Alcohol-induced one-carbon metabolism impairment promotes dysfunction of DNA base excision repair in adult brain

Journal of Biological Chemistry

Volumn 287, Issue 52, 2012, Pages 43533-43542

  Fowler, Anna Kate ^a   Hewetson, Aveline ^a   Agrawal, Rajiv G ^a   Dagda, Marisela ^a   Dagda, Raul ^a   Moaddel, Ruin ^b   Balbo, Silvia ^c   Sanghvi, Mitesh ^b   Chen, Yukun ^a   Hogue, Ryan J ^a   Bergeson, Susan E ^a   Henderson, George I ^a   Kruman, Inna I ^a  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT BRAIN; ADULT MICE; ADVERSE EFFECT; ALCOHOL ABUSE; BASE EXCISION REPAIRS; BIOCHEMICAL ASSAY; BRAIN DAMAGE; CHRONIC EXPOSURE; DNA DAMAGES; DNA METHYLATION; DNA REPAIR; GENOMIC INSTABILITY; GENOMIC STABILITY; HOMOCYSTEINES; HUMAN POPULATION; IMMUNOHISTOCHEMISTRY; KEY FACTORS; METHYL GROUP; METHYLENETETRAHYDROFOLATE REDUCTASE; NEURONAL DEATH; NEUROTOXICITY;

CARBON; ETHANOL; FUNCTIONAL GROUPS; GENES; METABOLISM; PHYSIOLOGY; REPAIR; STABILITY;

DNA;

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ALCOHOL; BIOLOGICAL MARKER; HOMOCYSTEINE; REACTIVE OXYGEN METABOLITE;

ALCOHOL CONSUMPTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN LEVEL; CARBON METABOLISM; CONTROLLED STUDY; DNA METHYLATION; EXCISION REPAIR; GENOMIC INSTABILITY; IMMUNOHISTOCHEMISTRY; LONG TERM EXPOSURE; MALE; MOUSE; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; STEREOLOGY;

ADULT; ALCOHOL DRINKING; ANIMALS; CARBON; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DNA DAMAGE; DNA REPAIR; ETHANOL; GENOMIC INSTABILITY; HOMOCYSTEINE; HUMANS; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MICE; MICE, MUTANT STRAINS; MUTATION;

MUS;

EID: 84871567346     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.401497     Document Type: Article

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