Revisiting the prognostic value of regulatory T cells in patients with cancer

Journal of Clinical Oncology

Volumn 27, Issue 19, 2009, Pages

  Badoual, Cecile ^a,b,c   Hans, Stephane ^c   Fridman, Wolf H ^c   Brasnu, Daniel ^c   Erdman, Susan ^d   Tartour, Eric ^a,b,c  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b ECOLE NATIONALE VÉTÉRINAIRE D ALFORT   (France)

^c HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GRANZYME; GROWTH FACTOR; PERFORIN; TRANSCRIPTION FACTOR FOXP3;

ADOPTIVE IMMUNOTHERAPY; ADOPTIVE TRANSFER; APOPTOSIS; CANCER PATIENT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DEATH; COLORECTAL CANCER; DISEASE FREE INTERVAL; FOLLICULAR LYMPHOMA; GENE INACTIVATION; HEAD AND NECK CANCER; HODGKIN DISEASE; HUMAN; IMMUNOHISTOCHEMISTRY; INNATE IMMUNITY; LETTER; LUNG NON SMALL CELL CANCER; LYMPHOCYTIC INFILTRATION; NONHUMAN; OVARY CANCER; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; TUMOR ASSOCIATED LEUKOCYTE; TUMOR GROWTH; TUMOR REGRESSION; TUMOR SUPPRESSOR GENE; ANIMAL; IMMUNOLOGY; MORTALITY; MOUSE; NEOPLASM; NOTE;

ANIMALS; HUMANS; LYMPHOCYTES, TUMOR-INFILTRATING; MICE; NEOPLASMS; PROGNOSIS; T-LYMPHOCYTES, REGULATORY;

EID: 67650315186     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2009.23.0680     Document Type: Letter

References (24)

1. + T regulatory cells show strong prognostic significance in colorectal cancer. J Clin Oncol 27:186-192, 2009
2. Curiel TJ, Coukos G, Zou L, et al: Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med 10:942-949, 2004
3. Hiraoka N, Onozato K, Kosuge T, et al: Prevalence of FOXP3+ regulatory T cells increases during the progression of pancreatic ductal adenocarcinoma and its premalignant lesions. Clin Cancer Res 12:5423-5434, 2006
4. Kobayashi N, Hiraoka N, Yamagami W, et al: FOXP3+ regulatory T cells affect the development and progression of hepatocarcinogenesis. Clin Cancer Res 13:902-911, 2007
5. Erdman SE, Sohn JJ, Rao VP, et al: CD4+CD25+ regulatory lymphocytes induce regression of intestinal tumors in ApcMin/+ mice. Cancer Res 65:3998-4004, 2005
6. Erdman SE, Poutahidis T, Tomczak M, et al: CD4+CD25+ regulatory T lymphocytes inhibit microbially induced colon cancer in Rag2-deficient mice. Am J Pathol 162:691-702, 2003
7. Lee AM, Clear AJ, Calaminici M, et al: Number of CD4+ cells and location of forkhead box protein P3-positive cells in diagnostic follicular lymphoma tissue microarrays correlates with outcome. J Clin Oncol 24:5052-5059, 2006
8. Alvaro T, Lejeune M, Salvado MT, et al: Outcome in Hodgkin's lymphoma can be predicted from the presence of accompanying cytotoxic and regulatory T cells. Clin Cancer Res 11:1467-1473, 2005
9. Carreras J, Lopez-Guillermo A, Fox BC, et al: High numbers of tumor-infiltrating FOXP3-positive regulatory T cells are associated with improved overall survival in follicular lymphoma. Blood 108:2957-2964, 2006
10. Badoual C, Hans S, Rodriguez J, et al: Prognostic value of tumor-infiltrating CD4+ T-cell subpopulations in head and neck cancers. Clin Cancer Res 12:465-472, 2006
11. Strauss L, Bergmann C, Gooding W, et al: The frequency and suppressor function of CD4+CD25highFoxp3+ T cells in the circulation of patients with squamous cell carcinoma of the head and neck. Clin Cancer Res 13:6301-6311, 2007
12. Petersen RP, Campa MJ, Sperlazza J, et al: Tumor infiltrating Foxp3+ regulatory T-cells are associated with recurrence in pathologic stage I NSCLC patients. Cancer 107:2866-2872, 2006
13. Leffers N, Gooden MJ, de Jong RA, et al: Prognostic significance of tumor-infiltrating T-lymphocytes in primary and metastatic lesions of advanced stage ovarian cancer. Cancer Immunol Immunother 58:449-459, 2009
14. Elpek KG, Lacelle C, Singh NP, et al: CD4+CD25+ T regulatory cells dominate multiple immune evasion mechanisms in early but not late phases of tumor development in a B cell lymphoma model. J Immunol 178:6840-6848, 2007
15. Sato E, Olson SH, Ahn J, et al: Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer. Proc Natl Acad Sci U S A 102:18538-18543, 2005
16. Gao Q, Qiu SJ, Fan J, et al: Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection. J Clin Oncol 25:2586-2593, 2007
17. Walker MR, Kasprowicz DJ, Gersuk VH, et al: Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25- T cells. J Clin Invest 112:1437-1443, 2003
18. Roncador G, Brown PJ, Maestre L, et al: Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level. Eur J Immunol 35:1681-1691, 2005
19. Cosmi L, Liotta F, Lazzeri E, et al: Human CD8+CD25+ thymocytes share phenotypic and functional features with CD4+CD25+ regulatory thymocytes. Blood 102:4107-4114, 2003
20. Badoual C, Bouchaud G, Agueznay Nel H, et al: The soluble alpha chain of interleukin-15 receptor: A proinflammatory molecule associated with tumor progression in head and neck cancer. Cancer Res 68:3907-3914, 2008
21. Schottelius AJ, Dinter H: Cytokines, NF-kappaB, microenvironment, intestinal inflammation and cancer. Cancer Treat Res 130:67-87, 2006
22. Maloy KJ, Salaun L, Cahill R, et al: CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms. J Exp Med 197:111-119, 2003
23. Venet F, Pachot A, Debard AL, et al: Human CD4+CD25+ regulatory T lymphocytes inhibit lipopolysaccharide-induced monocyte survival through a Fas/Fas ligand-dependent mechanism. J Immunol 177:6540-6547, 2006
24. Grossman WJ, Verbsky JW, Barchet W, et al: Human T regulatory cells can use the perforin pathway to cause autologous target cell death. Immunity 21:589-601, 2004