MicroRNAs as biomarkers in solid organ transplantation

American Journal of Transplantation

Volumn 13, Issue 1, 2013, Pages 11-19

  Mas, V R ^a   Dumur, C I ^b   Scian, M J ^a   Gehrau, R C ^a   Maluf, D G ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Acute allograft rejection; biomarker; chronic allograft dysfunction; miRNA; tolerance; transplantation genomics

Indexed keywords

BIOLOGICAL MARKER; CD3 ANTIGEN; DICER; IMMUNOSUPPRESSIVE AGENT; LET 7C; MICRORNA; MICRORNA 10B; MICRORNA 142; MICRORNA 146A; MICRORNA 148A; MICRORNA 155; MICRORNA 187; MICRORNA 192; MICRORNA 194; MICRORNA 199A 3P; MICRORNA 20A; MICRORNA 21; MICRORNA 214; MICRORNA 223; MICRORNA 296; MICRORNA 30A; MICRORNA 30E; MICRORNA 805; MICRORNA INHIBITOR; PROTEIN INHIBITOR; RNA; RNA PRECURSOR; SMALL UNTRANSLATED RNA; UNCLASSIFIED DRUG; UNINDEXED DRUG; UNTRANSLATED RNA;

ACUTE GRAFT REJECTION; BIOGENESIS; BODY FLUID; CHRONIC ALLOGRAFT DYSFUNCTION; CLINICAL PRACTICE; CYTOPLASM; EXOSOME; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE TARGETING; GRAFT DYSFUNCTION; HEPATITIS C; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; IN SITU HYBRIDIZATION; IN VITRO STUDY; IN VIVO STUDY; KIDNEY TRANSPLANTATION; LIVER BIOPSY; LIVER CELL CARCINOMA; LIVER ISCHEMIA; LIVER PERFUSION; LIVER TRANSPLANTATION; NONHUMAN; NORTHERN BLOTTING; ORGAN PERFUSION; ORGAN SIZE; ORGAN TRANSPLANTATION; PLASMA; PRIORITY JOURNAL; PROGNOSIS; PROTEIN MICROARRAY; REAL TIME POLYMERASE CHAIN REACTION; REPERFUSION INJURY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; RNA SEQUENCE; SALIVA; SENSITIVITY AND SPECIFICITY; SERUM; SOLID ORGAN TRANSPLANTATION; SURGICAL RISK; URINE;

BIOLOGICAL MARKERS; GRAFT REJECTION; HUMANS; MICRORNAS; ORGAN TRANSPLANTATION; REPERFUSION INJURY; TISSUE DONORS;

EID: 84871722014     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2012.04313.x     Document Type: Review

References (42)

1. Organ Procurement and Transplantation Network (OPTN) and Scientific Registry of Transplant Recipients (SRTR). OPTN/SRTR. 2010; Annual Data Report. Rockville, MD: Department of Health and Human Services, Health Resources and Services Administration, Healthcare Systems Bureau, Division of Transplantation; 2011.
2. Gieser G, Harigaya H, Colangelo PM, Burckart G,. Biomarkers in solidorgan transplantation. Clin Pharmacol Ther 2011; 90: 217-220.
3. Orlando G,. Finding the right time for weaning off immunosuppression in solid-organ transplant recipients. Expert Rev Clin Immunol 2010; 6: 879-892.
4. Levitsky J., Operational tolerance: Past lessons and future prospects. Liver Transplant 2011; 17: 222-232.
5. Hübscher SG,. Transplantation pathology. Semin Liver Dis 2009; 29: 74-90.
6. Williams WW, Taheri D, Tolkoff-Rubin N, Colvin RB,. Clinical role of the renal transplant biopsy. Nat Rev Nephrol 2012; 8: 110-121.
7. Serõn D, Moreso F,. Protocol biopsies in renal transplantation: prognostic value of structural monitoring. Kidney Int 2007; 72: 690-697.
8. Kozakowski N, Regele H,. Biopsy diagnostics in renal allograft rejection: from histomorphology to biological function. Transpl Int 2009; 22: 945-953.
9. Schold JD, Kaplan B,. The elephant in the room: Failings of current clinical endpoints in kidney transplantation. Am J Transplant 2010; 10: 1163-6.
10. Mas VR, Mueller TF, Archer KJ, Maluf DG,. Identifying biomarkers as diagnostic tools in kidney transplantation. Expert Rev Mol Diagn 2011; 11: 183-196.
11. Naesens M, Sarwal MM,. Molecular diagnostics in transplantation. Nat Rev Nephrol 2010; 6: 614-628.
12. Halloran PF,. T cell-mediated rejection of kidney transplants: A personal viewpoint. Am J Transplant 2010; 10: 1126-1134.
13. Pritchard CC, Cheng HH, Tewari M,. MicroRNA profiling: approaches and considerations. Nat Rev Genet 2012; 13: 358-369.
14. Mendell JT, Olson EN,. MicroRNAs in stress signaling and human disease. Cell 2012; 148: 1172-1187.
15. Fleissner F, Goerzig Y, Haverich A, Thum T,. Microvesicles as novel biomarkers and therapeutic targets in transplantation medicine. Am J Transplant 2012; 12: 289-297.
16. Wang XW, Heegaard NH, Orum H,. MicroRNAs in Liver Disease. Gastroenterology 2012; 142: 1431-1443.
17. Lund E, Guttinger S, Calado A, Dahlberg JE, Kutay U,. Nuclear export of microRNA precursors. Science 2004; 303: 95-98.
18. Lutter D, Marr C, Krumsiek J, Lang EW, Theis FJ,. Intronic microRNAs support their host genes by mediating synergistic and antagonistic regulatory effects. BMC Genomics 2010; 11: 224.
19. Chandrasekaran K, Karolina DS, Sepramaniam S, et al.. Role of microRNAs in kidney homeostasis and disease. Kidney Int 2012; 81: 617-27.
20. Esteller M,. Non-coding RNAs in human disease. Nat Rev Genet 2011; 12: 861-874.
21. Buermans HP, Ariyurek Y, van Ommen G, den Dunnen JT, 't Hoen PA,. New methods for next generation sequencing based microRNA expression profiling. BMC Genomics 2010; 11: 716.
22. vanRooij E,. The art of microRNAresearch. Circ Res 2011; J108: 219.
23. Verhoueven J, Farid RR, de Ruiter EE, et al.. MicroRNAs in preservation solution are more predictive of graft quality than their expression in liver tissue. Liver Transplant 2012; 18: S116.
24. Shapiro MD, Bagley J, Latz J, et al.. MicroRNA expression data reveals a signature of kidney damage following ischemia reperfusion injury. PLoS One 2011; 6: e23011.
25. Godwin JG, Ge X, Stephan K, Jurisch A, Tullius SG, Iacomini J,. Identification of a microRNA signature of renal ischemia reperfusion injury. Proc Natl Acad Sci USA 2010; 107: 14339-14344.
26. Farid WR, Pan Q, van der Meer AJ, et al.. Hepatocyte-derived microRNAs as serum biomarkers of hepatic injury and rejection after liver transplantation. Liver Transplant 2012; 18: 290-297.
27. Cravedi P, Heeger PS,. Immunologic monitoring in transplantation revisited. Curr Opin Organ Transplant 2012; 17: 26-32.
28. Anglicheau D, Muthukumar T, Suthanthiran M,. MicroRNAs: Small RNAs with big effects. Transplantation 2010; 90: 105-112.
29. Harris A, Krams SM, Martinez OM,. MicroRNAs as immune regulators: Implications for transplantation. Am J Transplant 2010; 10: 713-719.
30. Sui W, Dai Y, Huang Y, Lan H, Yan Q, Huang H,. Microarray analysis of MicroRNA expression in acuterejection after renal transplantation. Transplant Immunol 2008; 19: 81-85.
31. Anglicheau D, Sharma VK, Ding R, et al.. MicroRNA expression profiles predictive of human renal allograft status. Proc Natl Acad Sci USA 2009; 106: 5330-5335.
32. Asaoka T, Sotolongo B, Island ER, et al.. MicroRNA signature of intestinal acute cellular rejection in formalin-fixed paraffin-embedded mucosal biopsies. Am J Transplant 2012; 12: 458-468.
33. Li JY, Yong TY, Michael MZ, Gleadle JM,. Review: The role of microRNAs in kidney disease. Nephrology 2010; 15: 599-608.
34. Lorenzen JM, Volkmann I, Fiedler J, et al.. Urinary miR-210 as a mediator of acute T-cell mediated rejection in renal allograft recipients. Am J Transplant 2011; 11: 2221-2227.
35. Mannon RB., Immune monitoring and biomarkers to predict chronic allograft dysfunction. Kidney Int Suppl 2010; 119: S59-S65.
36. Kalluri R, Neilson EG,. Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest 2003; 112: 1776-1784.
37. Gregory PA, Bert AG, Paterson EL, et al.. The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat Cell Biol 2008; 10: 593-601.
38. Korpal M, Lee ES, Hu G, Kang Y,. The miR-200 family inhibits epithelial-mesenchymal transition and cancer cells by targeting the E-cadherin transcriptional repressors ZEB1 and ZEB2. J Biol Chem 2008; 283: 14910-14914.
39. Scian MJ, Maluf DG, David KG, et al.. MicroRNA profiles in allograft tissues and paired urines associate with chronic allograft dysfunction with IF/TA. Am J Transplant 2011; 11: 2110-2122.
40. Londoño MC, Danger R, Giral M, Soulillou JP, Sánchez-Fueyo A, Brouard S,. A need for biomarkers of operational tolerance in liver and kidney transplantation. Am J Transplant 2012; 12: 1370-1377.
41. Danger R, Pallier A, Giral M, et al.. Upregulation of miR-142-3p in peripheral blood mononuclear cells of operationally tolerant patients with a renal transplant. J Am SocNephrol 2012; 23: 597-606.
42. Shan J, Feng L, Luo L, et al.. MicroRNAs: Potential biomarker in organ transplantation. TransplImmunol 2011; 24: 210-215.