Proteomic analysis of mouse models of Niemann-Pick C disease reveals alterations in the steady-state levels of lysosomal proteins within the brain

Proteomics

Volumn 12, Issue 23-24, 2012, Pages 3499-3509

  Sleat, David E ^a,b   Wiseman, Jennifer A ^a   Sohar, Istvan ^a   El Banna, Mukarram ^a   Zheng, Haiyan ^a   Moore, Dirk F ^c   Lobel, Peter ^a,b  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

Author keywords

Cell biology; Lysosome; Mannose 6 phosphate; Mouse; Niemann Pick C; Spectral counting

Indexed keywords

BETA N ACETYLHEXOSAMINIDASE; GLYCOSIDASE; GLYCOSPHINGOLIPID; LYSOSOME PROTEIN; MANNOSE 6 PHOSPHATE; PROSAPOSIN; PROTEIN; PROTEINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; DISEASE ASSOCIATION; EXPERIMENTAL MODEL; LIPOLYSIS; LIQUID CHROMATOGRAPHY; MOUSE; NIEMANN PICK C DISEASE; NIEMANN PICK DISEASE; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEOMICS; STEADY STATE; TANDEM MASS SPECTROMETRY;

ANIMALS; BRAIN; GENE DELETION; MICE; MICE, INBRED BALB C; NIEMANN-PICK DISEASES; PROTEINS; PROTEOMICS; TANDEM MASS SPECTROMETRY; TRANSCRIPTOME; VESICULAR TRANSPORT PROTEINS;

MUS;

EID: 84871348271     PISSN: 16159853     EISSN: 16159861     Source Type: Journal    
DOI: 10.1002/pmic.201200205     Document Type: Article

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