Using multiple phenotype assays and epistasis testing to enhance the reliability of RNAi screening and identify regulators of muscle protein degradation

Genes

Volumn 3, Issue 4, 2012, Pages 686-701

  Lehmann, Susann ^a   Shephard, Freya ^b   Jacobson, Lewis A ^c   Szewczyk, Nathaniel J ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^c UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

C. elegans; Functional genomics; Muscle; Network biology; Proteolysis; RNAi; Systems biology

Indexed keywords

COMPLEMENTARY DNA; DOUBLE STRANDED RNA; MUSCLE PROTEIN; SHORT HAIRPIN RNA; SMALL INTERFERING RNA;

BIOINFORMATICS; CAENORHABDITIS ELEGANS; FALSE NEGATIVE RESULT; FALSE POSITIVE RESULT; FUNCTIONAL GENOMICS; GENE FUNCTION; GENE MUTATION; GENETIC EPISTASIS; GENETIC SCREENING; NONHUMAN; PHENOTYPE; PROTEIN DEGRADATION; PROTEIN RNA BINDING; REVIEW; RNA INTERFERENCE; RNA SEQUENCE; SYSTEMS BIOLOGY;

CAENORHABDITIS ELEGANS;

EID: 84871555327     PISSN: None     EISSN: 20734425     Source Type: Journal    
DOI: 10.3390/genes3040686     Document Type: Review

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