Mechanisms of CYP3A induction by glucocorticoids in human fetal liver cells

Drug Metabolism and Pharmacokinetics

Volumn 27, Issue 6, 2012, Pages 653-657

  Matsunaga, Tamihide ^a,b   Maruyama, Masataka ^a,c   Matsubara, Tsutomu ^d,e   Nagata, Kiyoshi ^f   Yamazoe, Yasushi ^d   Ohmori, Shigeru ^a  

^a SHINSHU UNIVERSITY HOSPITAL   (Japan)

^b NAGOYA CITY UNIVERSITY   (Japan)

^c Fujimi Kogen Hospital   (Japan)

^d TOHOKU UNIVERSITY   (Japan)

^e OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^f TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

CYP3A; Glucocorticoid; Glucocorticoid receptor; Human fetal liver cells; Induction; Small interfering RNA; Specific small interfering RNA

Indexed keywords

BETAMETHASONE; CORTISONE; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; CYTOCHROME P450 3A7; DEXAMETHASONE; FLUDROCORTISONE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; HYDROCORTISONE; MESSENGER RNA; PREDNISOLONE; SMALL INTERFERING RNA;

ANTIINFLAMMATORY ACTIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; ENZYME INDUCTION; FETUS; FETUS LIVER; GENE ACTIVATION; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; LIVER CELL; NOTE; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE;

EID: 84871676496     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.DMPK-12-NT-018     Document Type: Article

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