Identification of heat shock protein 27 as a radioresistance-related protein in nasopharyngeal carcinoma cells

Journal of Cancer Research and Clinical Oncology

Volumn 138, Issue 12, 2012, Pages 2117-2125

  Zhang, Bin ^a   Qu, Jia Quan ^b   Xiao, Liang ^b   Yi, Hong ^b   Zhang, Peng Fei ^b   Li, Mao Yu ^b   Hu, Rong ^b   Wan, Xun Xun ^b   He, Qiu Yan ^b   Li, Jian Huang ^b   Ye, Xu ^b   Xiao, Zhi Qiang ^b   Feng, Xue Ping ^b  

^a Central South University   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Heat shock protein 27; Nasopharyngeal carcinoma; Proteomics; Radioresistance

Indexed keywords

HEAT SHOCK PROTEIN 27;

AMINO ACID SEQUENCE; APOPTOSIS; ARTICLE; CARCINOMA CELL; CELL GROWTH; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; IONIZING RADIATION; NASOPHARYNX CARCINOMA; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEOMICS; RADIATION DOSE; RADIOSENSITIVITY; UPREGULATION; WESTERN BLOTTING;

APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; CELL SURVIVAL; DOWN-REGULATION; HSP27 HEAT-SHOCK PROTEINS; HUMANS; NASOPHARYNGEAL NEOPLASMS; PROTEOMICS; RADIATION TOLERANCE; UP-REGULATION;

EID: 84871327738     PISSN: 01715216     EISSN: 14321335     Source Type: Journal    
DOI: 10.1007/s00432-012-1293-0     Document Type: Article

References (36)

1. Avanzo M, Stancanello J, Franchin G, Sartor G, Jena R, Drigo A et al (2010) Correlation of a hypoxia based tumor control model with observed local control rates in nasopharyngeal carcinoma treated with chemoradiotherapy. Med Phys 37:1533-1544
2. Bruey JM, Ducasse C, Bonniaud P, Ravagnan L, Susin SA, Diaz- Latoud C et al (2000) Hsp27 negatively regulates cell death by interacting with cytochrome c. Nat Cell Biol 2:645-652
3. Calderwood SK, Khaleque MA, Sawyer DB, Ciocca DR (2006) Heat shock proteins in cancer: chaperones of tumorigenesis. Trends Biochem Sci 31:164-172
4. Caponigro F, Longo F, Ionna F, Perri F (2010) Treatment approaches to nasopharyngeal carcinoma: a review. Anticancer Drugs 21:471-477
5. Chang JT, Chan SH, Lin CY, Lin TY, Wang HM, Liao CT et al (2007) Differentially expressed genes in radioresistant nasopharyngeal cancer cells: gp96 and GDF15. Mol Cancer Ther 6:2271-2279
6. Choi SH, Lee YJ, Seo WD, Lee HJ, Nam JW, Lee YJ et al (2011) Altered cross-linking of HSP27 by zerumbone as a novel strategy for overcoming HSP27-mediated radioresistance. Int J Radiat Oncol Biol Phys 79:1196-1205
7. Ciocca DR, Calderwood SK (2005) Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications. Cell Stress Chaperones 10:86-103
8. Ciocca DR, Oesterreich S, Chamness GC, McGuire WL, Fuqua SA (1993) Biological and clinical implications of heat shock protein 27,000 (Hsp27): a review. J Natl Cancer Inst 85:558-1570
9. Ehrnsperger M, Gräber S, Gaestel M, Buchner J (1997) Binding of non-native protein to Hsp25 during heat shock creates a reservoir of folding intermediates for reactivation. EMBO J 16:221-229
10. Ekedahl J, Joseph B, Marchetti P, Fauvel H, Formstecher P, Lewensohn R et al (2003) Heat shock protein 72 does not modulate ionizing radiation-induced apoptosis in U1810 nonsmall cell lung carcinoma cells. Cancer Biol Ther 2:663-669
11. Feng XP, Yi H, Li MY, Li XH, Yi B, Zhang PF et al (2010) Identification of biomarkers for predicting nasopharyngeal carcinoma response to radiotherapy by proteomics. Cancer Res 70:3450-3462
12. Fortin A, Raybaud-Diogéne H, Têtu B, Deschenes R, Huot J, Landry J (2000) Overexpression of the 27 kDa heat shock protein is associated with thermoresistance and chemoresistance but not with radioresistance. Int J Radiat Oncol Biol Phys 46:1259-1266
13. Garrido C, Gurbuxani S, Ravagnan L, Kroemer G (2001) Heat shock proteins: endogenous modulators of apoptotic cell death. Biochem Biophys Res Commun 286:433-442
14. Gudkov AV, Komarova EA (2003) The role of p53 in determining sensitivity to radiotherapy. Nat Rev Cancer 3:117-129
15. Jayasurya A, Bay BH, Yap WM, Tan NG (2000) Correlation of metallothionein expression with apoptosis in nasopharyngeal carcinoma. Br J Cancer 82:1198-1203
16. Konishi H, Matsuzaki H, Tanaka M, Takemura Y, Kuroda S, Ono Y et al (1997) Activation of protein kinase B (Akt/RAC-protein kinase) by cellular stress and its association with heat shock protein Hsp27. FEBS Lett 410:493-498
17. Kristensen CA, Kjaer-Kristoffersen F, Sapru W, Berthelsen AK, Loft A, Specht L (2007) Nasopharyngeal carcinoma. Treatment planning with IMRT and 3D conformal radiotherapy. Acta Oncol 46:214-220
18. Lee AW, Poon YF, Foo W, Law SC, Cheung FK, Chan DK, Tung SY (1992) Retrospective analysis of 5037 patients with nasopharyngeal carcinoma treated during 1976-1985: overall survival and patterns of failure. Int J Radiat Oncol Biol Phys 23:261-270
19. Lee AW, Tung SY, Chua DT, Ngan RK, Chappell R, Tung R et al (2010) Randomized trial of radiotherapy plus concurrent-adjuvant chemotherapy vs radiotherapy alone for regionally advanced nasopharyngeal carcinoma. J Natl Cancer Inst 102:1188-1198
20. Lee HJ, Kim EH, Seo WD, Choi TH, Cheon GJ, Lee YJ et al (2011) Heat shock protein 27-targeted heptapeptide of the PKCDelta catalytic V5 region sensitizes tumors with radio- and chemoresistance. Int J Radiat Oncol Biol Phys 80:221-230
21. Leung SF, Teo PM, Shiu WW, Tsao SY, Leung TW (1991) Clinical features and management of distant metastases of nasopharyngeal carcinoma. J Otolaryngol 20:27-29
22. Liu XF, Xia YF, Li MZ, Wang HM, He YX, Zheng ML et al (2006) The effect of p21 antisense oligodeoxynucleotides on the radiosensitivity of nasopharyngeal carcinoma cells with normal p53 function. Cell Biol Int 30:283-287
23. Lu ZX, Ma XQ, Yang LF, Wang ZL, Zeng L, Li ZJ et al (2008) DNAzymes targeted to EBV-encoded latent membrane protein-1 induce apoptosis and enhance radiosensitivity in nasopharyngeal carcinoma. Cancer Lett 265:226-238
24. Ma X, Yang L, Xiao L, Tang M, Liu L, Li Z et al (2011) Downregulation of EBV-LMP1 radio-sensitizes nasopharyngeal carcinoma cells via NF-jB regulated ATM expression. PLoS One 6:e24647
25. Maliutina IaV, Kabakov AE (2007) Pre irradiation heat shock protein induction increases cellular radioresistance. Radiats Biol Radioecol 47:273-279
26. Mehlen P, Kretz-Remy C, Preville X, Arrigo AP (1996) Human hsp27, Drosophila hsp27 and human alphaB-crystallin expression- mediated increase in glutathione is essential for the protective activity of these proteins against TNFalpha-induced cell death. EMBO J 15:2695-2706
27. Ong YK, Solares CA, Lee S, Snyderman CH, Fernandez-Miranda J, Gardner PA (2011) Endoscopic nasopharyngectomy and its role in managing locally recurrent nasopharyngeal carcinoma. Otolaryngol Clin North Am 44:1141-1154
28. Rocchi P, So A, Kojima S, Signaevsky M, Beraldi E, Fazli L et al (2004) Heat shock protein 27 increases after androgen ablation and plays a cytoprotective role in hormone-refractory prostate cancer. Cancer Res 64:6595-6602
29. Teo P, Yu P, Lee WY, Leung SF, Kwan WH, Yu KH et al (1996) Significant prognosticators after primary radiotherapy in 903 non disseminated nasopharyngeal carcinoma evaluated by computer tomography. Int J Radiat Oncol Biol Phys 36:291-304
30. Trautinger F, Kokesch C, Herbacek I, Knobler RM, Kindas-Mugge I (1997) Overexpression of the small heat shock protein, hsp27, confers resistance to hyperthermia, but not to oxidative stress and UV-induced cell death, in a stably transfected squamous cell carcinoma cell line. J Photochem Photobiol, B 39:90-95
31. Wano C, Kita K, Takahashi S, Sugaya S, Hino M, Hosoya H et al (2004) Protective role of HSP27 against UVC-induced cell death in human cells. Exp Cell Res 298:584-592
32. Yang YX, Xiao ZQ, Chen ZC, Zhang GY, Yi H, Zhang PF et al (2006) Proteome analysis of multidrug resistance in vincristineresistant human gastric cancer cell line SGC7901/VCR. Proteomics 6:2009-2021
33. Yang S, Wu J, Zuo Y, Tan L, Jia H, Yan H et al (2010) ZD6474, a small molecule tyrosine kinase inhibitor, potentiates the anti-tumor and anti-metastasis effects of radiation for human nasopharyngeal carcinoma. Curr Cancer Drug Targets 10:611-622
34. Zhang Z, Zhu W, Zhang J, Guo L (2011) Tyrosine kinase Etk/BMX protects nasopharyngeal carcinoma cells from apoptosis induced by radiation. Cancer Biol Ther 11:690-698
35. Zhou BB, Elledge SJ (2000) The DNA damage response: putting checkpoints in perspective. Nature 408:433-439
36. Zhuang H, Jiang W, Cheng W, Qian K, Dong W, Cao L et al (2010) Down-regulation of HSP27 sensitizes TRAIL-resistant tumor cell to TRAIL-induced apoptosis. Lung Cancer 68:27-38