-
1
-
-
33751074919
-
Metals and Alzheimer's disease
-
Adlard P. Bush A. (2006) Metals and Alzheimer's disease. J Alzheimers Dis 10: 145–163.
-
(2006)
J Alzheimers Dis
, vol.10
, pp. 145-163
-
-
Adlard, P.1
Bush, A.2
-
2
-
-
33845388059
-
A phase II study targeting amyloid-beta with 3APS in mild-to-moderate Alzheimer disease
-
Aisen P. Saumier D. Briand R. Laurin J. Gervais F. Tremblay P. et al. (2006) A phase II study targeting amyloid-beta with 3APS in mild-to-moderate Alzheimer disease. Neurology 67: 1757–1763.
-
(2006)
Neurology
, vol.67
, pp. 1757-1763
-
-
Aisen, P.1
Saumier, D.2
Briand, R.3
Laurin, J.4
Gervais, F.5
Tremblay, P.6
-
3
-
-
0037638809
-
Effects of rofecoxib or naproxen vs placebo on Alzheimer's disease progression: a randomized controlled trial
-
Aisen P. Schafer K. Grundman M. Pfeiffer E. Sano M. Davis K. et al. (2003) Effects of rofecoxib or naproxen vs placebo on Alzheimer's disease progression: a randomized controlled trial. JAMA 289: 2819–2826.
-
(2003)
JAMA
, vol.289
, pp. 2819-2826
-
-
Aisen, P.1
Schafer, K.2
Grundman, M.3
Pfeiffer, E.4
Sano, M.5
Davis, K.6
-
4
-
-
0037046179
-
Randomized pilot study of nimesulide treatment in Alzheimer's disease
-
Aisen P. Schmeidler J. Pasinetti G. (2002) Randomized pilot study of nimesulide treatment in Alzheimer's disease. Neurology 58: 1050–1054.
-
(2002)
Neurology
, vol.58
, pp. 1050-1054
-
-
Aisen, P.1
Schmeidler, J.2
Pasinetti, G.3
-
5
-
-
79960040736
-
Progress in the development of beta-secretase inhibitors for Alzheimer's disease
-
Albert J.S. (2009) Progress in the development of beta-secretase inhibitors for Alzheimer's disease. Prog Med Chem 48: 133–361.
-
(2009)
Prog Med Chem
, vol.48
, pp. 133-361
-
-
Albert, J.S.1
-
7
-
-
1842845118
-
Preserved cognitive function after 12 months of treatment with rivastigmine in mild Alzheimer's disease in comparison with untreated AD and MCI patients
-
Almkvist O. Darreh-Shori T. Stefanova E. Spiegel R. Nordberg A. (2004) Preserved cognitive function after 12 months of treatment with rivastigmine in mild Alzheimer's disease in comparison with untreated AD and MCI patients. Eur J Neurol 11: 253–261.
-
(2004)
Eur J Neurol
, vol.11
, pp. 253-261
-
-
Almkvist, O.1
Darreh-Shori, T.2
Stefanova, E.3
Spiegel, R.4
Nordberg, A.5
-
8
-
-
68349127509
-
Relative tolerability of Alzheimer's disease treatments
-
Alva G. Cummings J. (2008) Relative tolerability of Alzheimer's disease treatments. Psychiatry (Edgmont) 5: 27–36.
-
(2008)
Psychiatry (Edgmont)
, vol.5
, pp. 27-36
-
-
Alva, G.1
Cummings, J.2
-
9
-
-
77956193823
-
Management of neuropsychiatric symptoms in people with dementia
-
Ballard C. Corbett A. (2010) Management of neuropsychiatric symptoms in people with dementia. CNS Drugs 24: 729–739.
-
(2010)
CNS Drugs
, vol.24
, pp. 729-739
-
-
Ballard, C.1
Corbett, A.2
-
10
-
-
70350141271
-
Management of agitation and aggression associated with Alzheimer's disease: controversies and possible solutions
-
Ballard C. Corbett A. Chitramohan R. Aarsland D. (2009) Management of agitation and aggression associated with Alzheimer's disease: controversies and possible solutions. Curr Opin Psychiatry 22: 532–540.
-
(2009)
Curr Opin Psychiatry
, vol.22
, pp. 532-540
-
-
Ballard, C.1
Corbett, A.2
Chitramohan, R.3
Aarsland, D.4
-
11
-
-
79960908306
-
Sertraline or mirtazapine for depression in dementia (HTA-SADD): a randomised, multicentre, double-blind, placebo-controlled trial
-
Banerjee S. Hellier J. Dewey M. Romeo R. Ballard C. Baldwin R. (2011) Sertraline or mirtazapine for depression in dementia (HTA-SADD): a randomised, multicentre, double-blind, placebo-controlled trial. Lancet 378: 403–411.
-
(2011)
Lancet
, vol.378
, pp. 403-411
-
-
Banerjee, S.1
Hellier, J.2
Dewey, M.3
Romeo, R.4
Ballard, C.5
Baldwin, R.6
-
12
-
-
53749102630
-
Therapeutic strategies for Alzheimer's disease
-
Barten D. Albright C. (2008) Therapeutic strategies for Alzheimer's disease. Mol Neurobiol 37: 171–186.
-
(2008)
Mol Neurobiol
, vol.37
, pp. 171-186
-
-
Barten, D.1
Albright, C.2
-
13
-
-
0019972810
-
The cholinergic hypothesis of geriatric memory dysfunction
-
Bartus R. Dean R. Beer B. Lippa A. (1982) The cholinergic hypothesis of geriatric memory dysfunction. Science 217: 408–414.
-
(1982)
Science
, vol.217
, pp. 408-414
-
-
Bartus, R.1
Dean, R.2
Beer, B.3
Lippa, A.4
-
14
-
-
1842427909
-
Colostrinin (a naturally occurring, proline-rich, polypeptide mixture) in the treatment of Alzheimer's disease
-
Bilikiewicz A. Gaus W. (2004). Colostrinin (a naturally occurring, proline-rich, polypeptide mixture) in the treatment of Alzheimer's disease. J Alzheimers Dis 6: 17–26.
-
(2004)
J Alzheimers Dis
, vol.6
, pp. 17-26
-
-
Bilikiewicz, A.1
Gaus, W.2
-
15
-
-
42749100518
-
Cholinesterase inhibitors for Alzheimer's disease
-
CD005593.
-
Birks J. (2006) Cholinesterase inhibitors for Alzheimer's disease. Cochrane Database Syst Rev (1): CD005593.
-
(2006)
Cochrane Database Syst Rev
, vol.1
-
-
Birks, J.1
-
16
-
-
34547614787
-
Caregiver preference for rivastigmine patches versus capsules for the treatment of Alzheimer disease
-
Blesa R. Ballard C. Orgogozo R. Lane J. Thomas S. (2007) Caregiver preference for rivastigmine patches versus capsules for the treatment of Alzheimer disease. Neurology 69: 23–28.
-
(2007)
Neurology
, vol.69
, pp. 23-28
-
-
Blesa, R.1
Ballard, C.2
Orgogozo, R.3
Lane, J.4
Thomas, S.5
-
17
-
-
47949132196
-
Active and passive immunotherapy for neurodegenerative disorders
-
Brody D. Holtzman D. (2008) Active and passive immunotherapy for neurodegenerative disorders. Annu Rev Neurosci 31: 175–193.
-
(2008)
Annu Rev Neurosci
, vol.31
, pp. 175-193
-
-
Brody, D.1
Holtzman, D.2
-
18
-
-
38049061575
-
Optimizing phase II of drug development for disease-modifying compounds
-
Cummings J. (2008 a) Optimizing phase II of drug development for disease-modifying compounds. Alzheimers Dement 4(1 Suppl. 1): 15–20.
-
(2008)
Alzheimers Dement
, vol.4
, Issue.1 Suppl. 1
, pp. 15-20
-
-
Cummings, J.1
-
19
-
-
39749156940
-
The black book of Alzheimer's disease, part 1
-
Cummings J. (2008 b) The black book of Alzheimer's disease, part 1. Primary Psychiatry 15: 66–76.
-
(2008)
Primary Psychiatry
, vol.15
, pp. 66-76
-
-
Cummings, J.1
-
20
-
-
0031949925
-
The cholinergic hypothesis of neuropsychiatric symptoms in Alzheimer's disease
-
Cummings J. Back C. (1998) The cholinergic hypothesis of neuropsychiatric symptoms in Alzheimer's disease. Am J Geriatr Psychiatry 6: 64–78.
-
(1998)
Am J Geriatr Psychiatry
, vol.6
, pp. 64-78
-
-
Cummings, J.1
Back, C.2
-
22
-
-
77949962484
-
Intravenous immunoglobulins as a treatment for Alzheimer's disease: rationale and current evidence
-
Dodel R. Neff F. Noelker C. Pul R. Du Y. Bacher M. et al. (2010) Intravenous immunoglobulins as a treatment for Alzheimer's disease: rationale and current evidence. Drugs 70: 513–528.
-
(2010)
Drugs
, vol.70
, pp. 513-528
-
-
Dodel, R.1
Neff, F.2
Noelker, C.3
Pul, R.4
Du, Y.5
Bacher, M.6
-
24
-
-
0036993442
-
A clinical overview of cholinesterase inhibitors in Alzheimer's disease
-
Farlow M. (2002) A clinical overview of cholinesterase inhibitors in Alzheimer's disease. Int Psychogeriatr 14(Suppl. 1): 93–126.
-
(2002)
Int Psychogeriatr
, vol.14
, pp. 93-126
-
-
Farlow, M.1
-
25
-
-
74549199412
-
A 25-week, open label trial investigating rivastigmine transdermal patches with concomitant memantine in mild-to-moderate Alzheimer's disease: a post hoc analysis
-
Farlow M. Alva G. Meng X. Olin J. (2010) A 25-week, open label trial investigating rivastigmine transdermal patches with concomitant memantine in mild-to-moderate Alzheimer's disease: a post hoc analysis. Curr Med Res Opin 26: 263–269.
-
(2010)
Curr Med Res Opin
, vol.26
, pp. 263-269
-
-
Farlow, M.1
Alva, G.2
Meng, X.3
Olin, J.4
-
26
-
-
0033679259
-
A 52-week study of the efficacy of rivastigmine in patients with mild to moderately severe Alzheimer's disease
-
Farlow M. Anand R. Messina J. Hartman R. Jr Veach J. (2000) A 52-week study of the efficacy of rivastigmine in patients with mild to moderately severe Alzheimer's disease. Eur Neurol. 44: 236–241.
-
(2000)
Eur Neurol
, vol.44
, pp. 236-241
-
-
Farlow, M.1
Anand, R.2
Messina, J.3
Hartman, R.4
Veach, J.5
-
27
-
-
77954344206
-
PBT 2 rapidly improves cognition in Alzheimer's disease: additional phase II analyses
-
Faux N. Ritchie C. Gunn A. Rembach A. Tsatsanis A. Bedo J. et al. (2010) PBT 2 rapidly improves cognition in Alzheimer's disease: additional phase II analyses. J Alzheimers Dis 20: 509–516.
-
(2010)
J Alzheimers Dis
, vol.20
, pp. 509-516
-
-
Faux, N.1
Ritchie, C.2
Gunn, A.3
Rembach, A.4
Tsatsanis, A.5
Bedo, J.6
-
28
-
-
77949908687
-
Randomized controlled trial of atorvastatin in mild to moderate Alzheimer disease: LEADe
-
Feldman H. Doody R. Kivipelto M. Sparks D. Waters D. Jones R. et al. (2010) Randomized controlled trial of atorvastatin in mild to moderate Alzheimer disease: LEADe. Neurology 74: 956–964.
-
(2010)
Neurology
, vol.74
, pp. 956-964
-
-
Feldman, H.1
Doody, R.2
Kivipelto, M.3
Sparks, D.4
Waters, D.5
Jones, R.6
-
29
-
-
33845439410
-
Memantine MEM-MD-02 Study Group
-
ADL in moderate-to-severe Alzheimer disease: an analysis of the treatment effects of memantine in patients receiving stable donepezil treatment
-
Feldman H. Schmitt F. Olin J. Memantine MEM-MD-02 Study Group (2006) ADL in moderate-to-severe Alzheimer disease: an analysis of the treatment effects of memantine in patients receiving stable donepezil treatment. Alzheimer Dis Assoc Disord 20: 263–268.
-
(2006)
Alzheimer Dis Assoc Disord
, vol.20
, pp. 263-268
-
-
Feldman, H.1
Schmitt, F.2
Olin, J.3
-
31
-
-
79955546563
-
Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial
-
Forlenza O. Diniz B. Radanovic M. Santos F. Talib L. Gattaz W. (2011) Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial. Br J Psychiatry 198: 351–356.
-
(2011)
Br J Psychiatry
, vol.198
, pp. 351-356
-
-
Forlenza, O.1
Diniz, B.2
Radanovic, M.3
Santos, F.4
Talib, L.5
Gattaz, W.6
-
32
-
-
79959370222
-
Disease-modifying treatments for Alzheimer's disease
-
Galimberti D. Scarpini E. (2011) Disease-modifying treatments for Alzheimer's disease. Ther Adv Neurol Disord 4: 203–216.
-
(2011)
Ther Adv Neurol Disord
, vol.4
, pp. 203-216
-
-
Galimberti, D.1
Scarpini, E.2
-
33
-
-
70349637413
-
Effect of tramiprosate in patients with mild-to-moderate Alzheimer's disease: exploratory analyses of the MRI sub-group of the Alphase study
-
Gauthier S. Aisen P. Ferris S. Saumier D. Duong A. Haine D. et al. (2009) Effect of tramiprosate in patients with mild-to-moderate Alzheimer's disease: exploratory analyses of the MRI sub-group of the Alphase study. J Nutr Health Aging 13: 550–557.
-
(2009)
J Nutr Health Aging
, vol.13
, pp. 550-557
-
-
Gauthier, S.1
Aisen, P.2
Ferris, S.3
Saumier, D.4
Duong, A.5
Haine, D.6
-
34
-
-
84655162702
-
Developing β-secretase inhibitors for treatment of Alzheimer's disease
-
Ghosh A. Brindisi M. Tang J. (2012) Developing β-secretase inhibitors for treatment of Alzheimer's disease. J Neurochem 120: 71–83.
-
(2012)
J Neurochem
, vol.120
, pp. 71-83
-
-
Ghosh, A.1
Brindisi, M.2
Tang, J.3
-
35
-
-
66149160502
-
Syncope and its consequences in patients with dementia receiving cholinesterase inhibitors: a population-based cohort study
-
Gill S. Anderson G. Fischer H. Bell C. Li P. Normand S. et al. (2009) Syncope and its consequences in patients with dementia receiving cholinesterase inhibitors: a population-based cohort study. Arch Intern Med 169: 867–873.
-
(2009)
Arch Intern Med
, vol.169
, pp. 867-873
-
-
Gill, S.1
Anderson, G.2
Fischer, H.3
Bell, C.4
Li, P.5
Normand, S.6
-
36
-
-
20944448555
-
Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial
-
Gilman S. Koller M. Black R. Jenkins L. Griffith S. Fox N. et al. (2005) Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial. Neurology 64: 1553–1562.
-
(2005)
Neurology
, vol.64
, pp. 1553-1562
-
-
Gilman, S.1
Koller, M.2
Black, R.3
Jenkins, L.4
Griffith, S.5
Fox, N.6
-
37
-
-
13544272023
-
The Abeta hypothesis: leading us to rationally-designed therapeutic strategies for the treatment or prevention of Alzheimer disease
-
Golde T. (2005) The Abeta hypothesis: leading us to rationally-designed therapeutic strategies for the treatment or prevention of Alzheimer disease. Brain Pathol 15: 84–87.
-
(2005)
Brain Pathol
, vol.15
, pp. 84-87
-
-
Golde, T.1
-
38
-
-
33644869901
-
Inflammation and neurodegenerative diseases
-
Griffin W. (2006) Inflammation and neurodegenerative diseases. Am J Clin Nutr 3(Suppl.): 470–474.
-
(2006)
Am J Clin Nutr
, vol.3
, pp. 470-474
-
-
Griffin, W.1
-
39
-
-
39349087157
-
Perispinal etanercept: potential as an Alzheimer therapeutic
-
Griffin W. (2008) Perispinal etanercept: potential as an Alzheimer therapeutic. J Neuroinflammation 5: 3.
-
(2008)
J Neuroinflammation
, vol.5
, pp. 3
-
-
Griffin, W.1
-
40
-
-
51349134160
-
Hope in Alzheimer's fight emerges from unexpected places
-
Gura T. (2008) Hope in Alzheimer's fight emerges from unexpected places. Nat Med 14: 894.
-
(2008)
Nat Med
, vol.14
, pp. 894
-
-
Gura, T.1
-
41
-
-
67649206084
-
Lithium trial in Alzheimer's disease: a randomized, single-blind, placebo-controlled, multicenter 10-week study
-
Hampel H. Ewers M. Bürger K. Annas P. Mörtberg A. Bogstedt A. et al. (2009) Lithium trial in Alzheimer's disease: a randomized, single-blind, placebo-controlled, multicenter 10-week study. J Clin Psychiatry 70: 922–931.
-
(2009)
J Clin Psychiatry
, vol.70
, pp. 922-931
-
-
Hampel, H.1
Ewers, M.2
Bürger, K.3
Annas, P.4
Mörtberg, A.5
Bogstedt, A.6
-
42
-
-
47849119964
-
Efficacy and safety of donepezil, galantamine, and rivastigmine for the treatment of Alzheimer's disease: a systematic review and meta-analysis
-
Hansen R. Gartlehner G. Webb A. Morgan L. Moore C. Jonas D. (2008) Efficacy and safety of donepezil, galantamine, and rivastigmine for the treatment of Alzheimer's disease: a systematic review and meta-analysis. Clin Interv Aging 3: 211–225.
-
(2008)
Clin Interv Aging
, vol.3
, pp. 211-225
-
-
Hansen, R.1
Gartlehner, G.2
Webb, A.3
Morgan, L.4
Moore, C.5
Jonas, D.6
-
43
-
-
80053439054
-
Mucosal immunotherapy in an Alzheimer mouse model by recombinant Sendai virus vector carrying Aβ1-43/IL-10 cDNA
-
Hara H. Mouri A. Yonemitsu Y. Nabeshima T. Tabira T. (2011) Mucosal immunotherapy in an Alzheimer mouse model by recombinant Sendai virus vector carrying Aβ1-43/IL-10 cDNA. Vaccine 29: 7474–7482.
-
(2011)
Vaccine
, vol.29
, pp. 7474-7482
-
-
Hara, H.1
Mouri, A.2
Yonemitsu, Y.3
Nabeshima, T.4
Tabira, T.5
-
44
-
-
80053971718
-
Current and emerging drug treatment options for Alzheimer's disease: a systematic review
-
Herrmann N. Chau S. Kircanski I. Lanctôt K. (2011) Current and emerging drug treatment options for Alzheimer's disease: a systematic review. Drugs 71: 2031–2065.
-
(2011)
Drugs
, vol.71
, pp. 2031-2065
-
-
Herrmann, N.1
Chau, S.2
Kircanski, I.3
Lanctôt, K.4
-
45
-
-
84940833907
-
Single dose administration of the b-secretase inhibitor CTS 21166 (ASP1720) reduces plasma Aβ40 in human subjects
-
Presented by Dr Koelsch in the International Conference on Alzheimer's Disease (ICAD) Chicago, IL, USA Available at
-
Hey J. Koelsch G. Bilcer G. Jacobs A. Tolar M. Tang J. et al (2008) Single dose administration of the b-secretase inhibitor CTS 21166 (ASP1720) reduces plasma Aβ40 in human subjects. Presented by Dr Koelsch in the International Conference on Alzheimer's Disease (ICAD), Chicago, IL, USA, 26–31 July 2008. Available at: http://www.alzforum.org/new/detail.asp?id=1790
-
(2008)
-
-
Hey, J.1
Koelsch, G.2
Bilcer, G.3
Jacobs, A.4
Tolar, M.5
Tang, J.6
-
46
-
-
33744478433
-
Clinical observations with AN 1792 using TAPIR analyses
-
Hock C. Nitsch R. (2005) Clinical observations with AN 1792 using TAPIR analyses. Neurodegener Dis 2: 273–276.
-
(2005)
Neurodegener Dis
, vol.2
, pp. 273-276
-
-
Hock, C.1
Nitsch, R.2
-
47
-
-
42249103252
-
Fatty acids, lipid metabolism and Alzheimer pathology
-
Hooijmans C. Kiliaan A. (2008) Fatty acids, lipid metabolism and Alzheimer pathology. Eur J Pharmacol 585: 176–196.
-
(2008)
Eur J Pharmacol
, vol.585
, pp. 176-196
-
-
Hooijmans, C.1
Kiliaan, A.2
-
49
-
-
79959944588
-
γ-Secretase inhibitors and modulators for the treatment of Alzheimer's disease: disappointments and hopes
-
Imbimbo B. Giardina G. (2011) γ-Secretase inhibitors and modulators for the treatment of Alzheimer's disease: disappointments and hopes. Curr Top Med Chem 11: 1555–1570.
-
(2011)
Curr Top Med Chem
, vol.11
, pp. 1555-1570
-
-
Imbimbo, B.1
Giardina, G.2
-
51
-
-
79951541046
-
Potent BACE-1 inhibitor design using pharmacophore modeling, in silico screening and molecular docking studies
-
John S. Thangapandian S. Sakkiah S. Lee K. (2011) Potent BACE-1 inhibitor design using pharmacophore modeling, in silico screening and molecular docking studies. BMC Bioinformatics 12(Suppl. 1): 28.
-
(2011)
BMC Bioinformatics
, vol.12
, pp. 28
-
-
John, S.1
Thangapandian, S.2
Sakkiah, S.3
Lee, K.4
-
52
-
-
38049005871
-
Efficacy of memantine on behavioral and psychological symptoms related to dementia: a systematic meta-analysis
-
Maidment I. Fox C. Boustani M. Rodriguez J. Brown R. Katona C. (2008) Efficacy of memantine on behavioral and psychological symptoms related to dementia: a systematic meta-analysis. Ann Pharmacother 42: 32–38.
-
(2008)
Ann Pharmacother
, vol.42
, pp. 32-38
-
-
Maidment, I.1
Fox, C.2
Boustani, M.3
Rodriguez, J.4
Brown, R.5
Katona, C.6
-
54
-
-
54249140068
-
GSK-3 inhibitors: a ray of hope for the treatment of Alzheimer's disease?
-
Martinez A. Perez D. (2008) GSK-3 inhibitors: a ray of hope for the treatment of Alzheimer's disease? J Alzheimers Dis 15: 181–191.
-
(2008)
J Alzheimers Dis
, vol.15
, pp. 181-191
-
-
Martinez, A.1
Perez, D.2
-
57
-
-
70349093083
-
Disease-modifying approach to the treatment of Alzheimer's disease: from alpha-secretase activators to gamma-secretase inhibitors and modulators
-
Panza F. Solfrizzi V. Frisardi V. Capurso C. D'Introno A. Colacicco A.M. et al. (2009) Disease-modifying approach to the treatment of Alzheimer's disease: from alpha-secretase activators to gamma-secretase inhibitors and modulators. Drugs Aging 26: 537–555.
-
(2009)
Drugs Aging
, vol.26
, pp. 537-555
-
-
Panza, F.1
Solfrizzi, V.2
Frisardi, V.3
Capurso, C.4
D'Introno, A.5
Colacicco, A.M.6
-
58
-
-
41049104686
-
American College of Physicians / American Academy of Family Physicians Panel on Dementia
-
Current pharmacologic treatment of dementia: a clinical practice guideline from the American College of Physicians and the American Academy of Family Physicians
-
Qaseem A. Snow V. Cross J. Forciea M. Jr Hopkins R. Shekelle P. Jr et al. American College of Physicians / American Academy of Family Physicians Panel on Dementia (2008) Current pharmacologic treatment of dementia: a clinical practice guideline from the American College of Physicians and the American Academy of Family Physicians. Ann Intern Med 148: 370–378.
-
(2008)
Ann Intern Med
, vol.148
, pp. 370-378
-
-
Qaseem, A.1
Snow, V.2
Cross, J.3
Forciea, M.4
Hopkins, R.5
Shekelle, P.6
-
59
-
-
77954952538
-
Analysis of three plasmid systems for use in DNA A beta 42 immunization as therapy for Alzheimer's disease
-
Qu B. Lambracht-Washington D. Fu M. Eagar T. Stüve O. Rosenberg R. (2010) Analysis of three plasmid systems for use in DNA A beta 42 immunization as therapy for Alzheimer's disease. Vaccine 28: 5280–5287.
-
(2010)
Vaccine
, vol.28
, pp. 5280-5287
-
-
Qu, B.1
Lambracht-Washington, D.2
Fu, M.3
Eagar, T.4
Stüve, O.5
Rosenberg, R.6
-
60
-
-
34547215215
-
Immunotherapy against APP beta-secretase cleavage site improves cognitive function and reduces neuroinflammation in Tg 2576 mice without a significant effect on brain abeta levels
-
Rakover I. Arbel M. Solomon B. (2007) Immunotherapy against APP beta-secretase cleavage site improves cognitive function and reduces neuroinflammation in Tg 2576 mice without a significant effect on brain abeta levels. Neurodegener Dis 4: 392–402.
-
(2007)
Neurodegener Dis
, vol.4
, pp. 392-402
-
-
Rakover, I.1
Arbel, M.2
Solomon, B.3
-
61
-
-
67649678412
-
Oxidative stress in diabetes and Alzheimer's disease
-
Reddy V. Zhu X. Perry G. Smith M. (2009) Oxidative stress in diabetes and Alzheimer's disease. J Alzheimers Dis 16: 763–774.
-
(2009)
J Alzheimers Dis
, vol.16
, pp. 763-774
-
-
Reddy, V.1
Zhu, X.2
Perry, G.3
Smith, M.4
-
63
-
-
82255179817
-
ELND005-AD201 Investigators
-
A phase 2 randomized trial of ELND005, scyllo-inositol, in mild to moderate Alzheimer disease
-
Salloway S. Sperling R. Keren R. Porsteinsson A. van Dyck C. Tariot P. et al. ELND005-AD201 Investigators (2011) A phase 2 randomized trial of ELND005, scyllo-inositol, in mild to moderate Alzheimer disease. Neurology 77: 1253–1262.
-
(2011)
Neurology
, vol.77
, pp. 1253-1262
-
-
Salloway, S.1
Sperling, R.2
Keren, R.3
Porsteinsson, A.4
van Dyck, C.5
Tariot, P.6
-
64
-
-
84858195896
-
New pharmacological strategies for treatment of Alzheimer's disease: focus on disease modifying drugs
-
Salomone S. Caraci F. Leggio G. Fedotova J. Drago F. (2011) New pharmacological strategies for treatment of Alzheimer's disease: focus on disease modifying drugs. Br J Clin Pharmacol 73: 504–517.
-
(2011)
Br J Clin Pharmacol
, vol.73
, pp. 504-517
-
-
Salomone, S.1
Caraci, F.2
Leggio, G.3
Fedotova, J.4
Drago, F.5
-
65
-
-
80053336026
-
A randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease
-
Sano M. Bell K. Galasko D. Galvin J. Thomas R. van Dyck C. et al. (2011) A randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease. Neurology 77: 556–563.
-
(2011)
Neurology
, vol.77
, pp. 556-563
-
-
Sano, M.1
Bell, K.2
Galasko, D.3
Galvin, J.4
Thomas, R.5
van Dyck, C.6
-
66
-
-
35748977086
-
Tramiprosate, a drug of potential interest for the treatment of Alzheimer's disease, promotes an abnormal aggregation of tau
-
Santa-Maria I. Hernández F. Del Rio J. Moreno F. Avila J. (2007) Tramiprosate, a drug of potential interest for the treatment of Alzheimer's disease, promotes an abnormal aggregation of tau. Mol Neurodegener 2: 17.
-
(2007)
Mol Neurodegener
, vol.2
, pp. 17
-
-
Santa-Maria, I.1
Hernández, F.2
Del Rio, J.3
Moreno, F.4
Avila, J.5
-
67
-
-
21544458621
-
Safety, tolerability, and changes in amyloid β concentrations after administration of a γ-secretase inhibitor in volunteers
-
Siemers E. Skinner M. Dean R. Gonzales C. Satterwhite J. Farlow M. et al. (2005) Safety, tolerability, and changes in amyloid β concentrations after administration of a γ-secretase inhibitor in volunteers. Clin Neuropharmacol 28: 126–132.
-
(2005)
Clin Neuropharmacol
, vol.28
, pp. 126-132
-
-
Siemers, E.1
Skinner, M.2
Dean, R.3
Gonzales, C.4
Satterwhite, J.5
Farlow, M.6
-
68
-
-
62249167406
-
Boom in the development of non-peptidic beta-secretase (BACE1) inhibitors for the treatment of Alzheimer's disease
-
Silvestri R. (2009) Boom in the development of non-peptidic beta-secretase (BACE1) inhibitors for the treatment of Alzheimer's disease. Med Res Rev 29: 295–338.
-
(2009)
Med Res Rev
, vol.29
, pp. 295-338
-
-
Silvestri, R.1
-
69
-
-
79956098248
-
Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
-
Sperling R. Aisen P. Beckett L. Bennett D. Craft S. Fagan A. et al. (2011) Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 7: 280–292.
-
(2011)
Alzheimers Dement
, vol.7
, pp. 280-292
-
-
Sperling, R.1
Aisen, P.2
Beckett, L.3
Bennett, D.4
Craft, S.5
Fagan, A.6
-
70
-
-
58149220667
-
Cholesterol in Alzheimer's disease: unresolved questions
-
Stefani M. Liguri G. (2009) Cholesterol in Alzheimer's disease: unresolved questions. Curr Alzheimer Res 6: 15–29.
-
(2009)
Curr Alzheimer Res
, vol.6
, pp. 15-29
-
-
Stefani, M.1
Liguri, G.2
-
71
-
-
0345872128
-
Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: a randomized controlled trial
-
Tariot P. Farlow M. Grossberg G. Graham S. McDonald S. Gergel I. (2004) Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: a randomized controlled trial. JAMA 291: 317–324.
-
(2004)
JAMA
, vol.291
, pp. 317-324
-
-
Tariot, P.1
Farlow, M.2
Grossberg, G.3
Graham, S.4
McDonald, S.5
Gergel, I.6
-
72
-
-
84863343191
-
Multicenter, randomized, double-blind, placebo-controlled, single-ascending dose study of the oral γ-secretase inhibitor BMS-708163: tolerability profile, pharmacokinetic parameters, and pharmacodynamic markers
-
Tong G. Wang J. Sverdlov O. Huang S. Slemmon R. Croop R. et al. (2012) Multicenter, randomized, double-blind, placebo-controlled, single-ascending dose study of the oral γ-secretase inhibitor BMS-708163: tolerability profile, pharmacokinetic parameters, and pharmacodynamic markers. Clin Ther 34: 654–667.
-
(2012)
Clin Ther
, vol.34
, pp. 654-667
-
-
Tong, G.1
Wang, J.2
Sverdlov, O.3
Huang, S.4
Slemmon, R.5
Croop, R.6
-
73
-
-
4344630985
-
BACE1: the beta-secretase enzyme in Alzheimer's disease
-
Vassar R. (2004) BACE1: the beta-secretase enzyme in Alzheimer's disease. J Mol Neurosci 23: 105–114.
-
(2004)
J Mol Neurosci
, vol.23
, pp. 105-114
-
-
Vassar, R.1
-
75
-
-
33845346815
-
Disease-modifying trials in Alzheimer's disease: a European Task Force consensus
-
Vellas B. Andrieu S. Sampaio C. Wilcock G. (2007) Disease-modifying trials in Alzheimer's disease: a European Task Force consensus. Lancet Neurol 6: 56–62.
-
(2007)
Lancet Neurol
, vol.6
, pp. 56-62
-
-
Vellas, B.1
Andrieu, S.2
Sampaio, C.3
Wilcock, G.4
-
76
-
-
79954458099
-
EHT0202/002 study group
-
EHT0202 in Alzheimer's disease: a 3-month, randomized, placebo-controlled, double-blind study
-
Vellas B. Sol O. Snyder P. Ousset P. Haddad R. Maurin M. et al. EHT0202/002 study group (2011) EHT0202 in Alzheimer's disease: a 3-month, randomized, placebo-controlled, double-blind study. Curr Alzheimer Res 8: 203–212.
-
(2011)
Curr Alzheimer Res
, vol.8
, pp. 203-212
-
-
Vellas, B.1
Sol, O.2
Snyder, P.3
Ousset, P.4
Haddad, R.5
Maurin, M.6
-
77
-
-
33845904135
-
Amyloid-beta vaccination, but not nitro-nonsteroidal anti-inflammatory drug treatment, increases vascular amyloid and microhemorrhage while both reduce parenchymal amyloid
-
Wilcock D. Jantzen P. Li Q. Morgan D. Gordon M. (2007) Amyloid-beta vaccination, but not nitro-nonsteroidal anti-inflammatory drug treatment, increases vascular amyloid and microhemorrhage while both reduce parenchymal amyloid. Neuroscience 144: 950–960.
-
(2007)
Neuroscience
, vol.144
, pp. 950-960
-
-
Wilcock, D.1
Jantzen, P.2
Li, Q.3
Morgan, D.4
Gordon, M.5
-
78
-
-
48949085739
-
Amyloid-β immunization for Alzheimer's disease
-
Wisniewski T. Konietzko U. (2008) Amyloid-β immunization for Alzheimer's disease. Lancet Neurol 7: 805–811.
-
(2008)
Lancet Neurol
, vol.7
, pp. 805-811
-
-
Wisniewski, T.1
Konietzko, U.2
-
79
-
-
11144355129
-
Chronic treatment with the γ-secretase inhibitor LY-411,575 inhibit β-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation
-
Wong G. Manfra D. Poulet F. Zhang Q. Josien H. Bara T. et al. (2004) Chronic treatment with the γ-secretase inhibitor LY-411,575 inhibit β-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation. J Biol Chem 279: 12876–12882.
-
(2004)
J Biol Chem
, vol.279
, pp. 12876-12882
-
-
Wong, G.1
Manfra, D.2
Poulet, F.3
Zhang, Q.4
Josien, H.5
Bara, T.6
-
81
-
-
55549083841
-
Non-pharmacological and pharmacological treatment of the cognitive and behavioral symptoms of Alzheimer disease
-
Zec R. Burkett N. (2008) Non-pharmacological and pharmacological treatment of the cognitive and behavioral symptoms of Alzheimer disease. NeuroRehabilitation 23: 425–438.
-
(2008)
NeuroRehabilitation
, vol.23
, pp. 425-438
-
-
Zec, R.1
Burkett, N.2
|