ABCA7: A potential mediator between cholesterol homeostasis and the host defense system

Clinical Lipidology

Volumn 7, Issue 6, 2012, Pages 677-687

  Abe Dohmae, Sumiko ^a   Yokoyama, Shinji ^b  

^a NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^b CHUBU UNIVERSITY   (Japan)

Author keywords

ABCA1; ABCA7; Alzheimer's disease; apolipoprotein; cholesterol; HDL; phagocytosis; SREBP2; statin

Indexed keywords

ABC TRANSPORTER A1; ABC TRANSPORTER A7; CARRIER PROTEINS AND BINDING PROTEINS; CHOLESTEROL; MESSENGER RNA; UNCLASSIFIED DRUG;

ABC TRANSPORTER A1 GENE; ABC TRANSPORTER A7 GENE; CELL TYPE; CHOLESTEROL HOMEOSTASIS; GENE EXPRESSION REGULATION; GENE LOCUS; GENE STRUCTURE; GENETIC VARIABILITY; HOMEOSTASIS; HOST RESISTANCE; HUMAN; INTRACELLULAR TRANSPORT; LIPID TRANSPORT; NONHUMAN; PHAGOCYTOSIS AND RELATED PHENOMENA; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PROCESSING; REVIEW; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; STRUCTURAL HOMOLOGY; TRANSCRIPTION REGULATION;

EID: 84871382611     PISSN: 17584299     EISSN: 17584302     Source Type: Journal    
DOI: 10.2217/clp.12.67     Document Type: Review

References (55)

1. Dean M, Rzhetsky A, Allikmets R. The human ATP-binding cassette (ABC) transporter superfamily. Genome Res. 11(7), 1156-1166 (2001). (Pubitemid 32677289)
2. Tanaka AR, Ikeda Y, Abe-Dohmae S et al. Human ABCA1 contains a large amino-terminal extracellular domain homologous to an epitope of Sjogren's syndrome. Biochem. Biophys. Res. Commun. 283(5), 1019-1025 (2001). (Pubitemid 32912869)
3. Ikeda Y, Abe-Dohmae S, Munehira Y et al. Posttranscriptional regulation of human ABCA7 and its function for the apoA-I-dependent lipid release. Biochem. Biophys. Res. Commun. 311(2), 313-318 (2003). (Pubitemid 37340078)
4. Tanaka AR, Abe-Dohmae S, Ohnishi T et al. Effects of mutations of ABCA1 in the first extracellular domain on subcellular trafficking and ATP binding/hydrolysis. J. Biol Chem. 278(10), 8815-8819 (2003). (Pubitemid 36800640)
5. Brooks-Wilson A, Marcil M, Clee SM et al. Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency. Nat. Genet. 22(4), 336-345 (1999). (Pubitemid 29369523)
6. Bodzioch M, Orso E, Klucken J et al. The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease. Nat. Genet. 22(4), 347-351 (1999). (Pubitemid 29369524)
7. Rust S, Rosier M, Funke H et al. Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1. Nat. Genet. 22(4), 352-355 (1999). (Pubitemid 29369525)
8. Marcil M, Brooks-Wilson A, Clee SM et al. Mutations in the ABC 1 gene in familial HDL deficiency with defective cholesterol efflux. Lancet 354(9187), 1341-1346 (1999). (Pubitemid 29481630)
9. Remaley AT, Rust S, Rosier M et al. Human ATP-binding cassette transporter 1 (ABC1): genomic organization and identification of the genetic defect in the original Tangier disease kindred. Proc. Natl Acad. Sci. USA 96(22), 12685-12690 (1999). (Pubitemid 29513563)
10. Kaminski WE, Orso E, Diederich W, Klucken J, Drobnik W, Schmitz G. Identification of a novel human sterol-sensitive ATP-binding cassette transporter (ABCA7). Biochem. Biophys. Res. Commun. 273(2), 532-538 (2000). (Pubitemid 30599020)
11. Broccardo C, Osorio J, Luciani MF et al. Comparative analysis of the promoter structure and genomic organization of the human and mouse ABCA7 gene encoding a novel ABCA transporter. Cytogenet. Cell Genet. 92(3-4), 264-270 (2001). (Pubitemid 32642005)
12. Iwamoto N, Abe-Dohmae S, Sato R, Yokoyama S. ABCA7 expression is regulated by cellular cholesterol through the SREBP2 pathway and associated with phagocytosis. J. Lipid Res. 47(9), 1915-1927 (2006). (Pubitemid 44401979)
13. Tanaka N, Abe-Dohmae S, Iwamoto N, Fitzgerald ML, Yokoyama S. HMG-CoA reductase inhibitors enhance phagocytosis by upregulating ATP-binding cassette transporter A7. Atherosclerosis 217(2), 407-414 (2011).
14. Kaminski WE, Piehler A, Schmitz G. Genomic organization of the human cholesterol-responsive ABC transporter ABCA7: tandem linkage with the minor histocompatibility antigen HA-1 gene. Biochem. Biophys. Res. Commun. 278(3), 782-789 (2000).
15. Costet P, Luo Y, Wang N, Tall AR. Steroldependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor. J. Biol Chem. 275(36), 28240-28245 (2000).
16. Tamehiro N, Shigemoto-Mogami Y, Kakeya T et al. Sterol regulatory element-binding protein-2- and liver X receptor-driven dual promoter regulation of hepatic ABC transporter A1 gene expression: mechanism underlying the unique response to cellular cholesterol status. J. Biol Chem. 282(29), 21090-21099 (2007). (Pubitemid 47099939)
17. Ohoka N, Okuhira K, Cui H et al. HNF4alpha increases liver-specific human ATP-binding cassette transporter A1 expression and cholesterol efflux to apolipoprotein A-I in response to cholesterol depletion. Arterioscler. Thromb. Vasc. Biol. 32(4), 1005-1014 (2012).
18. Kim WS, Fitzgerald ML, Kang K et al. Abca7 null mice retain normal macrophage phosphatidylcholine and cholesterol efflux activity despite alterations in adipose mass and serum cholesterol levels. J. Biol Chem. 280(5), 3989-3995 (2005). (Pubitemid 40223868)
19. Linsel-Nitschke P, Jehle AW, Shan J et al. Potential role of ABCA7 in cellular lipid efflux to apoA-I. J. Lipid Res. 46(1), 86-92 (2005). (Pubitemid 40066674)
20. Meurs I, Calpe-Berdiel L, Habets KL et al. Effects of deletion of macrophage ABCA7 on lipid metabolism and the development of atherosclerosis in the presence and absence of ABCA1. PLoS ONE 7(3), e30984 (2012).
21. Hollingworth P, Harold D, Sims R et al. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat. Genet. 43(5), 429-435 (2011).
22. Naj AC, Jun G, Beecham GW et al. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat. Genet. 43(5), 436-441 (2011).
23. Schellenberg GD, Montine TJ. The genetics and neuropathology of Alzheimer's disease. Acta Neuropathol. 124(3), 305-323 (2012).
24. Chen X, Sun C, Chen Q et al. Apoptotic engulfment pathway and schizophrenia. PLoS ONE 4(9), e6875 (2009).
25. Oram JF, Heinecke JW. ATP-binding cassette transporter A1: a cell cholesterol exporter that protects against cardiovascular disease. Physiol. Rev. 85(4), 1343-1372 (2005). (Pubitemid 41362273)
26. Wang N, Lan D, Gerbod-Giannone M et al. ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux. J. Biol Chem. 278(44), 42906-42912 (2003). (Pubitemid 37345901)
27. Tachikawa M, Watanabe M, Hori S et al. Distinct spatio-temporal expression of ABCA and ABCG transporters in the developing and adult mouse brain. J. Neurochem. 95(1), 294-304 (2005). (Pubitemid 41384447)
28. Kim WS, Guillemin GJ, Glaros EN, Lim CK, Garner B. Quantitation of ATP-binding cassette subfamily-A transporter gene expression in primary human brain cells. Neuroreport 17(9), 891-896 (2006). (Pubitemid 43869954)
29. Sasaki M, Shoji A, Kubo Y, Nada S, Yamaguchi A. Cloning of rat ABCA7 and its preferential expression in platelets. Biochem. Biophys. Res. Commun. 304(4), 777-782 (2003). (Pubitemid 36513556)
30. Niessen J, Jedlitschky G, Grube M et al. Expression of ABC-type transport proteins in human platelets. Pharmacogenet. Genomics 20(6), 396-400 (2010).
31. Morales CR, Marat AL, Ni X et al. ATPbinding cassette transporters ABCA1, ABCA7, and ABCG1 in mouse spermatozoa. Biochem. Biophys. Res. Commun. 376(3), 472-477 (2008).
32. Abe-Dohmae S, Ikeda Y, Matsuo M et al. Human ABCA7 supports apolipoprotein-mediated release of cellular cholesterol and phospholipid to generate high density lipoprotein. J. Biol Chem. 279(1), 604-611 (2004). (Pubitemid 38044864)
33. Arakawa R, Yokoyama S. Helical apolipoproteins stabilize ATP-binding cassette transporter A1 by protecting it from thiol protease-mediated degradation. J. Biol Chem. 277(25), 22426-22429 (2002). (Pubitemid 34967213)
34. Wang N, Chen W, Linsel-Nitschke P et al. A PEST sequence in ABCA1 regulates degradation by calpain protease and stabilization of ABCA1 by apoA-I. J. Clin. Invest. 111(1), 99-107 (2003). (Pubitemid 36134853)
35. Lu R, Arakawa R, Ito-Osumi C, Iwamoto N, Yokoyama S. ApoA-I facilitates ABCA1 recycle/accumulation to cell surface by inhibiting its intracellular degradation and increases HDL generation. Arterioscler. Thromb. Vasc. Biol. 28(10), 1820-1824 (2008).
36. Tanaka N, Abe-Dohmae S, Iwamoto N, Fitzgerald ML, Yokoyama S. Helical apolipoproteins of high-density lipoprotein enhance phagocytosis by stabilizing ATP-binding cassette transporter A7. J. Lipid Res. 51(9), 2591-2599 (2010).
37. Jehle AW, Gardai SJ, Li S et al. ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages. J. Cell Biol. 174(4), 547-556 (2006).
38. Abe-Dohmae S, Ueda K, Yokoyama S. ABCA7, a molecule with unknown function. FEBS Lett. 580(4), 1178-1182 (2006). (Pubitemid 43185297)
39. Hayashi M, Abe-Dohmae S, Okazaki M, Ueda K, Yokoyama S. Heterogeneity of high density lipoprotein generated by ABCA1 and ABCA7. J. Lipid Res. 46(8), 1703-1711 (2005). (Pubitemid 41099337)
40. Abe-Dohmae S, Kato KH, Kumon Y et al. Serum amyloid A generates high density lipoprotein with cellular lipid in an ABCA1- or ABCA7-dependent manner. J. Lipid Res. 47(7), 1542-1550 (2006). (Pubitemid 44079909)
41. Chan SL, Kim WS, Kwok JB et al. ATP-binding cassette transporter A7 regulates processing of amyloid precursor protein in vitro. J. Neurochem. 106(2), 793-804 (2008).
42. Wang N, Lan D, Chen W, Matsuura F, Tall AR. ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins. Proc. Natl Acad. Sci. USA 101(26), 9774-9779 (2004). (Pubitemid 38869312)
43. Christiansen-Weber TA, Voland JR, Wu Y et al. Functional loss of ABCA1 in mice causes severe placental malformation, aberrant lipid distribution, and kidney glomerulonephritis as well as high-density lipoprotein cholesterol deficiency. Am. J. Pathol. 157(3), 1017-1029 (2000). (Pubitemid 32109393)
44. McNeish J, Aiello RJ, Guyot D et al. High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1. Proc. Natl Acad. Sci. USA 97(8), 4245-4250 (2000). (Pubitemid 30226118)
45. Davis BK. Timing of fertilization in mammals: sperm cholesterol/ phospholipid ratio as a determinant of the capacitation interval. Proc. Natl Acad. Sci. USA 78(12), 7560-7564 (1981). (Pubitemid 12186182)
46. Visconti PE, Krapf D, de la Vega-Beltrán JL, Acevedo JJ, Darszon A. Ion channels, phosphorylation and mammalian sperm capacitation. Asian J. Androl. 13(3), 395-405 (2011).
47. Castoreno AB, Wang Y, Stockinger W et al. Transcriptional regulation of phagocytosis-induced membrane biogenesis by sterol regulatory element binding proteins. Proc. Natl Acad. Sci. USA 102(37), 13129-13134 (2005). (Pubitemid 41324990)
48. Tanaka N, Abe-Dohmae S, Iwamoto N, Yokoyama S. Roles of ATP-binding cassette transporter A7 in cholesterol homeostasis and host defense system. J. Atheroscler. Thromb. 18(4), 274-281 (2011).
49. Bu G. Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy. Nat. Rev. Neurosci. 10(5), 333-344 (2009).
50. Chen X, Wang X, Chen Q et al. MEGF10 association with schizophrenia. Biol Psychiatry 63(5), 441-448 (2008).
51. Suzuki E, Nakayama M. MEGF10 is a mammalian ortholog of CED-1 that interacts with clathrin assembly protein complex 2 medium chain and induces large vacuole formation. Exp. Cell Res. 313(17), 3729-3742 (2007). (Pubitemid 47464230)
52. Liu QA, Hengartner MO. Human CED-6 encodes a functional homologue of the Caenorhabditis elegans engulfment protein CED-6. Curr. Biol. 9(22), 1347-1350 (1999).
53. Ellis RE, Jacobson DM, Horvitz HR. Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans. Genetics 129(1), 79-94 (1991).
54. Okuhira K, Tsujita M, Yamauchi Y et al. Potential involvement of dissociated apoA-I in the ABCA1-dependent cellular lipid release by HDL. J. Lipid Res. 45(4), 645-652 (2004). (Pubitemid 38405670)
55. Arakawa R, Hayashi M, Remaley AT, Brewer BH, Yamauchi Y, Yokoyama S. Phosphorylation and stabilization of ATP binding cassette transporter A1 by synthetic amphiphilic helical peptides. J. Biol Chem. 279(8), 6217-6220 (2004). (Pubitemid 38248753)