Antagonizing 5-HT2A receptors with M100907 and stimulating 5-HT2C receptors with Ro60-0175 blocks cocaine-induced locomotion and zif268 mRNA expression in Sprague-Dawley rats

Behavioural Brain Research

Volumn 240, Issue 1, 2013, Pages 171-181

  Burton, Christie L ^a,b   Rizos, Zoë ^b   Diwan, Mustansir ^b   Nobrega, José N ^a,b   Fletcher, Paul J ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

Author keywords

5 HT2A; 5 HT2C; Cocaine; Locomotor; Serotonin; Zif

Indexed keywords

2 (6 CHLORO 5 FLUORO 1 INDOLYL) 1 METHYLETHYLAMINE; COCAINE; MESSENGER RNA; SEROTONIN 2A RECEPTOR; SEROTONIN 2C RECEPTOR; VOLINANSERIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CAUDATE NUCLEUS; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; IMMEDIATE EARLY GENE; IN SITU HYBRIDIZATION; LOCOMOTION; MALE; NONHUMAN; NUCLEUS ACCUMBENS; ORBITAL CORTEX; PRIORITY JOURNAL; RAT; ZIF268 GENE;

ANIMALS; BEHAVIOR, ANIMAL; CAUDATE NUCLEUS; COCAINE; DOPAMINE; DOPAMINE UPTAKE INHIBITORS; EARLY GROWTH RESPONSE PROTEIN 1; ETHYLAMINES; FLUOROBENZENES; FRONTAL LOBE; INDOLES; MALE; MOTOR ACTIVITY; NUCLEUS ACCUMBENS; PIPERIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTOR, SEROTONIN, 5-HT2C; RNA, MESSENGER; SEROTONIN 5-HT2 RECEPTOR AGONISTS; SEROTONIN 5-HT2 RECEPTOR ANTAGONISTS;

EID: 84871527704     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2012.11.030     Document Type: Article

References (95)

1. Deakin J.F. The role of serotonin in panic, anxiety and depression. International Clinical Psychopharmacology 1998, 13(Suppl. 4):S1-S5.
2. Naughton M., Mulrooney J.B., Leonard B.E. A review of the role of serotonin receptors in psychiatric disorders. Human Psychopharmacology 2000, 15:397-415.
3. (2C) receptors. European Journal of Pharmacology 2003, 480:151-162.
4. 2C receptors as potential targets for modulation of psychostimulant use and dependence. Current Topics in Medicinal Chemistry 2006, 6:1971-1985.
5. Dalley J.W., Mar A.C., Economidou D., Robbins T.W. Neurobehavioral mechanisms of impulsivity: fronto-striatal systems and functional neurochemistry. Pharmacology, Biochemistry, and Behavior 2008, 90:250-260.
6. Oades R.D. Dopamine-serotonin interactions in attention-deficit hyperactivity disorder (ADHD). Progress in Brain Research 2008, 172:543-565.
7. Remington G. Alterations of dopamine and serotonin transmission in schizophrenia. Progress in Brain Research 2008, 172:117-140.
8. Kapur S., Remington G. Serotonin-dopamine interaction and its relevance to schizophrenia. The American Journal of Psychiatry 1996, 153:466-476.
9. (2C) receptors in the control of brain dopaminergic function. Pharmacology, Biochemistry, and Behavior 2002, 71:727-734.
10. Alex K.D., Pehek E.A. Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission. Pharmacology & Therapeutics 2007, 113:296-320.
11. 2C receptors for the treatment of depression. Progress in Brain Research 2008, 172:287-305.
12. 2R pharmacotherapy in psychostimulant abuse. Progress in Brain Research 2008, 172:319-346.
13. Fletcher P.J., Le A.D., Higgins G.A. Serotonin receptors as potential targets for modulation of nicotine use and dependence. Progress in Brain Research 2008, 172:361-383.
14. 2C/2B receptor subtypes modulate dopamine release induced in vivo by amphetamine and morphine in both the rat nucleus accumbens and striatum. Neuropsychopharmacology 2002, 26:311-324.
15. 2C receptor antagonist but not agonist modulates cocaine-induced dopamine outflow in the rat nucleus accumbens and striatum. Neuropsychopharmacology 2004, 29:319-326.
16. (2C) receptors. Brain Research 2000, 865:85-90.
17. (2C) receptors tonically suppress the activity of mesocortical dopaminergic and adrenergic, but not serotonergic, pathways: a combined dialysis and electrophysiological analysis in the rat. Synapse 2000, 36:205-221.
18. 2C receptor antagonist, increases dopaminergic transmission in the mesolimbic system. Neuropharmacology 1999, 38:1195-1205.
19. 2A/2C receptor agonist, potentiates amphetamine-induced dopamine release in rat striatum. Brain Research 1995, 698:204-208.
20. (2A) antagonist, attenuates dopamine release in the rat medial prefrontal cortex. Brain Research 2001, 888:51-59.
21. (2A) receptor stimulation in rats pretreated with intermittent cocaine. Brain Research 2000, 863:254-258.
22. 2A receptors in the d-amphetamine-induced release of dopamine: comparison with previous data on alpha1b-adrenergic receptors. Journal of Neurochemistry 2004, 91:318-326.
23. 2 receptor antagonism reduces hyperactivity induced by amphetamine, cocaine, and MK-801 but not D1 agonist C-APB. Pharmacology, Biochemistry, and Behavior 1999, 63:237-243.
24. (2C) receptor antagonist SB242084 on cocaine-induced locomotor activity, cocaine self-administration and cocaine-induced reinstatement of responding. Neuropsychopharmacology 2002, 27:576-586.
25. (2A) receptor blockade. Neuropharmacology 2011, 61:468-477.
26. 2A receptor antagonist M100907 on nicotine self-administration and reinstatement. Neuropharmacology 2012, 62:2288-2298.
27. 2A receptor suppresses cue-evoked reinstatement of cocaine-seeking behavior in a rat self-administration model. Behavioral Neuroscience 2009, 123:382-396.
28. (2A) receptors attenuates the behavioral effects of cocaine in rats. The Journal of Pharmacology and Experimental Therapeutics 2001, 297:357-363.
29. 2A receptor antagonist MDL 100,907 on MDMA-induced locomotor stimulation in rats. Neuropsychopharmacology 1996, 15:116-124.
30. 2A receptors in the medial prefrontal cortex attenuates reinstatement of cue-elicited cocaine-seeking behavior in rats. Psychopharmacology (Berl) 2011, 213:307-320.
31. Steed E., Jones C.A., McCreary A.C. Serotonergic involvement in methamphetamine-induced locomotor activity: a detailed pharmacological study. Behavioural Brain Research 2011, 220:9-19.
32. 2) receptor-targeting ligands and nicotine: locomotor activity studies in rats. Synapse 2009, 63:653-661.
33. (2C) receptor agonist Ro60-0175 reduces cocaine self-administration and reinstatement induced by the stressor yohimbine, and contextual cues. Neuropsychopharmacology 2007, 33:1402-1412.
34. 2C receptor agonist Ro60-0175 into the ventral tegmental area reduces cocaine-induced locomotor activity and cocaine self-administration. Neuropsychopharmacology 2004, 29:308-318.
35. 2C receptors. Journal of Neuroscience 2001, 21:7781-7787.
36. (2C) receptors on cocaine- and food-maintained behavior. The Journal of Pharmacology and Experimental Therapeutics 2000, 295:1183-1191.
37. 2A receptors in cocaine-induced c-Fos expression. Behavioral Neuroscience 2005, 119:1173-1183.
38. 2A antagonist with a favorable CNS safety profile. The Journal of Pharmacology and Experimental Therapeutics 1996, 277:968-981.
39. 2C receptor agonists: pharmacological characteristics and therapeutic potential. The Journal of Pharmacology and Experimental Therapeutics 1998, 286:913-924.
40. Worley P.F., Christy B.A., Nakabeppu Y., Bhat R.V., Cole A.J., Baraban J.M. Constitutive expression of zif268 in neocortex is regulated by synaptic activity. Proceedings of the National Academy of Sciences of the United States of America 1991, 88:5106-5110.
41. Paxinos G., Watson C. The rat brain in stereotaxic coordinates 1998, Academic Press, Sydney. 4th ed.
42. Bhat R.V., Cole A.J., Baraban J.M. Role of monoamine systems in activation of zif268 by cocaine. Journal of Psychiatry & Neuroscience 1992, 17:94-102.
43. Bhat R.V., Baraban J.M. Activation of transcription factor genes in striatum by cocaine: role of both serotonin and dopamine systems. The Journal of Pharmacology and Experimental Therapeutics 1993, 267:496-505.
44. Marie-Claire C., Laurendeau I., Canestrelli C., Courtin C., Vidaud M., Roques B., et al. Fos but not Cart (cocaine and amphetamine regulated transcript) is overexpressed by several drugs of abuse: a comparative study using real-time quantitative polymerase chain reaction in rat brain. Neuroscience Letters 2003, 345:77-80.
45. Valjent E., Corvol J.C., Pages C., Besson M.J., Maldonado R., Caboche J. Involvement of the extracellular signal-regulated kinase cascade for cocaine-rewarding properties. Journal of Neuroscience 2000, 20:8701-8709.
46. Jouvert P., Pain L., Aunis D., Zwiller J. The anesthetics propofol and ketamine inhibit cocaine-induced egr-1 gene expression in rat forebrain. European Journal of Pharmacology 2002, 449:239-243.
47. Uslaner J., Badiani A., Day H.E., Watson S.J., Akil H., Robinson T.E. Environmental context modulates the ability of cocaine and amphetamine to induce c-Fos mRNA expression in the neocortex, caudate nucleus, and nucleus accumbens. Brain Research 2001, 920:106-116.
48. Bhattacharyya A.K., Pradhan S.N. Interactions between motor activity and sterotypy in cocaine-treated rats. Psychopharmacology (Berl) 1979, 63:311-312.
49. Graybiel A.M., Canales J.J. The neurobiology of repetitive behaviors: clues to the neurobiology of Tourette syndrome. Advances in Neurology 2001, 85:123-131.
50. Antoniou K., Kafetzopoulos E., Papadopoulou-Daifoti Z., Hyphantis T., Marselos M. d-Amphetamine, cocaine and caffeine: a comparative study of acute effects on locomotor activity and behavioural patterns in rats. Neuroscience and Biobehavioral Reviews 1998, 23:189-196.
51. Aliane V., Perez S., Nieoullon A., Deniau J.M., Kemel M.L. Cocaine-induced stereotypy is linked to an imbalance between the medial prefrontal and sensorimotor circuits of the basal ganglia. European Journal of Neuroscience 2009, 30:1269-1279.
52. Kuczenski R., Segal D.S., Aizenstein M.L. Amphetamine, cocaine, and fencamfamine: relationship between locomotor and stereotypy response profiles and caudate and accumbens dopamine dynamics. Journal of Neuroscience 1991, 11:2703-2712.
53. Fink J.S., Smith G.P. Abnormal pattern of amphetamine locomotion after 6-OHDA lesion of anteromedial caudate. Pharmacology, Biochemistry, and Behavior 1979, 11:23-30.
54. Moratalla R., Robertson H.A., Graybiel A.M. Dynamic regulation of NGFI-A (zif268, egr1) gene expression in the striatum. Journal of Neuroscience 1992, 12:2609-2622.
55. Daunais J.B., McGinty J.F. Acute and chronic cocaine administration differentially alters striatal opioid and nuclear transcription factor mRNAs. Synapse 1994, 18:35-45.
56. (2C) receptor activation interact to reduce cocaine hyperlocomotion and Fos protein expression in the caudate-putamen. Synapse 2012, 66:989-1001.
57. Velazquez-Sanchez C., Ferragud A., Hernandez-Rabaza V., Nacher A., Merino V., Carda M., et al. The dopamine uptake inhibitor 3 alpha-[bis(4'-fluorophenyl)metoxy]-tropane reduces cocaine-induced early-gene expression, locomotor activity, and conditioned reward. Neuropsychopharmacology 2009, 34:2497-2507.
58. Graybiel A.M., Moratalla R., Robertson H.A. Amphetamine and cocaine induce drug-specific activation of the c-Fos gene in striosome-matrix compartments and limbic subdivisions of the striatum. Proceedings of the National Academy of Sciences of the United States of America 1990, 87:6912-6916.
59. St-Hilaire M., Tremblay P.O., Levesque D., Barden N., Rouillard C. Effects of cocaine on c-Fos and NGFI-B mRNA expression in transgenic mice underexpressing glucocorticoid receptors. Neuropsychopharmacology 2003, 28:478-489.
60. Thiriet N., Jouvert P., Gobaille S., Solov'eva O., Gough B., Aunis D., et al. C-type natriuretic peptide (CNP) regulates cocaine-induced dopamine increase and immediate early gene expression in rat brain. European Journal of Neuroscience 2001, 14:1702-1708.
61. Trinh J.V., Nehrenberg D.L., Jacobsen J.P., Caron M.G., Wetsel W.C. Differential psychostimulant-induced activation of neural circuits in dopamine transporter knockout and wild type mice. Neuroscience 2003, 118:297-310.
62. McDougall S.A., Charntikov S., Cortez A.M., Amodeo D.A., Martinez C.E., Crawford C.A. Persistence of one-trial cocaine-induced behavioral sensitization in young rats: regional differences in Fos immunoreactivity. Psychopharmacology (Berl) 2009, 203:617-628.
63. Fuchs R.A., Evans K.A., Parker M.P., See R.E. Differential involvement of orbitofrontal cortex subregions in conditioned cue-induced and cocaine-primed reinstatement of cocaine seeking in rats. Journal of Neuroscience 2004, 24:6600-6610.
64. Everitt B.J., Hutcheson D.M., Ersche K.D., Pelloux Y., Dalley J.W., Robbins T.W. The orbital prefrontal cortex and drug addiction in laboratory animals and humans. Annals of the New York Academy of Sciences 2007, 1121:576-597.
65. Thomas K.L., Arroyo M., Everitt B.J. Induction of the learning and plasticity-associated gene zif268 following exposure to a discrete cocaine-associated stimulus. European Journal of Neuroscience 2003, 17:1964-1972.
66. Winstanley C.A., LaPlant Q., Theobald D.E., Green T.A., Bachtell R.K., Perrotti L.I., et al. DeltafosB induction in orbitofrontal cortex mediates tolerance to cocaine-induced cognitive dysfunction. Journal of Neuroscience 2007, 27:10497-10507.
67. Tanabe J., Tregellas J.R., Dalwani M., Thompson L., Owens E., Crowley T., et al. Medial orbitofrontal cortex gray matter is reduced in abstinent substance-dependent individuals. Biological Psychiatry 2009, 65:160-164.
68. Volkow N.D., Fowler J.S. Addiction, a disease of compulsion and drive: involvement of the orbitofrontal cortex. Cerebral Cortex 2000, 10:318-325.
69. (2A) receptor occupancy. European Journal of Pharmacology 2008, 591:136-141.
70. 2C receptors. Neuropsychopharmacology 1998, 18:339-351.
71. Koe B.K. Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain. The Journal of Pharmacology and Experimental Therapeutics 1976, 199:649-661.
72. Bradberry C.W., Nobiletti J.B., Elsworth J.D., Murphy B., Jatlow P., Roth R.H. Cocaine and cocaethylene: microdialysis comparison of brain drug levels and effects on dopamine and serotonin. Journal of Neurochemistry 1993, 60:1429-1435.
73. 2C receptors in CHO-K1 cells. British Journal of Pharmacology 1999, 128:13-20.
74. (2C) receptor agonist Ro60-0175 reduces cocaine self-administration and reinstatement induced by the stressor yohimbine, and contextual cues. Neuropsychopharmacology 2008, 33:1402-1412.
75. 2 receptor subtypes to the hyperlocomotor effects of cocaine: acute and chronic pharmacological analyses. The Journal of Pharmacology and Experimental Therapeutics 2004, 310:1246-1254.
76. (2C) receptor antagonists on acute and chronic dyskinetic effects induced by haloperidol in rats. Behavioural Brain Research 2011, 219:273-279.
77. (2A) receptor antagonist M100,907 attenuates motor and 'impulsive-type' behaviours produced by NMDA receptor antagonism. Psychopharmacology (Berl) 2003, 170:309-319.
78. 2C receptors. Brain Research. Molecular Brain Research 1994, 23:163-178.
79. 2C receptor protein in the rat CNS. Neuropharmacology 2000, 39:123-132.
80. 2A receptor in the central nervous system of adult rat. The Journal of Comparative Neurology 1999, 409:187-209.
81. Kelly P.H., Iversen S.D. Selective 6OHDA-induced destruction of mesolimbic dopamine neurons: abolition of psychostimulant-induced locomotor activity in rats. European Journal of Pharmacology 1976, 40:45-56.
82. 2A receptor in dopaminergic neurons in the ventral tegmental area. Brain Research 2000, 864:176-185.
83. 2C receptors in the ventral tegmental area. Neuroscience 2007, 146:286-297.
84. (2C) receptors localize to dopamine and GABA neurons in the rat mesoaccumbens pathway. PLoS ONE 2011, 6:e20508.
85. (2C/2B) receptor agonists: a combined in vivo electrophysiological and microdialysis study. Synapse 2000, 35:53-61.
86. (2A/2C) receptor antagonist, potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens. Neuropsychopharmacology 2002, 27:430-441.
87. 2C receptors in the ventral tegmental area and the nucleus accumbens: an in vivo microdialysis study with cocaine. Neuropsychopharmacology 2008, 33:237-246.
88. Di Chiara G., Imperato A. Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proceedings of the National Academy of Sciences of the United States of America 1988, 85:5274-5278.
89. Beckstead R.M., Domesick V.B., Nauta W.J. Efferent connections of the substantia nigra and ventral tegmental area in the rat. Brain Research 1979, 175:191-217.
90. (2A) receptors in afferents of the rat striatum. Synapse 2001, 39:297-304.
91. 2C receptor agonists on the behavioral and neurochemical effects of cocaine in squirrel monkeys. The Journal of Pharmacology and Experimental Therapeutics 2012, 341:424-434.
92. Leichnetz G.R., Astruc J. Efferent connections of the orbitofrontal cortex in the marmoset (Saguinus oedipus). Brain Research 1975, 84:169-180.
93. Haber S.N., Kunishio K., Mizobuchi M., Lynd-Balta E. The orbital and medial prefrontal circuit through the primate basal ganglia. Journal of Neuroscience 1995, 15:4851-4867.
94. Svenningsson P., Nairn A.C., Greengard P. DARPP-32 mediates the actions of multiple drugs of abuse. The AAPS Journal 2005, 7:E353-E360.
95. Svenningsson P., Tzavara E.T., Liu F., Fienberg A.A., Nomikos G.G., Greengard P. DARPP-32 mediates serotonergic neurotransmission in the forebrain. Proceedings of the National Academy of Sciences of the United States of America 2002, 99:3188-3193.