The mast cell-nerve functional unit: A key component of physiologic and pathophysiologic responses

Chemical Immunology and Allergy

Volumn 98, Issue , 2012, Pages 196-221

  Forsythe, Paul ^a   Bienenstock, John ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; NERVE GROWTH FACTOR; NEUROPEPTIDE; SUBSTANCE P; VASOACTIVE INTESTINAL POLYPEPTIDE; CELL ADHESION MOLECULE;

ARTICLE; CELL INTERACTION; CHOLINERGIC NERVE CELL; MAST CELL; NERVE FUNCTION; NEUROMODULATION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SENSORY NERVE CELL; BRAIN; GASTROINTESTINAL TRACT; HUMAN; IMMUNOLOGY; LUNG; METABOLISM; NERVE CELL; PATHOLOGY; PHYSIOLOGY; SKIN; URINARY TRACT;

BRAIN; CALCITONIN GENE-RELATED PEPTIDE; CELL ADHESION MOLECULES; CHOLINERGIC NEURONS; GASTROINTESTINAL TRACT; HUMANS; LUNG; MAST CELLS; NERVE GROWTH FACTORS; NEURONS; NEUROPEPTIDES; SKIN; SUBSTANCE P; URINARY TRACT; VASOACTIVE INTESTINAL PEPTIDE;

EID: 84871685380     PISSN: 16602242     EISSN: 16622898     Source Type: Book Series    
DOI: 10.1159/00033652326     Document Type: Article

References (191)

1. Moon TC, St Laurent CD, Morris KE, et al: Advances in mast cell biology: new understanding of heterogeneity and function. Mucosal Immunol 2010;3: 111-128.
2. Rivera J, Olivera A: A current understanding of Fc epsilon RI- dependent mast cell activation. Curr Allergy Asthma Rep 2008;8: 14-20.
3. Marshall JS, Jawdat DM: Mast cells in innate immunity. J Allergy Clin Immunol 2004;114: 21-27.
4. Metz M, Piliponsky AM, Chen CC, et al: Mast cells can enhance resistance to snake and honeybee venoms. Science 2006;313: 526-530.
5. Malaviya R, Twesten NJ, Ross EA, Abraham SN, Pfeifer JD: Mast cells process bacterial Ags through a phagocytic route for class I MHC presentation to T cells. J Immunol 1996;156: 1490-1496.
6. Wang HW, Tedla N, Lloyd AR, Wakefield D, McNeil PH: Mast cell activation and migration to lymph nodes during induction of an immune response in mice. J Clin Invest 1998;102: 1617-1626.
7. de Vries VC, Pino- Lagos K, Elgueta R, Noelle RJ: The enigmatic role of mast cells in dominant tolerance. Curr Opin Organ Transplant 2009;14: 332-337.
8. Sayed BA, Walker ME, Brown MA: Cutting edge: mast cells regulate disease severity in a relapsingremitting model of multiple sclerosis. J Immunol 2011;186: 3294-3298.
9. Hueber AJ, Asquith DL, Miller AM, et al: Mast cells express IL- 17A in rheumatoid arthritis synovium. J Immunol 2010;184: 3336-3340.
10. Nienartowicz A, Sobaniec- Lotowska ME, Jarocka- Cyrta E, Lemancewicz D: Mast cells in neoangiogenesis. Med Sci Monit 2006;12:RA53-56.
11. Ribatti D, Crivellato E: Mast cells, angiogenesis and cancer. Adv Exp Med Biol 2011;716: 270-288.
12. Theoharides TC: The mast cell: a neuroimmunoendocrine master player. Int J Tissue React 1996;18: 1-21.
13. Frieling T, Cooke HJ, Wood JD: Histamine receptors on submucous neurons in guinea pig colon. Am J Physiol 1993;264:G74-80.
14. van Houwelingen AH, Kool M, de Jager SCA, et al: Mast cell- derived TNF- α primes sensory nerve endings in a pulmonary hypersensitivity reaction. J Immunol 2002;168: 5297-5302.
15. Leon A, Buriani A, Dal Toso R, et al: Mast cells synthesize, store, and release nerve growth factor. Proc Natl Acad Sci USA 1994;91: 3739-3743.
16. Kakurai M, Monteforte R, Suto H, Tsai M, Nakae S, Galli SJ: Mast cell- derived tumor necrosis factor can promote nerve fiber elongation in the skin during contact hypersensitivity in mice. Am J Pathol 2006; 169: 1713-1721.
17. Andersson RG, Grundstrom N: Innervation of airway smooth muscle. Efferent mechanisms. Pharmacol Ther 1987;32: 107-130.
18. Bienenstock J, Tomioka M, Matsuda H, et al: The role of mast cells in inflammatory processes: evidence for nerve/mast cell interactions. Int Arch Allergy Appl Immunol 1987;82: 238-243.
19. Stead RH, Tomioka M, Quinonez G, Simon GT, Felten SY, Bienenstock J: Intestinal mucosal mast cells in normal and nematode- infected rat intestines are in intimate contact with peptidergic nerves. Proc Natl Acad Sci USA 1987;84: 2975-2979.
20. Undem BJ, Riccio MM, Weinreich D, Ellis JL, Myers AC: Neurophysiology of mast cell- nerve interactions in the airways. Int Arch Allergy Immunol 1995;107: 199-201.
21. Spanos C, Pang X, Ligris K, et al: Stress- induced bladder mast cell activation: implications for interstitial cystitis. J Urol 1997;157: 669-672.
22. Bienenstock J, Denburg J, Scicchitano R, Stead R, Perdue M, Stanisz A: Role of neuropeptides, nerves and mast cells in intestinal immunity and physiology. Monogr Allergy 1988;24: 134-143.
23. Barnes PJ: Airway inflammation and autonomic control. Eur J Respir Dis Suppl 1986;147: 80-87.
24. Rychter JW, Van Nassauw L, Timmermans JP, Akkermans LM, Westerink RH, Kroese AB: CGRP1 receptor activation induces piecemeal release of protease- 1 from mouse bone marrow- derived mucosal mast cells. Neurogastroenterol Motil 2011; 23:e57-68.
25. Gottwald T, Lhotak S, Stead RH: Effect of truncal vagotomy and capsaicin on mast cells and IgApositive plasma cells in rat jejunal mucosa. Neurogastroenterol Motil 1997;9: 25-32.
26. Gottwald TP, Hewlett BR, Lhotak S, Stead RH: Electrical stimulation of the vagus nerve modulates the histamine content of mast cells in the rat jejunal mucosa. Neuroreport 1995;7: 313-317.
27. Kandere- Grzybowska K, Letourneau R, Kempuraj D, et al: IL- 1 induces vesicular secretion of IL- 6 without degranulation from human mast cells. J Immunol 2003;171: 4830-4836.
28. Vliagoftis H, Dimitriadou V, Theoharides TC: Progesterone triggers selective mast cell secretion of 5- hydroxytryptamine. Int Arch Allergy Appl Immunol 1990;93: 113-119.
29. Eggleston PA, Kagey- Sobotka A, Proud D, Adkinson NFJ, Lichtenstein LM: Disassociation of the release of histamine and arachidonic acid metabolites from osmotically activated basophils and human lung mast cells. Am Rev Respir Dis 1990;141: 960-964.
30. Krishnaswamy G, Ajitawi O, Chi DS: The human mast cell: an overview. Methods Mol Biol 2006;315: 13-34.
31. Ruitenberg EJ, Gustowska L, Elgersma A, Ruitenberg HM: Effect of fixation on the light microscopical visualization of mast cells in the mucosa and connective tissue of the human duodenum. Int Arch Allergy Appl Immunol 1982;67: 233-238.
32. Wingren U, Enerback L: Turnover of histamine in mucosal and connective tissue mast cells of the rat. Agents Actions 1984;14: 358-360.
33. Kitamura Y, Kanakura Y, Sonoda S, Asai H, Nakano T: Mutual phenotypic changes between connective tissue type and mucosal mast cells. Int Arch Allergy Appl Immunol 1987;82: 244-248.
34. Reed DE, Barajas- Lopez C, Cottrell G, et al: Mast cell tryptase and proteinase- activated receptor 2 induce hyperexcitability of guinea- pig submucosal neurons. J Physiol 2003;547: 531-542.
35. Yuan H, Zhu X, Zhou S, et al: Role of mast cell activation in inducing microglial cells to release neurotrophin. J Neurosci Res 2010;88: 1348-1354.
36. Amadesi S, Nie J, Vergnolle N, et al: Proteaseactivated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia. J Neurosci 2004;24: 4300-4312.
37. Linden DR, Manning BP, Bunnett NW, Mawe GM: Agonists of proteinase- activated receptor 2 excite guinea pig ileal myenteric neurons. Eur J Pharmacol 2001;431: 311-314.
38. Caughey GH, Leidig F, Viro NF, Nadel JA: Substance P and vasoactive intestinal peptide degradation by mast cell tryptase and chymase. J Pharmacol Exp Ther 1988;244: 133-137.
39. Steinhoff M, Vergnolle N, Young SH, et al: Agonists of proteinase- activated receptor 2 induce inflammation by a neurogenic mechanism. Nat Med 2000;6: 151-158.
40. Adcock IM, Caramori G, Ito K: New insights into the molecular mechanisms of corticosteroids actions. Curr Drug Targets 2006;7: 649-660.
41. Furuno T, Ito A, Koma Y, et al: The spermatogenic Ig superfamily/synaptic cell adhesion molecule mast- cell adhesion molecule promotes interaction with nerves. J Immunol 2005;174: 6934-6942.
42. Ito A, Oonuma J: Direct interaction between nerves and mast cells mediated by the SgIGSF/SynCAM adhesion molecule. J Pharmacol Sci 2006;102: 1-5.
43. Hagiyama M, Furuno T, Hosokawa Y, et al: Enhanced nerve- mast cell interaction by a neuronal short isoform of cell adhesion molecule- 1. J Immunol. 2011;186: 5983-5992.
44. Tegoshi T, Nishida M, Arizono N: Expression and role of E- cadherin and CD103beta7 (alphaEbeta7 integrin) on cultured mucosal- type mast cells. APMIS 2005;113: 91-98.
45. Suzuki A, Suzuki R, Furuno T, Teshima R, Nakanishi M: N- cadherin plays a role in the synapse- like structures between mast cells and neurites. Biol Pharm Bull 2004;27: 1891-1894.
46. Marshall JS, Gomi K, Blennerhassett MG, Bienenstock J: Nerve growth factor modifies the expression of inflammatory cytokines by mast cells via a prostanoid- dependent mechanism. J Immunol 1999;162: 4271-4276.
47. Woolf CJ, Ma QP, Allchorne A, Poole S: Peripheral cell types contributing to the hyperalgesic action of nerve growth factor in inflammation. J Neurosci 1996;16: 2716-2723.
48. Mazurek N, Weskamp G, Erne P, Otten U: Nerve growth factor induces mast cell degranulation without changing intracellular calcium levels. FEBS Lett 1986;198: 315-320.
49. Marshall JS, Stead RH, McSharry C, Nielsen L, Bienenstock J: The role of mast cell degranulation products in mast cell hyperplasia. I. Mechanism of action of nerve growth factor. J Immunol 1990;144: 1886-1892.
50. Braun A, Quarcoo D, Schulte- Herbruggen O, Lommatzsch M, Hoyle G, Renz H: Nerve growth factor induces airway hyperresponsiveness in mice. Int Arch Allergy Immunol 2001;124: 205-207.
51. Braun A, Appel E, Baruch R, et al: Role of nerve growth factor in a mouse model of allergic airway inflammation and asthma. Eur J Immunol 1998; 28: 3240-3251.
52. Flugel A, Matsumuro K, Neumann H, et al: Antiinflammatory activity of nerve growth factor in experimental autoimmune encephalomyelitis: inhibition of monocyte transendothelial migration. Eur J Immunol 2001;31: 11-22.
53. di Mola FF, Friess H, Zhu ZW, et al: Nerve growth factor and Trk high affinity receptor (TrkA) gene expression in inflammatory bowel disease. Gut 2000;46: 670-679.
54. Reinshagen M, Rohm H, Steinkamp M, et al: Protective role of neurotrophins in experimental inflammation of the rat gut. Gastroenterology 2000; 119: 368-376.
55. Sann H, Dux M, Schemann M, Jancso G: Neurogenic inflammation in the gastrointestinal tract of the rat. Neurosci Lett 1996;219: 147-150.
56. Shanahan F, Anton P: Neuroendocrine modulation of the immune system. Possible implications for inflammatory bowel disease. Dig Dis Sci 1988;33: 41S- 49S.
57. Baluk P: Neurogenic inflammation in skin and airways. J Invest Dermatol Symp Proc 1997;2: 76-81.
58. Mayer EA, Raybould H, Koelbel C: Neuropeptides, inflammation, and motility. Dig Dis Sci 1988;33: 71S- 77S.
59. Jessop DS, Renshaw D, Larsen PJ, Chowdrey HS, Harbuz MS: Substance P is involved in terminating the hypothalamo- pituitary- adrenal axis response to acute stress through centrally located neurokinin- 1 receptors. Stress 2000;3: 209-220.
60. Joos GF, De Swert KO, Pauwels RA: Airway inflammation and tachykinins: prospects for the development of tachykinin receptor antagonists. Eur J Pharmacol 2001;429: 239-250.
61. Lee HR, Ho WZ, Douglas SD: Substance P augments tumor necrosis factor release in human monocyte- derived macrophages. Clin Diagn Lab Immunol 1994;1: 419-423.
62. Suzuki R, Furuno T, McKay DM, et al: Direct neurite- mast cell communication in vitro occurs via the neuropeptide substance P. J Immunol 1999;163: 2410-2415.
63. Anzai R, Seki S, Ogasawara K, et al: Interleukin- 12 induces cytotoxic NK1+ alpha beta T cells in the lungs of euthymic and athymic mice. Immunology 1996;88: 82-89.
64. Azzolina A, Bongiovanni A, Lampiasi N: Substance P induces TNF- alpha and IL- 6 production through NF kappa B in peritoneal mast cells. Biochim Biophys Acta 2003;1643: 75-83.
65. Janiszewski J, Bienenstock J, Blennerhassett MG: Picomolar doses of substance P trigger electrical responses in mast cells without degranulation. Am J Physiol 1994;267:C138-45.
66. Okabe T, Hide M, Hiragun T, Morita E, Koro O, Yamamoto S: Bone marrow derived mast cell acquire responsiveness to substance P with Ca(2+) signals and release of leukotriene B(4) via mitogenactivated protein kinase. J Neuroimmunol 2006;181: 1-12.
67. Karimi K, Redegeld FA, Blom R, Nijkamp FP: Stem cell factor and interleukin- 4 increase responsiveness of mast cells to substance P. Exp Hematol 2000;28: 626-634.
68. Bischoff SC, Schwengberg S, Lorentz A, et al: Substance P and other neuropeptides do not induce mediator release in isolated human intestinal mast cells. Neurogastroenterol Motil 2004;16: 185-193.
69. Mori N, Suzuki R, Furuno T, et al: Nerve- mast cell (RBL) interaction: RBL membrane ruffling occurs at the contact site with an activated neurite. Am J Physiol Cell Physiol 2002;283:C1738-C17 44.
70. Blennerhassett MG, Bienenstock J: Sympathetic nerve contact causes maturation of mast cells in vitro. J Neurobiol 1998;35: 173-182.
71. Suzuki A, Suzuki R, Furuno T, Teshima R, Nakanishi M: Calcium response and FcepsilonRI expression in bone marrow- derived mast cells co- cultured with SCG neurites. Biol Pharm Bull 2005;28: 1963-1965.
72. Singh LK, Pang X, Alexacos N, Letourneau R, Theoharides TC: Acute immobilization stress triggers skin mast cell degranulation via corticotropin releasing hormone, neurotensin, and substance P: a link to neurogenic skin disorders. Brain Behav Immun 1999;13: 225-239.
73. Joachim RA, Cifuentes LB, Sagach V, et al: Stress induces substance P in vagal sensory neurons innervating the mouse airways. Clin Exp Allergy 2006; 36: 1001-1010.
74. Joachim RA, Quarcoo D, Arck PC, Herz U, Renz H, Klapp BF: Stress enhances airway reactivity and airway inflammation in an animal model of allergic bronchial asthma. Psychosom Med 2003;65: 811-815.
75. Joachim RA, Sagach V, Quarcoo D, Dinh QT, Arck PC, Klapp BF: Neurokinin- 1 receptor mediates stress- exacerbated allergic airway inflammation and airway hyperresponsiveness in mice. Psychosom Med 2004;66: 564-571.
76. Fest S, Zenclussen AC, Joachim R, Hagen E, Demuth HU, Hoffmann T: Stress and substance P but not the substance P- metabolite SP5-11 trigger murine abortion by augmenting TNF- alpha levels at the feto- maternal interface. Scand J Immunol 2006;63: 42-49.
77. Peters EM, Kuhlmei A, Tobin DJ, Muller- Rover S, Klapp BF, Arck PC: Stress exposure modulates peptidergic innervation and degranulates mast cells in murine skin. Brain Behav Immun 2005;19: 252-262.
78. Pavlovic S, Daniltchenko M, Tobin DJ, et al: Further exploring the brain- skin connection: stress worsens dermatitis via substance P- dependent neurogenic inflammation in mice. J Invest Dermatol 2008;128: 434-446.
79. Kulka M, Sheen CH, Tancowny BP, Grammer LC, Schleimer RP: Neuropeptides activate human mast cell degranulation and chemokine production. Immunology 2008;123: 398-410.
80. Ottosson A, Edvinsson L: Release of histamine from dural mast cells by substance P and calcitonin generelated peptide. Cephalalgia 1997;17: 166-174.
81. Schwenger N, Dux M, de Col R, Carr R, Messlinger K: Interaction of calcitonin gene- related peptide, nitric oxide and histamine release in neurogenic blood flow and afferent activation in the rat cranial dura mater. Cephalalgia 2007;27: 481-491.
82. Forsythe P, McGarvey LP, Heaney LG, MacMahon J, Ennis M: Sensory neuropeptides induce histamine release from bronchoalveolar lavage cells in both nonasthmatic coughers and cough variant asthmatics. Clin Exp Allergy 2000;30: 225-232.
83. De Jonge F, Van Nassauw L, Adriaensen D, et al: Effect of intestinal inflammation on capsaicinsensitive afferents in the ileum of Schistosoma mansoni- infected mice. Histochem Cell Biol 2003; 119: 477-484.
84. Reinshagen M, Flamig G, Ernst S, et al: Calcitonin gene- related peptide mediates the protective effect of sensory nerves in a model of colonic injury. J Pharmacol Exp Ther 1998;286: 657-661.
85. Bulut K, Felderbauer P, Deters S, et al: Sensory neuropeptides and epithelial cell restitution: the relevance of SP- and CGRP- stimulated mast cells. Int J Colorectal Dis 2008;23: 535-541.
86. Abad C, Gomariz RP, Waschek JA: Neuropeptide mimetics and antagonists in the treatment of inflammatory disease: focus on VIP and PACAP. Curr Top Med Chem 2006;6: 151-163.
87. Sherwood NM, Krueckl SL, McRory JE: The origin and function of the pituitary adenylate cyclaseactivating polypeptide (PACAP)/glucagon superfamily. Endocr Rev 2000;21: 619-670.
88. Goetzl EJ, Sreedharan SP, Turck CW: Structurally distinctive vasoactive intestinal peptides from rat basophilic leukemia cells. J Biol Chem 1988;263: 9083-9086.
89. Goetzl EJ, Pankhaniya RR, Gaufo GO, Mu Y, Xia M, Sreedharan SP: Selectivity of effects of vasoactive intestinal peptide on macrophages and lymphocytes in compartmental immune responses. Ann NY Acad Sci 1998;840: 540-550.
90. Undem BJ, Dick EC, Buckner CK: Inhibition by vasoactive intestinal peptide of antigen- induced histamine release from guinea- pig minced lung. Eur J Pharmacol 1983;88: 247-250.
91. Tuncel N, Tore F, Sahinturk V, Ak D, Tuncel M:. Vasoactive intestinal peptide inhibits degranulation and changes granular content of mast cells: a potential therapeutic strategy in controlling septic shock. Peptides 2000;21: 81-89.
92. Akahoshi M, Song CH, Piliponsky AM, et al: Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice. J Clin Invest 2011;121: 4180-4191.
93. Tam EK, Caughey GH: Degradation of airway neuropeptides by human lung tryptase. Am J Respir Cell Mol Biol 1990;3: 27-32.
94. Tuncel N, Sener E, Cerit C, et al: Brain mast cells and therapeutic potential of vasoactive intestinal peptide in a Parkinson's disease model in rats: brain microdialysis, behavior, and microscopy. Peptides 2005;26: 827-836.
95. El-Shazly A, Berger P, Girodet PO, et al: Fraktalkine produced by airway smooth muscle cells contributes to mast cell recruitment in asthma. J Immunol 2006;176: 1860-1868.
96. Rimaniol AC, Till SJ, Garcia G, et al: The CX3C chemokine fractalkine in allergic asthma and rhinitis. J Allergy Clin Immunol 2003;112: 1139-1146.
97. Borovikova LV, Ivanova S, Zhang M, et al: Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 2000;405: 458-462.
98. Ghia JE, Blennerhassett P, Kumar- Ondiveeran H, Verdu EF, Collins SM: The vagus nerve: a tonic inhibitory influence associated with inflammatory bowel disease in a murine model. Gastroenterology 2006;131: 1122-1130.
99. Wang H, Yu M, Ochani M, et al: Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. Nature 2003;421: 384-388.
100. Karimi K, Bienenstock J, Wang L, Forsythe P: The vagus nerve modulates CD4+ T cell activity. Brain Behav Immun 2010;24: 316-323.
101. Williams RM, Berthoud HR, Stead RH: Vagal afferent nerve fibres contact mast cells in rat small intestinal mucosa. Neuroimmunomodulation 1997;4: 266-270.
102. Luyer MD, Greve JW, Hadfoune M, Jacobs JA, Dejong CH, Buurman WA: Nutritional stimulation of cholecystokinin receptors inhibits inflammation via the vagus nerve. J Exp Med 2005;202: 1023-1029.
103. Tracey KJ: Fat meets the cholinergic antiinflammatory pathway. J Exp Med 2005;202: 1017-1021.
104. Kageyama- Yahara N, Suehiro Y, Yamamoto T, Kadowaki M: IgE- induced degranulation of mucosal mast cells is negatively regulated via nicotinic acetylcholine receptors. Biochem Biophys Res Commun 2008;377: 321-325.
105. Mishra NC, Rir- sima- ah J, Boyd RT, et al: Nicotine inhibits Fc epsilon RI- induced cysteinyl leukotrienes and cytokine production without affecting mast cell degranulation through alpha 7/alpha 9/ alpha 10- nicotinic receptors. J Immunol 2010;185: 588-596.
106. Kindt F, Wiegand S, Niemeier V, et al: Reduced expression of nicotinic alpha subunits 3, 7, 9 and 10 in lesional and nonlesional atopic dermatitis skin but enhanced expression of alpha subunits 3 and 5 in mast cells. Br J Dermatol 2008;159: 847-857.
107. Fantozzi R, Masini E, Blandina P, Mannaioni PF, Bani- Sacchi T: Release of histamine from rat mast cells by acetylcholine. Nature 1978;273: 473-474.
108. Masini E, Fantozzi R, Conti A, Blandina P, Brunelleschi S, Mannaioni PF: Mast cell heterogeneity in response to cholinergic stimulation. Int Arch Allergy Appl Immunol 1985;77: 184-185.
109. Leung KB, Pearce FL: A comparison of histamine secretion from peritoneal mast cells of the rat and hamster. Br J Pharmacol 1984;81: 693-701.
110. Kazimierczak W, Adamas B, Maslinski C: Failure of acetylcholine to release histamine from rat mast cells. Agents Actions 1980;10: 1-3.
111. Rossi R, Johansson O: Cutaneous innervation and the role of neuronal peptides in cutaneous inflammation: a minireview. Eur J Dermatol 1998;8: 299-306.
112. Ansel JC, Armstrong CA, Song I, et al: Interactions of the skin and nervous system. J Investig Dermatol Symp Proc 1997;2: 23-26.
113. Church MK, el- Lati S, Caulfield JP: Neuropeptideinduced secretion from human skin mast cells. Int Arch Allergy Appl Immunol 1991;94: 310-318.
114. Siebenhaar F, Magerl M, Peters EM, Hendrix S, Metz M, Maurer M: Mast cell- driven skin inflammation is impaired in the absence of sensory nerves. J Allergy Clin Immunol 2008;121: 955-961.
115. Hart PH, Grimbaldeston MA, Swift GJ, Jaksic A, Noonan FP, Finlay- Jones JJ: Dermal mast cells determine susceptibility to ultraviolet B- induced systemic suppression of contact hypersensitivity responses in mice. J Exp Med 1998;187: 2045-2053.
116. Hart PH, Townley SL, Grimbaldeston MA, Khalil Z, Finlay- Jones JJ: Mast cells, neuropeptides, histamine, and prostaglandins in UV- induced systemic immunosuppression. Methods 2002;28: 79-89.
117. Jarvikallio A, Harvima IT, Naukkarinen A: Mast cells, nerves and neuropeptides in atopic dermatitis and nummular eczema. Arch Dermatol Res 2003; 295: 2-7.
118. Detmar M, Brown LF, Schon MP, et al: Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice. J Invest Dermatol 1998;111: 1-6.
119. Arck P, Paus R: From the brain- skin connection: the neuroendocrine- immune misalliance of stress and itch. Neuroimmunomodulation 2006;13: 347-356.
120. Theoharides TC, Zhang B, Kempuraj D, et al: IL- 33 augments substance P- induced VEGF secretion from human mast cells and is increased in psoriatic skin. Proc Natl Acad Sci USA 2010;107: 4448-4453.
121. Theoharides TC, Spanos C, Pang X, et al: Stressinduced intracranial mast cell degranulation: a corticotropin- releasing hormone- mediated effect. Endocrinology 1995;136: 5745-5750.
122. Asadi S, Alysandratos KD, Angelidou A, et al: Substance P (SP) induces expression of functional corticotropin- releasing hormone receptor- 1 (CRHR- 1) in human mast cells. J Invest Dermatol 2012;132: 324-329.
123. Stead RH: Nerve remodelling during intestinal inflammation. Ann NY Acad Sci 1992;664: 443-455.
124. Newson B, Dahlstrom A, Enerback L, Ahlman H: Suggestive evidence for a direct innervation of mucosal mast cells. Neuroscience 1983;10: 565-570.
125. Shanahan F, Denburg JA, Fox J, Bienenstock J, Befus D: Mast cell heterogeneity: effects of neuroenteric peptides on histamine release. J Immunol 1985;135: 1331-1337.
126. Raithel M, Schneider HT, Hahn EG: Effect of substance P on histamine secretion from gut mucosa in inflammatory bowel disease. Scand J Gastroenterol 1999;34: 496-503.
127. Koon HW, Pothoulakis C: Immunomodulatory properties of substance P: the gastrointestinal system as a model. Ann NY Acad Sci 2006;1088: 23-40.
128. Jiang W, Kreis ME, Eastwood C, Kirkup AJ, Humphrey PP, Grundy D: 5- HT(3) and histamine H(1) receptors mediate afferent nerve sensitivity to intestinal anaphylaxis in rats. Gastroenterology 2000;119: 1267-1275.
129. Castagliuolo I, Riegler M, Pasha A, et al: Neurokinin- 1 (NK- 1) receptor is required in Clostridium difficile- induced enteritis. J Clin Invest 1998;101: 1547-1550.
130. Linard C, Marquette C, Strup C, Aigueperse J, Mathe D: Involvement of primary afferent nerves after abdominal irradiation: consequences on ileal contractile activity and inflammatory mediator release in the rat. Dig Dis Sci 2003;48: 688-697.
131. Margolis KG, Gershon MD: Neuropeptides and inflammatory bowel disease. Curr Opin Gastroenterol 2009;25: 503-511.
132. Carraway R, Cochrane DE, Lansman JB, Leeman SE, Paterson BM, Welch HJ: Neurotensin stimulates exocytotic histamine secretion from rat mast cells and elevates plasma histamine levels. J Physiol 1982; 323: 403-414.
133. Cochrane DE, Carraway RE, Harrington K, Laudano M, Rawlings S, Feldberg RS: HMC- 1 human mast cells synthesize neurotensin (NT) precursor, secrete bioactive NT- like peptide(s) and express NT receptor NTS1. Inflamm Res 2011;60: 1139-1151.
134. Wershil BK, Castagliuolo I, Pothoulakis C: Direct evidence of mast cell involvement in Clostridium difficile toxin A- induced enteritis in mice. Gastroenterology 1998;114: 956-964.
135. Wood JD: Neuropathophysiology of functional gastrointestinal disorders. World J Gastroenterol 2007; 13: 1313-1332.
136. Wang L, Stanisz AM, Wershil BK, Galli SJ, Perdue MH: Substance P induces ion secretion in mouse small intestine through effects on enteric nerves and mast cells. Am J Physiol 1995;269:G85-92.
137. Wang YZ, Palmer JM, Cooke HJ: Neuroimmune regulation of colonic secretion in guinea pigs. Am J Physiol 1991;260:G307-314.
138. Santos J, Saunders PR, Hanssen NP, et al: Corticotropin- releasing hormone mimics stressinduced colonic epithelial pathophysiology in the rat. Am J Physiol 1999;277:G391-399.
139. Wallon C, Yang PC, Keita AV, et al: Corticotropinreleasing hormone (CRH) regulates macromolecular permeability via mast cells in normal human colonic biopsies in vitro. Gut 2008;57: 50-58.
140. Wood JD: Neuropathophysiology of irritable bowel syndrome. J Clin Gastroenterol 2002;35:S11-22.
141. Pang X, Boucher W, Triadafilopoulos G, Sant GR, Theoharides TC: Mast cell and substance P- positive nerve involvement in a patient with both irritable bowel syndrome and interstitial cystitis. Urology 1996;47: 436-438.
142. Tunc B, Filik L, Altintas E, Turhan N, Ulker A, Dagli U: Mucosal mast cells in irritable bowel syndrome and inflammatory bowel disease. Acta Medica (Hradec Kralove) 2005;48: 163-164.
143. Cremon C, Gargano L, Morselli- Labate AM, et al: Mucosal immune activation in irritable bowel syndrome: gender- dependence and association with digestive symptoms. Am J Gastroenterol 2009; 104: 392-400.
144. Barbara G, Stanghellini V, De Giorgio R, et al: Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome. Gastroenterology 2004;126: 693-702.
145. Park CH, Joo YE, Choi SK, Rew JS, Kim SJ, Lee MC: Activated mast cells infiltrate in close proximity to enteric nerves in diarrhea- predominant irritable bowel syndrome. J Korean Med Sci 2003;18: 204-210.
146. Park JH, Rhee PL, Kim HS, et al: Mucosal mast cell counts correlate with visceral hypersensitivity in patients with diarrhea predominant irritable bowel syndrome. J Gastroenterol Hepatol 2006;21: 71-78.
147. O'Sullivan M, Clayton N, Breslin NP, et al: Increased mast cells in the irritable bowel syndrome. Neurogastroenterol Motil 2000;12: 449-457.
148. Carr MJ, Undem BJ: Bronchopulmonary afferent nerves. Respirology 2003;8: 291-301.
149. Akiyama H, Amano H, Bienenstock J: Rat tracheal epithelial responses to water avoidance stress. J Allergy Clin Immunol 2005;116: 318-324.
150. Sestini P, Bienenstock J, Crowe SE, et al: Ion transport in rat tracheal epithelium in vitro. Role of capsaicin- sensitive nerves in allergic reactions. Am Rev Respir Dis. 1990;141: 393-397.
151. Cyphert JM, Kovarova M, Allen IC, et al: Cooperation between mast cells and neurons is essential for antigen- mediated bronchoconstriction. J Immunol 2009;182: 7430-7439.
152. Rogerio AP, Andrade EL, Calixto JB: C- fibers, but not the transient potential receptor vanilloid 1 (TRPV1), play a role in experimental allergic airway inflammation. Eur J Pharmacol 2011;662: 55-62.
153. Myers AC, Undem BJ, Weinreich D: Influence of antigen on membrane properties of guinea pig bronchial ganglion neurons. J Appl Physiol 1991;71: 970-976.
154. Kajekar R, Undem BJ, Myers AC: Role of cyclooxygenase activation and prostaglandins in antigeninduced excitability changes of bronchial parasympathetic ganglia neurons. Am J Physiol Lung Cell Mol Physiol 2003;284:L581-587.
155. Mitchell RW, Ndukuw IM, Ikeda K, Arbetter K, Leff AR: Effect of immune sensitization on stimulated ACh release from trachealis muscle in vitro. Am J Physiol 1993;265:L13-18.
156. Weigand LA, Myers AC, Meeker S, Undem BJ: Mast cell- cholinergic nerve interaction in mouse airways. J Physiol 2009;587: 3355-3362.
157. Kushnir- Sukhov NM, Brown JM, Wu Y, Kirshenbaum A, Metcalfe DD: Human mast cells are capable of serotonin synthesis and release. J Allergy Clin Immunol 2007;119: 498-499.
158. Davis C, Kannan MS, Jones TR, Daniel EE: Control of human airway smooth muscle: in vitro studies. J Appl Physiol 1982;53: 1080-1087.
159. Keith IM, Jin J, Saban R: Nerve- mast cell interaction in normal guinea pig urinary bladder. J Comp Neurol 1995;363: 28-36.
160. Theoharides TC, Pang X, Letourneau R, Sant GR: Interstitial cystitis: a neuroimmunoendocrine disorder. Ann NY Acad Sci 1998;840: 619-634.
161. Saban R, Saban MR, Nguyen NB, et al: Neurokinin- 1 (NK- 1) receptor is required in antigen- induced cystitis. Am J Pathol 2000;156: 775-780.
162. Jasmin L, Janni G, Ohara PT, Rabkin SD: CNS induced neurogenic cystitis is associated with bladder mast cell degranulation in the rat. J Urol 2000;164: 852-855.
163. Kastrup J, Hald T, Larsen S, Nielsen VG: Histamine content and mast cell count of detrusor muscle in patients with interstitial cystitis and other types of chronic cystitis. Br J Urol 1983;55: 495-500.
164. Larsen MS, Mortensen S, Nordling J, Horn T: Quantifying mast cells in bladder pain syndrome by immunohistochemical analysis. BJU Int 2008;102: 204-207.
165. Letourneau R, Sant GR, el- Mansoury M, Theoharides TC: Activation of bladder mast cells in interstitial cystitis. Int J Tissue React 1992;14: 307-312.
166. Silver R, Silverman AJ, Vitkovic L, Lederhendler II: Mast cells in the brain: evidence and functional significance. Trends Neurosci 1996;19: 25-31.
167. Zhuang X, Silverman AJ, Silver R: Distribution and local differentiation of mast cells in the parenchyma of the forebrain. J Comp Neurol 1999;408: 477-488.
168. Rozniecki JJ, Hauser SL, Stein M, Lincoln R, Theoharides TC: Elevated mast cell tryptase in cerebrospinal fluid of multiple sclerosis patients. Ann Neurol 1995;37: 63-66.
169. Dines KC, Powell HC: Mast cell interactions with the nervous system: relationship to mechanisms of disease. J Neuropathol Exp Neurol 1997;56: 627-640.
170. Lin B, Pirrung MC, Deng L, Li Z, Liu Y, Webster NJ: Neuroprotection by small molecule activators of the nerve growth factor receptor. J Pharmacol Exp Ther 2007;322: 59-69.
171. Nguyen N, Lee SB, Lee YS, Lee KH, Ahn JY: Neuroprotection by NGF and BDNF against neurotoxin- exerted apoptotic death in neural stem cells are mediated through Trk receptors, activating PI3- kinase and MAPK pathways. Neurochem Res 2009;34: 942-951.
172. Zhu Y, Yang GY, Ahlemeyer B, et al: Transforming growth factor- beta 1 increases bad phosphorylation and protects neurons against damage. J Neurosci 2002;22: 3898-3909.
173. Zhang ZG, Lu TS, Yuan HY: Neuroprotective effects of ultra- low- molecular- weight heparin in vitro and vivo models of ischemic injury. Fundam Clin Pharmacol 2011;25: 300-303.
174. Knyihar- Csillik E, Chadaide Z, Okuno E, et al: Kynurenine aminotransferase in the supratentorial dura mater of the rat: effect of stimulation of the trigeminal ganglion. Exp Neurol 2004;186: 242-247.
175. Ibrahim MZ: The mast cells of the mammalian central nervous system. IX. Development of the mast cells in the brain of the young rat. Acta Anat (Basel) 1985;124: 149-158.
176. Florenzano F, Bentivoglio M: Degranulation, density, and distribution of mast cells in the rat thalamus: a light and electron microscopic study in basal conditions and after intracerebroventricular administration of nerve growth factor. J Comp Neurol 2000;424: 651-669.
177. Dropp JJ: Mast cells in the human brain. Acta Anat (Basel) 1979;105: 505-513.
178. Theoharides TC: Mast cells: the immune gate to the brain. Life Sci 1990;46: 607-617.
179. Zhuang X, Silverman AJ, Silver R: Brain mast cell degranulation regulates blood- brain barrier. J Neurobiol 1996;31: 393-403.
180. Cirulli F, Pistillo L, de Acetis L, Alleva E, Aloe L: Increased number of mast cells in the central nervous system of adult male mice following chronic subordination stress. Brain Behav Immun 1998;12: 123-133.
181. Kriegsfeld LJ, Hotchkiss AK, Demas GE, Silverman AJ, Silver R, Nelson RJ: Brain mast cells are influenced by chemosensory cues associated with estrus induction in female prairie voles (Microtus ochrogaster). Horm Behav 2003;44: 377-384.
182. Cirulli F, Pistillo L, de Acetis L, Alleva E, Aloe L: Increased number of mast cells in the central nervous system of adult male mice following chronic subordination stress. Brain Behav Immun 1998;12: 123-133.
183. Serviere J, Dubayle D, Menetrey D: Increase of rat medial habenular mast cell numbers by systemic administration of cyclophosphamide. Toxicol Lett 2003;145: 143-152.
184. Amat J, Sparks PD, Matus- Amat P, Griggs J, Watkins LR, Maier SF: The role of the habenular complex in the elevation of dorsal raphe nucleus serotonin and the changes in the behavioral responses produced by uncontrollable stress. Brain Res 2001;917: 118-126.
185. Shumake J, Gonzalez- Lima F: Brain systems underlying susceptibility to helplessness and depression. Behav Cogn Neurosci Rev 2003;2: 198-221.
186. Morris JS, Smith KA, Cowen PJ, Friston KJ, Dolan RJ: Covariation of activity in habenula and dorsal raphe nuclei following tryptophan depletion. Neuroimage 1999;10: 163-172.
187. Porzionato A, Macchi V, Parenti A, De Caro R: The distribution of mast cells in the human area postrema. J Anat 2004;204: 141-147.
188. Silverman AJ, Millar RP, King JA, Zhuang X, Silver R: Mast cells with gonadotropin- releasing hormonelike immunoreactivity in the brain of doves. Proc Natl Acad Sci USA 1994;91: 3695-3699.
189. Matsumoto I, Inoue Y, Shimada T, Aikawa T: Brain mast cells act as an immune gate to the hypothalamicpituitary- adrenal axis in dogs. J Exp Med 2001;194: 71-78.
190. Barnes PJ: Corticosteroid effects on cell signalling. Eur Respir J 2006;27: 413-426.
191. Nautiyal KM, Ribeiro AC, Pfaff DW, Silver R: Brain mast cells link the immune system to anxiety- like behavior. Proc Natl Acad Sci USA 2008;105: 18053-18057.