESIS; METHYLATION; MICROTUBULE; MOLECULAR GENETICS; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

ARSENIC; ASBESTOS; CARCINOGENS, ENVIRONMENTAL; ENVIRONMENTAL EXPOSURE; HUMANS; LUNG NEOPLASMS; RADON;

NICOTIANA TABACUM;

EID: 84871727873     PISSN: None     EISSN: 1476069X     Source Type: Journal    
DOI: 10.1186/1476-069X-11-89     Document Type: Review

References (152)

1. Global cancer statistics, 2002. Parkin DM, Bray F, Ferlay J, Pisani P, CA Cancer J Clin 2005 55 2 74 108 10.3322/canjclin.55.2.74 15761078
2. Lung cancer in never smokers-a different disease. Sun S, Schiller JH, Gazdar AF, Nat Rev Cancer 2007 7 10 778 790 10.1038/nrc2190 17882278
3. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM, Int J Cancer 2010 127 12 2893 2917 10.1002/ijc.25516 21351269
4. Characteristics of lung cancer patients-the shaukat khanum memorial experience. Badar F, Meerza F, Khokhar RA, Ali FA, Irfan N, Kamran S, Shahid N, Mahmood S, Asian Pac J Cancer Prev 2006 7 2 245 248 16839217
5. Lung cancer in never smokers: a review. Subramanian J, Govindan R, Journal of clinical oncology: official journal of the American Society of Clinical Oncology 2007 25 5 561 570 10.1200/JCO.2006.06.8015
6. IARC, IARC monographs on the evaluation of carcinogenic risks to humans Lyon, France: International Agency for Research on Cancer 1987
7. Some drinking-water disinfectants and contaminants, including arsenic. Monographs on chloramine, chloral and chloral hydrate, dichloroacetic acid, trichloroacetic acid and 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone. IARC, IARC Monogr Eval Carcinog Risks Hum 2004 84 269 477 15645578
8. Epidemiology of lung cancer: looking to the future. Alberg AJ, Brock MV, Samet JM, Journal of clinical oncology: official journal of the American Society of Clinical Oncology 2005 23 14 3175 3185 10.1200/JCO.2005.10.462
9. Human cancer from environmental pollutants: the epidemiological evidence. Boffetta P, Mutat Res 2006 608 2 157 162 10.1016/j.mrgentox.2006.02.015 16843042
10. Contribution of environmental factors to cancer risk. Boffetta P, Nyberg F, Br Med Bull 2003 68 71 94 10.1093/bmp/ldg023 14757710
11. Impact of occupational carcinogens on lung cancer risk in a general population. De Matteis S, Consonni D, Lubin JH, Tucker M, Peters S, Vermeulen RC, Kromhout H, Bertazzi PA, Caporaso NE, Pesatori AC, et al. Int J Epidemiol 2012 41 3 711 721 10.1093/ije/dys042 22467291
12. Potential lung cancer risk from indoor radon exposure. Harley NH, Harley JH, CA Cancer J Clin 1990 40 5 265 275 10.3322/canjclin.40.5.265 2118410
13. Chronic exposure to fine particles and mortality: an extended follow-Up of the harvard Six cities study from 1974 to 2009. Lepeule J, Laden F, Dockery D, Schwartz J, Environ Health Perspect 2012 120 7 965 970 10.1289/ehp.1104660 22456598
14. Induction of human squamous cell-type carcinomas by arsenic. Martinez VD, Becker-Santos DD, Vucic EA, Lam S, Lam WL, J Skin Cancer 2011 2011 454157 22175027
15. Arsenic exposure and the induction of human cancers. Martinez VD, Vucic EA, Becker-Santos DD, Gil L, Lam WL, J Toxicol 2011 2011 431287 22174709
16. Radon and lung cancer. Sethi TK, El-Ghamry MN, Kloecker GH, Clin Adv Hematol Oncol 2012 10 3 157 164 22402423
17. Long-term ambient fine particulate matter Air pollution and lung cancer in a large cohort of never smokers. Turner MC, Krewski D, Pope Iii CA, Chen Y, Gapstur SM, Thun MJ, Am J Respir Crit Care Med 2011 84 12 1374 1381
18. Lung cancer and indoor radon exposure in the north of Portugal-an ecological study. Veloso B, Nogueira JR, Cardoso MF, Cancer Epidemiol 2012 36 1 26 e32 10.1016/j.canep.2011.10.005 22075535
19. A current global view of environmental and occupational cancers. Yang M, J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2011 29 3 223 249 21929381
20. Worldwide asbestos supply and consumption trends from 1900 through 2003. Virta RL, Reston, Virginia: U.S. Geological Survey Circular 1298. 2006 80 http://pubs.usgs.gov/circ/2006/1298/c1298.pdf
21. Mineral commodity summaries 2011. U.S. Geological Survey, Reston, Virginia: U.S. Geological Survey 2011 198 http://minerals.usgs.gov/minerals/ pubs/mcs/2011/mcs2011.pdf
22. Arsenic in groundwater worldwide: probability of occurrence of excesive concentration on global scale. Brunt RVL, Vasak L, Griffioen J, Utrecht International groundwater resources assessment centre. 2004 15 http://www.un-igrac.org/dynamics/modules/SFIL0100/view.php?fil-Id=124
23. UNSCEAR 2000 Report. United Nations Scientific Committee on the Effects of Atomic Radiation, UNSCEAR Sources and effects of ionizing radiation. 2000 649 http://www.unscear.org/unscear/publications/2000-1.html
24. Mclaughlin Centre, World Map of national residential radon levels http://www.mclaughlincentre.ca/research/map.shtml
25. Advances in chemical carcinogenesis: a historical review and prospective. Loeb LA, Harris CC, Cancer Res 2008 68 17 6863 6872 10.1158/0008-5472.CAN-08- 2852 18757397
26. WHO, Evaluation of certain contaminants in food India 959 World health organ tech Rep Ser. 2011 1 105 115p. [ http://whqlibdoc.who.int/trs/who-trs-959- eng.pdf ]
27. Contamination of drinking-water by arsenic in bangladesh: a public health emergency. Smith AH, Lingas EO, Mahfuzar R, Bull World Health Organ 2000 78 9 1093 1103 11019458
28. Exposure to arsenic at levels found inU.S. Drinking water modifies expression in the mouse lung. Andrew AS, Bernardo V, Warnke LA, Davey JC, Hampton T, Mason RA, Thorpe JE, Ihnat MA, Hamilton JW, Toxicological sciences: an official journal of the Society of Toxicology 2007 100 1 75 87 10.1093/toxsci/kfm200
29. Lung cancer in a U.S. Population with low to moderate arsenic exposure. Heck JE, Andrew AS, Onega T, Rigas JR, Jackson BP, Karagas MR, Duell EJ, Environ Health Perspect 2009 117 11 1718 1723 20049123
30. Arsenic in the aetiology of cancer. Tapio S, Grosche B, Mutat Res 2006 612 3 215 246 10.1016/j.mrrev.2006.02.001 16574468
31. Arsenic in drinking water: 2001 update. NRC (National Research Council), Washington DC: The National Academy Press 2001 244
32. Association of arsenic exposure with lung cancer incidence rates in the united states. Putila JJ, Guo NL, PLoS One 2011 6 10 25886 10.1371/journal.pone. 0025886 22003413
33. Ingested arsenic, cigarette smoking, and lung cancer risk: a follow-up study in arseniasis-endemic areas in taiwan. Chen CL, Hsu LI, Chiou HY, Hsueh YM, Chen SY, Wu MM, Chen CJ, JAMA 2004 292 24 2984 2990 10.1001/jama.292.24.2984 15613666
34. Never-smokers with lung cancer: epidemiologic evidence of a distinct disease entity. Toh CK, Gao F, Lim WT, Leong SS, Fong KW, Yap SP, Hsu AA, Eng P, Koong HN, Thirugnanam A, et al. Journal of clinical oncology: official journal of the American Society of Clinical Oncology 2006 24 15 2245 2251 10.1200/JCO.2005.04.8033
35. Lung cancer in never-smokers. Toh CK, Lim WT, J Clin Pathol 2007 60 4 337 340 16916998
36. Ingested arsenic, characteristics of well water consumption and risk of different histological types of lung cancer in northeastern taiwan. Chen CL, Chiou HY, Hsu LI, Hsueh YM, Wu MM, Chen CJ, Environ Res 2010 110 5 455 462 10.1016/j.envres.2009.08.010 19735913
37. Arsenic-related DNA copy-number alterations in lung squamous cell carcinomas. Martinez VD, Buys TP, Adonis M, Benitez H, Gallegos I, Lam S, Lam WL, Gil L, Br J Cancer 2010 103 8 1277 1283 10.1038/sj.bjc.6605879 20842114
38. The pathogenesis of mesothelioma. Carbone M, Kratzke RA, Testa JR, Semin Oncol 2002 29 1 2 17 12577236
39. Estimating the asbestos-related lung cancer burden from mesothelioma mortality. McCormack V, Peto J, Byrnes G, Straif K, Boffetta P, Br J Cancer 2012 106 3 575 584 10.1038/bjc.2011.563 22233924
40. Malignant mesothelioma 2008. Zervos MD, Bizekis C, Pass HI, Curr Opin Pulm Med 2008 14 4 303 309 10.1097/MCP.0b013e328302851d 18520263
41. Occupational exposure to carcinogens and risk of lung cancer: results from the netherlands cohort study. van Loon AJ, Kant IJ, Swaen GM, Goldbohm RA, Kremer AM, van den Brandt PA, Occup Environ Med 1997 54 11 817 824 10.1136/oem.54.11.817 9538355
42. Asbestos, lung cancers, and mesotheliomas: from molecular approaches to targeting tumor survival pathways. Heintz NH, Janssen-Heininger YM, Mossman BT, Am J Respir Cell Mol Biol 2010 42 2 133 139 10.1165/rcmb.2009-0206TR 20068227
43. Hydroxyl radicals are formed in the rat lung after asbestos instillation in vivo. Schapira RM, Ghio AJ, Effros RM, Morrisey J, Dawson CA, Hacker AD, Am J Respir Cell Mol Biol 1994 10 5 573 579 8179922
44. Biopersistence, fiber length, and cancer risk assessment for inhaled fibers. Moolgavkar SH, Brown RC, Turim J, Inhal Toxicol 2001 13 9 755 772 11570360
45. Asbestos: scientific developments and implications for public policy. Mossman BT, Bignon J, Corn M, Seaton A, Gee JB, Science 1990 247 4940 294 301 10.1126/science.2153315 2153315
46. Ecological association between asbestos-related diseases and historical asbestos consumption: an international analysis. Lin RT, Takahashi K, Karjalainen A, Hoshuyama T, Wilson D, Kameda T, Chan CC, Wen CP, Furuya S, Higashi T, et al. Lancet 2007 369 9564 844 849 10.1016/S0140-6736(07)60412-7 17350453
47. U.S. Environmental Protection Agency, Radon health risks Washington D.C.: U.S. Environmental Protection Agency 2012
48. Lung cancer in radon-exposed miners and estimation of risk from indoor exposure. Lubin JH, Boice JD Jr, Edling C, Hornung RW, Howe GR, Kunz E, Kusiak RA, Morrison HI, Radford EP, Samet JM, et al. J Natl Cancer Inst 1995 87 11 817 827 10.1093/jnci/87.11.817 7791231
49. Lung cancer also affects nonsmokers. Simon S, The American Cancer Society 2011 http://www.cancer.org/cancer/news/lung-cancer-also-affects-nonsmokers
50. Health effects of radon: a review of the literature. Al-Zoughool M, Krewski D, Int J Radiat Biol 2009 85 1 57 69 10.1080/09553000802635054 19205985
51. Lung cancer in never smokers: clinical epidemiology and environmental risk factors. Samet JM, Avila-Tang E, Boffetta P, Hannan LM, Olivo-Marston S, Thun MJ, Rudin CM, Clin Cancer Res 2009 15 18 5626 5645 10.1158/1078-0432.CCR- 09-0376 19755391
52. Committee on the Biological Effects of Ionizing Radiations, National Research Council, Health risks of radon and other internally deposited alpha-emitters:BEIR IV Washington D.C.: The National Academies Press 1988
53. Uranium mining and lung cancer in navajo men. Samet JM, Kutvirt DM, Waxweiler RJ, Key CR, N Engl J Med 1984 310 23 1481 1484 10.1056/ NEJM198406073102301 6717538
54. Lung cancer among uranium miners in the united states. Archer VE, Wagoner JK, Lundin FE, Health Phys 1973 25 4 351 371 10.1097/00004032-197310000-00001 4361970
55. Lung cancer mortality among nonsmoking uranium miners exposed to radon daughters. Roscoe RJ, Steenland K, Halperin WE, Beaumont JJ, Waxweiler RJ, JAMA 1989 262 5 629 633 10.1001/jama.1989.03430050045024 2746814
56. Report of the radon working group on a new radon guideline for Canada (Rev. 03-10-2006). Health Canada Dp, Presented to the Federal Provincial Territorial Radiation Protection Committee Ottawa: Health Canada D 2006
57. Residential radon exposure, histologic types, and lung cancer risk. A case-control study in galicia, spain. Barros-Dios JM, Ruano-Ravina A, Perez-Rios M, Castro-Bernardez M, Abal-Arca J, Tojo-Castro M, Canc Epidemiol Biomarkers Prev 2012 21 6 951 958 10.1158/1055-9965.EPI-12-0146-T
58. Arsenic speciation in the environment. Cullen WR, Reimer KJ, Chem Rev 1989 89 713 10.1021/cr00094a002
59. The role of biomethyl-ation in toxicity and carcinogenicity of arsenic: a research update. Styblo M, Drobna Z, Jaspers I, Lin S, Thomas DJ, Environ Health Persp 2002 110 767 10.1289/ehp.02110s5767
60. The cellular metabolism and systemic toxicity of arsenic. Thomas DJ, Styblo M, Lin S, Toxicol Appl Pharmacol 2001 176 2 127 144 10.1006/taap.2001. 9258 11601889
61. Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells. Styblo M, Del Razo LM, Vega L, Germolec DR, LeCluyse EL, Hamilton GA, Reed W, Wang C, Cullen WR, Thomas DJ, Arch Toxicol 2000 74 6 289 299 10.1007/s002040000134 11005674
62. Monomethylarsonous acid (MMA(III)) is more toxic than arsenite in chang human hepatocytes. Petrick JS, Ayala-Fierro F, Cullen WR, Carter DE, Vasken Aposhian H, Toxicol Appl Pharmacol 2000 163 2 203 207 10.1006/taap.1999.8872 10698679
63. Arsenicals affect base excision repair by several mechanisms. Ebert F, Weiss A, Bultemeyer M, Hamann I, Hartwig A, Schwerdtle T, Mutat Res 2011 715 1-2 32 41 21782832
64. Polynucleotide phosphorylase and mitochondrial ATP synthase mediate reduction of arsenate to the more toxic arsenite by forming arsenylated analogues of ADP and ATP. Nemeti B, Regonesi ME, Tortora P, Gregus Z, Toxicological sciences: an official journal of the Society of Toxicology 2010 117 2 270 281 10.1093/toxsci/kfq141
65. Purification of arsenic (+3 oxidation state) methyltransferase from rat liver cytosol. Drobna Z, Styblo M, Thomas DJ, Curr Protoc Toxicol 2009 42 4.34 1 13
66. Mechanism of arsenic carcinogenesis: an integrated approach. Rossman TG, Mutat Res 2003 533 1-2 37 65 14643412
67. Genetic and epigenetic effects of environmental arsenicals. Rossman TG, Klein CB, Metallomics 2011 3 11 1135 1141 10.1039/c1mt00074h 21976018
68. Increased serum level of epidermal growth factor receptor in liver cancer patients and its association with exposure to arsenic. Sung TI, Wang YJ, Chen CY, Hung TL, Guo HR, Sci Total Environ 2012 424 74 78 22446113
69. Arsenic: toxicity, oxidative stress and human disease. Jomova K, Jenisova Z, Feszterova M, Baros S, Liska J, Hudecova D, Rhodes CJ, Valko M, J Appl Toxicol 2011 31 2 95 107 21321970
70. Oxidative mechanism of arsenic toxicity and carcinogenesis. Shi H, Shi X, Liu KJ, Mol Cell Biochem 2004 255 1-2 67 78 14971647
71. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M, Chem Biol Interact 2006 160 1 1 40 10.1016/j.cbi.2005.12.009 16430879
72. Oxidative stress as a possible mode of action for arsenic carcinogenesis. Kitchin KT, Ahmad S, Toxicol Lett 2003 137 1-2 3 13 12505428
73. Arsenic induces oxidative DNA damage in mammalian cells. Kessel M, Liu SX, Xu A, Santella R, Hei TK, Mol Cell Biochem 2002 234-235 1-2 301 308 19444596
74. Mechanisms of action of arsenic trioxide. Miller WH Jr, Schipper HM, Lee JS, Singer J, Waxman S, Cancer Res 2002 62 14 3893 3903 12124315
75. Arsenic induced mitochondrial DNA damage and altered mitochondrial oxidative function: implications for genotoxic mechanisms in mammalian cells. Partridge MA, Huang SX, Hernandez-Rosa E, Davidson MM, Hei TK, Cancer Res 2007 67 11 5239 5247 10.1158/0008-5472.CAN-07-0074 17545603
76. Sodium arsenite induces ROS generation, DNA oxidative damage, HO-1 and c-Myc proteins, NF-kappaB activation and cell proliferation in human breast cancer MCF-7 cells. Ruiz-Ramos R, Lopez-Carrillo L, Rios-Perez AD, De Vizcaya-Ruiz A, Cebrian ME, Mutat Res 2009 674 1-2 109 115 18996220
77. The role of oxidative DNA damage in human arsenic carcinogenesis: detection of 8-hydroxy-2'-deoxyguanosine in arsenic-related Bowen's disease. Matsui M, Nishigori C, Toyokuni S, Takada J, Akaboshi M, Ishikawa M, Imamura S, Miyachi Y, J Invest Dermatol 1999 113 1 26 31 10.1046/j.1523-1747.1999.00630.x 10417614
78. Methylated arsenicals: the implications of metabolism and carcinogenicity studies in rodents to human risk assessment. Cohen SM, Arnold LL, Eldan M, Lewis AS, Beck BD, Crit Rev Toxicol 2006 36 2 99 133 10.1080/10408440500534230 16736939
79. Genotoxic mechanisms of asbestos fibers: role of extranuclear targets. Xu A, Huang X, Lien YC, Bao L, Yu Z, Hei TK, Chem Res Toxicol 2007 20 5 724 733 10.1021/tx600364d 17447795
80. Asbestos fibers and interleukin-1 upregulate the formation of reactive nitrogen species in rat pleural mesothelial cells. Choe N, Tanaka S, Kagan E, Am J Respir Cell Mol Biol 1998 19 2 226 236 9698594
81. Behavior of crocidolite asbestos during mitosis in living vertebrate lung epithelial cells. Ault JG, Cole RW, Jensen CG, Jensen LC, Bachert LA, Rieder CL, Cancer Res 1995 55 4 792 798 7850791
82. Biopersistence and potential adverse health impacts of fibrous nanomaterials: what have we learned from asbestos? Sanchez VC, Pietruska JR, Miselis NR, Hurt RH, Kane AB, Wiley Interdiscip Rev Nanomed Nanobiotechnol 2009 1 5 511 529 10.1002/wnan.41 20049814
83. Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis. Nagai H, Okazaki Y, Chew SH, Misawa N, Yamashita Y, Akatsuka S, Ishihara T, Yamashita K, Yoshikawa Y, Yasui H, et al. Proc Natl Acad Sci USA 2011 108 49 1330 E1338 10.1073/pnas.1110013108 22084097
84. Mechanism of fiber carcinogenesis: from reactive radical species to silencing of the beta igH3 gene. Hei TK, Xu A, Huang SX, Zhao Y, Inhal Toxicol 2006 18 12 985 990 10.1080/08958370600835310 16920672
85. Cyto-genotoxicity of amphibole asbestos fibers in cultured human lung epithelial cell line: role of surface iron. Srivastava RK, Lohani M, Pant AB, Rahman Q, Toxicol Ind Health 2010 26 9 575 582 10.1177/0748233710374464 20554628
86. Mitochondrial-derived free radicals mediate asbestos-induced alveolar epithelial cell apoptosis. Panduri V, Weitzman SA, Chandel NS, Kamp DW, Am J Physiol Lung Cell Mol Physiol 2004 286 6 1220 L1227 10.1152/ajplung.00371.2003 14766669
87. Asbestos causes apoptosis in alveolar epithelial cells: role of iron-induced free radicals. Aljandali A, Pollack H, Yeldandi A, Li Y, Weitzman SA, Kamp DW, J Lab Clin Med 2001 137 5 330 339 10.1067/mlc.2001.114826 11329530
88. The role of oxidative stress in carcinogenesis. Klaunig JE, Kamendulis LM, Annu Rev Pharmacol Toxicol 2004 44 239 267 10.1146/annurev.pharmtox.44. 101802.121851 14744246
89. Meeting report: mode(s) of action of asbestos and related mineral fibers. Gwinn MR, DeVoney D, Jarabek AM, Sonawane B, Wheeler J, Weissman DN, Masten S, Thompson C, Environ Health Perspect 2011 119 12 1806 1810 10.1289/ehp.1003240 21807578
90. Role of mutagenicity in asbestos fiber-induced carcinogenicity and other diseases. Huang SX, Jaurand MC, Kamp DW, Whysner J, Hei TK, J Toxicol Environ Health B Crit Rev 2011 14 1-4 179 245 21534089
91. Agency for Toxic Substances and Disease Registry (ATSDR), Toxicological profile for radon Atlanta; U.S: Department of Health and Human Services, Public Health Service 2012
92. Adams GED, Introduction to the cellular and molecular biology of cancer Oxford: Oxford University Press 1986
93. Free radicals in biology: oxidative stress and the effects of ionizing radiation. Riley PA, Int J Radiat Biol 1994 65 1 27 33 10.1080/09553009414550041 7905906
94. Induction of a bystander mutagenic effect of alpha particles in mammalian cells. Zhou H, Randers-Pehrson G, Waldren CA, Vannais D, Hall EJ, Hei TK, Proc Natl Acad Sci USA 2000 97 5 2099 2104 10.1073/pnas.030420797 10681418
95. Biologic damage resulting from exposure to tobacco smoke and from radon: implication for preventive interventions. Alavanja MC, Oncogene 2002 21 48 7365 7375 10.1038/sj.onc.1205798 12379879
96. Human lung cancer risks from radon-part I-influence from bystander effects-a microdose analysis. Leonard BE, Thompson RE, Beecher GC, Dose-response: a publication of International Hormesis Society 2011 9 2 243 292 23240113
97. Biological effects of alpha particle radiation exposure on human monocytic cells. Chauhan V, Howland M, Kutzner B, McNamee JP, Bellier PV, Wilkins RC, Int J Hyg Environ Health 2012 215 3 339 344 10.1016/j.ijheh.2011.11. 002 22153871
98. Epigenetics in cancer. Sharma S, Kelly TK, Jones PA, Carcinogenesis 2010 31 1 27 36 10.1093/carcin/bgp220 19752007
99. Arsenic activates EGFR pathway signaling in the lung. Andrew AS, Mason RA, Memoli V, Duell EJ, Toxicological sciences: an official journal of the Society of Toxicology 2009 109 2 350 357 10.1093/toxsci/kfp015
100. Role and mechanism of arsenic in regulating angiogenesis. Liu LZ, Jiang Y, Carpenter RL, Jing Y, Peiper SC, Jiang BH, PLoS One 2011 6 6 20858 10.1371/journal.pone.0020858 21687637
101. Down-regulation of Mcl-1 through GSK-3beta activation contributes to arsenic trioxide-induced apoptosis in acute myeloid leukemia cells. Wang R, Xia L, Gabrilove J, Waxman S, Jing Y, Leukemia 2012 10 advance online publication 10.1038/leu.2012.180
102. Reactive oxygen species mediate arsenic induced cell transformation and tumorigenesis through Wnt/beta-catenin pathway in human colorectal adenocarcinoma DLD1 cells. Zhang Z, Wang X, Cheng S, Sun L, Son YO, Yao H, Li W, Budhraja A, Li L, Shelton BJ, et al. Toxicol Appl Pharmacol 2011 256 2 114 121 10.1016/j.taap.2011.07.016 21854796
103. Age and exposure to arsenic alter base excision repair transcript levels in mice. Osmond MJ, Kunz BA, Snow ET, Mutagenesis 2010 25 5 517 522 10.1093/mutage/geq037 20643705
104. Induction of lung-specific DNA damage by metabolically methylated arsenics via the production of free radicals. Yamanaka K, Okada S, Environ Health Perspect 1994 102 Suppl 3 37 40 10.1289/ehp.94102s337 7737040
105. Neoplastic transformation of human small airway epithelial cells induced by arsenic. Wen G, Calaf GM, Partridge MA, Echiburu-Chau C, Zhao Y, Huang S, Chai Y, Li B, Hu B, Hei TK, Mol Med 2008 14 1-2 2 10 18037969
106. The gamma-glutamylcysteine synthetase and glutathione regulate asbestos-induced expression of activator protein-1 family members and activity. Shukla A, Flanders T, Lounsbury KM, Mossman BT, Cancer Res 2004 64 21 7780 7786 10.1158/0008-5472.CAN-04-1365 15520183
107. Gene expression profiles in asbestos-exposed epithelial and mesothelial lung cell lines. Nymark P, Lindholm PM, Korpela MV, Lahti L, Ruosaari S, Kaski S, Hollmen J, Anttila S, Kinnula VL, Knuutila S, BMC Genomics 2007 8 62 10.1186/1471-2164-8-62 17331233
108. Transcriptional up-regulation of MMP12 and MMP13 by asbestos occurs via a PKCdelta-dependent pathway in murine lung. Shukla A, Barrett TF, Nakayama KI, Nakayama K, Mossman BT, Lounsbury KM, FASEB J 2006 20 7 997 999 10.1096/fj.05-4554fje 16571779
109. Lung cancer and past occupational exposure to asbestos. Role of p53 and K-ras mutations. Husgafvel-Pursiainen K, Karjalainen A, Kannio A, Anttila S, Partanen T, Ojajarvi A, Vainio H, Am J Respir Cell Mol Biol 1999 20 4 667 674 10100998
110. Mutations in the p53 gene in lung cancer are associated with cigarette smoking and asbestos exposure. Wang X, Christiani DC, Wiencke JK, Fischbein M, Xu X, Cheng TJ, Mark E, Wain JC, Kelsey KT, Canc Epidemiol Biomarkers Prev 1995 4 5 543 548
111. p16INK4A Inactivation mechanisms in non-small-cell lung cancer patients occupationally exposed to asbestos. Andujar P, Wang J, Descatha A, Galateau-Salle F, Abd-Alsamad I, Billon-Galland MA, Blons H, Clin B, Danel C, Housset B, et al. Lung Cancer 2010 67 1 23 30 10.1016/j.lungcan.2009.03.018 19375815
112. Karyotype analysis of tumorigenic human bronchial epithelial cells transformed by chrysolite asbestos using chemically induced premature chromosome condensation technique. Suzuki M, Piao CQ, Zhao YL, Hei TK, Int J Mol Med 2001 8 1 43 47 11408947
113. Specificity of asbestos-induced chromosomal aberrations in short-term cultured human mesothelial cells. Olofsson K, Mark J, Cancer Genet Cytogenet 1989 41 1 33 39 10.1016/0165-4608(89)90105-2 2766251
114. Multiple mechanisms for the carcinogenic effects of asbestos and other mineral fibers. Barrett JC, Lamb PW, Wiseman RW, Environ Health Perspect 1989 81 81 89 2667990
115. Role of fibre characteristics on cytotoxicity and induction of anaphase/telophase aberrations in rat pleural mesothelial cells in vitro: correlations with in vivo animal findings. Yegles M, Janson X, Dong HY, Renier A, Jaurand MC, Carcinogenesis 1995 16 11 2751 2758 10.1093/carcin/16.11.2751 7586195
116. Induction by asbestos fibers of anaphase abnormalities: mechanism for aneuploidy induction and possibly carcinogenesis. Hesterberg TW, Barrett JC, Carcinogenesis 1985 6 3 473 475 10.1093/carcin/6.3.473 3978760
117. A review of studies of ionizing radiation-induced double-strand break clustering. Prise KM, Pinto M, Newman HC, Michael BD, Radiat Res 2001 156 5 Pt 2 572 576 11604074
118. p53 And K-ras in radon-associated lung adenocarcinoma. McDonald JW, Taylor JA, Watson MA, Saccomanno G, Devereux TR, Canc Epidemiol Biomarkers Prev 1995 4 7 791 793
119. Mutations of p53 and ras genes in radon-associated lung cancer from uranium miners. Vahakangas KH, Samet JM, Metcalf RA, Welsh JA, Bennett WP, Lane DP, Harris CC, Lancet 1992 339 8793 576 580 10.1016/0140-6736(92)90866-2 1347094
120. Identification of specific gene copy number changes in asbestos-related lung cancer. Nymark P, Wikman H, Ruosaari S, Hollmen J, Vanhala E, Karjalainen A, Anttila S, Knuutila S, Cancer Res 2006 66 11 5737 5743 10.1158/0008-5472.CAN- 06-0199 16740712
121. DNA copy number loss and allelic imbalance at 2p16 in lung cancer associated with asbestos exposure. Kettunen E, Aavikko M, Nymark P, Ruosaari S, Wikman H, Vanhala E, Salmenkivi K, Pirinen R, Karjalainen A, Kuosma E, et al. Br J Cancer 2009 100 8 1336 1342 10.1038/sj.bjc.6605012 19337251
122. Gene expression and copy number profiling suggests the importance of allelic imbalance in 19p in asbestos-associated lung cancer. Wikman H, Ruosaari S, Nymark P, Sarhadi VK, Saharinen J, Vanhala E, Karjalainen A, Hollmen J, Knuutila S, Anttila S, Oncogene 2007 26 32 4730 4737 10.1038/sj.onc.1210270 17297452
123. Molecular analysis of the Ink4a/Rb1-Arf/Tp53 pathways in radon-induced rat lung tumors. Bastide K, Guilly MN, Bernaudin JF, Joubert C, Lectard B, Levalois C, Malfoy B, Chevillard S, Lung Cancer 2009 63 3 348 353 10.1016/j.lungcan.2008.06.007 18656278
124. k-ras mutation and occupational asbestos exposure in lung adenocarcinoma: asbestos-related cancer without asbestosis. Nelson HH, Christiani DC, Wiencke JK, Mark EJ, Wain JC, Kelsey KT, Cancer Res 1999 59 18 4570 4573 10493509
125. Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Filipowicz W, Bhattacharyya SN, Sonenberg N, Nat Rev Genet 2008 9 2 102 114 18197166
126. Croce CM: microRNA involvement in human cancer. Iorio MV, Carcinogenesis 2012 33 6 1126 1133 10.1093/carcin/bgs140 22491715
127. Clinical outcome prediction by microRNAs in human cancer: a systematic review. Nair VS, Maeda LS, Ioannidis JP, J Natl Cancer Inst 2012 104 7 528 540 10.1093/jnci/djs027 22395642
128. MicroRNA signatures in human cancers. Calin GA, Croce CM, Nat Rev Cancer 2006 6 11 857 866 10.1038/nrc1997 17060945
129. Arsenic alters cytosine methylation patterns of the promoter of the tumor suppressor gene p53 in human lung cells: a model for a mechanism of carcinogenesis. Mass MJ, Wang L, Mutat Res 1997 386 3 263 277 10.1016/S1383-5742(97)00008-2 9219564
130. Chronic oral exposure to inorganic arsenate interferes with methylation status of p16INK4a and RASSF1A and induces lung cancer in a/J mice. Cui X, Wakai T, Shirai Y, Hatakeyama K, Hirano S, Toxicological sciences: an official journal of the Society of Toxicology 2006 91 2 372 381 10.1093/toxsci/kfj159
131. Reversal and prevention of arsenic-induced human bronchial epithelial cell malignant transformation by microRNA-200b. Wang Z, Zhao Y, Smith E, Goodall GJ, Drew PA, Brabletz T, Yang C, Toxicological sciences: an official journal of the Society of Toxicology 2011 121 1 110 122 10.1093/toxsci/kfr029
132. CpG island methylation and expression of tumour-associated genes in lung carcinoma. Dammann R, Strunnikova M, Schagdarsurengin U, Rastetter M, Papritz M, Hattenhorst UE, Hofmann HS, Silber RE, Burdach S, Hansen G, Eur J Cancer 2005 41 8 1223 1236 10.1016/j.ejca.2005.02.020 15911247
133. Chromosomal alterations in lung adenocarcinoma from smokers and nonsmokers. Sanchez-Cespedes M, Ahrendt SA, Piantadosi S, Rosell R, Monzo M, Wu L, Westra WH, Yang SC, Jen J, Sidransky D, Cancer Res 2001 61 4 1309 1313 11245426
134. Integrative analysis of microRNA, mRNA and aCGH data reveals asbestos- and histology-related changes in lung cancer. Nymark P, Guled M, Borze I, Faisal A, Lahti L, Salmenkivi K, Kettunen E, Anttila S, Knuutila S, Genes Chromosomes Cancer 2011 50 8 585 597 10.1002/gcc.20880 21563230
135. Aberrant promoter methylation of p16(INK4a) and O(6)-methylguanine-DNA methyltransferase genes in workers at a chinese uranium mine. Su S, Jin Y, Zhang W, Yang L, Shen Y, Cao Y, Tong J, J Occup Health 2006 48 4 261 266 10.1539/joh.48.261 16902270
136. Plutonium targets the p16 gene for inactivation by promoter hypermethylation in human lung adenocarcinoma. Belinsky SA, Klinge DM, Liechty KC, March TH, Kang T, Gilliland FD, Sotnic N, Adamova G, Rusinova G, Telnov V, Carcinogenesis 2004 25 6 1063 1067 10.1093/carcin/bgh096 14742312
137. Effects of arsenic exposure on DNA methylation in cord blood samples from newborn babies and in a human lymphoblast cell line. Intarasunanont P, Navasumrit P, Woraprasit S, Chaisatra K, Suk WA, Mahidol C, Ruchirawat M, Environmental health: a global access science source 2012 11 1 31
138. Epigenetic remodeling during arsenical-induced malignant transformation. Jensen TJ, Novak P, Eblin KE, Gandolfi AJ, Futscher BW, Carcinogenesis 2008 29 8 1500 1508 10.1093/carcin/bgn102 18448484
139. Epigenetic mediated transcriptional activation of WNT5A participates in arsenical-associated malignant transformation. Jensen TJ, Wozniak RJ, Eblin KE, Wnek SM, Gandolfi AJ, Futscher BW, Toxicol Appl Pharmacol 2009 235 1 39 46 10.1016/j.taap.2008.10.013 19061910
140. Arsenite alters global histone H3 methylation. Zhou X, Sun H, Ellen TP, Chen H, Costa M, Carcinogenesis 2008 29 9 1831 1836 10.1093/carcin/bgn063 18321869
141. Acetylated H4K16 by MYST1 protects UROtsa cells from arsenic toxicity and is decreased following chronic arsenic exposure. Jo WJ, Ren X, Chu F, Aleshin M, Wintz H, Burlingame A, Smith MT, Vulpe CD, Zhang L, Toxicol Appl Pharmacol 2009 241 3 294 302 10.1016/j.taap.2009.08.027 19732783
142. Association of arsenic-induced malignant transformation with DNA hypomethylation and aberrant gene expression. Zhao CQ, Young MR, Diwan BA, Coogan TP, Waalkes MP, Proc Natl Acad Sci USA 1997 94 20 10907 10912 10.1073/pnas.94.20.10907 9380733
143. Arsenic removal from water/wastewater using adsorbents-a critical review. Mohan D, Pittman CU Jr, J Hazard Mater 2007 142 1-2 1 53 17324507
144. Arsenic remediation of drinking water using iron-oxide coated coal bottom ash. Mathieu JL, Gadgil AJ, Addy SE, Kowolik K, J Environ Sci Health, Part A: Tox Hazard Subst Environ Eng 2010 45 11 1446 1460 10.1080/10934529.2010.500940
145. Arsenic removal from an aqueous solution by a modified fungal biomass. Pokhrel D, Viraraghavan T, Water Res 2006 40 3 549 552 10.1016/j.watres.2005.11. 040 16406478
146. Guidelines for asbestos remediation at italian superfund sites. Paglietti F, Malinconico S, Molfetta VD, Giangrasso M, J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2012 30 3 253 286 22970721
147. Treatment and recycling of asbestos-cement containing waste. Colangelo F, Cioffi R, Lavorgna M, Verdolotti L, De Stefano L, J Hazard Mater 2011 195 391 397 21924550
148. Recycling of the product of thermal inertization of cement-asbestos for various industrial applications. Gualtieri AF, Giacobbe C, Sardisco L, Saraceno M, Gualtieri ML, Lusvardi G, Cavenati C, Zanatto I, Waste Manag 2011 31 1 91 100 10.1016/j.wasman.2010.07.006 20708915
149. The global reorganization and revitalization of the asbestos industry, 1970-2007. Rice J, Int J Health Serv 2011 41 2 239 254 10.2190/HS.41.2.d 21563623
150. Radon control systems in existing and new construction: a review. Rahman NM, Tracy BL, Radiat Prot Dosimetry 2009 135 4 243 255 10.1093/rpd/ncp112 19622543
151. Environmental exposure measurement in cancer epidemiology. Wild CP, Mutagenesis 2009 24 2 117 125 19033256
152. 'Environment' In cancer causation and etiological fraction: limitations and ambiguities. Boffetta P, McLaughlin JK, la Vecchia C, Autier P, Boyle P, Carcinogenesis 2007 28 5 913 915 17361013