Activation of ATP-sensitive potassium channels protects vascular endothelial cells from hypertension and renal injury induced by hyperuricemia

Journal of Hypertension

Volumn 26, Issue 12, 2008, Pages 2326-2338

  Long, Chao Liang ^a   Qin, Xiu Chuan ^a,b   Pan, Zhi Yuan ^a   Chen, Kai ^a   Zhang, Yan Fang ^a   Cui, Wen Yu ^a   Liu, Guo Shu ^b   Wang, Hai ^a,c,d  

^a BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

^b CHINESE PLA GENERAL HOSPITAL   (China)

^c INSTITUTE OF HEALTH AND ENVIRONMENTAL MEDICINE   (China)

^d Thadweik Academy of Medicine   (China)

Author keywords

ATP sensitive potassium channel opener; Endothelial function; Hyperuricemia; Iptakalim; Renal function

Indexed keywords

6 OXOPROSTAGLANDIN F1 ALPHA; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; ANGIOTENSIN; ANGIOTENSIN II; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTHELIN 1; GLIBENCLAMIDE; INTERCELLULAR ADHESION MOLECULE 1; IPTAKALIM; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; NITRIC OXIDE; OXONIC ACID; PROSTACYCLIN; RENIN; URIC ACID; VASCULAR CELL ADHESION MOLECULE 1; ANGIOTENSIN DERIVATIVE; N (1 METHYLETHYL) 1,1,2 TRIMETHYLPROPYLAMINE; N-(1-METHYLETHYL)-1,1,2-TRIMETHYLPROPYLAMINE; PROPYLAMINE; UNCLASSIFIED DRUG; URATE OXIDASE; XANTHINE OXIDASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; GENE OVEREXPRESSION; HYPERTENSION; HYPERURICEMIA; KIDNEY INJURY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; SYSTOLIC BLOOD PRESSURE; VASCULAR ENDOTHELIUM; ANIMAL; CELL CULTURE; CHEMICALLY INDUCED DISORDER; CYTOLOGY; DISEASE MODEL; DRUG POTENTIATION; KIDNEY; KIDNEY DISEASE; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT; VASCULARIZATION;

6-KETOPROSTAGLANDIN F1 ALPHA; ANGIOTENSIN II; ANGIOTENSINS; ANIMALS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ENDOTHELIN-1; ENDOTHELIUM, VASCULAR; HYPERTENSION; HYPERURICEMIA; KATP CHANNELS; KIDNEY; KIDNEY DISEASES; MALE; NITRIC OXIDE; OXONIC ACID; PROPYLAMINES; RATS; RATS, SPRAGUE-DAWLEY; URATE OXIDASE; URIC ACID; XANTHINE OXIDASE;

EID: 59849087929     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/HJH.0b013e328312c8c1     Document Type: Article

References (10)

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