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Volumn 94, Issue 1, 2013, Pages 77-83

Expression and inducibility of CYP1A1, 1A2, 1B1 by β-naphthoflavone and CYP2B22, CYP3As by rifampicin in heart regions and coronary arteries of pig

Author keywords

Naphthoflavone; Coronary arteries; Heart; Pig CYPs; Rifampicin

Indexed keywords

BETA NAPHTHOFLAVONE; COMPLEMENTARY DNA; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 1B1; CYTOCHROME P450 2B22; CYTOCHROME P450 3A; PURINERGIC P2X RECEPTOR; RIFAMPICIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

EID: 84871518260     PISSN: 00345288     EISSN: 15322661     Source Type: Journal    
DOI: 10.1016/j.rvsc.2012.07.015     Document Type: Article
Times cited : (15)

References (59)
  • 1
    • 0021318441 scopus 로고
    • Catalase in vitro. (Estabrook R.W., Pulman E.E. (Eds.)), Methods in Enzymology
    • Aebi, H.,1984. Catalase in vitro. (Estabrook R.W., Pulman E.E. (Eds.)), Methods in Enzymology, 105, 121-126.
    • (1984) , vol.105 , pp. 121-126
    • Aebi, H.1
  • 2
    • 71249135631 scopus 로고    scopus 로고
    • 3-Methylcholanthrene and benzo(a)pyrene mudulate cardiac cytochrome P450 gene expression and arachidonic acid metabolism in male Sprague Dawley rats
    • Aboutabl M.E., Zardoky B.N.M., El-Kadi A.O.S. 3-Methylcholanthrene and benzo(a)pyrene mudulate cardiac cytochrome P450 gene expression and arachidonic acid metabolism in male Sprague Dawley rats. British Journal of Pharmacology 2009, 158:1808-1819.
    • (2009) British Journal of Pharmacology , vol.158 , pp. 1808-1819
    • Aboutabl, M.E.1    Zardoky, B.N.M.2    El-Kadi, A.O.S.3
  • 4
    • 0038650989 scopus 로고    scopus 로고
    • Verapamil: metabolism in cultures of primary human coronary arterial endothelial cells
    • Borlak J., Walles M., Levsen K., Thum T. Verapamil: metabolism in cultures of primary human coronary arterial endothelial cells. Drug Metabolism and Disposition 2003, 31:888-891.
    • (2003) Drug Metabolism and Disposition , vol.31 , pp. 888-891
    • Borlak, J.1    Walles, M.2    Levsen, K.3    Thum, T.4
  • 6
    • 0021112030 scopus 로고
    • Isolation and characterization of canine cardiac sarcoplasmic reticulum with improved Ca++ transport properties
    • Chamberlain B.K., Levitsky D.O., Fleisher S. Isolation and characterization of canine cardiac sarcoplasmic reticulum with improved Ca++ transport properties. Journal of Biological Chemistry 1983, 258:6602-6609.
    • (1983) Journal of Biological Chemistry , vol.258 , pp. 6602-6609
    • Chamberlain, B.K.1    Levitsky, D.O.2    Fleisher, S.3
  • 7
    • 34548849104 scopus 로고    scopus 로고
    • Inducibility of AhR-regulated CYP genes by beta-naphthoflavone in the liver, lung, kidney and heart of the pig
    • Chirulli V., Marvasi L., Zaghini A., Fiorio R., Longo V., Gervasi P.G. Inducibility of AhR-regulated CYP genes by beta-naphthoflavone in the liver, lung, kidney and heart of the pig. Toxicology 2007, 240:25-37.
    • (2007) Toxicology , vol.240 , pp. 25-37
    • Chirulli, V.1    Marvasi, L.2    Zaghini, A.3    Fiorio, R.4    Longo, V.5    Gervasi, P.G.6
  • 12
    • 33749364917 scopus 로고    scopus 로고
    • Cytochrome P450 enzymes: central players in cardiovascular health and disease
    • Elbekai R.H., El-Kadi A.O. Cytochrome P450 enzymes: central players in cardiovascular health and disease. Pharmacology and Therapeutics 2006, 112:564-587.
    • (2006) Pharmacology and Therapeutics , vol.112 , pp. 564-587
    • Elbekai, R.H.1    El-Kadi, A.O.2
  • 13
    • 0035955607 scopus 로고    scopus 로고
    • Cytochrome P450 enzymes in vascular homeostasis
    • Fleming I. Cytochrome P450 enzymes in vascular homeostasis. Circulation Research 2001, 89:753-762.
    • (2001) Circulation Research , vol.89 , pp. 753-762
    • Fleming, I.1
  • 15
    • 0034541770 scopus 로고    scopus 로고
    • Cytochrome P450 dependent binding of 7,12-dimethylbenz(a)anthracene (DMBA) and Benzo(a)pyrene (B[a]P) in murine heart, lung and liver endothelial cells
    • Granberg A.L., Brunstrom B., Brandt I. Cytochrome P450 dependent binding of 7,12-dimethylbenz(a)anthracene (DMBA) and Benzo(a)pyrene (B[a]P) in murine heart, lung and liver endothelial cells. Archives of Toxicology 2000, 74:593-601.
    • (2000) Archives of Toxicology , vol.74 , pp. 593-601
    • Granberg, A.L.1    Brunstrom, B.2    Brandt, I.3
  • 17
    • 84892246340 scopus 로고    scopus 로고
    • Human cytochrome P450 enzymes
    • Kluwer Academic/Plenum Publishers, New York, P.R. Ortiz de Montellano (Ed.)
    • Guengerich F.P. Human cytochrome P450 enzymes. Cytochrome P450, Structure, Mechanism and Biochemistry 2005, 377-463. Kluwer Academic/Plenum Publishers, New York. third ed. P.R. Ortiz de Montellano (Ed.).
    • (2005) Cytochrome P450, Structure, Mechanism and Biochemistry , pp. 377-463
    • Guengerich, F.P.1
  • 18
    • 0016275313 scopus 로고
    • Glutathione S-transferase. The first enzymatic step in mercapturic acid formation
    • Habig W.H., Pabst M.J., Jakoby W.B. Glutathione S-transferase. The first enzymatic step in mercapturic acid formation. Journal of Biological Chemistry 1974, 249:7130-7139.
    • (1974) Journal of Biological Chemistry , vol.249 , pp. 7130-7139
    • Habig, W.H.1    Pabst, M.J.2    Jakoby, W.B.3
  • 20
    • 0035964804 scopus 로고    scopus 로고
    • Constitutive and inducible expression of Cyp1a1 and Cyp1b1 in vascular smooth muscle cells. Role of the Ahr bHLH/PAS transcriptional factor
    • Kerzee J.K., Ramos K.S. Constitutive and inducible expression of Cyp1a1 and Cyp1b1 in vascular smooth muscle cells. Role of the Ahr bHLH/PAS transcriptional factor. Circulation Research 2001, 89:573-582.
    • (2001) Circulation Research , vol.89 , pp. 573-582
    • Kerzee, J.K.1    Ramos, K.S.2
  • 21
    • 34247603065 scopus 로고    scopus 로고
    • Coordinate regulation of phase I and II xenobiotic metabolisms by the Ah receptor and Nrf2
    • Kohle C., Bock K.W. Coordinate regulation of phase I and II xenobiotic metabolisms by the Ah receptor and Nrf2. Biochemical Pharmacology 2007, 73:1853-1862.
    • (2007) Biochemical Pharmacology , vol.73 , pp. 1853-1862
    • Kohle, C.1    Bock, K.W.2
  • 22
    • 38949188693 scopus 로고    scopus 로고
    • A novel-gender-related difference in the constitutive expression of hepatic cytochrome P4501A subfamily enzymes in Meishan pigs
    • Kojima M., Sekimoto M., Degawa M. A novel-gender-related difference in the constitutive expression of hepatic cytochrome P4501A subfamily enzymes in Meishan pigs. Biochemical Pharmacology 2008, 75:1076-1082.
    • (2008) Biochemical Pharmacology , vol.75 , pp. 1076-1082
    • Kojima, M.1    Sekimoto, M.2    Degawa, M.3
  • 23
    • 33746826948 scopus 로고    scopus 로고
    • The role of aryl hydrocarbon receptor in the pathogenesis of cardiovascular diseases
    • Korashy H.M., El-Kadi A.O.S. The role of aryl hydrocarbon receptor in the pathogenesis of cardiovascular diseases. Drug Metabolism Reviews 2006, 38:411-450.
    • (2006) Drug Metabolism Reviews , vol.38 , pp. 411-450
    • Korashy, H.M.1    El-Kadi, A.O.S.2
  • 24
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227:680-685.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 27
    • 0022350885 scopus 로고
    • Dealkylation of pentoxyresorufin: a rapid and sensitive assay for measuring induction of cytochrome(s) P-450 by phenobarbital and other xenobiotics in the rat
    • Lubet R.A., Mayer R.T., Cameron J.W., Nims R.W., Burke M.D., Wolf T., Guengerich F.P. Dealkylation of pentoxyresorufin: a rapid and sensitive assay for measuring induction of cytochrome(s) P-450 by phenobarbital and other xenobiotics in the rat. Archives of Biochemistry and Biophysics 1985, 238:43-48.
    • (1985) Archives of Biochemistry and Biophysics , vol.238 , pp. 43-48
    • Lubet, R.A.1    Mayer, R.T.2    Cameron, J.W.3    Nims, R.W.4    Burke, M.D.5    Wolf, T.6    Guengerich, F.P.7
  • 28
    • 0016272750 scopus 로고
    • Involvement of superoxide anion radical in the autooxidation of pyrogallol and convenient assay for superoxide dismutase
    • Marklund S., Marklund G. Involvement of superoxide anion radical in the autooxidation of pyrogallol and convenient assay for superoxide dismutase. European Journal of Biochemistry 1974, 47:469-474.
    • (1974) European Journal of Biochemistry , vol.47 , pp. 469-474
    • Marklund, S.1    Marklund, G.2
  • 29
    • 0027272647 scopus 로고
    • Microsomal cytochrome P4501A1 dependent monooxygenase activity in guinea pig heart: induction, inhibition, and increased activity by addition of exogenous NADPH-cytochrome P450 reductase
    • McCallum G.P., Horton J.E., Falkner C.K., Bend J.R. Microsomal cytochrome P4501A1 dependent monooxygenase activity in guinea pig heart: induction, inhibition, and increased activity by addition of exogenous NADPH-cytochrome P450 reductase. Canadian Journal of Physiology and Pharmacology 1993, 71:151-156.
    • (1993) Canadian Journal of Physiology and Pharmacology , vol.71 , pp. 151-156
    • McCallum, G.P.1    Horton, J.E.2    Falkner, C.K.3    Bend, J.R.4
  • 30
    • 56749170689 scopus 로고    scopus 로고
    • Purification, molecular cloning, heterologous expression and characterization of pig CYP1A2
    • Messina A., Chirulli V., Gervasi P.G., Longo V. Purification, molecular cloning, heterologous expression and characterization of pig CYP1A2. Xenobiotica 2008, 38:1453-1470.
    • (2008) Xenobiotica , vol.38 , pp. 1453-1470
    • Messina, A.1    Chirulli, V.2    Gervasi, P.G.3    Longo, V.4
  • 31
    • 67349113389 scopus 로고    scopus 로고
    • Expression and inducibility of CYP1A1, 1A2, 1B1 by β-naphthoflavone and CYP2B22, 3A22, 3A29, 3A46 by rifampicin in the respiratory and olfactory mucosa of pig
    • Messina A., Nannelli A., Fiorio R., Longo V., Gervasi P.G. Expression and inducibility of CYP1A1, 1A2, 1B1 by β-naphthoflavone and CYP2B22, 3A22, 3A29, 3A46 by rifampicin in the respiratory and olfactory mucosa of pig. Toxicology 2009, 260:47-52.
    • (2009) Toxicology , vol.260 , pp. 47-52
    • Messina, A.1    Nannelli, A.2    Fiorio, R.3    Longo, V.4    Gervasi, P.G.5
  • 32
    • 20144385916 scopus 로고    scopus 로고
    • Transcriptional regulation of NF-E2 p45-related factor (NRF2) expression by the aryl hydrocarbon receptor-xenobiotic response element signaling pathway
    • Miao W., Hu L., Scrivens J., Batist G. Transcriptional regulation of NF-E2 p45-related factor (NRF2) expression by the aryl hydrocarbon receptor-xenobiotic response element signaling pathway. Journal of Biological Chemistry 2005, 280:20340-20348.
    • (2005) Journal of Biological Chemistry , vol.280 , pp. 20340-20348
    • Miao, W.1    Hu, L.2    Scrivens, J.3    Batist, G.4
  • 33
    • 78650798184 scopus 로고    scopus 로고
    • Metabolic activity and mRNA levels of human cardiac CYPs involved in drug metabolism
    • Michaud V., Frappier M., Dumas M.-C., Turgeon J. Metabolic activity and mRNA levels of human cardiac CYPs involved in drug metabolism. PLoS One 2010, 5:e15666.
    • (2010) PLoS One , vol.5
    • Michaud, V.1    Frappier, M.2    Dumas, M.-C.3    Turgeon, J.4
  • 34
    • 0033004083 scopus 로고    scopus 로고
    • Isoforms of cytochrome P450 on organic nitrate-derived nitric oxide release in human heart vessels
    • Minamiyama Y., Takemura S., Akiyama T., Imaoka S., Inoue M., Funae Y., Okada S. Isoforms of cytochrome P450 on organic nitrate-derived nitric oxide release in human heart vessels. FEBS Letters 1999, 452:165-169.
    • (1999) FEBS Letters , vol.452 , pp. 165-169
    • Minamiyama, Y.1    Takemura, S.2    Akiyama, T.3    Imaoka, S.4    Inoue, M.5    Funae, Y.6    Okada, S.7
  • 35
    • 0036256351 scopus 로고    scopus 로고
    • Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoato X receptor (BXR) define three pharmacologically distinct cases of nuclear receptors
    • Moore L.B., Maglich J.M., McKee D.D., Wisely B., Willson T.M., Kliewer S.A., Lambert M.H., Moore J.T. Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoato X receptor (BXR) define three pharmacologically distinct cases of nuclear receptors. Molecular Endocrinology 2002, 16:977-986.
    • (2002) Molecular Endocrinology , vol.16 , pp. 977-986
    • Moore, L.B.1    Maglich, J.M.2    McKee, D.D.3    Wisely, B.4    Willson, T.M.5    Kliewer, S.A.6    Lambert, M.H.7    Moore, J.T.8
  • 37
    • 4544287555 scopus 로고    scopus 로고
    • Induction of phase II enzymes by 3H-1,2-dithiole-3-thione: dose-response study in rats
    • Munday R., Munday C.M. Induction of phase II enzymes by 3H-1,2-dithiole-3-thione: dose-response study in rats. Carcinogenesis 2004, 25:1721-1725.
    • (2004) Carcinogenesis , vol.25 , pp. 1721-1725
    • Munday, R.1    Munday, C.M.2
  • 38
    • 53349165544 scopus 로고    scopus 로고
    • Expression and induction by rifampicin of CAR- and PXR-regulated CYP2B and CYP3A in liver, kidney and airways of pig
    • Nannelli A., Chirulli V., Longo V., Gervasi P.G. Expression and induction by rifampicin of CAR- and PXR-regulated CYP2B and CYP3A in liver, kidney and airways of pig. Toxicology 2008, 252:105-112.
    • (2008) Toxicology , vol.252 , pp. 105-112
    • Nannelli, A.1    Chirulli, V.2    Longo, V.3    Gervasi, P.G.4
  • 39
    • 71749085239 scopus 로고    scopus 로고
    • Effect of β-naphthoflavone on AhR-regulated genes (CYP1A1, 1A2, 1B1, 2S1, Nrf2, and GST) and antioxidant enzymes in various brain regions of pig
    • Nannelli A., Rossignolo F., Tolando R., Rossato P., Longo V., Gervasi P.G. Effect of β-naphthoflavone on AhR-regulated genes (CYP1A1, 1A2, 1B1, 2S1, Nrf2, and GST) and antioxidant enzymes in various brain regions of pig. Toxicology 2009, 265:69-79.
    • (2009) Toxicology , vol.265 , pp. 69-79
    • Nannelli, A.1    Rossignolo, F.2    Tolando, R.3    Rossato, P.4    Longo, V.5    Gervasi, P.G.6
  • 40
    • 0033990325 scopus 로고    scopus 로고
    • Role of the aromatic hydrocarbon receptor and [Ah]gene battery in the oxidative stress response, cell cycle control and apoptosis
    • Nebert D.W., Roe A.L., Dieter M.Z., Solis W.A., Yang Y., Dalton T.P. Role of the aromatic hydrocarbon receptor and [Ah]gene battery in the oxidative stress response, cell cycle control and apoptosis. Biochemical Pharmacology 2000, 59:65-85.
    • (2000) Biochemical Pharmacology , vol.59 , pp. 65-85
    • Nebert, D.W.1    Roe, A.L.2    Dieter, M.Z.3    Solis, W.A.4    Yang, Y.5    Dalton, T.P.6
  • 41
    • 77954651175 scopus 로고    scopus 로고
    • Expression and inducibility by Phenobarbital of CYP2C33, CYP2C42, CYP2C49, CYP2B22 and CYP3As in porcine liver, kidney, small intestine and nasal tissues
    • Puccinelli E., Gervasi P.G., La Marca M., Beffy P., Longo V. Expression and inducibility by Phenobarbital of CYP2C33, CYP2C42, CYP2C49, CYP2B22 and CYP3As in porcine liver, kidney, small intestine and nasal tissues. Xenobiotica 2010, 40:525-535.
    • (2010) Xenobiotica , vol.40 , pp. 525-535
    • Puccinelli, E.1    Gervasi, P.G.2    La Marca, M.3    Beffy, P.4    Longo, V.5
  • 42
    • 79957952222 scopus 로고    scopus 로고
    • Xenobiotic metabolizing cytochrome P450 in pig, a promising animal model
    • Puccinelli E., Gervasi P.G., Longo V. Xenobiotic metabolizing cytochrome P450 in pig, a promising animal model. Current Drug Metabolism 2011, 12:507-525.
    • (2011) Current Drug Metabolism , vol.12 , pp. 507-525
    • Puccinelli, E.1    Gervasi, P.G.2    Longo, V.3
  • 43
    • 85043331480 scopus 로고    scopus 로고
    • Constitutive and inducible expression of cytochrome P4501A1 and 1B1 in human vascular endothelial and smooth muscle cells
    • Ramos K.S. Constitutive and inducible expression of cytochrome P4501A1 and 1B1 in human vascular endothelial and smooth muscle cells. In Vitro Cellular and Developmental Biology-Animal 1998, 34:671-673.
    • (1998) In Vitro Cellular and Developmental Biology-Animal , vol.34 , pp. 671-673
    • Ramos, K.S.1
  • 44
    • 30344456996 scopus 로고    scopus 로고
    • Bioactivation of polycyclic aromatic hydrocarbon carcinogens within the vascular wall: implications for human atherogenesis
    • Ramos K.S., Moorthy B. Bioactivation of polycyclic aromatic hydrocarbon carcinogens within the vascular wall: implications for human atherogenesis. Drug Metabolism Reviews 2005, 37:595-610.
    • (2005) Drug Metabolism Reviews , vol.37 , pp. 595-610
    • Ramos, K.S.1    Moorthy, B.2
  • 45
    • 0242331690 scopus 로고    scopus 로고
    • Dietary flavonoids modulate PCB-induced oxidative stress, CYP1A1 induction, and AhR-DNA binding activity in vascular endothelial cells
    • Ramadass P., Meerarani P., Toborek M., Robertson L.W., Henning B. Dietary flavonoids modulate PCB-induced oxidative stress, CYP1A1 induction, and AhR-DNA binding activity in vascular endothelial cells. Toxicology Sciences 2003, 76:212-219.
    • (2003) Toxicology Sciences , vol.76 , pp. 212-219
    • Ramadass, P.1    Meerarani, P.2    Toborek, M.3    Robertson, L.W.4    Henning, B.5
  • 49
    • 33745002984 scopus 로고    scopus 로고
    • Porcine cytochrome P450 and metabolism
    • Skaanild M.T. Porcine cytochrome P450 and metabolism. Current Pharmaceutical Design 2006, 12:1421-1427.
    • (2006) Current Pharmaceutical Design , vol.12 , pp. 1421-1427
    • Skaanild, M.T.1
  • 50
    • 27644548175 scopus 로고    scopus 로고
    • Toxicogenomic profile of 2,3,7,8-tetrachorodibenzo-p-dioxin in the murine fetal heart: modulation of cell cycle and extracellular matrix genes
    • Thackaberry E.A., Jang Z., Jhonson C.D., Ramos K.S., Walker M.K. Toxicogenomic profile of 2,3,7,8-tetrachorodibenzo-p-dioxin in the murine fetal heart: modulation of cell cycle and extracellular matrix genes. Toxicology Sciences 2005, 88:231-241.
    • (2005) Toxicology Sciences , vol.88 , pp. 231-241
    • Thackaberry, E.A.1    Jang, Z.2    Jhonson, C.D.3    Ramos, K.S.4    Walker, M.K.5
  • 51
    • 0034681831 scopus 로고    scopus 로고
    • Gene expression in distinct regions of the heart
    • Thum T., Borlak J. Gene expression in distinct regions of the heart. Lancet 2000, 355:979-983.
    • (2000) Lancet , vol.355 , pp. 979-983
    • Thum, T.1    Borlak, J.2
  • 52
    • 0033838338 scopus 로고    scopus 로고
    • Cytochrome P450 mono-oxygenase gene expression and protein activity in cultures of adult cardiomyocytes of the rat
    • Thum T., Borlak J. Cytochrome P450 mono-oxygenase gene expression and protein activity in cultures of adult cardiomyocytes of the rat. British Journal of Pharmacology 2000, 130:1745-1752.
    • (2000) British Journal of Pharmacology , vol.130 , pp. 1745-1752
    • Thum, T.1    Borlak, J.2
  • 53
    • 0036793580 scopus 로고    scopus 로고
    • Testosterone, cytochrome P450, and cardiac hypertrophy
    • Thum T., Borlak J. Testosterone, cytochrome P450, and cardiac hypertrophy. FASEB Journal 2002, 16:1537-1549.
    • (2002) FASEB Journal , vol.16 , pp. 1537-1549
    • Thum, T.1    Borlak, J.2
  • 55
    • 0027139782 scopus 로고
    • Enzyme-kinetic and immunochemical charateristic of mouse cDNA-expressed, microsomal and purified CYP1A1 and CYP1A2
    • Tsyrlov I.B., Goldfarb I.S., Gelboin H.V. Enzyme-kinetic and immunochemical charateristic of mouse cDNA-expressed, microsomal and purified CYP1A1 and CYP1A2. Archives of Biochemistry and Biophysics 1993, 307:259-266.
    • (1993) Archives of Biochemistry and Biophysics , vol.307 , pp. 259-266
    • Tsyrlov, I.B.1    Goldfarb, I.S.2    Gelboin, H.V.3
  • 56
    • 67650841094 scopus 로고    scopus 로고
    • Sex differences in the expression of hepatic drug metabolizing enzymes
    • Waxman D.J., Halloway M.G. Sex differences in the expression of hepatic drug metabolizing enzymes. Molecular Pharmacology 2009, 76:215-228.
    • (2009) Molecular Pharmacology , vol.76 , pp. 215-228
    • Waxman, D.J.1    Halloway, M.G.2
  • 58
    • 0025093631 scopus 로고
    • Automated assays for superoxide superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase activity
    • Wheeler C.R., Salzman J.A., Elsayed N.M., Omayed S.T., Korte D.W. Automated assays for superoxide superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase activity. Analytical of Biochemistry 1990, 184:193-199.
    • (1990) Analytical of Biochemistry , vol.184 , pp. 193-199
    • Wheeler, C.R.1    Salzman, J.A.2    Elsayed, N.M.3    Omayed, S.T.4    Korte, D.W.5
  • 59
    • 34548082616 scopus 로고    scopus 로고
    • Expression of constitutive androstane receptor, hepatic nuclear factor 4α, and P450 oxidoreductase genes determines interindividual variability in basal expression and activity of a broad scope of xenobiotic metabolism genes in the human liver
    • Wortham M., Czerwinki M., He L., Parkinson A., Wan Y.-J. Expression of constitutive androstane receptor, hepatic nuclear factor 4α, and P450 oxidoreductase genes determines interindividual variability in basal expression and activity of a broad scope of xenobiotic metabolism genes in the human liver. Drug Metabolism and Disposition 2007, 35:1700-1710.
    • (2007) Drug Metabolism and Disposition , vol.35 , pp. 1700-1710
    • Wortham, M.1    Czerwinki, M.2    He, L.3    Parkinson, A.4    Wan, Y.-J.5


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