A rapid solid-phase extraction method for measurement of non-metabolised peripheral benzodiazepine receptor ligands, [18F]PBR102 and [18F]PBR111, in rat and primate plasma

Nuclear Medicine and Biology

Volumn 38, Issue 1, 2011, Pages 137-148

  Katsifis, Andrew ^a   Loc'h, Christian ^a   Henderson, David ^b   Bourdier, Thomas ^a   Pham, Tien ^a   Greguric, Ivan ^a   Lam, Peter ^b   Callaghan, Paul ^a   Mattner, Filomena ^a   Eberl, Stefan ^b,c   Fulham, Michael ^b,c,d  

^a AUSTRALIAN NUCLEAR SCIENCE AND TECHNOLOGY ORGANISATION   (Australia)

^b ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

^d UNIVERSITY OF SYDNEY   (Australia)

Author keywords

18F PBR102; 18F PBR111; HPLC; Metabolite analysis; SPE; TLC

Indexed keywords

ACETONITRILE; BENZODIAZEPINE RECEPTOR AFFECTING AGENT; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; PBR 102 F 18; PBR 111 F 18; TRACER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BABOON; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG STRUCTURE; IMAGE ANALYSIS; INTERMETHOD COMPARISON; ISOTOPE LABELING; MALE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; QUANTITATIVE ANALYSIS; RAT; RELIABILITY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SEPARATION TECHNIQUE; SOLID PHASE EXTRACTION; STRUCTURE ANALYSIS; THIN LAYER CHROMATOGRAPHY;

ACETAMIDES; ANIMALS; BLOOD CHEMICAL ANALYSIS; CARRIER PROTEINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, THIN LAYER; FLUORINE RADIOISOTOPES; LIGANDS; MALE; PAPIO; RADIOPHARMACEUTICALS; RATS; RECEPTORS, GABA-A; REPRODUCIBILITY OF RESULTS; SOLID PHASE EXTRACTION; TIME FACTORS;

EID: 78650989995     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2010.07.008     Document Type: Article

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