Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 51, 2012, Pages 20913-20918

  Liu, Cong ^a   Zhao, Minglei ^a,d   Jiang, Lin ^b   Cheng, Pin Nan ^b   Park, Jiyong ^a   Sawaya, Michael R ^a   Pensalfini, Anna ^b   Gou, Dawei ^c   Berk, Arnold J ^c   Glabe, Charles G ^b   Nowick, James ^b   Eisenberg, David ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

BAMs; X ray crystallography

Indexed keywords

AMYLOID; CYLINDRIN; HYDROGEN; OLIGOMER; UNCLASSIFIED DRUG;

ARTICLE; BETA SHEET; CRYSTAL STRUCTURE; CYTOTOXICITY; HYDROGEN BOND; PRIORITY JOURNAL;

AMYLOID; BETA 2-MICROGLOBULIN; CONGO RED; CRYSTALLOGRAPHY, X-RAY; FLUORESCENT DYES; HUMANS; HYDROGEN BONDING; MICROSCOPY, ELECTRON, TRANSMISSION; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PEPTIDES; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEINS; THERMODYNAMICS; X-RAY DIFFRACTION;

EID: 84871398573     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1218792109     Document Type: Article

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