Impact of bioavailability on the correlation between in vitro cytotoxic and in vivo acute fish toxic concentrations of chemicals

Aquatic Toxicology

Volumn 72, Issue 4, 2005, Pages 327-337

  Gülden, Michael ^a   Seibert, Hasso ^a  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

Bioavailability; Cytotoxic potency; Fish acute toxicity; In vitro in vivo extrapolation; Lipophilicity; Protein binding

Indexed keywords

LIPID; OCTANOL; ORGANIC COMPOUND; SERUM ALBUMIN; WATER;

BIOAVAILABILITY; CHEMICAL POLLUTANT; FISH; HAZARD ASSESSMENT; TOXICITY;

ACCURACY; ACUTE TOXICITY; ALGORITHM; ANIMAL CELL; ARTICLE; BIOAVAILABILITY; CELL CULTURE; CONTROLLED STUDY; CORRELATION ANALYSIS; CULTURE MEDIUM; CYTOTOXICITY TEST; EMBRYO; FISH; LC 50; LIPOPHILICITY; MATHEMATICAL COMPUTING; MOUSE; NONHUMAN; ORYZIAS; PARTITION COEFFICIENT; PRIORITY JOURNAL; PROTEIN BINDING; RAINBOW TROUT;

ONCORHYNCHUS MYKISS; PHOXINUS PHOXINUS; PIMEPHALES PROMELAS; SALMONIDAE;

EID: 17444380414     PISSN: 0166445X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.aquatox.2005.02.002     Document Type: Article

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