Cocoa polyphenols suppress TNF-α-induced vascular endothelial growth factor expression by inhibiting phosphoinositide 3-kinase (PI3K) and mitogen-activated protein kinase kinase-1 (MEK1) activities in mouse epidermal cells

British Journal of Nutrition

Volumn 104, Issue 7, 2010, Pages 957-964

  Kim, Jong Eun ^a   Son, Joe Eun ^a   Jung, Sung Keun ^a,b   Kang, Nam Joo ^b,c   Lee, Chang Yong ^d   Lee, Ki Won ^b   Lee, Hyong Joo ^a  

^a Seoul National University   (South Korea)

^b Konkuk University   (South Korea)

^c Kyungpook National University   (South Korea)

^d Department of Molecular Biology and Genetics   (United States)

Author keywords

Cocoa polyphenols; Mitogen activated protein kinase kinase 1; Phosphoinositide 3 kinase; TNF :; Vascular endothelial growth factor

Indexed keywords

COCOA EXTRACT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PLANT EXTRACT; POLYPHENOL DERIVATIVE; PROTEIN KINASE B; S6 KINASE; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULOTROPIN; ANTIOXIDANT; FLAVONOID; MAP2K1 PROTEIN, MOUSE; PHENOL DERIVATIVE; POLYPHENOLS; VASCULOTROPIN A;

ANIMAL CELL; ARTICLE; CACAO; CONTROLLED STUDY; DRUG DETERMINATION; DRUG ISOLATION; DRUG MECHANISM; DRUG TARGETING; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; EPIDERMIS CELL; MOUSE; NONHUMAN; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; TRANSCRIPTION INITIATION; ANIMAL; CELL LINE; CHEMISTRY; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; EPIDERMIS; METABOLISM; PLANT SEED;

THEOBROMA CACAO;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTIOXIDANTS; CACAO; CELL LINE; EPIDERMIS; FLAVONOIDS; MAP KINASE KINASE 1; MICE; PHENOLS; PLANT EXTRACTS; SEEDS; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 77957908629     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114510001704     Document Type: Article

References (43)

1. Balkwill F (2002) Tumor necrosis factor or tumor promoting factor? Cytokine Growth Factor Rev 13, 135-141.
2. Locksley RM, Killeen N & Lenardo MJ (2001) The TNF and TNF receptor superfamilies: Integrating mammalian biology. Cell 104, 487-501.
3. MacEwan DJ (2002) TNF ligands and receptors - a matter of life and death. Br J Pharmacol 135, 855-875.
4. Ferrara N, Gerber HP & LeCouter J (2003) The biology of VEGF and its receptors. Nat Med 9, 669-676.
5. Larcher F, Murillas R, Bolontrade M, et al. (1998) VEGF/VPF overexpression in skin of transgenic mice induces angiogenesis, vascular hyperpermeability and accelerated tumor development. Oncogene 17, 303-311.
6. Borchers AT, Keen CL, Hannum SM, et al. (2000) Cocoa and chocolate: Composition, bioavailability, and health implications. J Med Food 3, 77-105.
7. Corti R, Flammer AJ, Hollenberg NK, et al. (2009) Cocoa and cardiovascular health. Circulation 119, 1433-1441.
8. Serafini M, Bugianesi R, Maiani G, et al. (2003) Plasma antioxidants from chocolate. Nature 424, 1013.
9. McShea A, Ramiro-Puig E, Munro SB, et al. (2008) Clinical benefit and preservation of flavonols in dark chocolate manufacturing. Nutr Rev 66, 630-641.
10. Lee KW, Kim YJ, Lee HJ, et al. (2003) Cocoa has more phenolic phytochemicals and a higher antioxidant capacity than teas and red wine. J Agric Food Chem 51, 7292-7295.
11. Lee KW, Hwang ES, Joo KN, et al. (2005) Extraction and chromatographic separation of anticarcinogenic fractions from cacao bean husk. BioFactors 23, 141-150.
12. Lee KW, Kundu JK, Sue OK, et al. (2006) Cocoa polyphenols inhibit phorbol ester-induced superoxide anion formation in cultured HL-60 cells and expression of cyclooxygenase-2 and activation of NF-kB andMAPKs in mouse skin in vivo. J Nutr 136, 1150-1155.
13. Lee KW, Kang NJ, Oak MH, et al. (2008) Cocoa procyanidins inhibit expression and activation of MMP-2 in vascular smooth muscle cells by direct inhibition of MEK and MT1-MMP activities. Cardiovasc Res 79, 34-41.
14. Kang NJ, Lee KW, Lee DE, et al. (2008) Cocoa procyanidins suppress transformation by inhibiting mitogen-activated protein kinase kinase. J Biol Chem 283, 20664-20673.
15. Kwon JY, Lee KW, Kim JE, et al. (2009) Delphinidin suppresses ultraviolet B-induced cyclooxygenases-2 expression through inhibition of MAPKK4 and PI-3 kinase. Carcinogenesis 30, 1932-1940.
16. Lee KW, Kang NJ, Rogozin EA, et al. (2007) Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1. Carcinogenesis 28, 1918-1927.
17. Nomura M,Kaji A,He Z, et al. (2001) Inhibitorymechanismsof tea polyphenols on the ultraviolet B-activated phosphatidylinositol 3-kinase-dependent pathway. J Biol Chem276, 46624-46631.
18. Lee KW, Kang NJ, Oak M-H, et al. (2008) Cocoa procyanidins inhibit expression and activation of MMP-2 in vascular smooth muscle cells by direct inhibition of MEK and MT1-MMP activities. Cardiovasc Res 79, 34-41.
19. Kang NJ, Lee KW, Lee DE, et al. (2008) Cocoa procyanidins suppress transformation by inhibiting mitogen-activated protein kinase kinase. J Biol Chem 283, 20664-20673.
20. 41 cells. J Cell Sci 119, 2985-2994.
21. Arnott CH, Scott KA, Moore RJ, et al. (2004) Expression of both TNF-a receptor subtypes is essential for optimal skin tumour development. Oncogene 23, 1902-1910.
22. Moore RJ, Owens DM, Stamp G, et al. (1999) Mice deficient in tumor necrosis factor-a are resistant to skin carcinogenesis. Nat Med 5, 828-831.
23. Scott KA, Moore RJ, Arnott CH, et al. (2003) An anti-tumor necrosis factor-a antibody inhibits the development of experimental skin tumors. Mol Cancer Ther 2, 445-451.
24. Kim JE, Kwon JY, Seo SK, et al. (2010) Cyanidin suppresses ultraviolet B-induced COX-2 expression in epidermal cells by targeting MKK4, MEK1, and Raf-1. Biochem Pharmacol 79, 1473-1482.
25. Choi KH, Kim J-E, Song NR, et al. (2010) Phosphoinositide- 3-kinase is a novel target of piceatannol for inhibiting PDGFBB- induced proliferation and migration in human aortic smooth muscle cells. Cardiovasc Res 85, 836-844.
26. Taubert D, Roesen R, Lehmann C, et al. (2007) Effects of low habitual cocoa intake on blood pressure and bioactive nitric oxide: A randomized controlled trial. JAMA 298, 49-60.
27. Spadafranca A, Martinez Conesa C, Sirini S, et al. (2010) Effect of dark chocolate on plasma epicatechin levels, DNA resistance to oxidative stress and total antioxidant activity in healthy subjects. Br J Nutr 103, 1008-1014.
28. Schroeter H, Heiss C, Balzer J, et al. (2006) (2)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans. Proc Natl Acad Sci U S A 103, 1024-1029.
29. Yamagishi M, Natsume M, Osakabe N, et al. (2002) Effects of cacao liquor proanthocyanidins on PhIP-induced mutagenesis in vitro, and in vivo mammary and pancreatic tumorigenesis in female Sprague-Dawley rats. Cancer Lett 185, 123-130.
30. Yamagishi M, Natsume M, Osakabe N, et al. (2003) Chemoprevention of lung carcinogenesis by cacao liquor proanthocyanidins in a male rat multi-organ carcinogenesis model. Cancer Lett 191, 49-57.
31. Osakabe N, Yamagishi M, Natsume M, et al. (2000) Antioxidative polyphenolic substances in cacao liquor. ACS Symp Ser 754, 88-101.
32. Szlosarek P, Charles KA & Balkwill FR (2006) Tumour necrosis factor-a as a tumour promoter. Eur J Cancer 42, 745-750.
33. Jośko J & Mazurek M (2004) Transcription factors having impact on vascular endothelial growth factor (VEGF) gene expression in angiogenesis. Med Sci Monit 10, RA89-RA98.
34. Shibata A, Nagaya T, Imai T, et al. (2002) Inhibition of NF-kB activity decreases the VEGF mRNA expression in MDA-MB-231 breast cancer cells. Breast Cancer Res Treat 73, 237-243.
35. Lee CC, Chen SC, Tsai SC, et al. (2006) Hyperbaric oxygen induces VEGF expression through ERK, JNK and c-Jun/AP-1 activation in human umbilical vein endothelial cells. J Biomed Sci 13, 143-156.
36. Ouyang W, Li J, Shi X, et al. (2005) Essential role of PI-3K, ERKs and calcium signal pathways in nickel-induced VEGF expression. Mol Cell Biochem 279, 35-43.
37. Sebolt-Leopold JS & English JM (2006) Mechanisms of drug inhibition of signalling molecules. Nature 441, 457-462.
38. Walker EH, Pacold ME, Perisic O, et al. (2000) Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine. Mol Cell 6, 909-919.
39. Cortes JR, Perez GM, Rivas MD, et al. (2007) Kaempferol inhibits IL-4-induced STAT6 activation by specifically targeting JAK3. J Immunol 179, 3881-3887.
40. Kang NJ, Lee KW, Rogozin EA, et al. (2007) Equol, a metabolite of the soybean isoflavone daidzein, inhibits neoplastic cell transformation by targeting the MEK/ERK/p90RSK/activator protein-1 pathway. J Biol Chem282, 32856-32866.
41. Raynaud FI, Eccles S, Clarke PA, et al. (2007) Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases. Cancer Res 67, 5840-5850.
42. Kim JE, Kwon JY, Lee DE, et al. (2009) MKK4 is a novel target for the inhibition of tumor necrosis factor-a-induced vascular endothelial growth factor expression by myricetin. Biochem Pharmacol 77, 412-421.
43. Vogt PK & Kang S (2006) Kinase inhibitors: Vice becomes virtue. Cancer Cell 9, 327-328.