Evidence for a glucocorticoid receptor beta splice variant in the rat and its physiological regulation in liver

Steroids

Volumn 78, Issue 2, 2013, Pages 312-320

  Dubois, Debra C ^a   Sukumaran, Siddharth ^a   Jusko, William J ^a   Almon, Richard R ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

Glucocorticoid receptor; Glucocorticoids; GR ; qRTPCR

Indexed keywords

ESCHERICHIA COLI LIPOPOLYSACCHARIDE; GLUCOCORTICOID RECEPTOR ALPHA; GLUCOCORTICOID RECEPTOR BETA; INSULIN; MESSENGER RNA;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHIMERA; CIRCADIAN RHYTHM; CONTROLLED STUDY; GENETIC VARIABILITY; IN VIVO STUDY; INSULIN BLOOD LEVEL; INTRON; LIVER; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSCILLATION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR DOWN REGULATION; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SPLICING; UPREGULATION;

ALTERNATIVE SPLICING; ANIMALS; CIRCADIAN RHYTHM; ELECTROPHORESIS, AGAR GEL; HUMANS; LIPOPOLYSACCHARIDES; LIVER; MALE; METHYLPREDNISOLONE; MICE; RATS; RATS, WISTAR; RECEPTORS, GLUCOCORTICOID; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, COMPLEMENTARY; RNA, MESSENGER; TIME FACTORS;

ANIMALIA; RATTUS;

EID: 84871597277     PISSN: 0039128X     EISSN: 18785867     Source Type: Journal    
DOI: 10.1016/j.steroids.2012.11.014     Document Type: Article

References (42)

1. M. Bialis, and P. Routledge Adverse effects of corticosteroids Adv Drug React Toxicol Rev 17 1998 227 235
2. H. Schacke, W.D. Docke, and K. Asadullah Mechanisms involved in the side effects of glucocorticoids Pharmacol Ther 96 2002 23 43
3. R.H. Oakley, and J.A. Cidlowski Cellular processing of the glucocorticoid receptor gene and protein: new mechanisms for generating tissue-specific actions of glucocorticoids J Biol Chem 286 2011 3177 3184
4. L. Pujols, J. Mullol, and C. Picado Glucocorticoid receptor in human respiratory epithelial cells Neuroimmunomodulation 16 2009 290 299
5. S.M. Hollenberg, C. Weinberger, E.S. Ong, G. Cerelli, A. Oro, R. Lebo, E.B. Thompson, M.G. Rosenfeld, and R.M. Evans Primary structure and expression of a functional human glucocorticoid receptor cdna Nature 318 1985 635 641
6. I.J. Encio, and S.D. Detera-Wadleigh The genomic structure of the human glucocorticoid receptor J Biol Chem 266 1991 7182 7188
7. C. Otto, H.M. Reichardt, and G. Schutz Absence of glucocorticoid receptor-beta in mice J Biol Chem 272 1997 26665 26668
8. T.D. Hinds, S. Ramakrishnan, H.A. Cash, L.A. Stechschulte, G. Heinrich, S.M. Najjar, and E.R. Sanchez Discovery of glucocorticoid receptor-beta in mice with a role in metabolism Mol Endocrinol 24 2010 1715 1727
9. A. Hazra, N. Pyszczynski, D.C. DuBois, R.R. Almon, and W.J. Jusko Modeling receptor/gene-mediated effects of corticosteroids on hepatic tyrosine aminotransferase dynamics in rats: dual regulation by endogenous and exogenous corticosteroids J Pharmacokinet Pharmacodyn 34 2007 643 667
10. R.R. Almon, E. Yang, W. Lai, I.P. Androulakis, D.C. DuBois, and W.J. Jusko Circadian variations in rat liver gene expression: relationships to drug actions J Pharmacol Exp Ther 326 2008 700 716
11. R.R. Almon, D.C. DuBois, W. Lai, B. Xue, J. Nie, and W.J. Jusko Gene expression analysis of hepatic roles in cause and development of diabetes in goto-kakizaki rats J Endocrinol 200 2009 331 346
12. S.A. Bustin, V. Benes, J.A. Garson, J. Hellemans, J. Huggett, M. Kubista, R. Mueller, T. Nolan, M.W. Pfaffl, G.L. Shipley, J. Vandesompele, and C.T. Wittwer The MIQE guidelines: minimum information for publication of quantitative real-time pcr experiments Clin Chem 55 2009 611 622
13. F. Orii, T. Ashida, M. Nomura, A. Maemoto, T. Fujiki, T. Ayabe, S. Imai, Y. Saitoh, and Y. Kohgo Quantitative analysis for human glucocorticoid receptor alpha/beta mrna in ibd Biochem Biophys Res Commun 296 2002 1286 1294
14. I. Strickland, K. Kisich, P.J. Hauk, A. Vottero, G.P. Chrousos, D.J. Klemm, and D.Y. Leung High constitutive glucocorticoid receptor beta in human neutrophils enables them to reduce their spontaneous rate of cell death in response to corticosteroids J Exp Med 193 2001 585 593
15. R. Towers, T. Naftali, G. Gabay, M. Carlebach, A. Klein, and B. Novis High levels of glucocorticoid receptors in patients with active crohn's disease may predict steroid resistance Clin Exp Immunol 141 2005 357 362
16. A. Vazquez-Tello, A. Semlali, J. Chakir, J.G. Martin, D.Y. Leung, D.H. Eidelman, and Q. Hamid Induction of glucocorticoid receptor-beta expression in epithelial cells of asthmatic airways by t-helper type 17 cytokines Clin Exp Allergy 40 2010 1312 1322
17. L.M. Colli, F.C. Do Amaral, N. Torres, and M. De Castro Interindividual glucocorticoid sensitivity in young healthy subjects: the role of glucocorticoid receptor alpha and beta isoforms ratio Horm Metab Res 39 2007 425 429
18. L. Pujols, J. Mullol, J. Roca-Ferrer, A. Torrego, A. Xaubet, J.A. Cidlowski, and C. Picado Expression of glucocorticoid receptor alpha- and beta-isoforms in human cells and tissues Am J Physiol Cell Physiol 283 2002 C1324 1331
19. C.M. Bamberger, A.M. Bamberger, M. De Castro, and G.P. Chrousos Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans J Clin Invest 95 1995 2435 2441
20. E. Charmandari, G.P. Chrousos, T. Ichijo, N. Bhattacharyya, A. Vottero, E. Souvatzoglou, and T. Kino The human glucocorticoid receptor (hgr) beta isoform suppresses the transcriptional activity of hgralpha by interfering with formation of active coactivator complexes Mol Endocrinol 19 2005 52 64
21. O. Fruchter, T. Kino, E. Zoumakis, S. Alesci, M. De Martino, G. Chrousos, and Z. Hochberg The human glucocorticoid receptor (gr) isoform beta differentially suppresses gr{alpha}-induced transactivation stimulated by synthetic glucocorticoids J Clin Endocrinol Metab 90 2005 3505 3509
22. E. Goleva, L.B. Li, P.T. Eves, M.J. Strand, R.J. Martin, and D.Y. Leung Increased glucocorticoid receptor beta alters steroid response in glucocorticoid-insensitive asthma Am J Respir Crit Care Med 173 2006 607 616
23. P.J. Hauk, E. Goleva, I. Strickland, A. Vottero, G.P. Chrousos, K.O. Kisich, and D.Y. Leung Increased glucocorticoid receptor beta expression converts mouse hybridoma cells to a corticosteroid-insensitive phenotype Am J Respir Cell Mol Biol 27 2002 361 367
24. L.B. Li, D.Y. Leung, C.F. Hall, and E. Goleva Divergent expression and function of glucocorticoid receptor beta in human monocytes and t cells J Leukoc Biol 79 2006 818 827
25. R.H. Oakley, C.M. Jewell, M.R. Yudt, D.M. Bofetiado, and J.A. Cidlowski The dominant negative activity of the human glucocorticoid receptor beta isoform. Specificity and mechanisms of action J Biol Chem 274 1999 27857 27866
26. R.H. Oakley, M. Sar, and J.A. Cidlowski The human glucocorticoid receptor beta isoform. Expression, biochemical properties, and putative function J Biol Chem 271 1996 9550 9559
27. Y. Taniguchi, Y. Iwasaki, M. Tsugita, M. Nishiyama, T. Taguchi, M. Okazaki, S. Nakayama, M. Kambayashi, K. Hashimoto, and Y. Terada Glucocorticoid receptor-beta and receptor-gamma exert dominant negative effect on gene repression but not on gene induction Endocrinology 151 2010 3204 3213
28. I.J. Brogan, I.A. Murray, G. Cerillo, M. Needham, A. White, and J.R. Davis Interaction of glucocorticoid receptor isoforms with transcription factors ap-1 and nf-kappab: lack of effect of glucocorticoid receptor beta Mol Cell Endocrinol 157 1999 95 104
29. P. De Lange, J.W. Koper, A.O. Brinkmann, F.H. De Jong, and S.W. Lamberts Natural variants of the beta isoform of the human glucocorticoid receptor do not alter sensitivity to glucocorticoids Mol Cell Endocrinol 153 1999 163 168
30. C. Gougat, D. Jaffuel, R. Gagliardo, C. Henriquet, J. Bousquet, P. Demoly, and M. Mathieu Overexpression of the human glucocorticoid receptor alpha and beta isoforms inhibits ap-1 and nf-kappab activities hormone independently J Mol Med (Berl) 80 2002 309 318
31. K. Hecht, J. Carlstedt-Duke, P. Stierna, J. Gustafsson, M. Bronnegard, and A.C. Wikstrom Evidence that the beta-isoform of the human glucocorticoid receptor does not act as a physiologically significant repressor J Biol Chem 272 1997 26659 26664
32. P. Piotrowski, M. Burzynski, M. Lianeri, M. Mostowska, M. Wudarski, H. Chwalinska-Sadowska, and P.P. Jagodzinski Glucocorticoid receptor beta splice variant expression in patients with high and low activity of systemic lupus erythematosus Folia Histochem Cytobiol 45 2007 339 342
33. T. Rai, K. Monoe, Y. Kanno, H. Saito, A. Takahashi, A. Irisawa, and H. Ohira Expression of human glucocorticoid receptor beta of peripheral blood mononuclear cells in patients with severe autoimmune hepatitis Fukushima J Med Sci 52 2006 65 70
34. A.R. Sousa, S.J. Lane, J.A. Cidlowski, D.Z. Staynov, and T.H. Lee Glucocorticoid resistance in asthma is associated with elevated in vivo expression of the glucocorticoid receptor beta-isoform J Allergy Clin Immunol 105 2000 943 950
35. H. Zhang, Q. Ouyang, Z.H. Wen, C. Fiocchi, W.P. Liu, D.Y. Chen, and F.Y. Li Significance of glucocorticoid receptor expression in colonic mucosal cells of patients with ulcerative colitis World J Gastroenterol 11 2005 1775 1778
36. M.J. Schaaf, D. Champagne, I.H. Van Laanen, D.C. Van Wijk, A.H. Meijer, O.C. Meijer, H.P. Spaink, and M.K. Richardson Discovery of a functional glucocorticoid receptor beta-isoform in zebrafish Endocrinology 149 2008 1591 1599
37. C.A. Butler, S. Mcquaid, C.C. Taggart, S. Weldon, R. Carter, G. Skibinski, T.J. Warke, D.F. Choy, L.P. Mcgarvey, P. Bradding, J.R. Arron, and L.G. Heaney Glucocorticoid receptor beta and histone deacetylase 1 and 2 expression in the airways of severe asthma Thorax 67 2011 392 398
38. S.H. Kim, D.H. Kim, P. Lavender, J.H. Seo, Y.S. Kim, J.S. Park, S.J. Kwak, and Y.K. Jee Repression of tnf-alpha-induced il-8 expression by the glucocorticoid receptor-beta involves inhibition of histone h4 acetylation Exp Mol Med 41 2009 297 306
39. A. Kelly, H. Bowen, Y.K. Jee, N. Mahfiche, C. Soh, T. Lee, C. Hawrylowicz, and P. Lavender The glucocorticoid receptor beta isoform can mediate transcriptional repression by recruiting histone deacetylases J Allergy Clin Immunol 121 203-208 2008 e201
40. T. Kino, I. Manoli, S. Kelkar, Y. Wang, Y.A. Su, and G.P. Chrousos Glucocorticoid receptor (gr) beta has intrinsic, gralpha-independent transcriptional activity Biochem Biophys Res Commun 381 2009 671 675
41. L.J. Lewis-Tuffin, C.M. Jewell, R.J. Bienstock, J.B. Collins, and J.A. Cidlowski Human glucocorticoid receptor beta binds ru-486 and is transcriptionally active Mol Cell Biol 27 2007 2266 2282
42. L. Pujols, J. Mullol, M. Perez, J. Roca-Ferrer, M. Juan, A. Xaubet, J.A. Cidlowski, and C. Picado Expression of the human glucocorticoid receptor alpha and beta isoforms in human respiratory epithelial cells and their regulation by dexamethasone Am J Respir Cell Mol Biol 24 2001 49 57