Microwave assisted synthesis of novel pyrimidine derivatives and investigation of their analgesic and ulcerogenic activity

Medicinal Chemistry Research

Volumn 21, Issue 11, 2012, Pages 3629-3645

  Chaudhary, Anshu ^a,c,e,f   Sharma, Pramod Kumar ^b   Verma, Prabhakar ^d,e   Kumar, Nitin ^b,f   Dudhe, Rupesh ^b,c  

^a Vishveshwarya Institute of Medical Science Dadri   (India)

^b MEERUT INSTITUTE OF ENGINEERING AND TECHNOLOGY   (India)

^c UTTARAKHAND TECHNICAL UNIVERSITY   (India)

^d NIMS UNIVERSITY   (India)

^e MAHARSHI DAYANAND UNIVERSITY   (India)

^f Near Gurunanak Inter College   (India)

Author keywords

Analgesic activity; Claisen Schmidt condensation; Knoevenagel reaction; Microwave method; Pyrimidines

Indexed keywords

3 [2 [(PIPERIDIN 1 YL) METHYLAMINO]] 6 [(3 METHOXYPHENYL)PYRIMIDIN 4 YL] 6 BROMO 2H CHROMEN 2 ONE; 3 [2 [(PIPERIDIN 1 YL)METHYLAMINO]] 6 [(2 BROMOPHENYL)PYRIMIDIN 4 YL] 6 BROMO 2H CHROMEN 2 ONE; 3 [2 [(PIPERIDIN 1 YL)METHYLAMINO]] 6 [(2 CHLOROPHENYL)PYRIMIDIN 4 YL] 6 BROMO 2H CHROMEN 2 ONE; 3 [2 [(PIPERIDIN 1 YL)METHYLAMINO]] 6 [(2 METHOXYPHENYL)PYRIMIDIN 4 YL] 6 BROMO 2H CHROMEN 2 ONE; 3 [2 [(PIPERIDIN 1 YL)METHYLAMINO]] 6 [(2,4 DICHLOROPHENYL)PYRIMIDIN 4 YL] 6 BROMO 2H CHROMEN 2 ONE; 3 [2 [(PIPERIDIN 1 YL)METHYLAMINO]] 6 [(2,6 DICHLOROPHENYL)PYRIMIDIN 4 YL] 6 BROMO 2H CHROMEN 2 ONE; 3 [2 [(PIPERIDIN 1 YL)METHYLAMINO]] 6 [(3 BROMOPHENYL)PYRIMIDINE 4 YL] 6 BROMO 2H CHROMEN 2 ONE; 3 [2 [(PIPERIDIN 1 YL)METHYLAMINO]] 6 [(3 CHLOROPHENYL)PYRIMIDIN 4 YL] 6 BROMO 2H CHROMEN 2 ONE; 3 [2 [(PIPERIDIN 1 YL)METHYLAMINO]] 6 [(4 BROMOPHENYL)PYRIMIDIN 4 YL] 6 BROMO 2H CHROMEN 2 ONE; 3 [2 [(PIPERIDIN 1 YL)METHYLAMINO]] 6 [(4 CHLOROPHENYL)PYRIMIDIN 4 YL] 6 BROMO 2H CHROMEN 2 ONE; 6 BROMO 3 [6 (2 BROMOPHENYL) 2 (MORPHOLINOMETHYLAMINO) PYRIMIDIN 4 YL] 2H CHROMEN 2 ONE; 6 BROMO 3 [6 (2 CHLOROPHENYL) 2 (MORPHOLINOMETHYLAMINO) PYRIMIDIN 4 YL] 2H CHROMEN 2 ONE; 6 BROMO 3 [6 (2 METHOXYPHENYL) 2 (MORPHOLINOMETHYLAMINO) PYRIMIDIN4 YL] 2H CHROMEN 2 ONE; 6 BROMO 3 [6 (2,4 DICHLOROPHENYL) 2 (MORPHOLINOMETHYLAMINO) PYRIMIDIN4 YL] 2H CHROMEN 2 ONE; 6 BROMO 3 [6 (3 BROMOPHENYL) 2 (MORPHOLINOMETHYLAMINO) PYRIMIDIN4 YL] 2H CHROMEN 2 ONE; 6 BROMO 3 [6 (3 CHLOROPHENYL) 2 (MORPHOLINOMETHYLAMINO) PYRIMIDIN 4 Y] 2H CHROMEN 2 ONE; 6 BROMO 3 [6 (3 METHOXYPHENYL) 2 (MORPHOLINOMETHYLAMINO) PYRIMIDIN4 YL] 2H CHROMEN 2 ONE; 6 BROMO 3 [6 (4 BROMOPHENYL) 2 (MORPHOLINOMETHYLAMINO) PYRIMIDIN4 YL] 2H CHROMEN 2 ONE; 6 BROMO 3 [6 (4 CHLOROPHENYL) 2 (MORPHOLINOMETHYLAMINO) PYRIMIDIN 4 YL) 2H CHROMEN 2 ONE; 7 BROMO 3 [6 (2,6 DICHLOROPHENYL) 2 (MORPHOLINOMETHYLAMINO) PYRIMIDIN4 YL] 2H CHROMEN 2 ONE; DICLOFENAC; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ARTICLE; DRUG SYNTHESIS; IN VIVO STUDY; LOCOMOTION; MICROWAVE RADIATION; MOUSE; NONHUMAN; ULCEROGENESIS;

EID: 84871407509     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-011-9907-7     Document Type: Article

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