Interaction of inorganic nanoparticles with the skin barrier: Current status and critical review

Nanomedicine: Nanotechnology, Biology, and Medicine

Volumn 9, Issue 1, 2013, Pages 39-54

  Labouta, Hagar I ^a,b   Schneider, Marc ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b Alexandria University Faculty of Pharmacy   (Egypt)

Author keywords

Inorganic nanoparticles; Nanoparticle penetration; Particle penetration enhancement

Indexed keywords

BIOLOGICAL BARRIER; CRITICAL REVIEW; CURRENT STATUS; ENHANCED PENETRATION; GOLD STANDARDS; HUMAN SKIN; IN-VITRO; INORGANIC NANOPARTICLE; MEDICAL SCIENCE; PARTICLE PENETRATION; POTENTIAL ABILITY; QUALITATIVE AND QUANTITATIVE ANALYSIS; SKIN PENETRATION; TRANSDERMAL; UNDERLYING MECHANISM;

MEDICAL NANOTECHNOLOGY; RESEARCH; TISSUE;

NANOPARTICLES;

GOLD NANOPARTICLE; INORGANIC NANOPARTICLE; MAGNETIC NANOPARTICLE; NANOPARTICLE; QUANTUM DOT; SILICON DIOXIDE; SILVER NANOPARTICLE; TITANIUM DIOXIDE; UNCLASSIFIED DRUG; ZINC OXIDE;

CONJUGATION; DERMAPORTATION; DRUG DELIVERY SYSTEM; HEALTH HAZARD; HUMAN; HYPERTHERMIA; IN VITRO STUDY; IONTOPHORESIS; NONHUMAN; PHYSICAL CHEMISTRY; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; REVIEW; SKIN PENETRATION; SKIN PERMEABILITY; SONOPHORESIS; ULTRASOUND; ULTRAVIOLET RADIATION;

HUMANS; NANOPARTICLES; SKIN ABSORPTION;

EID: 84871405143     PISSN: 15499634     EISSN: 15499642     Source Type: Journal    
DOI: 10.1016/j.nano.2012.04.004     Document Type: Review

References (120)

1. Balogh L.P. Why do we have so many definitions for nanoscience and nanotechnology?. Nanomed Nanotechnol Biol Med 2010, 6:397-398.
2. Ramsden J.J. What is nanotechnology?. Applied nanotechnology 2009, 3-12. William Andrew Publishing, Boston.
3. Everts M. Thermal scalpel to target cancer. Expert Rev Med Devices 2007, 4:131-136.
4. Nanotechnology-Big things from a tiny world The United States National Nanotechnology Initiative, [cited 2010 November 23]; Available from:. http://www.nano.gov/sites/default/files/pub_resource/nanotechnology_bigthingsfromatinyworld-print.pdf.
5. Delouise L.A. Applications of nanotechnology in dermatology. J Invest Dermatol 2012, 132(3 Pt 2):964-975.
6. Labouta H.I., Schneider M. Tailor-made biofunctionalized nanoparticles using layer-by-layer technology. Int J Pharm 2010, 395:236-242.
7. Mazumder S., Dey R., Mitra M.K., Mukherjee S., Das G.C. Review: biofunctionalized quantum dots in biology and medicine. J Nanomater 2009, [(article ID 815734). 17 pp].
8. Peng C.-W., Li Y. Application of quantum dots-based biotechnology in cancer diagnosis: current status and future perspectives. J Nanomater 2010, [(article ID 676839): 11 pp].
9. Gao X., Cui Y., Levenson R.M., Chung L.W., Nie S. In vivo cancer targeting and imaging with semiconductor quantum dots. Nat Biotechnol 2004, 22:969-976.
10. Michalet X., Pinaud F.F., Bentolila L.A., Tsay J.M., Doose S., Li J.J., et al. Quantum dots for live cells, in vivo imaging, and diagnostics. Science 2005, 307:538-544.
11. Knopp D., Tang D., Niessner R. Review: bioanalytical applications of biomolecule-functionalized nanometer-sized doped silica particles. Anal Chim Acta 2009, 647:14-30.
12. Wang L., Zhao W., Tan W. Bioconjugated silica nanoparticles: development and applications. Nano Res 2008, 1:99-115.
13. Atiyeh B.S., Costagliola M., Hayek S.N., Dibo S.A. Effect of silver on burn wound infection control and healing: review of the literature. Burns 2007, 33:139-148.
14. Yen H.J., Hsu S.H., Tsai C.L. Cytotoxicity and immunological response of gold and silver nanoparticles of different sizes. Small 2009, 5:1553-1561.
15. Morones J.R., Elechiguerra J.L., Camacho A., Holt K., Kouri J.B., Ramirez J.T., et al. The bactericidal effect of silver nanoparticles. Nanotechnology 2005, 16:2346.
16. Wong K.K.Y., Liu X. Silver nanoparticles-the real "silver bullet" in clinical medicine?. Med Chem Comm 2010, 1:125-131.
17. Rai M., Yadav A., Gade A. Silver nanoparticles as a new generation of antimicrobials. Biotechnol Adv 2009, 27:76-83.
18. Pal S., Tak Y.K., Song J.M. Does the antibacterial activity of silver nanoparticles depend on the shape of the nanoparticle? A study of the gram-negative bacterium Escherichia coli. Appl Environ Microbiol 2007, 73:1712-1720.
19. Sperling R.A., Rivera Gil P., Zhang F., Zanella M., Parak W.J. Biological applications of gold nanoparticles. Chem Soc Rev 2008, 37:1896-1908.
20. El-Brolossy T.A., Abdallah T., Mohamed M.B., Abdallah S., Easawi K., Negm S., et al. Shape and size dependence of the surface plasmon resonance of gold nanoparticles studied by photoacoustic technique. Eur Phys J Special Topics 2008, 153:361-364.
21. Bhattacharya R., Mukherjee P. Biological properties of "naked" metal nanoparticles. Adv Drug Deliv Rev 2008, 60:1289-1306.
22. Jain P.K., El-Sayed I.H., El-Sayed M.A. Au nanoparticles target cancer. Nano Today 2007, 2:18-29.
23. Huang X., Qian W., El-Sayed I.H., El-Sayed M.A. The potential use of the enhanced nonlinear properties of gold nanospheres in photothermal cancer therapy. Lasers Surg Med 2007, 39:747-753.
24. Ghosh P., Han G., De M., Kim C.K., Rotello V.M. Gold nanoparticles in delivery applications. Adv Drug Deliv Rev 2008, 60:1307-1315.
25. Pissuwan D., Niidome T., Cortie M.B. The forthcoming applications of gold nanoparticles in drug and gene delivery systems. J Control Release 2011, 149:65-71.
26. Reum N., Fink-Straube C., Klein T., Hartmann R.W., Lehr C.M., Schneider M. Multilayer coating of gold nanoparticles with drug-polymer coadsorbates. Langmuir 2010, 26:16901-16908.
27. Brown S.D., Nativo P., Smith J.-A., Stirling D., Edwards P.R., Venugopal B., et al. Gold nanoparticles for the improved anticancer drug delivery of the active component of oxaliplatin. J Am Chem Soc 2010, 132:4678-4684.
28. Chen Y.-H., Tsai C.-Y., Huang P.-Y., Chang M.-Y., Cheng P.-C., Chou C.-H., et al. Methotrexate conjugated to gold nanoparticles inhibits tumor growth in a syngeneic lung tumor model. Mol Pharmaceutics 2007, 4:713-722.
29. Bhumkar D., Joshi H., Sastry M., Pokharkar V. Chitosan reduced gold nanoparticles as novel carriers for transmucosal delivery of insulin. Pharm Res 2007, 24:1415-1426.
30. Wang H., Huang H., Huang X. Differential effects of abscisic acid and ethylene on the fruit maturation of Litchi chinensis Sonn. Plant Growth Regul 2007, 52:189-198.
31. Thomas M., Klibanov A.M. Conjugation to gold nanoparticles enhances polyethylenimine's transfer of plasmid DNA into mammalian cells. Proc Natl Acad Sci USA 2003, 100:9138-9143.
32. Oishi M., Nakaogami J., Ishii T., Nagasaki Y. Smart PEGylated gold nanoparticles for the cytoplasmic delivery of siRNA to induce enhanced gene silencing. Chem Lett 2006, 35:1046-1047.
33. Häfeli U.O. Magnetically modulated therapeutic systems. Int J Pharm 2004, 277:19-24.
34. Vatta L.L., Sanderson R.D., Koch K.R. Magnetic nanoparticles: properties and potential applications. Pure Appl Chem 2006, 78:1793-1801.
35. Pankhurst Q.A., Connolly J., Jones S.K., Dobson J. Applications of magnetic nanoparticles in biomedicine. J Phys D: Appl Phys 2003, 36:R167-R181.
36. Berry C.C., Curtis A.S.G. Functionalisation of magnetic nanoparticles for applications in biomedicine. J Phys D: Appl Phys 2003, 36:R198-R206.
37. Gao J., Gu H., Xu B. Multifunctional magnetic nanoparticles: design, synthesis, and biomedical applications. Acc Chem Res 2009, 42:1097-1107.
38. Newman M.D., Stotland M., Ellis J.I. The safety of nanosized particles in titanium dioxide- and zinc oxide-based sunscreens. J Am Acad Dermatol 2009, 61:685-692.
39. Jones N., Ray B., Ranjit K.T., Manna A.C. Antibacterial activity of ZnO nanoparticle suspensions on a broad spectrum of microorganisms. FEMS Microbiol Lett 2008, 279:71-76.
40. Menon G.K. New insights into skin structure: scratching the surface. Adv Drug Deliv Rev 2002, 54(Suppl. 1):S3-S17.
41. Lee S.H., Jeong S.K., Ahn S.K. An update of the defensive barrier function of skin. Yonsei Med J 2006, 47:293-306.
42. Cevc G., Vierl U. Nanotechnology and the transdermal route: a state of the art review and critical appraisal. J Control Release 2010, 141:277-299.
43. Schneider M., Stracke F., Hansen S., Schaefer U.F. Nanoparticles and their interactions with the dermal barrier. Dermatoendocrinol 2009, 1:197-206.
44. Tan M.H., Commens C.A., Burnett L., Snitch P.J. A pilot study on the percutaneous absorption of microfine titanium dioxide from sunscreens. Australas J Dermatol 1996, 37:185-187.
45. Cross S.E., Innes B., Roberts M.S., Tsuzuki T., Robertson T.A., McCormick P. Human skin penetration of sunscreen nanoparticles: in-vitro assessment of a novel micronized zinc oxide formulation. Skin Pharmacol Physiol 2007, 20:148-154.
46. Mavon A., Miquel C., Lejeune O., Payre B., Moretto P. In vitro percutaneous absorption and in vivo stratum corneum distribution of an organic and a mineral sunscreen. Skin Pharmacol Physiol 2007, 20:10-20.
47. 2 and ZnO nanoparticle percutaneous absorption. Skin Pharmacol Physiol 2009, 22:266-275.
48. Zvyagin A.V., Zhao X., Gierden A., Sanchez W., Ross J.A., Roberts M.S. Imaging of zinc oxide nanoparticle penetration in human skin in vitro and in vivo. J Biomed Opt 2008, 13:064031.
49. Durand L., Habran N., Henschel V., Amighi K. In vitro evaluation of the cutaneous penetration of sprayable sunscreen emulsions with high concentrations of UV filters. Int J Cosmet Sci 2009, 31:279-292.
50. Roberts M.S., Roberts M.J., Robertson T.A., Sanchez W., Thorling C., Zou Y., et al. In vitro and in vivo imaging of xenobiotic transport in human skin and in the rat liver. J Biophotonics 2008, 1:478-493.
51. Pflucker F., Wendel V., Hohenberg H., Gartner E., Will T., Pfeiffer S., et al. The human stratum corneum layer: an effective barrier against dermal uptake of different forms of topically applied micronised titanium dioxide. Skin Pharmacol Appl Skin Physiol 2001, 14(Suppl. 1):92-97.
52. Schulz J., Hohenberg H., Pflucker F., Gartner E., Will T., Pfeiffer S., et al. Distribution of sunscreens on skin. Adv Drug Deliv Rev 2002, 54(Suppl. 1):S157-S163.
53. Dussert A.S., Gooris E., Hemmerle J. Characterization of the mineral content of a physical sunscreen emulsion and its distribution onto human stratum corneum. Int J Cosmet Sci 1997, 19:119-129.
54. Pinheiro T., Pallon J., Alves L.C., Veríssimo A., Filipe P., Silva J.N., et al. The influence of corneocyte structure on the interpretation of permeation profiles of nanoparticles across skin. Nuclear Instrum Meth Phys Res B 2007, 260:119-123.
55. 2) nanoparticles into intact and damaged skin in vitro. J Toxicol Sci 2010, 35:107-113.
56. 2 particles at the high energy ion nanoprobe LIPSION. Nuclear Instrum Meth Phys Res B 2004, 219-220:82-86.
57. Gamer A.O., Leibold E., van Ravenzwaay B. The in vitro absorption of microfine zinc oxide and titanium dioxide through porcine skin. Toxicol in Vitro 2006, 20:301-307.
58. 2 particles. Toxicol Sci 2010, 115:156-166.
59. 2 nanoparticles in hairless mice and porcine skin after subchronic dermal exposure. Toxicol Lett 2009, 191:1-8.
60. Lekki J., Stachura Z., Dabros W., Stachura J., Menzel F., Reinert T., et al. On the follicular pathway of percutaneous uptake of nanoparticles: ion microscopy and autoradiography studies. Nuclear Instrum Meth Phys Res B 2007, 260:174-177. [Nuclear Microprobe Technology and Applications (ICNMTA2006) and Proton Beam Writing (PBW II), 10th International Conference on Nuclear Microprobe Technology and Applications and 2nd International Workshop on Proton Beam Writing].
61. Gontier E., Ynsa M.-D., Biro T., Hunyadi J., Kiss B., Gaspar K., et al. Is there penetration of titania nanoparticles in sunscreens through skin? A comparative electron and ion microscopy study. Nanotoxicology 2008, 2:218-231.
62. 2-penetration in the epidermis of human skin xenografts. Nuclear Instrum Meth Phys Res B 2005, 231:280-285.
63. Smijs T.G., Pavel S. Titanium dioxide and zinc oxide nanoparticles in sunscreens: focus on their safety and effectiveness. Nanotechnol Sci Appl 2011, 4:95-112.
64. Schilling K., Bradford B., Castelli D., Dufour E., Nash J.F., Pape W., et al. Human safety review of "nano" titanium dioxide and zinc oxide. Photochem Photobiol Sci 2010, 9:495-509.
65. Hahn T., Schaefer U.F., Lehr C.M. Measuring skin absorption in vitro. SOFW J 2010, 136:28-38.
66. Chu M., Wu Q., Wang J., Hou S., Miao Y., Peng J., et al. In vitro and in vivo transdermal delivery capacity of quantum dots through mouse skin. Nanotechnology 2007, 18:455103.
67. Sonavane G., Tomoda K., Sano A., Ohshima H., Terada H., Makino K. In vitro permeation of gold nanoparticles through rat skin and rat intestine: effect of particle size. Colloids Surf B 2008, 65:1-10.
68. Gopee N.V., Roberts D.W., Webb P., Cozart C.R., Siitonen P.H., Latendresse J.R., et al. Quantitative determination of skin penetration of PEG-coated CdSe quantum dots in dermabraded but not intact SKH-1 hairless mouse skin. Toxicol Sci 2009, 111:37-48.
69. Godin B., Touitou E. Transdermal skin delivery: predictions for humans from in vivo, ex vivo and animal models. Adv Drug Deliv Rev 2007, 59:1152-1161.
70. Netzlaff F., Schaefer U.F., Lehr C.M., Meiers P., Stahl J., Kietzmann M., et al. Comparison of bovine udder skin with human and porcine skin in percutaneous permeation experiments. Altern Lab Anim 2006, 34:499-513.
71. Jeong S.H., Kim J.H., Yi S.M., Lee J.P., Kim J.H., Sohn K.H., et al. Assessment of penetration of quantum dots through in vitro and in vivo human skin using the human skin equivalent model and the tape stripping method. Biochem Biophys Res Commun 2010, 394:612-615.
72. Netzlaff F., Lehr C.M., Wertz P.W., Schaefer U.F. The human epidermis models EpiSkin®, SkinEthic® and EpiDerm®: an evaluation of morphology and their suitability for testing phototoxicity, irritancy, corrosivity, and substance transport. Eur J Pharm Biopharm 2005, 60:167-178.
73. Huang Y., Yu F., Park Y.S., Wang J., Shin M.C., Chung H.S., et al. Co-administration of protein drugs with gold nanoparticles to enable percutaneous delivery. Biomaterials 2010, 31:9086-9091.
74. Mortensen L, Zheng H, Faulknor R, De Benedetto A, Beck L, DeLouise LA. Increased in vivo skin penetration of quantum dots with UVR and in vitro quantum dot cytotoxicity. Colloidal Quantum Dots Biomed Appl IV 2009;7189:718919-718919-12.
75. Organisation for Economic Co-operation and Development OECD guidelines for the testing of chemicals, section 4. Test no. 428: skin absorption: in vitro method. 23 November 2004 Available from:. http://www.oecd-ilibrary.org/environment/test-no-428-skin-absorption-in-vitro-method_9789264071087-en.
76. Chen H.-Y., Zhao Q., Su K.-L., Lin Y.-C. Development of transdermal delivery chip system: deliver gold nanoparticles into human stratum corneum 2008.
77. Labouta H.I., Kraus T., El-Khordagui L.K., Schneider M. Mechanism and determinants of nanoparticle penetration through human skin. Nanoscale 2011, 3:4989-4999.
78. Labouta H.I., Liu D.C., Lin L.L., Butler M.K., Jeffrey G.E., Raphael A., et al. Gold nanoparticle penetration and reduced metabolism in human skin by toluene. Pharm Res 2011, 28:2931-2944.
79. Clowes H.M., Scott R.C., Heylings J.R. Skin absorption: flow-through or static diffusion cells. Toxicol in Vitro 1994, 8:827-830.
80. Ryman-Rasmussen J.P., Riviere J.E., Monteiro-Riviere N.A. Penetration of intact skin by quantum dots with diverse physicochemical properties. Toxicol Sci 2006, 91:159-165.
81. Marro D., Guy R.H., Begoña Delgado-Charro M. Characterization of the iontophoretic permselectivity properties of human and pig skin. J Control Release 2001, 70:213-217.
82. Labouta H.I., El-Khordagui L.K., Schneider M. Could chemical enhancement of gold nanoparticle penetration be extrapolated from established approaches for drug permeation?. Skin Pharmacol Physiol 2012, [Forthcoming].
83. Glombitza B., Müller-Goymann C.C. Influence of different ceramides on the structure of in vitro model lipid systems of the stratum corneum lipid matrix. Chem Phys Lipids 2002, 117:29-44.
84. Baroli B., Ennas M.G., Loffredo F., Isola M., Pinna R., Lopez-Quintela M.A. Penetration of metallic nanoparticles in human full-thickness skin. J Invest Dermatol 2007, 127:1701-1712.
85. Jiang S.J., Chen J.Y., Lu Z.F., Yao J., Che D.F., Zhou X.J. Biophysical and morphological changes in the stratum corneum lipids induced by UVB irradiation. J Dermatol Sci 2006, 44:29-36.
86. Mortensen L.J., Oberdorster G., Pentland A.P., Delouise L.A. In vivo skin penetration of quantum dot nanoparticles in the murine model: the effect of UVR. Nano Lett 2008, 8:2779-2787.
87. Upadhyay P. Enhanced transdermal-immunization with diphtheria-toxoid using local hyperthermia. Vaccine 2006, 24:5593-5598.
88. Dixit N., Bali V., Baboota S., Ahuja A., Ali J. Iontophoresis-an approach for controlled drug delivery: a review. Curr Drug Deliv 2007, 4:1-10.
89. Krishnan G., Edwards J., Chen Y., Benson H.A. Enhanced skin permeation of naltrexone by pulsed electromagnetic fields in human skin in vitro. J Pharm Sci 2010, 99:2724-2731.
90. Ogura M., Paliwal S., Mitragotri S. Low-frequency sonophoresis: current status and future prospects. Adv Drug Deliv Rev 2008, 60:1218-1223.
91. Paliwal S., Menon G.K., Mitragotri S. Low-frequency sonophoresis: ultrastructural basis for stratum corneum permeability assessed using quantum dots. J Invest Dermatol 2006, 126:1095-1101.
92. Seto J.E., Polat B.E., Lopez R.F.V., Blankschtein D., Langer R. Effects of ultrasound and sodium lauryl sulfate on the transdermal delivery of hydrophilic permeants: comparative in vitro studies with full-thickness and split-thickness pig and human skin. J Control Release 2010, 145:26-32.
93. US Department of Health, Human Services Food, Administration Drug Guidance for industry: topical dermatological drug product NDAs and ANDAs-in vivo bioavailability, bioequivalence, in vitro release, and associated studies. June 1998 Available from:. http://www.fda.gov/ohrms/dockets/ac/00/backgrd/3661b1c.pdf.
94. Choi M.J., Zhai H., Löffler H., Dreher F., Maibach H.I. Effect of tape stripping on percutaneous penetration and topical vaccination. Exog Dermatol 2003, 2:262-269.
95. Gratieri T., Schaefer U.F., Jing L., Gao M., Lopez R.F.V., Schneider M. Penetration of quantum dot particles through human skin. J Biomed Nanotechnol 2010, 6:586-595.
96. Zhang L.W., Monteiro-Riviere N.A. Assessment of quantum dot penetration into intact, tape-stripped, abraded and flexed rat skin. Skin Pharmacol Physiol 2008, 21:166-180.
97. Brown M.B., Martin G.P., Jones S.A., Akomeah F.K. Dermal and transdermal drug delivery systems: current and future prospects. Drug Deliv 2006, 13:175-187.
98. Gill H.S., Andrews S.N., Sakthivel S.K., Fedanov A., Williams I.R., Garber D.A., et al. Selective removal of stratum corneum by microdermabrasion to increase skin permeability. Eur J Pharm Sci 2009, 38:95-103.
99. Lee W.-R., Shen S.-C., Wang K.-H., Hu C.-H., Fang J.-Y. Lasers and microdermabrasion enhance and control topical delivery of vitamin C. J Invest Dermatol 2003, 121:1118-1125.
100. Kendall M., Rishworth S., Carter F., Mitchell T. Effects of relative humidity and ambient temperature on the ballistic delivery of micro-particles to excised porcine skin. J Invest Dermatol 2004, 122:739-746.
101. Thong H.Y., Zhai H., Maibach H.I. Percutaneous penetration enhancers: an overview. Skin Pharmacol Physiol 2007, 20:272-282.
102. Kuo T.R., Wu C.L., Hsu C.T., Lo W., Chiang S.J., Lin S.J., et al. Chemical enhancer induced changes in the mechanisms of transdermal delivery of zinc oxide nanoparticles. Biomaterials 2009, 30:3002-3008.
103. Baroli B. Penetration of nanoparticles and nanomaterials in the skin: fiction or reality?. J Pharm Sci 2010, 99:21-50.
104. Potts R.O., Francoeur M.L. The influence of stratum corneum morphology on water permeability. J Invest Dermatol 1991, 96:495-499.
105. Zhang L.W., Yu W.W., Colvin V.L., Monteiro-Riviere N.A. Biological interactions of quantum dot nanoparticles in skin and in human epidermal keratinocytes. Toxicol Appl Pharmacol 2008, 228:200-211.
106. Lee S.E., Choi K.J., Menon G.K., Kim H.J., Choi E.H., Ahn S.K., et al. Penetration pathways induced by low-frequency sonophoresis with physical and chemical enhancers: iron oxide nanoparticles versus lanthanum nitrates. J Invest Dermatol 2010, 130:1063-1072.
107. Schaefer H., Redelmeier T.E. Skin barrier: principles of percutaneous absorption 1996, 310. Karger, Basel.
108. Lademann J., Patzelt A., Richter H., Antoniou C., Sterry W., Knorr F. Determination of the cuticula thickness of human and porcine hairs and their potential influence on the penetration of nanoparticles into the hair follicles. J Biomed Opt 2009, 14:021014.
109. Patzelt A., Richter H., Knorr F., Schafer U., Lehr C.M., Dahne L., et al. Selective follicular targeting by modification of the particle sizes. J Control Release 2011, 150:45-48.
110. Filon F.L., D'Agostin F., Crosera M., Adami G., Rosani R., Romano C., et al. In vitro percutaneous absorption of silver nanoparticles. G Ital Med Lav Ergon 2007, 29(Suppl. 3):451-452.
111. Larese F.F., D'Agostin F., Crosera M., Adami G., Renzi N., Bovenzi M., et al. Human skin penetration of silver nanoparticles through intact and damaged skin. Toxicology 2009, 255:33-37.
112. Guldbrand S., Simonsson C., Smedh M., Ericson M.B. Point spread function measured in human skin using two-photon fluorescence microscopy 2009.
113. Guldbrand S., Simonsson C., Goksor M., Smedh M., Ericson M.B. Two-photon fluorescence correlation microscopy combined with measurements of point spread function; investigations made in human skin. Opt Express 2010, 18:15289-15302.
114. Labouta H.I., Hampel M., Thude S., Reutlinger K., Kostka K.H., Schneider M. Depth profiling of gold nanoparticles and characterization of point spread functions in reconstructed and human skin using multiphoton microscopy. J Biophotonics 2011, 5:85-96.
115. Mahe B., Vogt A., Liard C., Duffy D., Abadie V., Bonduelle O., et al. Nanoparticle-based targeting of vaccine compounds to skin antigen-presenting cells by hair follicles and their transport in mice. J Invest Dermatol 2009, 129:1156-1164.
116. Labouta H.I., Kraus T., El-Khordagui L.K., Schneider M. Combined multiphoton imaging-pixel analysis for semiquantitation of skin penetration of gold nanoparticles. Int J Pharm 2011, 413:279-282.
117. Larese Filon F., Crosera M., Adami G., Bovenzi M., Rossi F., Maina G. Human skin penetration of gold nanoparticles through intact and damaged skin. Nanotoxicology 2011, 5:493-501.
118. Prow T.W., Monteiro-Riviere N.A., Inman A.O., Grice J.E., Chen X., Zhao X., et al. Quantum dot penetration into viable human skin. Nanotoxicology 2011, 6:173-185.
119. Samberg M.E., Oldenburg S.J., Monteiro-Riviere N.A. Evaluation of silver nanoparticle toxicity in skin in vivo and keratinocytes in vitro. Environ Health Perspect 2010, 118:407-413.
120. Kiss B., Biro T., Czifra G., Toth B.I., Kertesz Z., Szikszai Z., et al. Investigation of micronized titanium dioxide penetration in human skin xenografts and its effect on cellular functions of human skin-derived cells. Exp Dermatol 2008, 17:659-667.