Analysis of Amyloid Fibril Structure by Scanning Cysteine Mutagenesis

Methods in Enzymology

Volumn 413, Issue , 2006, Pages 182-198

  Shivaprasad, Shankaramma ^a   Wetzel, Ronald ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID; CYSTEINE;

GENE MUTATION; MOLECULAR DYNAMICS; MOLECULAR PROBE; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN STRUCTURE; REVIEW;

AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; CROSS-LINKING REAGENTS; CYSTEINE; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; POINT MUTATION; THERMODYNAMICS;

EID: 33746784978     PISSN: 00766879     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0076-6879(06)13010-4     Document Type: Review

References (29)

1. Alber T. Mutational effects on protein stability. Annu. Rev. Biochem. 58 (1989) 765-798
2. Chapman J.R. "Mass Spectrometry of Proteins and Peptides." (2000), Humana Press, Totowa, NJ
3. Couture R., Fournier A., Magnan J., St.-Pierre S., and Regoli D. Structure-activity studies on substance P. Can. J. Physiol. Pharmacol. 57 (1979) 1427-1436
4. Cunningham B.C., and Wells J.A. High-resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis. Science 244 (1989) 1081-1085
5. Guo J.-T., Wetzel R., and Xu Y. Molecular modeling of the core of Aβ amyloid fibrils. Proteins 57 (2004) 357-364
6. Kanaya E., Kanaya S., and Kikuchi M. Introduction of a non-native disulfide bridge to human lysozyme by cysteine scanning mutagenesis. Biochem. Biophys. Res. Commun. 173 (1991) 1194-1199
7. Kheterpal I., Williams A., Murphy C., Bledsoe B., and Wetzel R. Structural features of the Aβ amyloid fibril elucidated by limited proteolysis. Biochemistry 40 (2001) 11757-11767
8. Kheterpal I., Zhou S., Cook K.D., and Wetzel R. Abeta amyloid fibrils possess a core structure highly resistant to hydrogen exchange. Proc. Natl. Acad. Sci. USA 97 (2000) 13597-13601
9. LeVine H. Quantification of β-sheet amyloid fibril structures with thioflavin T. Methods Enzymol. 309 (1999) 274-284
10. Makin O.S., Atkins E., Sikorski P., Johansson J., and Serpell L.C. Molecular basis for amyloid fibril formation and stability. Proc. Natl. Acad. Sci. USA 102 (2005) 315-320
11. Matsumura M., Becktel W.J., Levitt M., and Matthews B.W. Stabilization of phage T4 lysozyme by engineered disulfide bonds. Proc. Natl. Acad. Sci. USA 86 (1989) 6562-6566
12. Means G.E., and Feeney R.E. "Chemical Modification of Proteins." (1971), Holden-Day, Inc, San Francisco, CA
13. Narimoto T., Sakurai K., Okamoto A., Chatani E., Hoshino M., Hasegawa K., Naiki H., and Goto Y. Conformational stability of amyloid fibrils of beta2-microglobulin probed by guanidine-hydrochloride-induced unfolding. FEBS Lett. 576 (2004) 313-319
14. Nelson R., Sawaya M.R., Balbirnie M., Madsen A.O., Riekel C., Grothe R., and Eisenberg D. Structure of the cross-beta spine of amyloid-like fibrils. Nature 435 (2005) 773-778
15. O'Nuallain B., Shivaprasad S., Kheterpal I., and Wetzel R. Thermodynamics of abeta(1-40) amyloid fibril elongation. Biochemistry 44 (2005) 12709-12718
16. O'Nuallain B., and Wetzel R. Conformational antibodies recognizing a generic amyloid fibril epitope. Proc. Natl. Acad. Sci. USA 99 (2002) 1485-1490
17. O'Nuallain B., Williams A.D., Westermark P., and Wetzel R. Seeding specificity in amyloid growth induced by heterologous fibrils. J. Biol. Chem. 279 (2004) 17490-17499
18. Pace C.N., Grimsley G.R., and Scholtz J.M. Denaturation of proteins by urea and guanidine hydrochloride. In: Buchner J., and Kiefhaber T. (Eds). "Protein Folding Handbook, Part I" Vol. 1 (2005), Wiley-VCH, Weinheim 45-69
19. Perry L.J., and Wetzel R. Disulfide bond engineered into T4 lysozyme: Stabilization of the protein toward thermal inactivation. Science 226 (1984) 555-557
20. Petkova A.T., Ishii Y., Balbach J.J., Antzutkin O.N., Leapman R.D., Delaglio F., and Tycko R. A structural model for Alzheimer's beta-amyloid fibrils based on experimental constraints from solid state NMR. Proc. Natl. Acad. Sci. USA 99 (2002) 16742-16747
21. Plunkett G., and Ryan C.A. Reduction and carboxamidomethylation of the single disulfide bond of proteinase inhibitor I from potato tubers. Effects on stability, immunological properties, and inhibitory activities. J. Biol. Chem. 255 (1980) 2752-2755
22. Shivaprasad S., and Wetzel R. An intersheet packing interaction in Aβ fibrils mapped by disulfide crosslinking. Biochemistry 43 (2004) 15310-15317
23. Shivaprasad S., and Wetzel R. Scanning cysteine mutagenesis analysis of Aβ(1-40) amyloid fibrils. J. Biol. Chem. 281 (2006) 993-1000
24. Tam J.P., Wu C.-R., Liu W., and Zhang J.-W. Disulfide bond formation in peptides in dimethyl sulfoxide. Scope and applications. J. Am. Chem. Soc. 113 (1991) 6657-6662
25. Wetzel R. Harnessing disulfide bonds using protein engineering. Trends Biochem. Sci. 12 (1987) 478-482
26. Whittemore N.A., Mishra R., Kheterpal I., Williams A.D., Wetzel R., and Serpersu E.H. Hydrogen-deuterium (H/D) exchange mapping of Aβ1-40 amyloid fibril secondary structure using NMR spectroscopy. Biochemistry 44 (2005) 4434-4441
27. Williams A.D., Portelius E., Kheterpal I., Guo J.T., Cook K.D., Xu Y., and Wetzel R. Mapping abeta amyloid fibril secondary structure using scanning proline mutagenesis. J. Mol. Biol. 335 (2004) 833-842
28. Williams A.D., Shivaprasad S., and Wetzel R. Alanine scanning mutagenesis of Aβ(1-40) amyloid fibril stability. J. Mol. Biol. 357 (2006) 1283-1294
29. Wood S.J., Wetzel R., Martin J.D., and Hurle M.R. Prolines and amyloidogenicity in fragments of the Alzheimer's peptide β/A4. Biochemistry 34 (1995) 724-730