The dosing determines mutagenicity of hydrophobic compounds in the Ames II assay with metabolic transformation: Passive dosing versus solvent spiking

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 750, Issue 1-2, 2013, Pages 12-18

  Smith, Kilian E C ^a   Heringa, Minne B ^b   Uytewaal, Marijan ^b   Mayer, Philipp ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b KWR WATERCYCLE RESEARCH INSTITUTE   (Netherlands)

Author keywords

Ames II assay; Hydrophobic compounds; Mutagenicity; Passive dosing; Solvent spiking

Indexed keywords

ACENAPHTHENE DERIVATIVE; BENZ[A]ANTHRACENE; BENZO[A]PYRENE; CHRYSENE; FLUORANTHENE; FLUORENE; NAPHTHALENE; PHENANTHRENE; POLYCYCLIC AROMATIC HYDROCARBON; PYRENE; SILICONE; SOLVENT;

AMES II BACTERIAL MUTAGENICITY ASSAY; AMES TEST; AQUEOUS SOLUTION; ARTICLE; BACTERIAL STRAIN; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DISSOLUTION; KINETICS; METABOLIC ACTIVATION; MUTAGENICITY; PRIORITY JOURNAL; SOLUBILITY;

BIOTRANSFORMATION; MUTAGENICITY TESTS; MUTAGENS; POLYCYCLIC HYDROCARBONS, AROMATIC; SALMONELLA TYPHIMURIUM; SOLUBILITY;

BACTERIA (MICROORGANISMS);

EID: 84871714041     PISSN: 13835718     EISSN: 18793592     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2012.07.006     Document Type: Article

References (41)

1. U.S. Food and Drug Administration, Redbook 2000, Guidance for industry and other stakeholders: toxicological principles for the safety assessment of food ingredients, 2000, revised 2007, Silver Spring, MD.
2. International Conference on the Harmonisation of technical requirements for registration of pharmaceuticals for human use (ICH), Draft consensus guideline: guidance on genotoxicity testing and data interpretation for pharmaceuticals intended for human use S2(R1), 2008, Geneva, Switzerland.
3. Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006. Official J. Eur. Union 2006, L396:1-849.
4. Committee on mutagenicity of chemicals in food, consumer products and the environment (COM), 2010. Guidance on a strategy for genotoxicity testing and mutagenic hazard assessment of chemical substances. Draft paper for consultation, London, United Kingdom.
5. Cimino M.C. Comparative overview of current international strategies and guidelines for genetic toxicology testing for regulatory purposes. Environ. Mol. Mutagen. 2006, 47:362-390.
6. Eastmond D.A., Hartwig A., Anderson D., Anwar W.A., Cimino M.C., Dobrev I., Douglas G.R., Nohmi T., Phillips D.H., Vickers C. Mutagenicity testing for chemical risk assessment: update of the WHO/IPCS harmonized scheme. Mutagenesis 2009, 24:341-349.
7. Ames B.N., Lee F.D., Durston W.E. An improved bacterial test system for the detection and classification of mutagens and carcinogens. Proc. Natl. Acad. Sci. U. S. A. 1973, 70:782-786.
8. McCann J., Choi E., Yamasaki E., Ames B.N. Detection of carcinogens as mutagens in Salmonella/microsome test: assay of 300 chemicals. Proc. Natl. Acad. Sci. U. S. A. 1975, 72:5135-5139.
9. McCann J., Ames B.N. Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals: discussion. Proc. Natl. Acad. Sci. U. S. A. 1976, 73:950-954.
10. Mortelmans K., Zeiger E. The Ames Salmonella/microsome mutagenicity assay. Mutation Res. - Fundam. Mol. Mech. Mutagen. 2000, 455:29-60.
11. Ames B.N., McCann J., Yamasaki E. Methods for detecting carcinogens and mutagens with Salmonella/mammalian-microsome mutagenicity test. Mutat. Res. 1975, 31:347-363.
12. Ku W.W., Bigger A., Brambilla G., Glatt H., Gocke E., Guzzie P.J., Hakura A., Honma M., Martus H.J., Obach R.S., Roberts S. Strategy for genotoxicity testing - metabolic considerations. Mutat. Res. Genet. Toxicol. Environ. Mutagen. 2007, 627:59-77.
13. Organisation for Economic Co-operation and Development, OECD Guideline for testing of chemicals, 471: bacterial reverse mutation test, 1997.
14. Maron D.M., Ames B.N. Revised methods for the Salmonella mutagenicity test. Mutat. Res. 1983, 113:173-215.
15. Gatehouse D., Haworth S., Cebula T., Gocke E., Kier L., Matsushima T., Melcion C., Nohmi T., Ohta T., Venitt S., Zeiger E. Recommendations for the performance of bacterial mutation assays. Mutat. Res. 1994, 312:217-233.
16. Gee P., Sommers C.H., Melick A.S., Gidrol X.M., Todd M.D., Burris R.B., Nelson M.E., Klemm R.C., Zeiger E. Comparison of responses of base-specific Salmonella tester strains with the traditional strains for identifying mutagens: the results of a validation study. Mutat. Res. Genet. Toxicol. Environ. Mutagen. 1998, 412:115-130.
17. Flückiger-Isler S., Baumeister A., Braun K., Gervais V., Hasler-Nguyen N., Reimann R., van Gompel J., Wunderlich H.G., Engelhardt G. Assessment of the performance of the Ames II™ assay: a collaborative study with 19 coded compounds. Mutat. Res. Genet. Toxicol. Environ. Mutagen. 2004, 558:181-197.
18. Kamber M., Flückiger-Isler S., Engelhardt G., Jaeckh R., Zeiger E. Comparison of the Ames II and traditional Ames test responses with respect to mutagenicity, strain specificities, need for metabolism and correlation with rodent carcinogenicity. Mutagenesis 2009, 24:359-366.
19. Schreiber R., Altenburger R., Paschke A., Kuster E. How to deal with lipophilic and volatile organic substances in microtiter plate assays. Environ. Toxicol. Chem. 2008, 27:1676-1682.
20. Riedl J., Altenburger R. Physicochemical substance properties as indicators for unreliable exposure in microplate-based bioassays. Chemosphere 2007, 67:2210-2220.
21. Heringa M.B., Schreurs R., Busser F., Van Der Saag P.T., Van Der Burg B., Hermens J.L.M. Toward more useful in vitro toxicity data with measured free concentrations. Environ. Sci. Technol. 2004, 38:6263-6270.
22. Gülden M., Seibert H. Impact of bioavailability on the correlation between in vitro cytotoxic and in vivo acute fish toxic concentrations of chemicals. Aquat. Toxicol. 2005, 72:327-337.
23. Kramer N.I., Busser F.J.M., Oosterwijk M.T.T., Schirmer K., Escher B.I., Hermens J.L.M. Development of a partition-controlled dosing system for cell assays. Chem. Res. Toxicol. 2010, 23:1806-1814.
24. Smith K.E.C., Oostingh G.J., Mayer P. Passive dosing for producing defined and constant exposure of hydrophobic organic compounds during in vitro toxicity tests. Chem. Res. Toxicol. 2010, 23:55-65.
25. Bougeard C., Gallampois C., Brack W. Passive dosing: an approach to control mutagen exposure in the Ames fluctuation test. Chemosphere 2011, 83:409-414.
26. ® assay. Environ. Toxicol. Chem. 2011, 30:898-904.
27. Brown R.S., Akhtar P., Akerman J., Hampel L., Kozin I.S., Villerius L.A., Klamer H.J.C. Partition controlled delivery of hydrophobic substances in toxicity tests using poly(dimethylsiloxane) (PDMS) films. Environ. Sci. Technol. 2001, 35:4097-4102.
28. Smith K.E.C., Rein A., Trapp S., Mayer P., Gosewinkel Karlson U. Dynamic passive dosing for studying the biotransformation of hydrophobic organic chemicals: microbial degradation as an example. Environ. Sci. Technol. 2012, 46:4852-4860.
29. Maron D., Katzenellenbogen J., Ames B.N. Compatibility of organic-solvents with the Salmonella-microsome test. Mutat. Res. 1981, 88:343-350.
30. Kirkland D., Aardema M., Henderson L., Muller L. Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens I. Sensitivity, specificity and relative predictivity. Mutat. Res. Genet. Toxicol. Environ. Mutagen. 2005, 584:1-256.
31. Xue W., Warshawsky D. Metabolic activation of polycyclic and heterocyclic aromatic hydrocarbons and DNA damage: a review. Toxicol. Appl. Pharmacol. 2005, 206:73-93.
32. Birch H., Gouliarmou V., Lutzhoft H.C.H., Mikkelsen P.S., Mayer P. Passive dosing to determine the speciation of hydrophobic organic chemicals in aqueous samples. Anal. Chem. 2010, 82:1142-1146.
33. Smith K.E.C., Dom N., Blust R., Mayer P. Controlling and maintaining exposure of hydrophobic organic compounds in aquatic toxicity tests by passive dosing. Aquat. Toxicol. 2010, 98:15-24.
34. Piegorsch W.W., Simmons S.J., Margolin B.H., Zeiger E., Gidrol X.M., Gee P. Statistical modeling and analyses of a base-specific Salmonella mutagenicity assay. Mutat. Res. Genet. Toxicol. Environ. Mutagen. 2000, 467:11-19.
35. Mayer P., Reichenberg F., Toräng L., A device and method for isolation, concentration and/or identification of compounds, World Intellectual Property Organization, International patent (WO 2008/113365 A2) published 23rd September 2008, 2008.
36. Gee P., Maron D.M., Ames B.N. Detection and classification of mutagens - a set of base-specific Salmonella tester strains. Proc. Natl. Acad. Sci. U. S. A. 1994, 91:11606-11610.
37. Mackay D., Shiu W.Y., Ma K.C., Lee C.L. Physical-Chemical Properties and Environmental Fate for Organic Chemicals on CD-ROM 2006, CRC Press, Taylor & Francis, Boca Raton, FL. second ed.
38. Glatt H., Seidel A., Bochnitschek W., Marquardt H., Hodgson R.M., Grover P.L., Oesch F. Mutagenic and cell-transforming activities of triol-epoxides as compared to other chrysene metabolites. Cancer Res. 1986, 46:4556-4565.
39. Sakai M., Yoshida D., Mizusaki S. Mutagenicity of polycyclic aromatic hydrocarbons and quinones on Salmonella typhimurium TA97. Mutat. Res. 1985, 156:61-67.
40. Simmon V.F., Kauhanen K., Tardiff R.G. Mutagenic activity of chemicals identified in drinking water. Dev. Toxicol. Environ. Sci. 1977, 2:249-258.
41. Kwon J.H., Wuethrich T., Mayer P., Escher B.I. Development of a dynamic delivery method for in vitro bioassays. Chemosphere 2009, 76:83-90.