Anatomy of the human mammary gland: Current status of knowledge

Clinical Anatomy

Volumn 26, Issue 1, 2013, Pages 29-48

  Hassiotou, Foteini ^a   Geddes, Donna ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

anatomy; breast; breast cancer; histology; lactation; lactocytes; mammary gland; stem cells

Indexed keywords

ANATOMY; BREAST CANCER; BREAST DEVELOPMENT; BREAST DUCTAL SYSTEM; BREAST LOBE; BREAST MILK; FETUS DEVELOPMENT; HISTOPATHOLOGY; HUMAN; LACTATION; MAMMARY GLAND; NIPPLE; PERINATAL DEVELOPMENT; POSTMENOPAUSE; POSTNATAL DEVELOPMENT; PREGNANCY; PRIORITY JOURNAL; PUBERTY; REVIEW;

EID: 84871409331     PISSN: 08973806     EISSN: 10982353     Source Type: Journal    
DOI: 10.1002/ca.22165     Document Type: Review

References (189)

1. AAP. 2005. American Academy of Pediatrics: Policy Statement, Section on Breastfeeding. Breastfeeding and the use of human milk. Pediatrics 115: 496-506.
2. AIHW. 2010. Australian Institute of Health and Welfare & Australasian Association of Cancer Registries. Cancer in Australia: an overview,2010. In: 2010 AIoHaWAAoCR, editor. Canberra: Australian Institute of Health and Welfare & Australasian Association of Cancer Registries.
3. Aljazaf K, Hale TW, Ilett KF, Hartmann PE, Mitoulas LR, Kristensen JH, Hackett LP,. 2003. Pseudoephedrine: Effects on milk production in women and estimation of infant exposure via breastmilk. Br J Clin Pharmacol 56: 18-24.
4. Aljazaf KM,. 2005. Ultrasound imaging in the analysis of the blood supply and blood flow in the human lactating breast. In: Chemistry and Biochemistry. Perth: The University of Western Australia.
5. Anbazhagan R, Gusterson BA,. 1994. Prenatal factors may influence predisposition to breast cancer. Eur J Cancer 30A: 1-3.
6. Anderson E, Clarke RB,. 2004. Steroid receptors and cell cycle in normal mammary epithelium. J Mammary Gland Biol Neoplasia 9: 3-13.
7. Anson BJ, Wright RR, Wolfer JA,. 1939. Blood supply of the mammary gland. Surg Gynaecol Obstet 68: 161-166.
8. Asselin-Labat ML, Vaillant F, Sheridan JM, Pal B, Wu D, Simpson ER, Yasuda H, Smyth GK, Martin TJ, Lindeman GJ, Visvader JE,. 2010. Control of mammary stem cell function by steroid hormone signalling. Nature 465: 798-802.
9. Aukland K, Reed RK,. 1993. Interstitial-lymphatic mechanisms in the control of extracellular fluid volume. Physiol Rev 73: 1-78.
10. Bachman KC,. 1982. Effect of exogenous estradiol and progesterone upon lipase activity and spontaneous lipolysis in bovine milk. JDairy Sci 65: 907-914.
11. Baker JL, Michaelson KF, Sørensen TI, Rasmussen KM,. 2007. High prepregnant body mass index is associated with early termination of full and any breastfeeding in Danish women. Am J Clin Nutr 86: 404-411.
12. Bessler H, Straussberg R, Hart J, Notti I, Sirota L,. 1996. Human colostrum stimulates cytokine production. Biol Neonate 69: 376-382.
13. Bissell MJ, Weaver VM, Lelievre SA, Wang F, Petersen OW, Schmeichel KL,. 1999. Tissue structure, nuclear organization, and gene expression in normal and malignant breast. Cancer Res 59: 1757-1764.
14. Bode L, Jantscher-Krenn E,. 2012. Structure-function relationships of human milk oligosaccharides. Adv Nutr 3: 383S-391S.
15. Borgstein PJ, Meijer S, Pijpers RJ, van Diest PJ,. 2000. Functional lymphatic anatomy for sentinel node biopsy in breast cancer: echoes from the past and the periareolar blue method. Ann Surg 232: 81-89.
16. Byers T, Nestle M, McTiernan A, Doyle C, Currie-Williams A, Gansler T, Thun M,. 2002. American Cancer Society guidelines on nutrition and physical activity for cancer prevention: Reducing the risk of cancer with healthy food choices and physical activity. CA Cancer J Clin 52: 92-119.
17. Ceriani RL,. 1974. Proceedings: Hormones and other factors controlling growth in the mammary gland: a review. J Invest Dermatol 63: 93-108.
18. Christensen K, Nielsen MO, Bauer R, Hilden K,. 1989. Evaluation of mammary blood flow measurements in lactating goats using the ultrasound Doppler principle. Comp Biochem Physiol A Comp Physiol 92: 385-392.
19. Cooper AP,. 1840. The Anatomy of the Breast. London: Longman, Orme, Green, Brown and Longmans.
20. Courtiss EH, Goldwyn RM,. 1976. Breast sensation before and after plastic surgery. Plast Reconstr Surg 58: 1-13.
21. Cowie AT,. 1974. Proceedings: Overview of the mammary gland. J Invest Dermatol 63: 2 -9.
22. Cowie AT, Forsyth IA, Hart IC,. 1980. Hormonal control of lactation. Monogr Endocrinol 15: I- XIV, 1-275.
23. Cox DB, Kent JC, Casey TM, Owens RA, Hartmann PE,. 1999. Breast growth and the urinary excretion of lactose during human pregnancy and early lactation: endocrine relationships. Exp Physiol 84: 421-434.
24. Cox DB, Owens RA, Hartmann PE,. 1996. Blood and milk prolactin and the rate of milk synthesis in women. Exp Physiol 81: 1007-1020.
25. Craig RD, Sykes PA,. 1970. Nipple sensitivity following reduction mammaplasty. Br J Plast Surg 23: 165-172.
26. Cunningham L,. 1977. The anatomy of the arteries and veins of the breast. J Surg Oncol 9: 71-85.
27. Czank C., 2007. Hormonal control of the lactation cycle. In:, Hale TW, Hartmann PE, editors. Textbook of Human Lactation. Amarillo, Texas: Hale Publishing.
28. Davis SR, Farr VC, Prosser CG,. 1995. Dose-dependent effects of oxytocin on the microcirculation in the mammary gland of the lactating rat. In:, Wilde CJ, editor. Intercellular Signalling in the Mammary Gland. New York: Plenum Press. p 267-268.
29. Donath SM, Amir LH,. 2000. Does maternal obesity adversely affect breastfeeding initiation and duration?. J Paediatr Child Health 36: 482-486.
30. Dontu G, Abdallah WM, Foley JM, Jackson KW, Clarke MF, Kawamura MJ, Wicha MS,. 2003. In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev 17: 1253-1270.
31. Doughty JC, McCarter DH, Kane E, Reid AW, Cooke TG, McArdle CS,. 1996. Anatomical basis of intra-arterial chemotherapy for patients with locally advanced breast cancer. Br J Surg 83: 1128-1130.
32. Eriksson M, Lundeberg T, Uvnas-Moberg K,. 1996. Studies on cutaneous blood flow in the mammary gland of lactating rats. Acta Physiol Scand 158: 1-6.
33. Farina MA, Newby BG, Alani HM,. 1980. Innervation of the nipple-areola complex. Plast Reconstr Surg 66: 497-501.
34. Flint DJ, Boutinaud M, Tonner E, Wilde CJ, Hurley W, Accorsi PA, Kolb AF, Whitelaw CB, Beattie J, Allan GJ,. 2005. Insulin-like growth factor binding proteins initiate cell death and extracellular matrix remodeling in the mammary gland. Domest Anim Endocrinol 29: 274-282.
35. Frank A, Bruhn JC, Lawrence CM,. 1988. Distribution of protein in California milk in 1983. J Dairy Sci 71: 2373.
36. Freeman JL, Walker EP, Wilson JS, Shaw HJ,. 1981. The vascular anatomy of the pectoralis major myocutaneous flap. Br J Plast Surg 34: 3-10.
37. Gardai SJ, Bratton DL, Ogden CA, Henson PM,. 2006. Recognition ligands on apoptotic cells: A perspective. J Leukoc Biol 79: 896-903.
38. Geddes DT,. 2007. Inside the lactating breast: The latest anatomy research. J Midwifery Womens Health 52: 556-563.
39. Geddes DT,. 2009. Ultrasound imaging of the lactating breast: Methodology and application. Int Breastfeed J 4: 4.
40. Geddes DT, Aljazaf KM, Kent JC, Prime DK, Spatz DL, Garbin CP, Lai CT, Hartmann PE,. 2012. Blood flow characteristics of the human lactating breast. J Hum Lact 28: 145-152.
41. Going JJ, Moffat DF,. 2004. Escaping from Flatland: Clinical and biological aspects of human mammary duct anatomy in three dimensions. J Pathol 203: 538-544.
42. Going JJ, Mohun TJ,. 2006. Human breast duct anatomy, the 'sick lobe' hypothesis and intraductal approaches to breast cancer. Breast Cancer Res Treat 97: 285-291.
43. Gooding MJ, Finlay J, Shipley JA, Halliwell M, Duck FA,. 2010. Three-dimensional ultrasound imaging of mammary ducts in lactating women: A feasibility study. J Ultrasound Med 29: 95-103.
44. Greendale GA, Palla SL, Ursin G, Laughlin GA, Crandall C, Pike MC, Reboussin BA,. 2005. The association of endogenous sex steroids and sex steroid binding proteins with mammographic density: Results from the Postmenopausal Estrogen/Progestin Interventions Mammographic Density Study. Am J Epidemiol 162: 826-834.
45. Grover PL, Martin FL,. 2002. The initiation of breast and prostate cancer. Carcinogenesis 23: 1095-1102.
46. Gusterson BA, Ross DT, Heath VJ, Stein T,. 2005. Basal cytokeratins and their relationship to the cellular origin and functional classification of breast cancer. Breast Cancer Res 7: 143-148.
47. Hakansson A, Andreasson J, Zhivotovsky B, Karpman D, Orrenius S, Svanborg C,. 1999. Multimeric alpha-lactalbumin from human milk induces apoptosis through a direct effect on cell nuclei. Exp Cell Res 246: 451-460.
48. Hakansson A, Zhivotovsky B, Orrenius S, Sabharwal H, Svanborg C,. 1995. Apoptosis induced by a human milk protein. Proc Natl Acad Sci USA 92: 8064-8068.
49. Hartmann PE,. 1991. The breast and breast-feeding. In:, Philipp EE, Setchell M, Ginsburg J, editor. Scientifc Foundations of Obstetrics and Gynaecology. 4th Ed. Oxford: Butterworth Heinemann.
50. Hartmann PE,. 2007. The lactating breast: An overview from down under. Breastfeed Med 2: 3-9.
51. Hartmann PE, Kulski JK,. 1978. Changes in the composition of the mammary secretion of women after abrupt termination of breast feeding. J Physiol 275: 1-11.
52. Hassiotou F, Filgueira L, Trengove N, Tat Lai C, Hartmann P,. 2011. Breastmilk contains embryonic-like stem cells. In: Milk Genomics International Conference, Melbourne, Australia.
53. Hassiotou F, Beltran A, Trengove N, Tat Lai C, Hartmann PE, Filgueira L, Blancafort P,. 2012a. Embryonic transcription factor upregulation during normal lactation and breast oncogenesis. In: International Society for Stem Cell Research, Yokohama, Japan.
54. Hassiotou F, Filgueira L, Hepworth A, Trengove N, Tat Lai C, Hartmann P,. 2012b. Coordinated response of the fat and cellular content of breastmilk to the degree of fullness of the breast. In: Minisymposium on Lactation: Biology of milk production and secretion, San Diego, USA.
55. Hassiotou F, Metzger P, Trengove N, Tat Lai C, Filgueira L, Hartmann PE,. 2012c. The immunological cellular and biochemical contents of breastmilk respond to maternal or infant infections. In: Minisymposium on Lactation: Biology of milk production and secretion, San Diego, USA.
56. Hassiotou F, Beltran A, Chetwynd E, Stuebe AM, Twigger A-J, Metzger P, Trengove N, Lai CT, Filgueira L, Blancafort P, Hartmann PE,. 2012d. Breastmilk is a novel source of stem cells with multi-lineage differentiation potential. Stem Cells (in press).
57. Hassiotou F, Trengove N, Tat Lai C, Filgueira L, Blancafort P, Hartmann PE,. 2012e. Breastmilk stem cells: An overview of the current knowledge. In: Breastfeeding and Lactation Symposium, Vienna, Austria.
58. Henderson JJ, Dickinson JE, Evans SF, McDonald SJ, Paech MJ,. 2003. Impact of intrapartum epidural analgesia on breast-feeding duration. Aust NZ J Obstet Gynaecol 43: 372-377.
59. Henson PM,. 2005. Engulfment: ingestion and migration with Rac, Rho and TRIO. Curr Biol 15: R29-R30.
60. Hennighausen L, Robinson GW,. 2005. Information networks in the mammary gland. Nature reviews. Mol Cell Biol 6: 715-725.
61. Hilson JA, Rasmussen KM, Kjolhede CL,. 1997. Maternal obesity and breast-feeding success in a rural population of white women. Am J Clin Nutr 66: 1371-1378.
62. Hovey RC, Trott JF, Vonderhaar BK,. 2002. Establishing a framework for the functional mammary gland: from endocrinology to morphology. J Mammary Gland Biol Neoplasia 7: 17-38.
63. Howard BA, Gusterson BA,. 2000. Human breast development. JMammary Gland Biol Neoplasia 5: 119-137.
64. Hughes K, Wickenden JA, Allen JE, Watson CJ,. 2012. Conditional deletion of Stat3 in mammary epithelium impairs the acute phase response and modulates immune cell numbers during post-lactational regression. J Pathol 227: 106-117.
65. Hultborn KA, Larsson LG, Ragnhult I,. 1955. The lymph drainage from the breast to the axillary and parasternal lymph nodes, studied with the aid of colloidal Au198. Acta Radiol 43: 52-64.
66. Humphreys RC, Bierie B, Zhao L, Raz R, Levy D, Hennighausen L,. 2002. Deletion of Stat3 blocks mammary gland involution and extends functional competence of the secretory epithelium in the absence of lactogenic stimuli. Endocrinology 143: 3641-3650.
67. Hurley WL,. 1989. Mammary gland function during involution. JDairy Sci 72: 1637-1646.
68. Hutson SW, Cowen PN, Bird CC,. 1985. Morphometric studies of age related changes in normal human breast and their significance for evolution of mammary cancer. J Clin Pathol 38: 281-287.
69. Jacobs LS,. 1977. The role of prolactin in mammogenesis and lactogenesis. Adv Exp Med Biol 80: 173-191.
70. Janbu T, Koss KS, Thoresen M, Wesche J,. 1985. Blood velocities to the female breast during lactation and following oxytocin injections. J Dev Physiol 7: 373-380.
71. Joshi PA, Jackson HW, Beristain AG, Di Grappa MA, Mote PA, Clarke CL, Stingl J, Waterhouse PD, Khokha R,. 2010. Progesterone induces adult mammary stem cell expansion. Nature 465: 803-807.
72. Kamikawa A, Ichii O, Yamaji D, Imao T, Suzuki C, Okamatsu-Ogura Y, Terao A, Kon Y, Kimura K,. 2009. Diet-induced obesity disrupts ductal development in the mammary glands of nonpregnant mice. Dev Dyn 238: 1092-1099.
73. Kent JC, Mitoulas LR, Cregan MD, Ramsay DT, Doherty DA, Hartmann PE,. 2006. Volume and frequency of breastfeedings and fat content of breast milk throughout the day. Pediatrics 117: e387-e395.
74. Key TJ, Verkasalo PK, Banks E,. 2001. Epidemiology of breast cancer. Lancet Oncol 2: 133-140.
75. Kim HH, Park CS,. 2004. A compensatory nutrition regimen during gestation stimulates mammary development and lactation potential in rats. J Nutr 134: 756-761.
76. Kotsopoulos J, Lubinski J, Salmena L, Lynch HT, Kim-Sing C, Foulkes WD, Ghadirian P, Neuhausen SL, Demsky R, Tung N, Ainsworth P, Senter L, Eisen A, Eng C, Singer C, Ginsburg O, Blum J, Huzarski T, Poll A, Sun P, Narod SA,. 2012. Breastfeeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. Breast Cancer Res 14: R42.
77. Kreuzaler PA, Staniszewska AD, Li W, Omidvar N, Kedjouar B, Turkson J, Poli V, Flavell RA, Clarkson RW, Watson CJ,. 2011. Stat3 controls lysosomal-mediated cell death in vivo. Nat Cell Biol 13: 303-309.
78. Kris-Etherton PM, Hecker KD, Bonanome A, Coval SM, Binkoski AE, Hilpert KF, Griel AE, Etherton TD,. 2002. Bioactive compounds in foods: Their role in the prevention of cardiovascular disease and cancer. Am J Med 113 Suppl 9B: 71S-88S.
79. Kugyelka JG, Rasmussen KM, Frongillo EA,. 2004. Maternal obesity is negatively associated with breastfeeding success among Hispanic but not Black women. J Nutr 134: 1746-1753.
80. Lacasse P, Prosser CG,. 2003. Mammary blood flow does not limit milk yield in lactating goats. J Dairy Sci 86: 2094-2097.
81. Lavialle F, Rainteau D, Massey-Harroche D, Metz F,. 2000. Establishment of plasma membrane polarity in mammary epithelial cells correlates with changes in prolactin trafficking and in annexin VI recruitment to membranes. Biochim Biophys Acta 1464: 83-94.
82. Leonard SA, Labiner-Wolfe J, Geraghty SR, Rasmussen KM,. 2011. Associations between high prepregnancy body mass index, breast-milk expression, and breast-milk production and feeding. Am J Clin Nutr 93: 556-563.
83. Li CI, Moe RE, Daling JR,. 2003a. Risk of mortality by histologic type of breast cancer among women aged 50 to 79 years. Arch Intern Med 163: 2149-2153.
84. Li R, Jewell S, Grummer-Strawn L., 2003b. Maternal obesity and breast-feeding practices. Am J Clin Nutr 77: 931-936.
85. Lin Y, Xia L, Turner JD, Zhao X,. 1995. Morphologic observation of neutrophil diapedesis across bovine mammary gland epithelium in vitro. Am J Vet Res 56: 203-207.
86. Linzell JL,. 1960. Mammary-gland blood flow and oxygen, glucose and volatile fatty acid uptake in the conscious goat. J Physiol 153: 492-509.
87. Linzell JL, Peaker M,. 1971. The permeability of mammary ducts. J Physiol 216: 701-716.
88. Liu J, Smith MG, Dobre MA, Ferguson JE,. 2010. Maternal obesity and breast-feeding practices among white and black women. Obesity 18: 175-182.
89. Lonnerdal B,. 2003. Nutritional and physiologic significance of human milk proteins. Am J Clin Nutr 77: 1537S-1543S.
90. Love SM, Barsky SH,. 2004. Anatomy of the nipple and breast ducts revisited. Cancer 101: 1947-1957.
91. Lovelady CA,. 2005. Is maternal obesity a cause of poor lactation performance. Nutr Rev 63: 352-355.
92. Lu X, Wang Q, Hu G, Van Poznak C, Fleisher M, Reiss M, Massague J, Kang Y,. 2009. ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis. Genes Dev 23: 1882-1894.
93. Maltz E, Blatchford DR, Peaker M,. 1984. Effects of frequent milking on milk secretion and mammary blood flow in the goat. Q J Exp Physiol 69: 127-132.
94. May CD, Sphyris N, Evans KW, Werden SJ, Guo W, Mani SA,. 2011. Epithelial-mesenchymal transition and cancer stem cells: A dangerously dynamic duo in breast cancer progression. Breast Cancer Res 13: 202.
95. McClellan HL, Miller SJ, Hartmann PE,. 2008. Evolution of lactation: Nutrition v. protection with special reference to five mammalian species. Nutr Res Rev 21: 97-116.
96. McDaniel SM, Rumer KK, Biroc SL, Metz RP, Singh M, Porter W, Schedin P,. 2006. Remodeling of the mammary microenvironment after lactation promotes breast tumor cell metastasis. Am J Pathol 168: 608-620.
97. Medina D,. 1996. The mammary gland: A unique organ for the study of development and tumorigenesis. J Mammary Gland Biol Neopasia 1: 5-19.
98. Meier PP, Engstrom JL, Patel AL, Jegier BJ, Bruns NE,. 2010. Improving the use of human milk during and after the NICU stay. Clin Perinatol 37: 217-245.
99. Merchant K, Martorell R, Haas J,. 1990. Maternal and fetal responses to the stresses of lactation concurrent with pregnancy and of short recuperative intervals. Am J Clin Nutr 52: 280-288.
100. Michaud DS, Augustsson K, Rimm EB, Stampfer MJ, Willet WC, Giovannucci E,. 2001. A prospective study on intake of animal products and risk of prostate cancer. Cancer Causes Control 12: 557-567.
101. Michie CA,. 1998. The long term effects of breastfeeding: A role for the cells in breast milk?. J Trop Pediatr 44: 2-3.
102. Mitoulas LR, Kent JC, Cox DB, Owens RA, Sherriff JL, Hartmann PE,. 2002. Variation in fat, lactose and protein in human milk over 24 h and throughout the first year of lactation. Br J Nutr 88: 29-37.
103. Moffat DF, Going JJ,. 1996. Three dimensional anatomy of complete duct systems in human breast: Pathological and developmental implications. J Clin Pathol 49: 48-52.
104. Mok E, Multon C, Piguel L, Barroso E, Goua V, Christin P, Perez MJ, Hankard R,. 2008. Decreased full breastfeeding, altered practices, perceptions, and infant weight change of prepregnant obese women: a need for extra support. Pediatrics 121: e1319-e1324.
105. Molenaar AJ, Davis SR, Wilkins RJ,. 1992. Expression of alpha-lactalbumin, alpha-S1-casein, and lactoferrin genes is heterogeneous in sheep and cattle mammary tissue. J Histochem Cytochem 40: 611-618.
106. Monks J, Geske FJ, Lehman L, Fadok VA,. 2002. Do inflammatory cells participate in mammary gland involution?. J Mammary Gland Biol Neopasia 7: 163-176.
107. Monks J, Henson PM,. 2009. Differentiation of the mammary epithelial cell during involution: Implications for breast cancer. J Mammary Gland Biol Neopasia 14: 159-170.
108. Monks J, Smith-Steinhart C, Kruk ER, Fadok VA, Henson PM,. 2008. Epithelial cells remove apoptotic epithelial cells during post-lactation involution of the mouse mammary gland. Biol Reprod 78: 586-594.
109. Montagna W, Macpherson EE,. 1974. Proceedings: Some neglected aspects of the anatomy of human breasts. J Invest Dermatol 63: 10-16.
110. Naccarato AG, Viacava P, Vignati S, Fanelli G, Bonadio AG, Montruccoli G, Bevilacqua G,. 2000. Bio-morphological events in the development of the human female mammary gland from fetal age to puberty. Virchows Arch 436: 431-438.
111. Nandi S,. 1958. Role of somatotropin in mammogenesis and lactogenesis in C3H/He CRGL mice. Science 128: 772-774.
112. Neville MC, McFadden TB, Forsyth I,. 2002. Hormonal regulation of mammary differentiation and milk secretion. J Mammary Gland Biol Neoplasia 7: 49-66.
113. NH&MRC. 2005. Hormone replacement therapy for women at or after the menopause: A comprehensive literature review. In: Australian National Health and Medical Research Council.
114. Ohtake T, Kimijima I, Fukushima T, Yasuda M, Sekikawa K, Takenoshita S, Abe R,. 2001. Computer-assisted complete three-dimensional reconstruction of the mammary ductal/lobular systems: implications of ductal anastomoses for breast-conserving surgery. Cancer 91: 2263-2272.
115. Osin P, Crook T, Powles T, Peto J, Gusterson B,. 1998. Hormone status of in-situ cancer in BRCA1 and BRCA2 mutation carriers. Lancet 351: 1487.
116. Oskarsson T, Acharyya S, Zhang XH, Vanharanta S, Tavazoie SF, Morris PG, Downey RJ, Manova-Todorova K, Brogi E, Massague J,. 2011. Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs. Nat Med 17: 867-874.
117. Pang WW, Hartmann PE,. 2007. Initiation of human lactation: Secretory differentiation and secretory activation. J Mammary Gland Biol Neoplasia 12: 211-221.
118. Pearl SL, Downey HF, Lepper TL,. 1973. Intramammary pressure and mammary blood flow in lactating goats. J Dairy Sci 56: 1319-1323.
119. Pece S, Tosoni D, Confalonieri S, Mazzarol G, Vecchi M, Ronzoni S, Bernard L, Viale G, Pelicci PG, Di Fiore PP,. 2010. Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content. Cell 140: 62-73.
120. Perou CM, Sorlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, Fluge O, Pergamenschikov A, Williams C, Zhu SX, Lonning PE, Borresen-Dale AL, Brown PO, Botstein D,. 2000. Molecular portraits of human breast tumours. Nature 406: 747-752.
121. Pike MC, Krailo MD, Henderson BE, Casagrande JT, Hoel DG,. 1983. 'Hormonal' risk factors, 'breast tissue age' and the age-incidence of breast cancer. Nature 303: 767-770.
122. Pirila S, Saarinen-Pihkala UM, Viljakainen H, Turanlahti M, Kajosaari M, Makitie O, Taskinen M,. 2012. Breastfeeding and determinants of adult body composition: A prospective study from birth to young adulthood. Horm Res Paediatr 77: 281-290.
123. Playford RJ, Macdonald CE, Johnson WS,. 2000. Colostrum and milk-derived peptide growth factors for the treatment of gastrointestinal disorders. Am J Clin Nutr 72: 5-14.
124. Prat A, Perou CM,. 2009. Mammary development meets cancer genomics. Nat Med 15: 842-844.
125. Prime DK, Geddes DT, Hepworth AR, Trengove NJ, Hartmann PE,. 2011. Comparison of the patterns of milk ejection during repeated breast expression sessions in women. Breastfeed Med 6: 183-190.
126. Prosser CG, Davis SR, Farr VC, Lacasse P,. 1996. Regulation of blood flow in the mammary microvasculature. J Dairy Sci 79: 1184-1197.
127. Ramsay DT, Kent JC, Hartmann RA, Hartmann PE,. 2005. Anatomy of the lactating human breast redefined with ultrasound imaging. J Anat 206: 525-534.
128. Ramsay DT, Kent JC, Owens RA, Hartmann PE,. 2004. Ultrasound imaging of milk ejection in the breast of lactating women. Pediatrics 113: 361-367.
129. Ramsay DT, Mitoulas LR, Kent JC, Cregan MD, Doherty DA, Larsson M, Hartmann PE,. 2006. Milk flow rates can be used to identify and investigate milk ejection in women expressing breast milk using an electric breast pump. Breastfeed Med 1: 14-23.
130. Rasmussen KM,. 2007. Association of maternal obesity before conception with poor lactation performance. Annu Rev Nutr 27: 103-121.
131. Renaudeau D, Lebreton Y, Noblet J, Dourmad JY,. 2002. Measurement of blood flow through the mammary gland in lactating sows: Methodological aspects. J Anim Sci 80: 196-201.
132. Robertson HA, King GJ,. 1979. Conjugated and unconjugated oestrogens in fetal and maternal fluids of the cow throughout pregnancy. J Reprod Fertil 55: 463-470.
133. Robinson JE, Short RV,. 1977. Changes in breast sensitivity at puberty, during the menstrual cycle, and at parturition. Br Med J 1: 1188-1191.
134. Rusby JE, Brachtel EF, Michaelson JS, Koerner FC, Smith BL,. 2007. Breast duct anatomy in the human nipple: Three-dimensional patterns and clinical implications. Breast Cancer Res Treat 106: 171-179.
135. Russo IH, Russo J,. 2011. Pregnancy-induced changes in breast cancer risk. J Mammary Gland Biol Neoplasia 16: 221-233.
136. Russo J, Calaf G, Roi L, Russo IH,. 1987. Influence of age and gland topography on cell kinetics of normal human breast tissue. J Natl Cancer Inst 78: 413-418.
137. Russo J, Hu YF, Silva ID, Russo IH,. 2001. Cancer risk related to mammary gland structure and development. Microsc Res Tech 52: 204-223.
138. Russo J, Romero AL, Russo IH,. 1994. Architectural pattern of the normal and cancerous breast under the influence of parity. Cancer Epidemiol Biomarkers Prev 3: 219-224.
139. Russo J, Russo IH,. 1992. The pathology of breast cancer: staging and prognostic indicators. J Am Med Womens Assoc 47: 181-187.
140. Russo J, Russo IR,. 2004. Development of the human breast. Maturitas 49: 2-15.
141. Russo J, Tay LK, Russo IH,. 1982. Differentiation of the mammary gland and susceptibility to carcinogenesis. Breast Cancer Res Treat 2: 5-73.
142. Saarela T, Kokkonen J, Koivisto M,. 2005. Macronutrient and energy contents of human milk fractions during the first six months of lactation. Acta Paediatr 94: 1176-1181.
143. Saint L, Smith M, Hartmann PE,. 1984. The yield and nutrient content of colostrum and milk of women from giving birth to 1 month post-partum. Bt J Nutr 52: 87-95.
144. Salmon M,. 1939. Les Arteres de la glande mammaire. Ann D'anat Pathol 16: 477-500.
145. Sarhadi NS, Shaw Dunn J, Lee FD, Soutar DS,. 1996. An anatomical study of the nerve supply of the breast, including the nipple and areola. Br J Plast Surg 49: 156-164.
146. Schlenz I, Kuzbari R, Gruber H, Holle J,. 2000. The sensitivity of the nipple-areola complex: an anatomic study. Plast Reconstr Surg 105: 905-909.
147. Schmidt H,. 1998. Supernumerary nipples: prevalence, size, sex and side predilection-a prospective clinical study. Eur J Pediatr 157: 821-823.
148. Seelig LL Jr, Beer AE,. 1981. Intraepithelial leukocytes in the human mammary gland. Biol Reprod 24: 1157-1163.
149. Sejrsen K, Huber JT, Tucker HA, Akers RM,. 1982. Influence of nutrition of mammary development in pre- and postpubertal heifers. J Dairy Sci 65: 793-800.
150. Sejrsen K, Purup S,. 1997. Influence of prepubertal feeding level on milk yield potential of dairy heifers: a review. J Anim Sci 75: 828-835.
151. Shackleton M, Vaillant F, Simpson KJ, Stingl J, Smyth GK, Asselin-Labat ML, Wu L, Lindeman GJ, Visvader JE,. 2006. Generation of a functional mammary gland from a single stem cell. Nature 439: 84-88.
152. Stavros AT,. 2004. Breast Ultrasound. Philadelphia: Lippincott Williams & Wilkins.
153. Stensheim H, Moller B, van Dijk T, Fossa SD,. 2009. Cause-specific survival for women diagnosed with cancer during pregnancy or lactation: a registry-based cohort study. J Clin Oncol 27: 45-51.
154. Sternlicht MD,. 2006. Key stages in mammary gland development: the cues that regulate ductal branching morphogenesis. Breast Cancer Res 8: 201.
155. Sternlicht MD, Dunning AM, Moore DH, Pharoah PD, Ginzinger DG, Chin K, Gray JW, Waldman FM, Ponder BA, Werb Z,. 2006a. Prognostic value of PAI1 in invasive breast cancer: evidence that tumor-specific factors are more important than genetic variation in regulating PAI1 expression. Cancer Epidemiol Biomarkers Prev 15: 2107-2114.
156. Sternlicht MD, Kouros-Mehr H, Lu P, Werb Z,. 2006b. Hormonal and local control of mammary branching morphogenesis. Differentiation 74: 365-381.
157. Stettler N,. 2011. Infant feeding practices and subsequent development of adipose tissue. Nestle Nutr Workshop Ser Paediatr Program 68: 215-225.
158. Stingl J, Caldas C,. 2007. Molecular heterogeneity of breast carcinomas and the cancer stem cell hypothesis. Nat Rev Cancer 7: 791-799.
159. Sutherland KD, Lindeman GJ, Visvader JE,. 2007. The molecular culprits underlying precocious mammary gland involution. J Mammary Gland Biol Neoplasia 12: 15-23.
160. Suzuki R, Atherton AJ, O'Hare MJ, Entwistle A, Lakhani SR, Clarke C,. 2000. Proliferation and differentiation in the human breast during pregnancy. Differentiation 66: 106-115.
161. Taneri F, Kurukahvecioglu O, Akyurek N, Tekin EH, Ilhan MN, Cifter C, Bozkurt S, Dursun A, Bayram O, Onuk E,. 2006. Microanatomy of milk ducts in the nipple. Eur Surg Res 38: 545-549.
162. Tanis PJ, Nieweg OE, Valdes Olmos RA, Kroon BB,. 2001. Anatomy and physiology of lymphatic drainage of the breast from the perspective of sentinel node biopsy. J Am Coll Surg 192: 399-409.
163. Tavassoli FA,. 1992. Atypical hyperplasia: a morphologic risk factor for subsequent development of invasive breast carcinoma. Cancer Invest 10: 433-441.
164. Taylor-Papadimitriou J, Shearer M, Stoker MG,. 1977. Growth requirements of human mammary epithelial cells in culture. Int J Cancer 20: 903-908.
165. Tezer M, Bakkaloǧlu H, Ergüven M, Bilir A, Kadıoǧlu A,. 2011. Smooth muscle morphology in the nipple-areola complex. J Morphol Sci 28: 171-175.
166. Thomas E, Zeps N, Rigby P, Hartmann P,. 2011. Reactive oxygen species initiate luminal but not basal cell death in cultured human mammary alveolar structures: A potential regulator of involution. Cell Death Dis 2: e189.
167. Thoresen M, Wesche J,. 1988. Doppler measurements of changes in human mammary and uterine blood flow during pregnancy and lactation. Acta Obstet Gynecol Scand 67: 741-745.
168. Tobon H, Salazar H,. 1974. Ultrastructure of the human mammary gland. I. Development of the fetal gland throughout gestation. J Clin Endocrinol Metab 39: 443-456.
169. Turner-Warwick RT,. 1955. The demonstration of lymphatic vessels. Lancet 269: 1371.
170. Turner-Warwick RT,. 1959. The lymphatics of the breast. Br J Surg 46: 574-582.
171. van Deventer PV,. 2004. The blood supply to the nipple-areola complex of the human mammary gland. Aesthetic Plast Surg 28: 393-398.
172. Van Keymeulen A, Rocha AS, Ousset M, Beck B, Bouvencourt G, Rock J, Sharma N, Dekoninck S, Blanpain C,. 2011. Distinct stem cells contribute to mammary gland development and maintenance. Nature 479: 189-193.
173. Vendrell-Torne E, Setoain-Quinquer J, Domenech-Torne FM,. 1972. Study of normal mammary lymphatic drainage using radioactive isotopes. J Nucl Med 13: 801-805.
174. Venta LA, Dudiak CM, Salomon CG, Flisak ME,. 1994. Sonographic evaluation of the breast. Radiographics 14: 29-50.
175. Ventura SJ,. 1989. Trends and variations in first births to older women, United States, 1970-86. Vital Health Stat 21: 1-27.
176. Vidal K, Labeta MO, Schiffrin EJ, Donnet-Hughes A,. 2001. Soluble CD14 in human breast milk and its role in innate immune responses. Acta Odontol Scand 59: 330-334.
177. Villadsen R, Fridriksdottir AJ, Ronnov-Jessen L, Gudjonsson T, Rank F, LaBarge MA, Bissell MJ, Petersen OW,. 2007. Evidence for a stem cell hierarchy in the adult human breast. J Cell Biol 177: 87-101.
178. Visvader JE,. 2009. Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis. Genes Dev 23: 2563-2577.
179. Vorherr H,. 1974. The Breast: Morphology, Physiology and Lactation. London: Academic Press.
180. Wagner KU, Boulanger CA, Henry MD, Sgagias M, Hennighausen L, Smith GH,. 2002. An adjunct mammary epithelial cell population in parous females: Its role in functional adaptation and tissue renewal. Development 129: 1377-1386.
181. Watson CJ,. 2006. Post-lactational mammary gland regression: molecular basis and implications for breast cancer. Expert Rev Mol Med 8: 1-15.
182. Watson CJ, Khaled WT,. 2008. Mammary development in the embryo and adult: A journey of morphogenesis and commitment. Development 135: 995-1003.
183. Watson CJ, Kreuzaler PA,. 2011. Remodeling mechanisms of the mammary gland during involution. Int J Dev Biol 55: 757-762.
184. Williams PL,. 1995. Gray's Anatomy. 38th Ed. New York, Edinburgh: Churchill Livingstone.
185. Wilson-Clay B, Hoover K,. 2005. The Breastfeeding Atlas. Texas: LactNew Press.
186. Wiseman BS, Werb Z,. 2002. Stromal effects on mammary gland development and breast cancer. Science 296: 1046-1049.
187. Zhao H, Huang M, Chen Q, Wang Q, Pan Y,. 2012. Comparative gene expression analysis in mouse models for identifying critical pathways in mammary gland development. Breast Cancer Res Treat 132: 969-977.
188. Zhou L, Jiang Y, Yan T, Di G, Shen Z, Shao Z, Lu J,. 2010. The prognostic role of cancer stem cells in breast cancer: A meta-analysis of published literatures. Breast Cancer Res Treat 122: 795-801.
189. Zhou L, Yoshimura Y, Huang Y, Suzuki R, Yokoyama M, Okabe M, Shimamura M,. 2000. Two independent pathways of maternal cell transmission to offspring: Through placenta during pregnancy and by breast-feeding after birth. Immunology 101: 570-580.